Katherine Gibson-Corley, DVM, PhD

Portrait
Director, Comparative Pathology Laboratory
Associate Professor of Pathology

Contact Information

Primary Office
1167 Medical Laboratories
Iowa City, IA 52242
319-384-4430

Education

BA, Biology and Molecular Biology, St. Olaf College, Northfield, MN
DVM, Iowa State University College of Veterinary Medicine
PhD, Veterinary Pathology, Iowa State University College of Veterinary Medicine
Resident, Veterinary Pathology (Anatomic), Department of Veterinary Pathology, Iowa State University

Research Summary

Interests: Animal models, Comparative pathology, Rodent pathology, Neuropathology, Adaptive immunity, Infectious diseases, Immunoparasitology.

Publications

Caswell, J. L., Bassel, L. L., Rothenburger, J. L., Gröne, A., Sargeant, J. M., Beck, A. P., Ekman, S., Gibson-Corley, K. N., Kuiken, T., LaDouceur EEB,, Meyerholz, D. K., Origgi, F. C., Posthaus, H., Priestnall, S. L., Ressel, L., Sharkey, L., Teixeira LBC,, Uchida, K., Ward, J. M., Webster, J. D. & Yamate, J. (2018). Observational Study Design in Veterinary Pathology, Part 1: Study Design. Veterinary pathology, 55(5), 607-621. PMID: 30071806.

Meyerholz, D. K., Stoltz, D. A., Gansemer, N. D., Ernst, S. E., Cook, D. P., Strub, M. D., LeClair, E. N., Barker, C. K., Adam, R. J., Leidinger, M. R., Gibson-Corley, K. N., Karp, P. H., Welsh, M. J. & McCray, Jr, P. B. (2018). Lack of cystic fibrosis transmembrane conductance regulator disrupts fetal airway development in pigs. Laboratory investigation; a journal of technical methods and pathology, 98(6), 825-838. PMID: 29467455.

Sandgren, J. A., Linggonegoro, D. W., Zhang, S. Y., Sapouckey, S. A., Claflin, K. E., Pearson, N. A., Leidinger, M. R., Pierce, G. L., Santillan, M. K., Gibson-Corley, K. N., Sigmund, C. D. & Grobe, J. L. (2018). Angiotensin AT1A receptors expressed in vasopressin-producing cells of the supraoptic nucleus contribute to osmotic control of vasopressin. American journal of physiology. Regulatory, integrative and comparative physiology, 314(6), R770-R780. PMID: 29364700.

Perschbacher, K. J., Deng, G., Fisher, R. A., Gibson-Corley, K. N., Santillan, M. K. & Grobe, J. L. (2018). Regulators of G-Protein Signaling in Cardiovascular Function During Pregnancy. Physiological genomics. PMID: 29702036.

Rauckhorst, A. J., Gray, L. R., Sheldon, R. D., Fu, X., Pewa, A. D., Feddersen, C. R., Dupuy, A. J., Gibson-Corley, K. N., Cox, J. E., Burgess, S. C. & Taylor, E. B. (2017). The mitochondrial pyruvate carrier mediates high fat diet-induced increases in hepatic TCA cycle capacity. Molecular metabolism, 6(11), 1468-1479. PMID: 29107293.

Grinnage-Pulley, T. L., Kabotso DEK,, Rintelmann, C. L., Roychoudhury, R., Schaut, R. G., Toepp, A. J., Gibson-Corley, K. N., Parrish, M., Pohl NLB, & Petersen, C. A. (2017). Leishmania-derived trimannose modulates inflammatory response to significantly reduce Leishmania (L.) major-induced lesions. Infection and immunity. PMID: 29061708.

Mangalam, A., Shahi, S. K., Luckey, D., Karau, M., Marietta, E., Luo, N., Choung, R. S., Ju, J., Sompallae, R., Gibson-Corley, K., Patel, R., Rodriguez, M., David, C., Taneja, V. & Murray, J. (2017). Human Gut-Derived Commensal Bacteria Suppress CNS Inflammatory and Demyelinating Disease. Cell reports, 20(6), 1269-1277. PMID: 28793252.

Itani, F. R., Sinha, S., Brate, A. A., Pewe, L. L., Gibson-Corley, K. N., Harty, J. T. & Karandikar, N. J. (2017). Suppression of autoimmune demyelinating disease by preferential stimulation of CNS-specific CD8 T cells using Listeria-encoded neuroantigen. Scientific reports, 7(1), 1519. PMID: 28484224.

Claflin, K. E., Sandgren, J. A., Lambertz, A. M., Weidemann, B. J., Littlejohn, N. K., Burnett, C. M., Pearson, N. A., Morgan, D. A., Gibson-Corley, K. N., Rahmouni, K. & Grobe, J. L. (2017). Angiotensin AT1A receptors on leptin receptor-expressing cells control resting metabolism. The Journal of clinical investigation, 127(4), 1414-1424. PMID: 28263184.

Varzavand, A., Hacker, W., Ma, D., Gibson-Corley, K., Hawayek, M., Tayh, O. J., Brown, J. A., Henry, M. D. & Stipp, C. S. (2016). a3ß1 Integrin Suppresses Prostate Cancer Metastasis via Regulation of the Hippo Pathway. Cancer research, 76(22), 6577-6587. PMID: 27680681.

Stanam, A., Gibson-Corley, K. N., Love-Homan, L., Ihejirika, N. & Simons, A. L. (2016). Interleukin-1 blockade overcomes erlotinib resistance in head and neck squamous cell carcinoma. Oncotarget, 7(46), 76087-76100. PMID: 27738319.

Wilson, S., Abode-Iyamah, K. O., Miller, J. W., Reddy, C. G., Safayi, S., Fredericks, D. C., Jeffery, N. D., DeVries-Watson, N. A., Shivapour, S. K., Viljoen, S., Dalm, B. D., Gibson-Corley, K. N., Johnson, M. D., Gillies, G. T. & Howard, 3rd, M. A. (2016). An ovine model of spinal cord injury. The journal of spinal cord medicine, 1-15. PMID: 27759502.

Wang, Y., Cao, Y., Mangalam, A. K., Guo, Y., LaFrance-Corey, R. G., Gamez, J. D., Atanga, P. A., Clarkson, B. D., Zhang, Y., Wang, E., Angom, R. S., Dutta, K., Ji, B., Pirko, I., Lucchinetti, C. F., Howe, C. L. & Mukhopadhyay, D. (2016). Neuropilin-1 modulates interferon-?-stimulated signaling in brain microvascular endothelial cells. Journal of cell science, 129(20), 3911-3921. PMID: 27591257.

Xiu, Y., Xue, W. Y., Lambertz, A., Leidinger, M., Gibson-Corley, K. & Zhao, C. (2016). Constitutive Activation of NIK Impairs the Self-Renewal of Hematopoietic Stem/Progenitor Cells and Induces Bone Marrow Failure. Stem cells. PMID: 27733012.

Yi, Y., Sun, X., Gibson-Corley, K., Xie, W., Liang, B., He, N., Tyler, S. R., Uc, A., Philipson, L. H., Wang, K., Hara, M., Ode, K. L., Norris, A. W. & Engelhardt, J. F. (2016). A Transient Metabolic Recovery from Early Life Glucose Intolerance in Cystic Fibrosis Ferrets Occurs During Pancreatic Remodeling. Endocrinology, 157(5), 1852-65. PMID: 26862997.

Zhang, L., Blackwell, K., Workman, L. M., Gibson-Corley, K. N., Olivier, A. K., Bishop, G. A. & Habelhah, H. (2016). TRAF2 exerts opposing effects on basal and TNFa-induced activation of the classic IKK complex in hematopoietic cells in mice. Journal of cell science, 129(7), 1455-67. PMID: 26872784.

Klaren, W. D., Flor, S., Gibson-Corley, K. N., Ludewig, G. & Robertson, L. W. (2016). Metallothionein's role in PCB126 induced hepatotoxicity and hepatic micronutrient disruption. Toxicology reports, 3, 21-28. PMID: 26770886.

Fredericks, D., Petersen, E. B., Watson, N., Grosland, N., Gibson-Corley, K. & Smucker, J. (2016). Comparison of Two Synthetic Bone Graft Products in a Rabbit Posterolateral Fusion Model. The Iowa orthopaedic journal, 36, 167-73. PMID: 27528855.

Li, K., Wohlford-Lenane, C., Perlman, S., Zhao, J., Jewell, A. K., Reznikov, L. R., Gibson-Corley, K. N., Meyerholz, D. K. & McCray, Jr, P. B. (2015). Middle East Respiratory Syndrome Coronavirus Causes Multiple Organ Damage and Lethal Disease in Mice Transgenic for Human Dipeptidyl Peptidase 4. The Journal of infectious diseases. PMID: 26486634.

Adamcakova-Dodd, A., Monick, M. M., Powers, L. S., Gibson-Corley, K. N. & Thorne, P. S. (2015). Effects of prenatal inhalation exposure to copper nanoparticles on murine dams and offspring. Particle and fibre toxicology, 12(1), 30. PMID: 26437892.

Gibson-Corley, K. N., Meyerholz, D. K. & Engelhardt, J. F. (2015). Pancreatic Pathophysiology in Cystic Fibrosis. The Journal of pathology. PMID: 26365583.

Olivier, A. K., Gibson-Corley, K. N. & Meyerholz, D. K. (2015). Animal models of gastrointestinal and liver diseases. Animal models of cystic fibrosis: gastrointestinal, pancreatic, and hepatobiliary disease and pathophysiology. American journal of physiology. Gastrointestinal and liver physiology, 308(6), G459-71. PMID: 25591863.

Wen, J. H., Wen, H., Gibson-Corley, K. N. & Glenn, K. A. (2015). FBG1 Is the Final Arbitrator of A1AT-Z Degradation. PloS one, 10(8), e0135591. PMID: 26295339.

Santillan, M. K., Pelham, C. J., Ketsawatsomkron, P., Santillan, D. A., Davis, D. R., Devor, E. J., Gibson-Corley, K. N., Scroggins, S. M., Grobe, J. L., Yang, B., Hunter, S. K. & Sigmund, C. D. (2015). Pregnant mice lacking indoleamine 2,3-dioxygenase exhibit preeclampsia phenotypes. Physiological reports, 3(1), e12257. PMID: 25602015.

Sandgren, J. A., Scroggins, S. M., Santillan, D. A., Devor, E. J., Gibson-Corley, K. N., Pierce, G. L., Sigmund, C. D., Santillan, M. K. & Grobe, J. L. (2015). Vasopressin: The Missing Link for Preeclampsia?. American journal of physiology. Regulatory, integrative and comparative physiology, [Epub ahead of print]. PMID: 25810383.

Gibson-Corley, K. N., Flouty, O., Oya, H., Gillies, G. T. & Howard, M. A. (2014). Postsurgical Pathologies Associated with Intradural Electrical Stimulation in the Central Nervous System: Design Implications for a New Clinical Device. BioMed Research International, 989175. PMID: 24800260.

Gibson-Corley, K. N., Bockenstedt, M. M., Li, H., Boggiatto, P. M., Phanse, Y., Petersen, C. A., Bellaire, B. H. & Jones, D. E. (2014). An in vitro model of antibody-enhanced killing of the intracellular parasite Leishmania amazonensis. PLoS One, 9(9), e106426. PMID: 25191842.

Zhou, B., Gibson-Corley, K. N., Herndon, M. E., Sun, Y., Gustafson-Wagner, E., Teoh-Fitzgerald, M., Domann, F. E., Henry, M. D. & Stipp, C. S. (2014). Integrin a3ß1 can function to promote spontaneous metastasis and lung colonization of invasive breast carcinoma. Molecular cancer research, 12(1), 143-154. PMID: 24002891.

Gibson-Corley, K. N., Rogers, L. M., Goeken, A., Dupuy, A. J. & Meyerholz, D. K. (2014). Keratoacanthoma Pathobiology in Mouse Models. Diseases, 2(2), 106-119.

Santillan, M. K., Santillan, D. A., Scroggins, S. M., Min, J. Y., Sandgren, J. A., Pearson, N. A., Leslie, K. K., Hunter, S. K., Zamba, G. K., Gibson-Corley, K. N. & Grobe, J. L. (2014). Vasopressin in Preeclampsia: A Novel Very Early Human Pregnancy Biomarker and Clinically Relevant Mouse Model. Hypertension, 64(4), 852-9.

Fredericks, D. C., Petersen, E. B., Sahai, N., Corley, K. G., Devries, N., Grosland, N. M. & Smucker, J. D. (2013). Evaluation of a novel silicate substituted hydroxyapatite bone graft substitute in a rabbit posterolateral fusion model. The Iowa orthopaedic journal, 33, 25-32. PMID: 24027457.

Gregory, N. S., Gibson-Corley, K., Frey-Law, L. & Sluka, K. A. (2013). Fatigue-enhanced hyperalgesia in response to muscle insult: induction and development occur in a sex-dependent manner. Pain, 154(12), 2668-76. PMID: 23906552.

Whittier, K. L., Boese, E. A., Gibson-Corley, K. N., Kirby, P. A., Darbro, B. W., Qian, Q., Ingram, W. J., Robertson, T., Remke, M., Taylor, M. D. & O'Dorisio, M. S. (2013). G-protein coupled receptor expression patterns delineate medulloblastoma subgroups. Acta Neuropathologica Communications, 1(1), 66. PMID: 24252460.

Flouty, O., Oya, H., Kawasaki, H., Reddy, C. G., Fredericks, D. C., Gibson-Corley, K., Jeffery, N. D., Gillies, G. T. & Howard, M. A. (2013). Intracranial somatosensory responses with direct spinal cord stimulation in anesthetized sheep. PLOS One, 8(2), e56266. PMID: 23457542.

Gibson-Corley, K. N., Olivier, A. K. & Meyerholz, D. K. (2013). Principles for valid histopathologic scoring in research. Veterinary Pathology, 50(6), 1007-1015. PMID: 23558974.

Simons, A. L., Lu, P., Gibson-Corley, K., Robinson, R. A., Meyerholz, D. K. & Colgan, J. D. (2013). The Justy mutant mouse strain produces a spontaneous murine model of salivary gland cancer with myoepithelial and basal cell differentiation. Laboratory Investigation, 93(6), 711-719. PMID: 23608756.

Flouty, O., Oya, H., Kawasaki, H., Wilson, S., Reedy, C., Jeffery, N. D., Brennan, T. J., Gibson-Corley, K., Utz, M., Gillies, G. T. & Howard, M. A. (2012). A new device concept for directly modulating spinal cord pathways: initial in vivo experimental results. Physiological Measurement, 33(12), 2003-15. PMID: 23151433.

Gibson-Corley, K., Haynes, J. S. (2012). Disseminated T-cell lymphoma in a bonobo (Pan paniscus). Journal of veterinary diagnostic investigation, 24(1), 238-40. PMID: 22362962.

Olivier, A. K., Naumann, P., Goeken, A., Hochstedler, C., Sturm, M., Rodgers, J. R., Gibson-Corley, K. & Meyerholz, D. K. (2012). Genetically modified species in research: Opportunities and challenges for the histology core laboratory. Journal of Histotechnology, 35(2), 63-67. PMID: 22904582.

Gibson-Corley, K., Oya, H., Flouty, O., Fredericks, D. C., Jeffery, N. D., Gillies, G. T. & Howard, M. A. (2012). Ovine tests of a novel spinal cord neuromodulator and dentate ligament fixation method. Journal of Investigative Surgery, 25(6), 366-374. PMID: 23215793.

Gibson-Corley, K., Boggiatto, P. M., Bockenstedt, M. M., Petersen, C. A., Waldschmidt, T. J. & Jones, D. E. (2012). Promotion of a functional B cell germinal center response after Leishmania species co-infection is associated with lesion resolution. The American journal of pathology, 180(5), 2009-17. PMID: 22429963.

Gibson-Corley, K., Hochstedler, C., Sturm, M., Rogers, J., Olivier, A. K. & Meyerholz, D. K. (2012). Successful Integration of the Histology Core Laboratory in Translational Research. Journal of Histotechnology, 35(1), 17-21. PMID: 22904581.

Boggiatto, P. M., Gibson-Corley, K., Metz, K., Gallup, J. M., Hostetter, J. M., Mullin, K. & Petersen, C. A. (2011). Transplacental transmission of Leishmania infantum as a means for continued disease incidence in North America. PLoS neglected tropical diseases, 5(4), e1019. PMID: 21532741.

Gibson-Corley, K., Boggiatto, P. M., Mukbel, R. M., Petersen, C. A. & Jones, D. E. (2010). A deficiency in the B cell response of C57BL/6 mice correlates with loss of macrophage-mediated killing of Leishmania amazonensis. International journal for parasitology, 40(2), 157-61. PMID: 20004204.

Boggiatto, P. M., Ramer-Tait, A. E., Metz, K., Kramer, E. E., Gibson-Corley, K., Mullin, K., Hostetter, J. M., Gallup, J. M., Jones, D. E. & Petersen, C. A. (2010). Immunologic indicators of clinical progression during canine Leishmania infantum infection. Clinical and vaccine immunology, 17(2), 267-73. PMID: 20032217.

Boggiatto, P. M., Jie, F., Ghosh, M., Gibson-Corley, K., Ramer-Tait, A. E., Jones, D. E. & Petersen, C. A. (2009). Altered dendritic cell phenotype in response to Leishmania amazonensis amastigote infection is mediated by MAP kinase, ERK. The American journal of pathology, 174(5), 1818-26. PMID: 19349356.

Gibson-Corley, K., Hostetter, J. M., Hostetter, S. J., Mullin, K., Ramer-Tait, A. E., Boggiatto, P. M. & Petersen, C. A. (2008). Disseminated Leishmania infantum infection in two sibling foxhounds due to possible vertical transmission. The Canadian veterinary journal, 49(10), 1005-8. PMID: 19119370.

Mukbel, R. M., Patten, C., Gibson-Corley, K., Ghosh, M., Petersen, C. & Jones, D. E. (2007). Macrophage killing of Leishmania amazonensis amastigotes requires both nitric oxide and superoxide. The American journal of tropical medicine and hygiene, 76(4), 669-75. PMID: 17426168.