M. Sue O'Dorisio, MD, PhD

Portrait
Pediatric Hematology/Oncology Fellowship Director
Professor of Pediatrics - Hematology Oncology

Contact Information

Primary Office: 3080 ML
Iowa City, IA 52242
319-356-7873

Education

BS, Mathematics, cum laude, Creighton University, Omaha, Nebraska
MS, Biochemistry, cum laude, University of Nebraska, Omaha, Nebraska
PhD, Biochemistry, cum laude, University of Nebraska, Omaha, Nebraska
MD, Medicine, cum laude, Ohio State University, Columbus, Ohio

Fellow, Biochemistry, Ohio State University, Columbus, Ohio
Fellow, Medicine, Ohio State University, Columbus, Ohio
Medicine, The Ohio State University
Resident, Pediatrics, Ohio State University, Columbus, Ohio
Fellow, Hematology/Oncology, Ohio State University, Columbus, Ohio

Education/Training Program Affiliations

Interdisciplinary Graduate Program in Neuroscience, Interdisciplinary Graduate Program in Translational Biomedicine, Medical Scientist Training Program

Research Summary

Role of neuropeptides in development of neural crest derivatives.

Nervous system tumors are the most common cause of death from pediatric malignancies and rank second only to accidents as a cause of death in this age group. These cancers arise in the developing nervous system during fetal growth or infancy. Neuropeptides are important modulators of neurodevelopment and provide neuroprotection for stem cells and neurons. Vasoactive intestinal peptide is both a differentiation factor and a neuroprotective agent. Somatostatin is a potent modulator of growth factor release and also modulates the signal transduction pathway for multiple growth factors. We are studying the role of vasoactive intestinal peptide and somatostatin in neural development using transgenic and knock out mice. This new understanding of the role of neuropeptides in neural crest development should allow us to develop new diagnostic and therapeutic options for children with neuroblastoma and medulloblastoma.