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Pablo Nakagawa, PhD

Address: 2-340 BSB
Phone: (319) 335-8926
Email: pablo-nakagawa@uiowa.edu

Mentor: Curt D. Sigmund, PhD

PhD Institution: University of Buenos Aires, 2014

Research Description

Role of brain-specific isoform of renin (renin-b) on the regulation of metabolic function and the cardiovascular system

Awards

  • Cardiovascular Interdisciplinary Research Fellowship (T32), 2017-present
  • Kidney Disease, Hypertension and Cell Biology Training Grant, 2016-2017

Publications

  1. Shinohara K, Nakagawa P, Gomez J, Morgan DA, Littlejohn NK, Folchert MD, Weidemann BJ, Liu X, Walsh SA, Ponto LL, Rahmouni K, Grobe JL, Sigmund CD.: Selective Deletion of Renin-b in the Brain Alters Drinking and Metabolism. Hypertension 79(5):990-997, 2017.  PMCID: PMC5679092
  2. Nakagawa P, and Sigmund CD.:  How is the Brain Renin-Angiotensin System Regulated? Hypertension. 70(1):10-18, 2017.  PMCID: PMC5511499
  3. Nakagawa P, Masjoan-Juncos JX, Basha H, Janic B, Worou ME, Liao TD, Romero CA, Peterson EL, Carretero OA.:  Effects of N-acetyl-seryl-asparyl-lysyl-proline on blood pressure, renal damage, and mortality in systemic lupus erythematosus. Physiol Rep 5(2):e13084, 2017.  PMCID: PMC5269407
  4. González GE, Rhaleb NE, D'Ambrosio MA, Nakagawa P, Liao TD, Peterson EL, Leung P, Dai X, Janic B, Liu YH, Yang XP, Carretero OA.:  Cardiac-deleterious role of galectin-3 in chronic angiotensin II-induced hypertension. A J Physiol Heart Circ Physiol 311(5):H1287-H1296, 2016.  PMCID: PMC5130499
  5. Kumar N, Nakagawa P, Janic B, Romero CA, Worou ME, Monu SR, Peterson EL, Shaw J, Valeriote F, Ongeri EM, Niyitegeka JM, Rhaleb NE, Carretero OA.:  The anti-inflammatory peptide Ac-SDKP is released from thymosin-β4 by renal meprin-α and prolyl oligopeptidase. Am J Physiol Renal Physiol 319(10:F1026-34, 2016.  PMCID: PMC4889319
  6. Zhu L, Yang XP, Janic B, Rhaleb NE, Harding P, Nakagawa P, Peterson EL, Carretero OA.:  Ac-SDKP suppresses TNF-α-induced ICAM-1 expression in endothelial cells via inhibition of IκB kinase and NF-κB activation. Am J Physiol Heart Circ Physiol 319(9):H1176-83, 2016.  PMCID: PMCC5243213
  7. Worou ME, Liao TD, D'Ambrosio M, Nakagawa P, Janic B, Peterson EL, Rhaleb NE, Carretero OA.:  Renal protective effect of N-acetyl-seryl-aspartyl-lysyl-proline in dahl salt-sensitive rats. Hypertension 66(4):816-22, 2015.  PMCID: PMC4658233
  8. Liao TD, Nakagawa P, Janic B, D'Ambrosio M, Worou ME, Peterson EL, Rhaleb NE, Yang XP, Carretero OA.:  N-Acetyl-Seryl-Aspartyl-Lysyl-Proline: mechanisms of renal protection in mouse model of systemic lupus erythematosus. Am J PHysiol Renal Physiol 308(10:F1146-54, 2015.  PMCID: PMC4436999
  9. González GE, Rhaleb NE, D'Ambrosio MA, Nakagawa P, Liu Y, Leung P, Dai X, Yang XP, Peterson EL, Carretero OA.:  Deletion of interleukin-6 prevents cardiac inflammation, fibrosis and dysfunction without affecting blood pressure in angiotensin II-high salt-induced hypertension. J Hypertens 33(1):144-52, 2015.  PMCID: PMC4256143
  10. González GE, Rhaleb NE, Nakagawa P, Liao TD, Liu Y, Leung P, Dai X, Yang XP, Carretero OA.:  N-acetyl-seryl-aspartyl-lysyl-proline reduces cardiac collagen cross-linking and inflammation in angiotensin II-induced hypertensive rats. Clin Sci (Lond). 126(1):85-94, 2014.  PMCID: PMC4240015
  11. Nakagawa P, Liu Y, Liao TD, Chen X, González GE, Bobbitt KR, Smolarek D, Peterson EL, Kedl R, Yang XP, Rhaleb NE, Carretero OA.:  Treatment with N-acetyl-seryl-aspartyl-lysyl-proline prevents experimental autoimmune myocarditis in rats. Am J Physiol Heart Circ Physiol 303(9):H1114-27, 2012.  PMCID: PMC3517643
  12. Cerrato BD, Frasch AP, Nakagawa P, Longo-Carbajosa N, Peña C, Höcht C, Gironacci MM.:  Angiotensin-(1-7) upregulates central nitric oxide synthase in spontaneously hypertensive rats. Brain Res 1453:1-7, 2012.  PMID: 22483959
  13. Peng H, Yang XP, Carretero OA, Nakagawa P, D'Ambrosio M, Leung P, Xu J, Peterson EL, González GE, Harding P, Rhaleb NE. Angiotensin II-induced dilated cardiomyopathy in Balb/c but not C57BL/6J mice. Exp Physiol. 96(8):756-64, 2011.  PMCID: PMC3256574
  14. Costa MA, Lopez Verrilli MA, Gomez KA, Nakagawa P, Peña C, Arranz C, Gironacci MM. Journal. Angiotensin-(1-7) upregulates cardiac nitric oxide synthase in spontaneously hypertensive rats. Am J Physiol Heart Circ Physiol. 2010 Oct;299(4):H1205-11, 2010.  PMID: 20675563