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Masashi Mukoda, DVM, PhD

Address: 2-340 BSB
Phone: (319) 335-8926
Email: masashi-mukoda@uiowa.edu

Mentor: Curt D. Sigmund, PhD

PhD Institution: Kitasato University, Aomori, Japan, 2012

Research Description

Role of Hypertension and CDK5 in Regulating PPARγ Activity

Awards

  • Postdoctoroal Fellow poster award, Iowa Physiological Society Meeting, University of Iowa, Iowa City, IA, 2017
  • APS Cardiovascular Section Research Recognition Award, 2017
  • APS Caroline tum Suden/Francis A. Hellebrandt Professional Opportunity Award (Declined), 2017
  • Veterinary Science Young Investigator Award, 2016
  • University of Iowa Postdoctoral Association (UIPDA) Travel Award, 2016
  • Finalist in the 2016 Juan Carlos Romero and APS Water & Electrolyte Homeostasis Section Postdoctoral Research Recognition Award, 2016
  • Selection of APSselect, The American Physiological Society, 2016
  • Onsite trainee poster award in Hypertension Conference (Declined), 2015
  • Annual Hypertension Conference Travel Awards for New Investigators, 2015
         (Instead of New Investigator Awards for Japanese Fellows)
  • New Investigator Award, Annual High Blood Pressure Research Conference, 2014
  • ASBMB Postdoctoral Travel Award, 2014

Research Interest

Molecular Mechanism of PPARg on Regulation of Inflammation and Vascular Tone in Vascular Smooth Muscle Study

Publications

  1. Mukohda M, Lu KT, Guo DF, Wu J, Keen HL, Liu X, Ketsawatsomkron P, Stump M, Rahmouni K, Quelle FW, Sigmund CD.:  Hypertension-causing mutation in Peroxisome Proliferator-Activated Receptor γ Impairs Nuclear Export of Nuclear Factor-kB p65 in Vascular Smooth Muscle. Hypertension. 70(1):174-182, 2017.  PMCID: PMC5472224 [Available on 2018-07-01]
  2. Stump M, Guo DF, Lu KT, Mukohda M, Cassell MD, Norris AW, Rahmouni K, Sigmund CD.:  Nervous System Expression of PPARγ and Mutant PPARγ Has Profound Effects on Metabolic Regulation and Brain Development. 157(11):4266-4275, 2016.  PMCID: PMC5086539
  3. Stump M, Guo DF, Lu KT, Mukohda M, Liu X, Rahmouni K, Sigmund CD.:  Effect of selective expression of dominant-negative PPARγ in pro-opiomelanocortin neurons on the control of energy balance. Physiol Genomics 48(7):491-501, 2016.  PMCID: PMC4967222
  4. Mukohda M, Stump M, Ketsawatsomkron P, Hu C, Quelle FW, Sigmund CD.:  Endothelial PPAR-γ provides vascular protection from IL-1β-induced oxidative stress. Am J Physiol Heart Circ Physiol 319(1):H39-48, 2016.  (HPSselect) PMCID: PMC4796462
  5. Hu C, Lu KT, Mukohda M, Davis DR, Faraci FM, Sigmund CD.:  Interference with PPARγ in endothelium accelerates angiotensin II-induced endothelial dysfunction. Physiol Genomics 48(2):124-34, 2016.  PMCID: PMC4729699
  6. Stump M, Mukohda M, Hu C, Sigmund CD.:  PPARγ Regulation in Hypertension and Metabolic Syndrome. Curr Hypertens Rep 17(12):89, 2015.  PMID: 26462805
  7. Mukohda M, Morita T, Okada M, Hara Y, Yamawaki H.: Long-term methylglyoxal treatment causes endothelial dysfunction of rat isolated mesenteric artery. J Vet Med Sci. 75(2):151-7, 2013.  PMID: 23018793
  8. Mukohda M, Okada M, Hara Y, Yamawaki H.: Methylglyoxal accumulation in arterial walls causes vascular contractile dysfunction in spontaneously hypertensive rats (Review). J Pharmacol Sci. 120(1):26-35, 2012.  PMID: 22971844  (Review)
  9. Mukohda M, Okada M, Hara Y, Yamawaki H.: Exploring mechanisms of diabetes-related macrovascular complications: role of methylglyoxal, a metabolite of glucose on regulation of vascular contractility. J Pharmacol Sci. 118(3):303-10, 2012.  PMID: 22333481
  10. Yamawaki H, Takahashi M, Mukohda M, Morita T, Okada M, Hara Y.: A novel adipocytokine, nesfatin-1 modulates peripheral arterial contractility and blood pressure in rats. Biochem Biophys Res Commun. 418(4):676-81, 2012.  PMID: 22293188
  11. Mukohda M, Morita T, Okada M, Hara Y, Yamawaki H.: Long-term methylglyoxal treatment impairs smooth muscle contractility in organ-cultured rat mesenteric artery. Pharmacol Res. 65(1):91-9, 2012.  PMID: 21884795
  12. Mukohda M, Yamawaki H, Okada M, Hara Y.Hideyuki Yamawaki, Muneyoshi Okada, Yukio Hara.: Methylglyoxal augments angiotensin II-induced contraction in rat isolated carotid artery. J Pharmacol Sci. 114(4):390-8, 2010.  PMID: 21076237
  13. Mukohda M, Ueno S, Kamibayashi M, Okada M, Yamawaki H, Hara Y.: Influences of organic solvents on CYPMPO-electron spin resonance spectra in in vitro radical generating systems. J Vet Med Sci. 72(12):1547-50, 2010.  PMID: 20661003
  14. Yamawaki H, Tsubaki N, Mukohda M, Okada M, Hara Y.: Omentin, a novel adipokine, induces vasodilation in rat isolated blood vessels. Biochem Biophys Res Commun. 393(4):668-72, 2010.  PMID: 20170632
  15. Mukohda M, Yamawaki H, Okada M, Hara Y.: Methylglyoxal enhances sodium nitroprusside-induced relaxation in rat aorta. J Pharmacol Sci. 112(2):176-83, 2010.  PMID: 20168042
  16. Mukohda M, Yamawaki H, Nomura H, Okada M, Hara Y.: Methylglyoxal inhibits smooth muscle contraction in isolated blood vessels. J Pharmacol Sci. 109(2):305-10, 2009.  PMID: 19202315
  17. Nomura H, Yamawaki H, Mukohda M, Okada M, Hara Y.: Mechanisms underlying pioglitazone-mediated relaxation in isolated blood vessel. J Pharmacol Sci. 108(3):258-65, 2008.  PMID: 18987433
  18. Baden T, Yamawaki H, Saito K, Mukohda M, Okada M, Hara Y.: Telmisartan inhibits methylglyoxal-mediated cell death in human vascular endothelium. Biochem Biophys Res Commun. 22;373(2):253-7, 2008.  PMID: 18565324