Kamal Rahmouni, PhD

Portrait
Professor of Pharmacology
Professor of Internal Medicine

Contact Information

Primary Office: 2-248 BSB
51 Newton Rd.
Iowa City, IA 52242
319-353-5256

Lab: 2-200 BSB
Iowa City, IA 52242
319-335-7895

Lab: 524 MRC
Iowa City, IA 52242
319-335-8976

Education

BS, Biochemistry, University of Science and Technology, Algiers, Algeria
MS, Pharmacology, Pharmacochemistry, University of Louis Pasteur, Strasbourg, France
PhD, Pharmacology, University of Louis Pasteur, Strasbourg, France

Post Doctoral Fellow, University of Iowa, Department of Internal Medicine
Resident, University of Iowa, Department of Internal Medicine
Fellow, Council for High Blood Pressure Research, American Heart Association

Education/Training Program Affiliations

Interdisciplinary Graduate Program in Molecular and Cellular Biology, Interdisciplinary Graduate Program in Neuroscience, Interdisciplinary Graduate Program in Translational Biomedicine, Medical Scientist Training Program

Research Summary

The work in my laboratory is focused on the neurobiology of metabolism, energy homeostasis and cardiovascular function and related disorders such as obesity, diabetes and hypertension. The central nervous system is a major player in the regulation of energy homeostasis as well as cardiovascular system. Our research is aimed at the identification of the neuroanatomical and molecular pathways involved in the regulation of metabolic, autonomic and cardiovascular functions. We also investigate the dysregulation of these pathways in disease condition such us obesity and diabetes. The lab uses multidisciplinary approaches including basic research tools, genetic models and sophisticated physiological techniques that allow us to address physiological questions at the molecular level. There are currently several ongoing studies aimed at elucidating the intracellular pathways involved in the central nervous system control of energy homeostasis and autonomic cardiovascular function by insulin and adipocyte-derived hormone, leptin. Specifically, we are focused at understanding the exact role of the different downstream pathways associated with the insulin and leptin receptors in the regulation of the physiological cues. For these studies, we rely on mouse models that have deletion is specific intracellular signaling pathways. We also use the Cre-LoxP technology to target specific areas in the brain to delineate the neuronal architectural network that control metabolism and autonomic cardiovascular function. Disease mechanisms are investigated in animal models of obesity and diabetes such as diet-induced obesity, but also rare monogenic models including mouse models of Bardet-Biedl Syndrome that mimic the human disorders. The study of monogenic models allow us to elucidate how basic cell biological mechanisms conserved in all organisms (i.e. intracellular transport and cilia function) and complex phenotypes (such as obesity and hypertension) that result when these mechanisms are perturbed.

Publications

Shinohara, K., Nakagawa, P., Gomez, J., Morgan, D. A., Littlejohn, N. K., Folchert, M. D., Weidemann, B. J., Liu, X., Walsh, S. A., Ponto, L. L., Rahmouni, K., Grobe, J. L. & Sigmund, C. D. (2017). Selective Deletion of Renin-b in the Brain Alters Drinking and Metabolism. Hypertension (Dallas, Tex. : 1979), 70(5), 990-997. PMID: 28874461.

Contreras, C., Nogueiras, R., Diéguez, C., Rahmouni, K. & López, M. (2017). Traveling from the hypothalamus to the adipose tissue: The thermogenic pathway. Redox biology, 12, 854-863. PMID: 28448947.

Flak, J. N., Arble, D., Pan, W., Patterson, C., Lanigan, T., Goforth, P. B., Sacksner, J., Joosten, M., Morgan, D. A., Allison, M. B., Hayes, J., Feldman, E., Seeley, R. J., Olson, D. P., Rahmouni, K. & Myers, Jr, M. G. (2017). A leptin-regulated circuit controls glucose mobilization during noxious stimuli. The Journal of clinical investigation, 127(8), 3103-3113. PMID: 28714862.

Chhabra, K. H., Morgan, D. A., Tooke, B. P., Adams, J. M., Rahmouni, K. & Low, M. J. (2017). Reduced renal sympathetic nerve activity contributes to elevated glycosuria and improved glucose tolerance in hypothalamus-specific Pomc knockout mice. Molecular metabolism, 6(10), 1274-1285. PMID: 29031726.

Martínez-Sánchez, N., Seoane-Collazo, P., Contreras, C., Varela, L., Villarroya, J., Rial-Pensado, E., Buqué, X., Aurrekoetxea, I., Delgado, T. C., Vázquez-Martínez, R., González-García, I., Roa, J., Whittle, A. J., Gomez-Santos, B., Velagapudi, V., Tung YCL,, Morgan, D. A., Voshol, P. J., de Martínez Morentin, P. B., López-González, T., Liñares-Pose, L., Gonzalez, F., Chatterjee, K., Sobrino, T., Medina-Gómez, G., Davis, R. J., Casals, N., Orešic, M., Coll, A. P., Vidal-Puig, A., Mittag, J., Tena-Sempere, M., Malagón, M. M., Diéguez, C., Martínez-Chantar, M. L., Aspichueta, P., Rahmouni, K., Nogueiras, R., Sabio, G., Villarroya, F. & López, M. (2017). Hypothalamic AMPK-ER Stress-JNK1 Axis Mediates the Central Actions of Thyroid Hormones on Energy Balance. Cell metabolism, 26(1), 212-229.e12. PMID: 28683288.

Mukohda, M., Lu, K. T., Guo, D. F., Wu, J., Keen, H. L., Liu, X., Ketsawatsomkron, P., Stump, M., Rahmouni, K., Quelle, F. W. & Sigmund, C. D. (2017). Hypertension-Causing Mutation in Peroxisome Proliferator-Activated Receptor ? Impairs Nuclear Export of Nuclear Factor-?B p65 in Vascular Smooth Muscle. Hypertension (Dallas, Tex. : 1979), 70(1), 174-182. PMID: 28507170.

Claflin, K. E., Sandgren, J. A., Lambertz, A. M., Weidemann, B. J., Littlejohn, N. K., Burnett, C. M., Pearson, N. A., Morgan, D. A., Gibson-Corley, K. N., Rahmouni, K. & Grobe, J. L. (2017). Angiotensin AT1A receptors on leptin receptor-expressing cells control resting metabolism. The Journal of clinical investigation, 127(4), 1414-1424. PMID: 28263184.

DeZwaan-McCabe, D., Sheldon, R. D., Gorecki, M. C., Guo, D. F., Gansemer, E. R., Kaufman, R. J., Rahmouni, K., Gillum, M. P., Taylor, E. B., Teesch, L. M. & Rutkowski, D. T. (2017). ER Stress Inhibits Liver Fatty Acid Oxidation while Unmitigated Stress Leads to Anorexia-Induced Lipolysis and Both Liver and Kidney Steatosis. Cell reports, 19(9), 1794-1806. PMID: 28564599.

Cui, H., López, M. & Rahmouni, K. (2017). The cellular and molecular bases of leptin and ghrelin resistance in obesity. Nature reviews. Endocrinology, 13(6), 338-351. PMID: 28232667.

Douris, N., Desai, B. N., Fisher, F. M., Cisu, T., Fowler, A. J., Zarebidaki, E., Nguyen NLT,, Morgan, D. A., Bartness, T. J., Rahmouni, K., Flier, J. S. & Maratos-Flier, E. (2017). Beta-adrenergic receptors are critical for weight loss but not for other metabolic adaptations to the consumption of a ketogenic diet in male mice. Molecular metabolism, 6(8), 854-862. PMID: 28752049.

Fink, B. D., Guo, D. F., Kulkarni, C. A., Rahmouni, K., Kerns, R. J. & Sivitz, W. I. (2017). Metabolic effects of a mitochondrial-targeted coenzyme Q analog in high fat fed obese mice. Pharmacology research & perspectives, 5(2), e00301. PMID: 28357127.

Lan, T., Morgan, D. A., Rahmouni, K., Sonoda, J., Fu, X., Burgess, S. C., Holland, W. L., Kliewer, S. A. & Mangelsdorf, D. J. (2017). FGF19, FGF21, and an FGFR1/ß-Klotho-Activating Antibody Act on the Nervous System to Regulate Body Weight and Glycemia. Cell metabolism, 26(5), 709-718.e3. PMID: 28988823.

Jiang, J., Cui, H. & Rahmouni, K. (2017). Optogenetics and pharmacogenetics: principles and applications. American journal of physiology. Regulatory, integrative and comparative physiology, 313(6), R633-R645. PMID: 28794102.

Beyer, A. M., Guo, D. F. & Rahmouni, K. (2013). Prolonged treatment with angiotensin 1-7 improves endothelial function in diet-induced obesity. Journal of hypertension, 31(4), 730-8. PMID: 23425706.

Harlan, S. M., Guo, D. F., Morgan, D. A., Fernandes-Santos, C. & Rahmouni, K. (2013). Hypothalamic mTORC1 signaling controls sympathetic nerve activity and arterial pressure and mediates leptin effects. Cell metabolism, 17(4), 599-606. PMID: 23541372.

Imbernon, M., Beiroa, D., Vazquez, M. J., Morgan, D. A., Veyrat-Durebex, C., Porteiro, B., Diaz-Arteaga, A., Senra, A., Busquets, S., Velasquez, D. A., Al-Massadi, O., Varela, L., Gandara, M., Lopez-Soriano, F. J., Gallego, R., Seoane, L. M., Argiles, J. M., Lopez, M., Davis, R. J., Sabio, G., Rohner-Jeanrenaud, F., Rahmouni, K., Dieguez, C. & Nogueiras, R. (2013). Central melanin-concentrating hormone influences liver and adipose metabolism via specific hypothalamic nuclei and efferent autonomic/JNK1 pathways. Gastroenterology, 144(3), 636-649.e6. PMID: 23142626.

Fernandes-Santos, C., Zhang, Z., Morgan, D. A., Guo, D. F., Russo, A. F. & Rahmouni, K. (2013). Amylin acts in the central nervous system to increase sympathetic nerve activity. Endocrinology, 154(7), 2481-8. PMID: 23645151.

Harlan, S. M., Rahmouni, K. (2013). Neuroanatomical determinants of the sympathetic nerve responses evoked by leptin. Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 23(1), 1-7. PMID: 22714900.

Chamling, X., Seo, S., Bugge, K., Searby, C., Guo, D. F., Drack, A. V., Rahmouni, K. & Sheffield, V. C. (2013). Ectopic expression of human BBS4 can rescue Bardet-Biedl syndrome phenotypes in Bbs4 null mice. PloS one, 8(3), e59101. PMID: 23554981.

Tanida, M., Yamamoto, N., Shibamoto, T. & Rahmouni, K. (2013). Involvement of hypothalamic AMP-activated protein kinase in leptin-induced sympathetic nerve activation. PloS one, 8(2), e56660. PMID: 23418591.

Grobe, J. L., Rahmouni, K., Liu, X. & Sigmund, C. D. (2013). Metabolic rate regulation by the renin-angiotensin system: brain vs. body. Pflugers Archiv : European journal of physiology, 465(1), 167-75. PMID: 22491893.

Whiteis, C. A., Post, C. E., Morgan, D. A., Rahmouni, K., Chapleau, M. W. & Abboud, F. M. (2012). Peripheral chemoreceptors contribute significantly to hypertension in Spontaneously Hypertensive Rats (SHR). (Vols. 26). pp. 703.15. FASEB Journal.

Muta, K., Grobe, J., Sigmund, C. D. & Rahmouni, K. (2012). mTOR/p70S6K signaling is a novel effector of neuronal action of angiotensin II. FASEB Journal.

Rahmouni, K. (2012). Leptin Signaling in the brain and energy homeostasis. In D. Robertson (Eds.) Primer on the Autonomic Nervous System. (3), pp. 131-134. Academic Press.

Harlan, S., Morgan, D. A. & Rahmouni, K. (2012). Leptin-induced arterial pressure increase: key role of the PI3K pathway. (Vols. 60). pp. A21. Hypertension.

Grobe, J. L., Rahmouni, K. (2012). Editorial focus: A fat contribution to RAS activation and blood pressure control: evidence from angiotensinogen conditional null mice. Focus on: "Adipocyte-specific deficiency of angiotensinogen decreases plasma angiotensinogen concentration and systolic. American journal of physiology. Regulatory, integrative and comparative physiology, 302(2), R242-3. PMID: 22071163.

Stauss, H. M., Morgan, D. A. & Rahmouni, K. (2012). Evidence for chemosensitive fibers in the aortic depressor nerve in mice but not in rats. FASEB Journal.

Morgan, D. A., Sheffield, V. C. & Rahmouni, K. (2012). Bardet Biedl syndrome genes are required for autonomic control of the circulation. FASEB Journal.

Harlan, S., Morgan, D. A. & Rahmouni, K. (2012). Leptin acts in POMC neurons to increase sympathetic nerve activity. (Vols. 60). pp. A109. Hypertension.

Hilzendeger, A. M., Morgan, D. A., Brooks, L., Dellsperger, D., Liu, X., Grobe, J. L., Rahmouni, K., Sigmund, C. D. & Mark, A. L. (2012). A brain leptin-renin angiotensin system interaction in the regulation of sympathetic nerve activity. American journal of physiology. Heart and circulatory physiology, 303(2), H197-206. PMID: 22610169.

Grobe, J. L., Rahmouni, K. (2012). The adipose/circulating renin-angiotensin system cross-talk enters a new dimension. Hypertension, 60(6), 1389-90. PMID: 23108659.

Patel, P. R., Ramakrishnan, S. K., Kaw, M. K., Raphael, C. K., Ghosh, S., Marino, J. S., Heinrich, G., Lee, S. J., Bourey, R. E., Hill, J. W., Jung, D. Y., Morgan, D. A., Kim, J. K., Rahmouni, K., Rahmouni, S. K. & Najjar, S. M. (2012). Increased metabolic rate and insulin sensitivity in male mice lacking the carcino-embryonic antigen-related cell adhesion molecule 2. Diabetologia, 55(3), 763-72. PMID: 22159884.

Lockie, S. H., Heppner, K. M., Chaudhary, N., Chabenne, J. R., Morgan, D. A., Veyrat-Durebex, C., Ananthakrishnan, G., Rohner-Jeanrenaud, F., Drucker, D. J., DiMarchi, R., Rahmouni, K., Oldfield, B. J., Tschop, M. H. & Perez-Tilve, D. (2012). Direct control of brown adipose tissue thermogenesis by central nervous system glucagon-like peptide-1 receptor signaling. Diabetes, 61(11), 2753-62. PMID: 22933116.

Whittle, A. J., Carobbio, S., Martins, L., Slawik, M., Hondares, E., Vazquez, M. J., Morgan, D., Csikasz, R. I., Gallego, R., Rodriguez-Cuenca, S., Dale, M., Virtue, S., Villarroya, F., Cannon, B., Rahmouni, K., Lopez, M. & Vidal-Puig, A. (2012). BMP8B increases brown adipose tissue thermogenesis through both central and peripheral actions. Cell, 149(4), 871-85. PMID: 22579288.

Tschop, M. H., Speakman, J. R., Arch, J. R., Auwerx, J., Bruning, J. C., Chan, L., Eckel, R. H., Farese, R. V., Galgani, J. E., Hambly, C., Herman, M. A., Horvath, T. L., Kahn, B. B., Kozma, S. C., Maratos-Flier, E., Muller, T. D., Munzberg, H., Pfluger, P. T., Plum, L., Reitman, M. L., Rahmouni, K., Shulman, G. I., Thomas, G., Kahn, C. R. & Ravussin, E. (2012). A guide to analysis of mouse energy metabolism. Nature methods, 9(1), 57-63. PMID: 22205519.

Castaneda, T. R., Abplanalp, W., Um, S. H., Pfluger, P. T., Schrott, B., Brown, K., Grant, E., Carnevalli, L., Benoit, S. C., Morgan, D. A., Gilham, D., Hui, D. Y., Rahmouni, K., Thomas, G., Kozma, S. C., Clegg, D. J. & Tschop, M. H. (2012). Metabolic control by S6 kinases depends on dietary lipids. PloS one, 7(3), e32631. PMID: 22412899.

Hilzendeger, A., Morgan, D. A., Rahmouni, K., Sigmund, C. D. & Mark, A. L. (2011). Brain angiotensin generation contributes to renal sympathetic nerve responses to leptin. (Vols. 25). pp. 1078.3. FASEB Journal.

Morgan, D. A., Despas, F. & Rahmouni, K. (2011). Direct sympathetic nerve activity recording in awake mice improves baroreflex sensitivity, but not the responses to leptin. (Vols. 58). pp. e71. Hypertension.

Guo, D. F., Beyer, A. M., Yang, B., Nishimura, D. Y., Sheffield, V. C. & Rahmouni, K. (2011). Inactivation of Bardet-Biedl syndrome genes causes kidney defects. American journal of physiology. Renal physiology, 300(2), F574-80. PMID: 21106857.

Pezzulo, A. A., Gutierrez, J., Duschner, K. S., McConnell, K. S., Taft, P. J., Ernst, S. E., Yahr, T. L., Rahmouni, K., Klesney-Tait, J., Stoltz, D. A. & Zabner, J. (2011). Glucose depletion in the airway surface liquid is essential for sterility of the airways. PloS one, 6(1), e16166. PMID: 21311590.

Harlan, S., Fernandes-Santos, C., Morgan, D. A., Guo, D. F. & Rahmouni, K. (2011). PI3K pathway is a critical node for leptin activation of hypothalamic mTOR signaling and renal sympathetic traffic. (Vols. 58). pp. e94. Hypertension.

Guo, D. F., Morgan, D. A. & Rahmouni, K. (2011). Hypothalamic mTOR signaling: a key mediator of the sympathetic and cardiovascular effects of leptin. (Vols. 58). pp. e41. Hypertension.

Guo, D. F., Rahmouni, K. (2011). Molecular basis of the obesity associated with Bardet-Biedl syndrome. Trends in endocrinology and metabolism: TEM, 22(7), 286-93. PMID: 21514177.

Harlan, S. M., Morgan, D. A., Dellsperger, D. J., Myers, M. G., Mark, A. L. & Rahmouni, K. (2011). Cardiovascular and sympathetic effects of disrupting tyrosine 985 of the leptin receptor. Hypertension, 57(3), 627-32. PMID: 21263121.

Zhang, Q., Nishimura, D., Seo, S., Vogel, T., Morgan, D. A., Searby, C., Bugge, K., Stone, E. M., Rahmouni, K. & Sheffield, V. C. (2011). Bardet-Biedl syndrome 3 (Bbs3) knockout mouse model reveals common BBS-associated phenotypes and Bbs3 unique phenotypes. Proceedings of the National Academy of Sciences of the United States of America, 108(51), 20678-83. PMID: 22139371.

Rahmouni, K., Davisson, R. L. & Sigmund, C. D. (2011). Inflaming hypothalamic neurons raises blood pressure. Cell metabolism, 14(1), 3-4. PMID: 21723497.

Zhang, Z., Liu, X., Morgan, D. A., Kuburas, A., Thedens, D. R., Russo, A. F. & Rahmouni, K. (2011). Neuronal receptor activity-modifying protein 1 promotes energy expenditure in mice. Diabetes, 60(4), 1063-71. PMID: 21357463.

Harlan, S. M., Morgan, D. A., Agassandian, K., Guo, D. F., Cassell, M. D., Sigmund, C. D., Mark, A. L. & Rahmouni, K. (2011). Ablation of the leptin receptor in the hypothalamic arcuate nucleus abrogates leptin-induced sympathetic activation. Circulation research, 108(7), 808-12. PMID: 21311043.

Morgan, D. A., Dellsperger, D., Mishimura, D. Y., Sheffield, V. C. & Rahmouni, K. (2010). Obesity, hypertension and sympathetic overdrive in a novel mouse model of Bardet-Biedl syndrome. (Vols. 56). pp. e96. Hypertension.

Harlan, S., Morgan, D. A., Dellsperger, D., Myers, M. G., Mark, A. L. & Rahmouni, K. (2010). Mutation of Tyr985 of the leptin receptor differentially alters regional sympathetic activation to leptin. (Vols. 24). pp. 1050.1. FASEB Journal.

Hilzendeger, A., Morgan, D. A., Brooks, L., Dellsperger, D., Liu, X., Rahmouni, K., Sigmund, C. D. & Mark, A. L. (2010). Evidence for a central neural interaction of leptin and angiotensin. (Vols. 56). pp. e101. Hypertension.

Sabharwal, R., Morgan, D. A., Whiteis, C. A., Rahmouni, K., Chapleau, M. W. & Abboud, F. M. (2010). ASIC2 Dependent Activation of the Baroreceptors is Required for the Arterial Baroreflex. (Vols. 24). pp. 625.1. FASEB Journal.

Tan, Z. Y., Morgan, D. A., Whiteis, C. A., Rahmouni, K., Chapleau, M. W. & Abboud, F. M. (2010). Peripheral Chemoreceptors Enhance Renal Sympathetic Nerve Activity and Hypertension in SHR. (Vols. 24). pp. 809.22. FASEB Journal.

Harlan, S., Morgan, D. A., Dellsperger, D., Myers, M. G., Mark, A. L. & Rahmouni, K. (2010). Disruption of leptin receptor signaling emanating from Tyr985 enhances the cardiovascular and sympathetic effects of leptin. (Vols. 56). pp. e107-108. Hypertension.

Rahmouni, K. (2010). Sympathetic tone in the young: the mother weighs in. Hypertension, 55(1), 21-2. PMID: 19901157.

Morgan, D. A., Rahmouni, K. (2010). Differential effects of insulin on sympathetic nerve activity in agouti obese mice. Journal of hypertension, 28(9), 1913-9. PMID: 20577122.

Beyer, A. M., Guo, D. F., Sheffield, V. C. & Rahmouni, K. (2010). Contrasting vascular effects caused by loss of Bardet-Biedl syndrome genes. American journal of physiology. Heart and circulatory physiology, 299(6), H1902-7. PMID: 20852044.

Rahmouni, K. (2010). Obesity, sympathetic overdrive, and hypertension: the leptin connection. Hypertension, 55(4), 844-5. PMID: 20194295.

Grobe, J. L., Grobe, C. L., Beltz, T. G., Westphal, S. G., Morgan, D. A., Xu, D., de Lange, W. J., Li, H., Sakai, K., Thedens, D. R., Cassis, L. A., Rahmouni, K., Mark, A. L., Johnson, A. K. & Sigmund, C. D. (2010). The brain Renin-angiotensin system controls divergent efferent mechanisms to regulate fluid and energy balance. Cell metabolism, 12(5), 431-42. PMID: 21035755.

Lopez, M., Varela, L., Vazquez, M. J., Rodriguez-Cuenca, S., Gonzalez, C. R., Velagapudi, V. R., Morgan, D. A., Schoenmakers, E., Agassandian, K., Lage, R., Martinez de Morentin, P. B., Tovar, S., Nogueiras, R., Carling, D., Lelliott, C., Gallego, R., Oresic, M., Chatterjee, K., Saha, A. K., Rahmouni, K., Dieguez, C. & Vidal-Puig, A. (2010). Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance. Nature medicine, 16(9), 1001-8. PMID: 20802499.

Rahmouni, K. (2010). Leptin-Induced Sympathetic Nerve Activation: Signaling Mechanisms and Cardiovascular Consequences in Obesity. Current hypertension reviews, 6(2), 104-209. PMID: 21562617.

Ramadori, G., Fujikawa, T., Fukuda, M., Anderson, J., Morgan, D. A., Mostoslavsky, R., Stuart, R. C., Perello, M., Vianna, C. R., Nillni, E. A., Rahmouni, K. & Coppari, R. (2010). SIRT1 deacetylase in POMC neurons is required for homeostatic defenses against diet-induced obesity. Cell metabolism, 12(1), 78-87. PMID: 20620997.

Mark, A. L., Brooks, L., Morgan, D. A., Sigmund, C. D. & Rahmouni, K. (2009). Brain angiotensin AT1 receptors mediate sympathetic nerve responses to leptin: evidence for a brain angiotensin-leptin interaction. (Vols. 54). pp. e99. Hypertension.

Beyer, A. M., Morgan, D. A., Anderson, M. G. & Rahmouni, K. (2009). Increased arterial pressure response to angiotensin II in mice with mutation in the Lysosomal Trafficking Regulator gene. (Vols. 23). pp. 814.2. FASEB Journal.

Borges, G. R., Morgan, D. A., Ketsawatsomkron, P., Rahmouni, K. & Sigmund, C. D. (2009). Tachycardia caused by interference with PPAR? in vascular smooth muscle in mice is related to autonomic imbalance and baroreflex dysfunction. (Vols. 54). pp. e101. Hypertension.

Guo, D. F., Beyer, A. M., HuiPing, L. i., Sigmund, C. D., Sheffield, V. C. & Rahmouni, K. (2009). Kidney Abnormities in Mouse Models of Bardet-Biedl Syndrome. (Vols. 54). pp. e61. Hypertension.

Rahmouni, K., Morgan, D. A. & Mark, A. L. (2009). Oxidative stress in the brain mediates thermogenic sympathetic activation to leptin. (Vols. 23). pp. 1021.6. FASEB Journal.

Harlan, S., Morgan, D. A., Agassandian, K., Cassell, M., Mark, A. L. & Rahmouni, K. (2009). A critical role of leptin receptors in the hypothalamic arcuate nucleus in mediating renal sympathetic activation of leptin. (Vols. 54). pp. e30. Hypertension.

Nogueiras, R., Perez-Tilve, D., Veyrat-Durebex, C., Morgan, D. A., Varela, L., Haynes, W. G., Patterson, J. T., Disse, E., Pfluger, P. T., Lopez, M., Woods, S. C., DiMarchi, R., Dieguez, C., Rahmouni, K., Rohner-Jeanrenaud, F. & Tschop, M. H. (2009). Direct control of peripheral lipid deposition by CNS GLP-1 receptor signaling is mediated by the sympathetic nervous system and blunted in diet-induced obesity. The Journal of neuroscience : the official journal of the Society for Neuroscience, 29(18), 5916-25. PMID: 19420258.

Beyer, A. M., Guo, D. F. & Rahmouni, K. (2009). Angiotensin 1-7 protects against vascular dysfunction associated with diet-induced obesity in mice. (Vols. 54). pp. e38. Hypertension.

Lu, Y., Ma, X., Sabharwal, R., Snitsarev, V., Morgan, D., Rahmouni, K., Drummond, H. A., Whiteis, C. A., Costa, V., Price, M., Benson, C., Welsh, M. J., Chapleau, M. W. & Abboud, F. M. (2009). The ion channel ASIC2 is required for baroreceptor and autonomic control of the circulation. Neuron, 64(6), 885-97. PMID: 20064394.

Seo, S., Guo, D. F., Bugge, K., Morgan, D. A., Rahmouni, K. & Sheffield, V. C. (2009). Requirement of Bardet-Biedl syndrome proteins for leptin receptor signaling. Human molecular genetics, 18(7), 1323-31. PMID: 19150989.

Mark, A. L., Agassandian, K., Morgan, D. A., Liu, X., Cassell, M. D. & Rahmouni, K. (2009). Leptin signaling in the nucleus tractus solitarii increases sympathetic nerve activity to the kidney. Hypertension, 53(2), 375-80. PMID: 19103999.

Rahmouni, K., Sigmund, C. D., Haynes, W. G. & Mark, A. L. (2009). Hypothalamic ERK mediates the anorectic and thermogenic sympathetic effects of leptin. Diabetes, 58(3), 536-42. PMID: 19066310.

Beyer, A. M., Trantow, C., Anderson, M. G. & Rahmouni, K. (2008). Vascular defects in mice with mutation in the Lysosomal Trafficking Regulator gene. (Vols. 22). pp. 1148.14. FASEB Journal.

Morgan, D. A., Rahmouni, K. (2008). Phosphoinositol-3 kinase mediates insulin-induced sympathetic activation in obesity. (Vols. 52). pp. e103-104. Hypertension.

Beyer, A. M., Guo, D. F., Didion, S. P., Sheffield, V. C. & Rahmouni, K. (2008). Bardet-Biedl Syndrome genes are involved in the control of vascular function. (Vols. 52). pp. e37-e38. Hypertension.

Mark, A. L., Agassandian, K., Morgan, D. A., Liu, X., Cassell, M. D. & Rahmouni, K. (2008). Sympathetic responses to microinjection of leptin into the nucleus tractus solitarii: Evidence for a distributed brain network of leptin action. (Vols. 52). pp. e81-e82. Hypertension.

Grobe, J. L., Morgan, D. A., Rahmouni, K. & Sigmund, C. D. (2008). Enhanced sympathetic and HPA-Axis activity contribute to increased metabolic rate in transgenic mice with overactivity of the central renin-angiotensin system. (Vols. 52). pp. e49-e50. Hypertension.

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