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Madeliene Stump

Address: 2-340 BSB
Phone: 335-8926
Email: madeliene-stump@uiowa.edu

Mentor: Curt D. Sigmund, PhD

Undergraduate Institution: Slippery Rock University

Graduate Program: Neuroscience | Medical Scientist Training Program

Year Entered Into Program: 2011

Research Description

The role of Peroxisome proliferator-activated receptor-gamma in neural control of feeding and energy homeostasis

Publication(s)

  1. Mukohda M, Lu KT, Guo DF, Wu J, Keen HL, Liu X, Ketsawatsomkron P, Stump M, Rahmouni K, Quelle FW, Sigmund CD.:  Hypertension-causing mutation in Peroxisome Proliferator-Activated Receptor γ Impairs Nuclear Export of Nuclear Factor-kB p65 in Vascular Smooth Muscle. Hypertension. 70(1):174-182, 2017.  PMCID: PMC5472224 [Available on 2018-07-01]
  2. Stump M, Guo DF, Lu KT, Mukohda M, Cassell MD, Norris AW, Rahmouni K, Sigmund CD.:  Nervous System Expression of PPARγ and Mutant PPARγ Has Profound Effects on Metabolic Regulation and Brain Development. Endocrinology 157(11):4266-4275, 2016.  PMCID: PMC5086539
  3. Stump M, Guo DF, Lu KT, Mukohda M, Liu X, Rahmouni K, Sigmund CD.:  Effect of selective expression of dominant-negative PPARγ in pro-opiomelanocortin neurons on the control of energy balance. Physiol Genomics 48(7):491-501, 2016.  PMCID: PMC4967222
  4. Ketsawatsomkron P, Keen HL, Davis DR, Lu KT, Stump M, De Silva TM, Hilzendeger AM, Grobe JL, Faraci FM, Sigmund CD.:  Protective Role for Tissue Inhibitor of Metalloproteinase-4, a Novel Peroxisome Proliferator-Activated Receptor-γ Target Gene, in Smooth Muscle in Deoxycorticosterone Acetate-Salt Hypertension. Hypertension 67(1):214-22, 2016.  PMCID: PMC4679422
  5. Mukohda M, Stump M, Ketsawatsomkron P, Hu C, Quelle FW, Sigmund CD.:  Endothelial PPAR-γ provides vascular protection from IL-1β-induced oxidative stress. Am J Physiol Heart Circ Physiol 310(1):H39-48, 2016.  PMCID: PMC4796462
  6. Stump M, Mukohda M, Hu C, Sigmund CD.:  PPARγ Regulation in Hypertension and Metabolic Syndrome. Curr Hypertens Rep 17(12):89, 2015.  PMID: 26462805
  7. Kreple CJ, Lu Y, Taugher RJ, Schwager-Gutman AL, Du J, Stump M, Wang Y, Ghobbeh A, Fan R, Cosme CV, Sowers LP, Welsh MJ, Radley JJ, LaLumiere RT, Wemmie JA.:  Acid-sensing ion channels contribute to synaptic transmission and inhibit cocaine-evoked plasticity. Nat Neurosci 17(8):1083-91, 2014.  PMCID: PMC4115047