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Jing Wu, PhD

Address: 2-340 BSB
Phone: (319) 335-8926
Email: jing-wu-2@uiowa.edu

Mentor: Curt D. Sigmund, PhD

PhD Institution: Vanderbilt University, Nashville, 2015

Research Description

The role of vascular PPAR-gamma and Cullin3 in renal vascular resistance, blood flow, and blood pressure regulation

Awards

  • AHA Kidney Council New Investigator Travel Award, Joint Hypertension Scientific Sessions, 2018
  • Caroline tum Suden/Frances Hellebrandt Professional Opportunity Award by American Physiological Society, 2018
  • Ranbir K. Bhatnagar Scholar Award, Department of Pharmacology, the University of Iowa, 2018
  • Gordon Research Conference on Angiotensin Travel Award, 2018
  • The University of Iowa Postdoctoral Association Travel Award, 2017
  • FUJIFILM VisualSonics Vevo Travel Award, 2017
  • American Heart Association Postdoctoral Fellowship, 2017-2019
  • 4th Annual Abboud Cardiovascular Research Center Symposium Poster Session Travel Award, 2017
  • Council on Hypertension Scientific Session Travel Award for New Investigators, 2017
  • Finalist in the 2017 Juan Carlos Romero and Water and Electrolyte Homeostasis Section Postdoctoral Research Recognition Award, 2017
  • American Physiology Society Travel Award, 2016
  • On-site Poster Competition Award, Council on Hypertension, AHA, 2016
  • Chinese Government Award for Outstanding Self-financed Students Abroad, 2016
  • Carver College of Medicine Postdoctoral Scholarship, University of Iowa, 2015

Publications  --  https://www.ncbi.nlm.nih.gov/sites/myncbi/jing.wu.3/collections/51909318/public/

  1. Sandgren JA, Deng G, Linggonegoro D, Scroggins SM, Perschbacher K, Nair AR, Nishimura T, Zhang SY, Agbor LN, Wu J, Keen HL, Naber MC, Pearson NA, Zimmerman K, Weiss RM, Bowdler N, Usachev Y, Santillan DA, Potthoff MJ, Pierce GL, Gibson-Corley KN, Sigmund CD, Santillan MK, Justin L. Grobe.: Arginine vasopressin infusion is sufficient to model clinical features of preeclampsia in mice. JCI Insight 3(19), pii: 99403, 2018.  PMCID: PMC6237463
  2. Nair AR, Agbor LN, Mukohda M, Liu X, Hu C, Wu J, Sigmund CD.: Interference with Endothelial PPARγ Causes Accelerated Cerebral Vascular Dysfunction in Response to Endogenous Renin-Angiotensin System Activation. Hypertension. 72(5):1227-1235, 2018.  PMCID: PMC6209120
  3. Norlander AE, Saleh MA, Pandey AK, Itani HA, Wu J, Xiao L, Kang J, Dale BL, Goleva SB, Du L, Harrison DG, Madhur MS.: A Salt Sensing Kinase in T Lymphocytes, SGK1, Drives Hypertension and Hypertensive End-Organ Damage. JCI Insight. 2(13):e92801, 2017. PMCID: PMC5499362
  4. Mukohda M, Lu KT, Guo DF, Wu J, Keen HL, Liu X, Ketsawatsomkron P, Stump M, Rahmouni K, Quelle FW, Sigmund CD.: Hypertension-Causing Mutation in Peroxisome Proliferator-Activated Receptor γ Impairs Nuclear Export of Nuclear Factor-κB p65 in Vascular Smooth Muscle. Hypertension 70(1):174-182, 2017.  PMCID: PMC5472224
  5. Hu C, Keen HL, Lu KT, Liu X, Wu J, Davis DR, Ibeawuchi SC, Vogel S, Quelle FW, Sigmund CD.:  Retinol-binding protein 7 is an endothelium-specific PPARγ cofactor mediating an antioxidant response through adiponectin.  JCI Insight. 2(6):e91738, 2017.  PMCID: PMC5358481
  6. Norlander AE, Saleh MA, Pandey AK, Itani HA, Wu J, Xiao L, Kang J, Dale BL, Goleva SB, Laroumanie F, Du L, Harrison DG, Madhur MS.: A salt-sensing kinase in T lymphocytes, SGK1, drives hypertension and hypertensive end-organ damage. JCI Insight 2(13), 2017. 
  7. Agbor LN, Ibeawuchi SC, Hu C, Wu J, Davis DR, Keen HL, Quelle FW, Sigmund CD.:  Cullin-3 mutation causes arterial stiffness and hypertension through a vascular smooth muscle mechanism. JCI Insight 1(19):e91015, 2016.  PMCID: PMC5111503
  8. Wu J, Sigmund CD.:  Hypertension: A Disease That Strikes Around the Clock. Hypertension 67(3):493-5, 2016.  PMCID: PMC4819989
  9. Wu J, Saleh MA, Kirabo A, Itani HA, Montaniel KRC, Xiao L, Chen W, Mernaugh RL, Cai H, Berstein KE, Goronzy JJ, Weyand CM, Curci JA, Barbaro NR, Moreno H, Davis SS, Roberts J, Madhur MS, Davies SS, Roberts J II, Harrison DG.:  Immune activation caused by vascular oxidation promotes fibrosis and hypertension. J Clin Invest. 126(1):50-67, 2016. PMCID: PMC4701546  (Highlighted by: Nature Reviews Nephrology. 12(1):4, 2016.
  10. Wu J, Montaniel KRC, Saleh MA, Xiao L, Chen W, Owens GK, Majesky MW, Hatzopoulos AK, Madhur MS, Harrison DG.:  Origin of Matrix-producing Cells that Contribute to Aortic Fibrosis in Hypertension. Hypertension. 67(2):461-8, 2016. PMCID: PMC4713264 (Editorial Comment: Hypertension. 67(2):272-4, 2016.
  11. Bersi MR*, Bellini C*, Wu J*, Montaniel KRC, Harrison DG, Humphrey JD.:  Excessive Adventitial Remodeling Leads to Early Aortic Maladaptation in Angiotensin-Induced Hypertension. Hypertension. 67(5):890-6, 2016. *These authors contributed equally. PMCID: PMC4833633 (Editorial Comment: Hypertension. 67(5):836-8, 2016. 
  12. Mikolajczyk TP, Nosalski R, Budzyn K, Osmenda G, Skiba D, Sagan A, Wu J, Vinh A, Marvar PJ, Drummond G, Guzik B, Podolec J, Lob HE, Harrison DG, Guzik TJ.:  Role of chemokine RANTES in the regulation of perivascular inflammation, T cell accumulation and vascular dysfunction in hypertension. FASEB J. 30(5):1987-99, 2016. PMCID: PMC4836375
  13. Itani HA, Xiao L, Saleh MA, Wu J, Pilkinton MA, Dale BL, Barbaro NR, Foss JD, Kirabo A, Montaniel KRC, Chen W, Madhur MS, Sato R, Navar LG, Elijovich F, Laffer CL, Mallal SA, Bernstein KE, Harrison DG.:  CD70 Exacerbates Blood Pressure Elevation and Renal Damage in Response to Repeated Hypertensive Stimuli. Circ Res. 118(8):1233-43, 2016. PMCID: PMC4833561
  14. Saleh MA, McMaster WG, Wu J, Norlander AE, Funt SA, Thabet SR, Kirabo A, Xiao L, Chen W, Itani HA, Huan T, Levy D, Harrison DG, Madhur MS.:  Lymphocyte adaptor protein LNK deficiency exacerbates hypertension and end-organ inflammation. J Clin Invest. 125(3):1189-202, 2015. PMCID: PMC4362266
  15. Xiao L, Kirabo A, Wu J, Saleh MA, Zhu L, Wang F, Takahashi T, Loperena R, Foss JD, Chen W, Osborn JW, Itani HA, Harrison DG.:  Renal denervation prevents immune cell activation and renal inflammation in hypertension. Circ Res. 117(6):547-57, 2015. PMCID: PMC4629828
  16. Wu J, Thabet S, Kirabo A, Trott DW, Saleh MA, Xiao L, Chen W, Madhur MS, Harrison DG.:  Inflammation and mechanical stretch promote aortic stiffening in hypertension through activation of p38 MAP kinase. Circ Res. 114(4):616-25, 2014.  PMCID: PMC4186716
  17. Wu J, Luft FC.:  Mineralcorticoid-Receptor Signaling in Vascular Smooth Muscle. Nephrology Dialysis Transplantation. 28(6):1360-2. 2014. PMCID: PMC4007112
  18. Trott DW, Thabet SR, Kirabo A, Saleh MA, Itani HA, Norlander AE, Wu J, Goldstein A, Arendshorst WJ, Madhur MS, Chen W, Li CI, Shyr Y, Titze JM, Harrison DG.:  Oligoclonal CD8+ T cells play a critical role in the development of hypertension. Hypertension. 64(5):1108-15, 2014. PMCID: PMC4191997
  19. Kirabo A, Fontana V, Faria AP, Loprena R, Galindo CL, Wu J, Bikineyeva AT, Dikalov S, Xiao L, Chen W, Saleh MA, Trott DW, Itani HA, Vinh A, Amarnath V, Amarnath K, Guzik TJ, Bernstein K, Shen XZ, Shyr Y, Chen S, Mernaugh RL, Laffer CL, Elijovich F, Davies SS, Moreno H, Madhur MS, Roberts J II, Harrison DG.:  Dendritic cell superoxide and isoketals activate T cells and promote angiotensin II Hypertension. J Clin Invest. 124(10):4642-56, 2014. PMCID: PMCC4220659
  20. Mai T, Wu J, Diedrich AM, Garland EM, Robertson D.:  Calcitonin gene related peptide (CGRP) in autonomic cardiovascular regulation and blood vessel structure. J Am Soc Hypertens. 8(5):286-96, 2014.  PMCID: PMC4072204
  21. Tong LX, Chen W, Wu J, Li HX.:  Folic acid-coupled nano-paclitaxel liposome reverses drug resistance in SKOV3/TAX ovarian cancer cells. Anti-cancer Drugs. 25(3):244-54, 2014.
  22. Wang YF, Wu J, Shen YH.:  An epidemiological study of gastro-esophageal reflux disease. Modern Preventive Medicine, 37(23):4413-4416, 2010.
  23. Ruan J, Wu J.:  Analysis of the blood pressure control rate and its risk factors of patients with hypertension in the community of medical senior intellectuals. Chinese Circulation Journal, 24(5):367-370, 2009.
  24. Fan SG, Wu J, Lu A.:  Long-term regulation of arterial pressure and essential hypertension-part II. Progress in Physiological Sciences 38(1):49-57, 2007.
  25. Fan SG, Wu J, Lu A.:  Long-term regulation of arterial pressure and essential hypertension-part I. Progress in Physiological Sciences 37(4):339-346, 2006.

Books / Chapters

  1. Wu J, Harrison DG. Oxidative stress and hypertension. Blood Pressure and Arterial Wall. Mechanics in Cardiovascular Diseases. Editors: Safar ME, O’Rouke MF and Frohlich ED. Springer-Verlag, London 2014. Chapter 15, Page 175-191. ISBN 978-1-4471-5198-2.

Patent

  • Harrison DG, Montaniel KRC, Wu J, Vickers KC, Humprey JD, Bersi M. US Utility Patent entitled “Treatment for Conditions Associated with Fibrosis and Collagen Deposition”, application number 15/265,813.