Donna L. Hammond, PhD

Portrait
Professor of Anesthesia
Professor of Pharmacology

Contact Information

Primary Office: 445 MRC
501 Newton Road
Iowa City, IA 52242
319-356-2633

Lab: 3000 ML
25 South Grand Avenue
Iowa City, IA 52242
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Education

BS, Biochemical Pharmacology, State University of New York at Buffalo
PhD, Pharmacology, University of Illinois at Chicago

Postdoctoral Fellow, Mayo Clinic
Postdoctoral Fellow, Mayo Clinic

Education/Training Program Affiliations

Interdisciplinary Graduate Program in Neuroscience, Interdisciplinary Graduate Program in Translational Biomedicine, Medical Scientist Training Program

Center, Program and Institute Affiliations

Pain Research Program

Research Summary

The overall goal of our research is to gain a better understanding of the neuroanatomy, neurophysiology and neuropharmacology of the central nervous system pathways that convey pain, as well as the bulbospinal pathways that modulate the transmission of nociceptive information. Our studies emphasize a systems-level approach that uses many different methodologies in concert, including behavioral pharmacology in normal, transgenic or knockout animals, neuroanatomical tract tracing, immunocytochemical labeling of neurons, measurement of neurotransmitter release by push-pull perfusion or microdialysis, and electrophysiological recordings from neurons in slices of the spinal cord or brainstem. We are particularly interested in the role that inhibitory neurotransmitters, such as gamma-aminobutyric acid (GABA) or the endogenous opioid peptides, play in the modulation of nociceptive sensitivity at the level of the spinal cord and brainstem. Our early studies focused on how these neurotransmitter systems dictate responses to acute or transient nociception. More recent investigations have focused on the role of these neurotransmitters in the response of the central nervous system to peripheral injury and the occurrence of persistent pain in either the neonate or the adult. Our results indicate that persistent pain can lead to long-term changes in the pharmacology and physiology of both the afferent pathways that convey pain, as well as the efferent pathways that suppress pain. These changes have significant consequences for the ability of drugs to produce analgesia and for the body to invoke its own homeostatic mechanisms for the control of pain. The plasticity of central nervous system pathways in response to persistent neuropathic and inflammatory pain will continue to be a focus of our work in the future.

Publications

Jareczek, F. J., White, S. R. & Hammond, D. L. (2017). Plasticity in brainstem mechanisms of pain modulation by nicotinic acetylcholine receptors in the rat. eNeuro, 4(1). PMID: 28197544.

Hammond, D. L., Walder, R. Y., Ourties, G., White, S. R. & Hamity, M. V. (2017). Paclitaxel alters enzymes involved in the biosynthesis of NAD+ in the dorsal root ganglia and dorsal horn of the rat: reversal by nicotinamide riboside.

Wattiez, A., Walder, R. Y., Sande, C. M., White, S. R. & Hammond, D. L. (2017). [EXPRESS] Peripheral inflammatory injury alters the relative abundance of Ga subunits in the dorsal horn of the spinal cord and in the rostral ventromedial medulla of male rats. Molecular pain, 13, 1744806917715210. PMID: 28604220.

Hamity, M. V., White, S. R., Gibson-Corley, K. N., Brenner, C. M. & Hammond, D. L. (2017). Relief of paclitaxel-induced peripheral neuropathy by nicotinamide riboside in tumor-bearing rats.

Hamity, M. V., White, S. R., Gibson-Corley, K. N. & Hammond, D. L. (2017). The nicotinamide adenine dinucleotide (NAD+) precursor nicotinamide riboside (NR) relieves paclitaxel-induced peripheral neuropathy in tumor bearing rats and does not facilitate tumor growth or interfere with the effects of paclitaxel.

Hamity, M. V., White, S. R., Walder, R. Y., Schmidt, M. S., Brenner, C. & Hammond, D. L. (2017). Nicotinamide riboside, a form of vitamin B3 and NAD+ precursor, relieves the nociceptive and aversive dimensions of paclitaxel-induced peripheral neuropathy in female rats. Pain, 158(5), 962-72. PMID: 28346814.

Maduka, U. P., Hamity, M. V., Walder, R. Y., White, S. R., Li, Y. & Hammond, D. L. (2016). Changes in the disposition of substance P in the rostral ventromedial medulla after inflammatory injury in the rat. Neuroscience, 317, 1-11. PMID: 26762802.

Hamity, M. V., White, S. R., Walder, R. Y., Schmidt, M., Brenner, C. D. & Hammond, D. L. (2016). Nicotinamide riboside: a novel approach to treating peripheral neuropathy induced by paclitaxel.

Jareczek, F., White, S. R., Sande, C. & Hammond, D. L. (2016). Behavioral and receptor pharmacology of nicotinic agonist epibatidine in key brainstem pain modulatory nuclei.

Wattiez, A., Sande, C. M., Walder, R. Y. & Hammond, D. L. (2015). Protein and Transcript Levels for G-mu Proteins in the Rostral Ventromedial Medulla and Dorsal Horn of the Spinal Cord of Rats with Peripheral Inflammatory Injury.

Hamity, M. V., Maduka, U. P. & Hammond, D. L. (2015). Dissecting the Mechanism of Substance P Release in the Rat Rostral Ventromedial Medulla during Inflammatory Injury.

Hamity, M. V., Walder, R. Y. & Hammond, D. L. (2014). Increased neuronal expression of neurokinin-1 receptor and stimulus-evoked internalization of the receptor in the rostral ventromedial medulla of the rat after peripheral inflammatory injury. The Journal of Comparative Neurology, 522(13), 3037-51. PMID: 24639151.

White, S., Marquez de Prado, B., Russo, A. F. & Hammond, D. L. (2014). Heat hyperalgesia and mechanical hypersensitivity induced by calcitonin gene-related peptide in a mouse model of neurofibromatosis. PloS One, 9(9), e106767. PMID: 25184332.

Walder, R. Y., Wattiez, A., White, S. R., Marquez de Prado, B., Hamity, M. V. & Hammond, D. L. (2014). Validation of four reference genes for quantitative mRNA expression studies in a rat model of inflammatory injury. Molecular Pain, 10, 55. PMID: 25187167.

Hammond, D. L. (2013). Descending Circuitry, Opioids. In G. F. Gebhart , R. F. Schmidt (Eds.) Encyclopedic Reference of Pain. pp. 897-904. New York, NY: Springer-Verlag LLC. DOI: 10.1007/978-3-642-28753-4_1050.

Wattiez, A., Walder, R. Y., White, S. R. & Hammond, D. L. (2013). Levels of Transcript for G-mu Proteins in the Rostral Ventromedial Medulla of Rats with Peripheral Inflammatory Injury.

Hamity, M. V., Maduka, U. P., Walters, K. S. & Hammond, D. L. (2013). Release of Substance P (SP) in the Rat Rostral Ventromedial Medulla (RVM): Modulation by Inflammatory Injury and Presynaptic N-methyl-D-aspartate Receptors (NMDARs).

Walder, R. Y., Cano, M., White, S. R. & Hammond, D. L. (2013). Dialysis of DAMGO in the Rostral Ventromedial Medulla (RVM) Alters Extracellular Concentrations of GABA and Glutamate (GLU) in Rats With Persistent Inflammation.

Engle, M. P., Merrill, M. A., Marquez De Prado, B. & Hammond, D. L. (2012). Spinal nerve ligation decreases ?-aminobutyric acidB receptors on specific populations of immunohistochemically identified neurons in L5 dorsal root ganglion of the rat. The Journal of Comparative Neurology, 520(8), 1663-77. PMID: 22120979.

Marquez de Prado, B., Hammond, D. L. (2011). Sex Dependent Enhancement of Pain Responses in a Mouse Model of Neurofibromatosis (NF).

Hammond, D. L. (2011). Disrupting ASIC1a increases met-enkephalin and alters opioid-dependent behavior.

Hahm, E., Hammond, D. L. & Proudfit, H. K. (2011). Substance P induces the reversible formation of varicosities in the dendrites of rat brainstem neurons. Brain Research, 1369, 36-45. PMID: 21044613.

Maduka, U. P., Hamity, M. V. & Hammond, D. L. (2011). Unilateral Inflammatory Injury Does Not Increase Levels of Substance P (SP) in the Rostral Ventromedial Medulla (RVM), Dorsal Root Ganglia (DRG), or Dorsal Horn of the Rat.

Hamity, M. V., Hammond, D. L. (2011). Persistent peripheral inflammation increases the number of neurokinin-1 receptor (NK1-R) expressing neurons in the rostral ventromedial medulla (RVM).

Hammond, D. L. (2011). Expression levels of G-protein inward rectifying potassium channel subunits (GIRK1-4) in the rostral ventromedial medulla (RVM) are unchanged in rats with persistent inflammatory pain.

Hammond, D. L. (2011). Persistent inflammatory nociception diminishes the antinociceptive, but not the antihyperalgesic efficacy of nicotinic cholinergic agonists in the rostroventral medulla (RVM).

Hamity, M. V., White, S. R. & Hammond, D. L. (2010). Effects of neurokinin-1 receptor agonism and antagonism in the rostral ventromedial medulla of rats with acute or persistent inflammatory nociception. Neuroscience, 165(3), 902-13. PMID: 19892001.

Marquez de Prado, B., Hammond, D. L. (2010). Recober A: Investigation the Role of CaMKII Binding to NR2B in models of inflammatory pain.

Zhang, L., Hammond, D. L. (2010). Cellular basis for opioid potentiation in the rostral ventromedial medulla of rats with persistent inflammatory nociception. Pain, 149(1), 107-16. PMID: 20172653.

Rossi, H. L., Hammond, D. L. & Recober, A. (2010). Effect of Sleep Deprivation on Trigeminally-Mediated Pain and on Activation of the Trigeminal Nucleus Caudalis in Mice.

Marquez de Prado, B., Hammond, D. L. & Russo, A. F. (2009). Genetic enhancement of calcitonin gene-related Peptide-induced central sensitization to mechanical stimuli in mice. The Journal of Pain, 10(9), 992-1000. PMID: 19628434.

Zhang, L., Hammond, D. L. (2009). Substance P enhances excitatory synaptic transmission on spinally projecting neurons in the rostral ventromedial medulla after inflammatory injury. Journal of Neurophysiology, 102(2), 1139-51. PMID: 19494188.

Price, T. J., Cervero, F., Gold, M. S., Hammond, D. L. & Prescott, S. A. (2009). Chloride regulation in the pain pathway. Brain Research Reviews, 60(1), 149-70. PMID: 19167425.

Jongeling, A. C., Johns, M. E., Murphy, A. Z. & Hammond, D. L. (2009). Persistent inflammatory pain decreases the antinociceptive effects of the mu opioid receptor agonist DAMGO in the locus coeruleus of male rats. Neuropharmacology, 56(6-7), 1017-26. PMID: 19265713.

Aldrich, B. T., Frakes, E. P., Kasuya, J., Hammond, D. L. & Kitamoto, T. (2009). Changes in expression of sensory organ-specific microRNAs in rat dorsal root ganglia in association with mechanical hypersensitivity induced by spinal nerve ligation. Neuroscience, 164(2), 711-23. PMID: 19699278.

Tsai, Y. H., Hammond, D. L. (2007). Spinal Antagonism of the Na-K-2Cl Cotransporter (NKCC1) Induces allodynia, but not Thermal Hyperalgesia in Rats.

Zhang, L., Jongeling, A. C. & Hammond, D. L. (2007). Suitability of the retrograde tracer Dil for electrophysiological studies of brainstem neurons: adverse ramifications for G-protein coupled receptor agonists. Journal of Neuroscience Methods, 160(1), 116-21. PMID: 17045656.

Hammond, D. L., Proudfit, H. K. (2007). Descending Circuitry, Opioids. In R. F. Schmidt , W. D. Willis (Eds.) Encyclopedic Reference of Pain. pp. 547-551. New York, NY: Springer-Verlag LLC. DOI: 10.1007/978-3-540-29805-2_1050.

Sykes, K. T., White, S. R., Hurley, R. W., Mizoguchi, H., Tseng, L. F. & Hammond, D. L. (2007). Mechanisms responsible for the enhanced antinociceptive effects of micro-opioid receptor agonists in the rostral ventromedial medulla of male rats with persistent inflammatory pain. The Journal of Pharmacology and Experimental Therapeutics, 322(2), 813-21. PMID: 17494863.

Zhang, L., Sykes, K. T., Buhler, A. V. & Hammond, D. L. (2006). Electrophysiological heterogeneity of spinally projecting serotonergic and nonserotonergic neurons in the rostral ventromedial medulla. Journal of Neurophysiology, 95(3), 1853-63. PMID: 16338998.

White, S., Zhang, L. & Hammond, D. L. (2006). Development of Mechanical and Thermal Hyperalgesia and Inflammation in Neonatal Rat.

Liang, Z., Hammond, D. L. (2006). Peripheral Inflammation Enhances the Efficacy of Excitatory Synaptic Transmission in Spinally Projecting Neurons in Rostral Ventromedial Medulla (RVM).

Engle, M. P., Hammond, D. L. (2006). Distribution of GABA(B) Receptors on Immunohistochemically Identified Neurons in the L4 and L5 Dorsal Root Ganglia of the Rat: Lack of Effect of Spinal Nerve Ligation.

Sykes, K., Hammond, D. L. (2006). DAMGO and Deltorphin (DELT) can Interact Synergistically in the Rostral Ventromedial Medulla (RVM) to Produce Antinociception.

Hammond, D. L. (2006). Opioids and Neuropathic Pain. In A. I. Basbaum , R. Dubner , J. N. Campbell , A. Dray , R. H. Dworkin , C. N. Sang (Eds.) Emerging Strategies for the Treatment of Neuropathic Pain. pp. 139-59. Seattle, WA: IASP Press.

Frakes, E., Cutkomp, J. & Hammond, D. L. (2006). Postural Asymmetry May Contribute to Reduced Mechanical Withdrawal Thresholds After Unilateral Nerve Injury.

Engle, M. P., Gassman, M., Sykes, K. T., Bettler, B. & Hammond, D. L. (2006). Spinal nerve ligation does not alter the expression or function of GABA(B) receptors in spinal cord and dorsal root ganglia of the rat. Neuroscience, 138(4), 1277-87. PMID: 16427742.

Jongeling, A. J., Zhang, L. & Hammond, D. L. (2005). Effect of Persistent Inflammation on Actions of DAMGO, a mu Opioid Receptor Agonist, on Locus Coeruleus Neurons in the Rat.

Hammond, D. L., Hines, C. I. & Proudfit, H. K. (2004). Dendritic Varicosities in NK1-IR GABA Neurons Mediate the Antinociception Produced by Microinjection of Morphine in the Rostral Ventromedial Medulla (RVM).

Hammond, D. L. (2004). Persistent Inflammatory Nociception and Opioid Actions in the Periphery, Spinal Cord and Brainstem. In H. Handwerker , K. Brune (Eds.) Hyperalgesias – From Molecular Mechanisms to Clinical Applications. pp. 291-309. Seattle, WA: Pain Research and Management/IASP Press.

Hammond, D. L., Ackerman, L., Holdsworth, R. & Elzey, B. (2004). Effects of spinal nerve ligation on immunohistochemically identified neurons in the L4 and L5 dorsal root ganglia of the rat. The Journal of Comparative Neurology, 475(4), 575-89. PMID: 15236238.

Frakes, E. P., Hammond, D. L. (2004). Effects of Spinal Nerve Ligation (SNL) on GABA(A) Receptor and Potassium-chloride Exporter (KCC2) in the Spinal Cord Dorsal Horn.

Engle, M. P., Hammond, D. L. (2004). Effects of Spinal Nerve Ligation on GABA(B) Receptor Expression in the Spinal Cord.

Zhang, L., Sykes, K. T. & Hammond, D. L. (2004). Peripheral inflammation increases the proportion of spinally projecting neurons that express functional mu opioid receptors in the rostral ventromedial medulla (RVM).

Naguib, M., Hammond, D. L., Schmid, 3rd, P. G., Baker, M. T., Cutkomp, J., Queral, L. & Smith, T. (2003). Pharmacological effects of intravenous melatonin: comparative studies with thiopental and propofol. British Journal of Anaesthesia, 90(4), 504-7. PMID: 12644425.

Hammond, D. L., Elzey, B., Ackerman, L. & Holdsworth, R. (2003). Spinal nerve ligation produces a time-dependent, reversible decrease in immunohistochemical markers for small size neurons in the L5, but not the L4 dorsal root ganglia (DRG).

Hurley, R. W., Banfor, P. & Hammond, D. L. (2003). Spinal pharmacology of antinociception produced by microinjection of mu or delta opioid receptor agonists in the ventromedial medulla of the rat. Neuroscience, 118(3), 789-96. PMID: 12710986.

Zhang, L., Buhler, A., Sykes, K., Proudfit, H. & Hammond, D. L. (2003). Effects of mu opioid and GABA(B) receptor agonists on identified neurons in the rostral ventromedial medulla (RVM).

Ackerman, L. L., Holdsworth, R. L., Elzey, B. & Hammond, D. L. (2002). Staining for IB(4)-immunoreactive neurons after spinal nerve root ligation in the rat.

Hurley, R. W., Chatterjea, D., Rose Feng, M. R., Taylor, C. P. & Hammond, D. L. (2002). Gabapentin and pregabalin can interact synergistically with naproxen to produce antihyperalgesia. Anesthesiology, 97(5), 1263-73. PMID: 12411814.

Parra, M. C., Nguyen, T. N., Hurley, R. W. & Hammond, D. L. (2002). Persistent inflammatory nociception increases levels of dynorphin 1-17 in the spinal cord, but not in supraspinal nuclei involved in pain modulation. The Journal of Pain, 3(4), 330-6. PMID: 14622757.

Arunkumar, R., Ackerman, L. L., Jones, R. C., Holdsworth, R., Proudfit, H. K. & Hammond, D. L. (2002). Loss of IB(4) staining in dorsal root ganglion neurons after spinal nerve ligation is not the result of cell death.

Hammond, D. L. (2001). GABA(B) receptors: new tricks by an old dog. Current Opinion in Pharmacology, 1(1), 26-30. PMID: 11712531.

Naguib, M., Hammond, D. L., Baker, M., Cutkomp, J. & Queral, L. (2001). Induction of general anesthesia by melatonin: Comparative dose-effect studies with thiopental and propofol. Anesthesiology.

Hurley, R. W., Hammond, D. L. (2001). Contribution of endogenous enkephalins to the enhanced analgesic effects of supraspinal mu opioid receptor agonists after inflammatory injury. The Journal of Neuroscience, 21(7), 2536-45. PMID: 11264327.

Hammond, D. L., Donald, M. C., Nguyen, T. & Hurley, R. W. (2001). Upregulation of dynorphin in the rostroventromedial medulla (RVM) after inflammation: Implications for the actions of opioid receptor agonists. (Vols. 2 Supplement). pp. 30. Journal of Pain.

Hammond, D. L. (2001). J.J. Bonica Lecture--2001: role of spinal GABA in acute and persistent nociception. Regional Anesthesia and Pain Medicine, 26(6), 551-7. PMID: 11707795.

Ackley, M. A., Hurley, R. W., Virnich, D. E. & Hammond, D. L. (2001). A cellular mechanism for the antinociceptive effect of a kappa opioid receptor agonist. Pain, 91(3), 377-88. PMID: 11275396.

Oh, S. B., Tran, P. B., Gillard, S. E., Hurley, R. W., Hammond, D. L. & Miller, R. J. (2001). Chemokines and glycoprotein120 produce pain hypersensitivity by directly exciting primary nociceptive neurons. The Journal of Neuroscience, 21(14), 5027-35. PMID: 11438578.

Ugarte, S. D., Homanics, G. E. & Hammond, D. L. (2001). Effect of embryonic knock-down of GABAA receptors on the levels of monoamines and their metabolites in the CNS of the mouse. Brain Research, 904(2), 290-7. PMID: 11406127.

Ugarte, S. D., Homanics, G. E., Firestone, L. L. & Hammond, D. L. (2000). Sensory thresholds and the antinociceptive effects of GABA receptor agonists in mice lacking the beta3 subunit of the GABA(A) receptor. Neuroscience, 95(3), 795-806. PMID: 10670447.

Hurley, R. W., Mizoguchi, H., Tseng, L. F. & Hammond, D. L. (2000). Effects of mu and delta opioid receptor ligands on G-protein activation in the rostral ventromedial medulla of rats with persistent inflammation. (Vols. 26). pp. 1066. Neuroscience.

Tran, P. B., Oh, S. B., Gillard, S. E., Bodner, A., Hurley, R. W. & Hammond, D. L. (2000). Allodynia resulting from the activation of sensory neuron chemokine receptors. (Vols. 26). pp. 1185. Neuroscience.

Hurley, R. W., Hammond, D. L. (2000). The analgesic effects of supraspinal mu and delta opioid receptor agonists are potentiated during persistent inflammation. The Journal of Neuroscience, 20(3), 1249-59. PMID: 10648729.

Graham, B. A., Hammond, D. L. & Proudfit, H. K. (2000). Synergistic interactions between two alpha(2)-adrenoceptor agonists, dexmedetomidine and ST-91, in two substrains of Sprague-Dawley rats. Pain, 85(1-2), 135-43. PMID: 10692612.

Kaneko, M., Mestre, C., Sánchez, E. H. & Hammond, D. L. (2000). Intrathecally administered gabapentin inhibits formalin-evoked nociception and the expression of Fos-like immunoreactivity in the spinal cord of the rat. The Journal of Pharmacology and Experimental Therapeutics, 292(2), 743-51. PMID: 10640314.

Ackley, M. A., Hurley, R. W. & Hammond, D. L. (1999). Kappa opioid receptor agonists in the rostral ventromedial medulla modulate synaptic transmission in vitro and are antinociceptive in vivo. (Vols. 25). pp. 1437. Neuroscience.

Grabow, T. S., Hammond, D. L. (1999). Noradrenergic mediation of supraspinal and spinal delta(2) receptor mediated antinociceptive synergy. Anesthesiology.

Hurley, R. W., Chatterjea, D., Lotarski, S. M., Taylor, C. P. & Hammond, D. L. (1999). Synergistic and additive interactions of gabapentin and naproxen.

Hurley, R. W., Hammond, D. L. (1999). Delta(2) opioid receptors mediate the enhanced antinociceptive effects of Mu-agonists in rats with persistent nociception. (Vols. 25). pp. 1437. Neuroscience.

Ugarte, S. D., Seiden, L. S., Vosner, G., Homanics, G. E. & Hammond, D. L. (1999). Development of monoaminergic systems in the mouse in largely unaffected by knock-down of GABA(A) receptors. (Vols. 25). pp. 1789. Neuroscience.

Grabow, T. S., Hurley, R. W., Banfor, P. N. & Hammond, D. L. (1999). Supraspinal and spinal delta(2) opioid receptor-mediated antinociceptive synergy is mediated by spinal alpha(2) adrenoceptors. Pain, 83(1), 47-55. PMID: 10506671.

Hurley, R. W., Grabow, T. S., Tallarida, R. J. & Hammond, D. L. (1999). Interaction between medullary and spinal delta1 and delta2 opioid receptors in the production of antinociception in the rat. The Journal of Pharmacology and Experimental Therapeutics, 289(2), 993-9. PMID: 10215679.

Hammond, D. L., Hurley, R. W., Grabow, T. S. & Tallarida, R. J. (1998). Characterization of the interaction between supraspinal and spinal delta(1) and delta(2) opioid receptors in the production of antinociception. (Vols. 24). pp. 891. Neuroscience.

Ugarte, S. D., Homaniacs, G. E., Quinlan, J. J., Firestone, L. L. & Hammond, D. L. (1998). Sensory thresholds and the antinociceptive effects of GABA receptor agonists in mice lacking the beta-3 subunit of the GABA(B) receptor. (Vols. 24). pp. 641. Neuroscience.

Hammond, D. L., Kaneko, M. & Mestre, C. (1998). Pharmacological and neuroanatomical studies of the antinociceptive effects of intrathecally administered gabapentin. (Vols. 47). pp. S229-30. Masui.

Hammond, D. L., Wang, H., Nakashima, N. & Basbaum, A. I. (1998). Differential effects of intrathecally administered delta and mu opioid receptor agonists on formalin-evoked nociception and on the expression of Fos-like immunoreactivity in the spinal cord of the rat. The Journal of Pharmacology and Experimental Therapeutics, 284(1), 378-87. PMID: 9435201.

Hammond, D. L., Nelson, V. & Thomas, D. A. (1998). Intrathecal methysergide antagonizes the antinociception, but not the hyperalgesia produced by microinjection of baclofen in the ventromedial medulla of the rat. Neuroscience Letters, 244(2), 93-6. PMID: 9572593.

Hammond, D. L., Kaneko, M. & Mestre, C. (1998). Pharmacological and neuroanatomical studies of the antinociceptive effects of intrathecally administered gabapentin. Masui: The Japanese Journal of Anesthesiology, 47 Suppl, S229-30. PMID: 9921192.

John, J. M., Kaneko, M. & Hammond, D. L. (1998). Intrathecal bicuculline does not increase formalin-induced inflammation. Brain Research, 794(2), 320-4. PMID: 9622664.

Hurley, R. W., Hammond, D. L. (1998). Enhancement of the antinociceptive effects of supraspinally administered mu and delta opioid receptor agonists under conditions of persistent inflammatory nociception. (Vols. 24). pp. 891. Neuroscience.

Hammond, D. L., Graham, B. A. (1997). GABAergic Drugs and the Clinical Management of Pain. In J. F. Biebuyck , C. Lynch , M. Maze , L. J. Saidman , T. L. Yaksh , W. M. Zapol (Eds.) Anesthesia: Biologic Foundations. pp. 969-75. New York, NY: Raven Press.

Kaneko, M., Hammond, D. L. (1997). Role of spinal gamma-aminobutyric acidA receptors in formalin-induced nociception in the rat. The Journal of Pharmacology and Experimental Therapeutics, 282(2), 928-38. PMID: 9262360.

Hama, A. T., Fritschy, J. & Hammond, D. L. (1997). Differential distribution of (GABA)A receptor subunits on bulbospinal serotonergic and nonserotonergic neurons of the ventromedial medulla of the rat. The Journal of Comparative Neurology, 384(3), 337-48. PMID: 9254031.

Hammond, D. L., Donahue, B. B. & Stewart, P. E. (1997). Role of spinal delta1 and delta2 opioid receptors in the antinociception produced by microinjection of L-glutamate in the ventromedial medulla of the rat. Brain Research, 765(1), 177-81. PMID: 9310411.

Thorat, S. N., Hammond, D. L. (1997). Modulation of nociception by microinjection of delta-1 and delta-2 opioid receptor ligands in the ventromedial medulla of the rat. The Journal of Pharmacology and Experimental Therapeutics, 283(3), 1185-92. PMID: 9399992.

Graham, B. A., Hammond, D. L. & Proudfit, H. K. (1997). Differences in the antinociceptive effects of alpha-2 adrenoceptor agonists in two substrains of Sprague-Dawley rats. The Journal of Pharmacology and Experimental Therapeutics, 283(2), 511-9. PMID: 9353364.

Kaneko, M., Hammond, D. L. (1997). GABA Acting at GABAA Receptors in the Spinal Cord Limits the Second, but Not the First Phase Response to Formalin in the Rat. In T. S. Jensen , J. A. Turner , Z. Wiesenfeld-Hallin (Eds.) Proceedings on the 8th World Congress on Pain. pp. 313-22. Seattle, WA: IASP Press.

Graham, B. A., Hammond, D. L. & Proudfit, H. K. (1997). Intrathecal dexmedetomidine (DEX) and ST-91 act synergistically to produce antinociception in the rat. (Vols. 23). pp. 1539. Neuroscience.

Iyadomi, I., Hammond, D. L. (1997). Paradoxical effects of the GABA(B) receptor CGP 35348 in the rat formalin test. (Vols. Supplement). pp. A370. Anesthesiology.

Hammond, D. L. (1997). Inhibitory Neurotransmitters and Nociception: Role of GABA and Glycine. In A. Dickenson , J. M. Besson (Eds.) Handbook of Experimental Pharmacology: The Pharmacology of Pain. pp. 361-84. Berlin, Heidelberg: Springer.

Kaneko, M., Hammond, D. L. (1997). Pharmacological characterization of the antinociception produced by microinjection of bicuculline into the ventromedial medulla (VMM) of the rat. (Vols. 23). pp. 1813. Neuroscience.

Banfor, P., Thorat, S., Skrocki, L. & Hammond, D. L. (1997). Delta(1) or delta(2) opioid receptor-mediated antinociception: Role of bulbospinal seroto-nergic neurons. (Vols. 23). pp. 1018. Neuroscience.

Thorat, S. N., Hammond, D. L. (1997). Role of medullary delta(1) or delta(2) opioid receptors in antinociception: studies with subtype selective antagonists. (Vols. 23). pp. 1019. Neuroscience.

Graham, B. A., Hammond, D. L. & Proudfit, H. K. (1996). Differential antinociceptive effects of delta-2 adrenoceptor agonists in substrains of Sprague-Dawley rats. (Vols. 85). (3A), pp. A665. Anesthesiology.

Hurley, R. W., Thorat, S. N. & Hammond, D. L. (1996). Analysis of the interaction of supraspinal and spinal delta-2 opioid receptors in the production of antinociception in the rat.

Thomas, D. A., Navarrete, I. M., Graham, B. A., McGowan, M. K. & Hammond, D. L. (1996). Antinociception produced by systemic R(+)-baclofen hydrochloride is attenuated by CGP 35348 administered to the spinal cord or ventromedial medulla of rats. Brain Research, 718(1-2), 129-37. PMID: 8773775.

Thorat, S. N., Hammond, D. L. (1996). Antinociception produced by microinjection of delta opioid receptor agonists into the ventromedial medulla of the rat. (Vols. 22). pp. 1364. Neuroscience.

Hammond, D. L., Gregory, S. A. (1996). Intrathecally administered cyclooxygenase-2 inhibitors attenuate carrageenan-induced thermal hyperalgesia in the rat. (Vols. 22). pp. 1814. Neuroscience.

Kaneko, M., Hammond, D. L. (1996). Activation of NMDA receptors mediates the enhancement of formalin-induced pain by intrathecal bicuculline. (Vols. 22). pp. 1361. Neuroscience.

McKinzie, S. L., Hammond, D. L., Grabau, C. & Tyce, G. M. (1996). Releases of norepinephrine and dopamine in ventriculocisternal perfusions in hepatectomized and laparotomized rats. Journal of Neurochemistry, 66(2), 569-78. PMID: 8592126.

Iyadomi, I., Hammond, D. L. (1996). Hyperalgesic effect of a low dose of intrathecal baclofen in the rat formalin test is mediated by NMDA receptors. (Vols. 85). (3A), pp. A661. Anesthesiology.

Mason, P., Owens, C. A. & Hammond, D. L. (1996). Antagonism of the antinocifensive action of halothane by intrathecal administration of GABAA receptor antagonists. Anesthesiology, 84(5), 1205-14. PMID: 8624015.

Graham, B. A., Hammond, D. L. & Proudfit, H. K. (1995). Spinal alpha 2-noradrenergic receptors differ in substrains of Sprague-Dawley (S-D) rat. (Vols. 21). pp. 1416. Neuroscience.

Hammond, D. L., Wang, H., Nakashima, N. & Basbaum, A. I. (1995). Intrathecal deltorphin or DPDPE produces antinociception, but does not suppress fos-like immunoreactivity (FLI) in the rat spinal cord. (Vols. 21). pp. 1170. Neuroscience.

Hama, A. T., Fritschy, J. M., Sieghart, W. & Hammond, D. L. (1995). GABA(A) receptor subunits on bulbospinal neurons of the rat. (Vols. 21). pp. 1639. Neuroscience.

Thomas, D. A., McGowan, M. K. & Hammond, D. L. (1995). Microinjection of baclofen in the ventromedial medulla of rats: antinociception at low doses and hyperalgesia at high doses. The Journal of Pharmacology and Experimental Therapeutics, 275(1), 274-84. PMID: 7562560.

Graham, B. A., Proudfit, H. K. & Hammond, D. L. (1995). Different adrenoceptor subtypes mediate the antinociceptive effects of delta(2) agonists in different substrains of Sprague-Dawley rats. (Vols. 80). pp. S55. Anesthesia and analgesia.

Thomas, D. A., Hammond, D. L. (1995). Microinjection of morphine into the rat medullary dorsal horn produces a dose-dependent increase in facial scratching. Brain Research, 695(2), 267-70. PMID: 8556343.

Hammond, D. L., Stewart, P. E. & Littell, L. (1995). Antinociception and delta-1 opioid receptors in the rat spinal cord: studies with intrathecal 7-benzylidenenaltrexone. The Journal of Pharmacology and Experimental Therapeutics, 274(3), 1317-24. PMID: 7562504.

Thomas, D. A., Navarette, I. M., Graham, B. A., McGowan, M. K. & Hammond, D. L. (1995). Contribution of spinal and brain stem sites to antinociception reduced by the systemic administration of baclofen. (Vols. 21). pp. 651. Neuroscience.

Thomas, D. A., Hammond, D. L. (1994). Morphine microinjected into the medullary dorsal horn produces dose-dependent, naloxone-reversible facial scratching in rats. (Vols. 20). pp. 751. Neuroscience.

Gebhart, G. F., Hammond, D. L., Jensen, T. S. (Eds.) (1994). In Proceedings of the 7th World Congress of Pain. (Vols. 2). Seattle, WA: IASP Press.

Hammond, D. L., Thomas, D. A. & McGowan, M. K. (1994). Microinjection of baclofen in the nucleus raphe magnus of the rat produces antinociception or hyperalgesia. (Vols. 20). pp. 765. Neuroscience.

Pitzele, B. S., Hamilton, R. W., Kudla, K. D., Tsymbalov, S., Stapelfeld, A., Savage, M. A., Clare, M., Hammond, D. L. & Hansen, Jr, D. W. (1994). Enkephalin analogs as systemically active antinociceptive agents: O- and N-alkylated derivatives of the dipeptide amide L-2,6-dimethyltyrosyl-N-(3-phenylpropyl)-D-alaninamide. Journal of Medicinal Chemistry, 37(7), 888-96. PMID: 7908696.

Stewart, P. E., Holper, E. M. & Hammond, D. L. (1994). Delta antagonist and kappa agonist activity of Naltriben: evidence for differential kappa interaction with the delta 1 and delta 2 opioid receptor subtypes. Life Sciences, 55(4), PL79-84. PMID: 8028443.

Glaum, S. R., Miller, R. J. & Hammond, D. L. (1994). Inhibitory actions of delta 1-, delta 2-, and mu-opioid receptor agonists on excitatory transmission in lamina II neurons of adult rat spinal cord. The Journal of Neuroscience, 14(8), 4965-71. PMID: 8046463.

Stewart, P. E., Hammond, D. L. (1994). Activation of spinal delta-1 or delta-2 opioid receptors reduces carrageenan-induced hyperalgesia in the rat. The Journal of Pharmacology and Experimental Therapeutics, 268(2), 701-8. PMID: 8113981.

Hammond, D. L., Stapelfeld, A., Drower, E. J., Savage, M. A., Tam, L. & Mazur, R. H. (1994). Antinociception produced by oral, subcutaneous or intrathecal administration of SC-39566, an opioid dipeptide arylalkylamide, in the rodent. The Journal of Pharmacology and Experimental Therapeutics, 268(2), 607-15. PMID: 8113971.

Stewart, P. E., Hammond, D. L. (1993). Opioid agonists on the paw flick test: measures of latency and tissue temperature. (Vols. 19). pp. 1413. Neuroscienc.

Stewart, P. E., Hammond, D. L. (1993). Intrathecal naltriben distinguishes between delta(1) and delta(2) opioid receptors in carrageenan-induced hyperalgesia.

McGowan, M. K., Hammond, D. L. (1993). Intrathecal benzodiazepines modulate the analgesia produced by intrathecal isoguvacine but not by intrathecal muscimol in the rat. (Vols. 19). pp. 1798. Neuroscience.

Glaum, S. R., Miller, R. J. & Hammond, D. L. (1993). Effects of delta(1) and delta(2) opioid agonists on excitatory afferent transmission in the neonatal rat spinal cord.

Glaum, S. R., Hammond, D. L. & Miller, R. J. (1993). Electrophysiology of mu and delta opioid receptor effects on afferent glutamatergic transmission in adult rat substantia gelatinosa. (Vols. 19). pp. 108. Neuroscience.

McKinzie, S. L., Hammond, D. L., Grabau, C. & Tyce, G. M. (1993). Catecholamine release from rat brain after hepatectomy. (Vols. 24). pp. 99. Transactions of the American Society for Neurochemistry.

Stewart, P. E., Hammond, D. L. (1993). Evidence for delta opioid receptor subtypes in rat spinal cord: studies with intrathecal naltriben, cyclic[D-Pen2, D-Pen5] enkephalin and [D-Ala2, Glu4]deltorphin. The Journal of Pharmacology and Experimental Therapeutics, 266(2), 820-8. PMID: 8394918.

McGowan, M. K., Hammond, D. L. (1993). Antinociception produced by microinjection of L-glutamate into the ventromedial medulla of the rat: mediation by spinal GABAA receptors. Brain Research, 620(1), 86-96. PMID: 8104668.

Hammond, D. L., Washington, J. D. (1993). Antagonism of L-baclofen-induced antinociception by CGP 35348 in the spinal cord of the rat. European Journal of Pharmacology, 234(2-3), 255-62. PMID: 8387011.

McGowan, M. K., Hammond, D. L. (1993). Intrathecal GABAB antagonists attenuate the antinociception produced by microinjection of L-glutamate into the ventromedial medulla of the rat. Brain Research, 607(1-2), 39-46. PMID: 8097668.

Hammond, D. L. (1993). Pharmacological Mechanisms of Pain Modulation: An Update on Delta Opioid Receptors. In C. R. Chapman , K. M. Foley (Eds.) Current & Emerging Issues in Cancer Pain: Research & Practice. pp. 175-83. New York, NY: Raven Press.

Hammond, D. L., Bloss, J. L. (1993). Antinociceptive effects of SC-39566, an opioid dipeptide arylalkylamide, in the Rhesus monkey. European Journal of Pharmacology, 231(2), 281-5. PMID: 8095901.

Stewart, P. E., Hammond, D. L. (1992). Naltrindole benzofuran is not a Delta-opioid selective antagonist in the rat spinal cord. (Vols. 18). pp. 1512. Neuroscience.

Stewart, P. E., Hammond, D. L. (1992). Opioid receptor selectivity of intrathecally administered naltrindole and naltrindole benzofuran in the rat: studies with the carrageenan-inflamed paw flick test. (Vols. 132). pp. 415. NIDA Monograph.

Hammond, D. L., Moy, M. L. (1992). Actions of 4-amino-3-(5-methoxybenzo(b)furan-2-yl) butanoic acid and 4-amino-3-benzo(b)furan-2-yl butanoic acid in the rat spinal cord. European Journal of Pharmacology, 229(2-3), 227-34. PMID: 1337047.

McGowan, M. K., Hammond, D. L. (1992). Intrathecal bicuculline attenuates antinociception produced by microinjection of glutamate into the nucleus raphe magnus in the rat. (Vols. 18). pp. 835. Neuroscience.

Stapelfeld, A., Hammond, D. L. & Rafferty, M. F. (1992). Antinociception after intracerebroventricular administration of naltrindole in the mouse. European Journal of Pharmacology, 214(2-3), 273-6. PMID: 1325358.

Hansen, Jr, D. W., Stapelfeld, A., Savage, M. A., Reichman, M., Hammond, D. L., Haaseth, R. C. & Mosberg, H. I. (1992). Systemic analgesic activity and delta-opioid selectivity in [2,6-dimethyl-Tyr1,D-Pen2,D-Pen5]enkephalin. Journal of Medicinal Chemistry, 35(4), 684-7. PMID: 1311764.

Chandrakumar, N. S., Yonan, P. K., Stapelfeld, A., Savage, M., Rorbacher, E., Contreras, P. C. & Hammond, D. L. (1992). Preparation and opioid activity of analogues of the analgesic dipeptide 2,6-dimethyl-L-tyrosyl-N-(3-phenylpropyl)-D-alaninamide. Journal of Medicinal Chemistry, 35(2), 223-33. PMID: 1346276.

Hammond, D. L., Presley, R., Gogas, K. R. & Basbaum, A. I. (1992). Morphine or U-50,488 suppresses Fos protein-like immunoreactivity in the spinal cord and nucleus tractus solitarii evoked by a noxious visceral stimulus in the rat. The Journal of Comparative Neurology, 315(2), 244-53. PMID: 1545011.

McGowan, M. K., Hammond, D. L. (1991). Intrathecal phaclofen attenuates analgesia produced by microinjection of glutamate into the nucleus raphe magnus in the rat. (Vols. 17). pp. 1011. Neuroscience.

Pitzele, B. S., Hamilton, R. W., Kudla, K. D., Stapelfeld, A., Savage, M. A., Clare, M., Hammond, D. L., Hansen Jr, D. W., Thompson, J. M., Rohrbacher, E., Tam, L. L. & Contreras, P. C. (1991). Enkephalin analogs as systemically active antinociceptive agents: Omicron- and N-Alkylated derivatives of the dipeptide amide SC-39566. (Vols. 17). pp. 295. Neuroscience.

Hammond, D. L., Ruda, M. A. (1991). Developmental alterations in nociceptive threshold, immunoreactive calcitonin gene-related peptide and substance P, and fluoride-resistant acid phosphatase in neonatally capsaicin-treated rats. The Journal of Comparative Neurology, 312(3), 436-50. PMID: 1721077.

Hammond, D. L. (1991). Do Opioids Relieve Central Pain?. In K. L. Casey (Eds.) Pain and Central Nervous System Disease: The Central Pain Syndromes. pp. 233-41. New York, NY: Raven Press.

Drower, E. J., Stapelfeld, A., Rafferty, M. F., de Costa, B. R., Rice, K. C. & Hammond, D. L. (1991). Selective antagonism by naltrindole of the antinociceptive effects of the delta opioid agonist cyclic[D-penicillamine2-D-penicillamine5]enkephalin in the rat. The Journal of Pharmacology and Experimental Therapeutics, 259(2), 725-31. PMID: 1658309.

Taksh, T. L., Hammond, D. L. & Tiseo, P. J. (1991). Characterization of the dose-dependent antagonism of spinal opioid receptors by naloxone and naltrindole. Further evidence for delta receptor subtypes?. (Vols. 17). pp. 592. Neuroscience.

Aran, S., Hammond, D. L. (1991). Antagonism of baclofen-induced antinociception by intrathecal administration of phaclofen or 2-hydroxy-saclofen, but not delta-aminovaleric acid in the rat. The Journal of Pharmacology and Experimental Therapeutics, 257(1), 360-8. PMID: 1850472.

Howard, D. L., Hammond, D. L. (1991). Effect of pentobarbital or diazepam on the antinociceptive actions of GABA(A) agonists in the spinal cord of the rat. (Vols. 75). pp. A579. Anesthesiology.

Hammond, D. L. (1990). Role of Serotonergic Systems in Morphine-Induced Antinociception. In J. M. Besson , H. Ollat (Eds.) Serotonin and Pain. pp. 251-61. Amsterdam: Elsevier Science Publishers.

Hammond, D. L. (1990). Discussions on the Physiological and Pharmacological Bases of the Transmission and Control of Nociceptive Messages. In A. I. Basbaum , J. M. Besson (Eds.) Towards a New Pharmacotherapy of Pain. pp. 107-21. Hoboken, NJ: John Wiley & Sons Ltd..

Hammond, D. L. (1990). Neurochemical, neuroendocrine, and immunologic measures in the diagnosis and treatment of chronic pain. Anesthesia Progress, 37(2-3), 106-7. PMID: 2085187.

Hammond, D. L., Aran, S. (1990). Antagonism of baclofen-induced antinociception by intrathecal phaclofen or 2-OH-saclofen, but not Delta-aminovaleric acid. (Vols. 16). pp. 567. Neuroscience.

Bloss, J. L., Hammond, D. L. (1989). Intermittent shock titration task in the rhesus monkey and its validity as an analgesiometric procedure. Brain Research, 499(2), 344-56. PMID: 2804681.

Drower, E. J., Stapelfeld, A., Rafferty, M. F., Hammond, D. L., Rice, K. C. & DeCosta, B. (1989). Specific antagonism of the antinociceptive effects of intrathecal DPDPE by naltrindole in rats. (Vols. 15). pp. 756. Neuroscience.

Rafferty, M. F., Drower, E. J. & Hammond, D. L. (1989). Antagonism of PGE(2)-induced hyperthermia in rats by antinociceptive prostaglandin antagonist. (Vols. 15). pp. 471. Neuroscience.

Hammond, D. L. (1989). New insights regarding the organization of spinal cord pain pathways. News in Physiological Sciences, 4, 98-101.

Hammond, D. L., Ruda, M. A. (1989). Developmental alterations in thermal nociceptive threshold and the distribution of immunoreactive calcitonin gene-related peptide and substance P after neonatal administration of capsaicin in the rat. Neuroscience Letters, 97(1-2), 57-62. PMID: 2465514.

Hammond, D. L. (1989). Inferences of Pain and its Modulation from Simple Behaviors. In J. Loeser , C. R. Chapman (Eds.) Issues in Pain Measurement. pp. 69-91. New York, NY: Raven Press.

Presley, R., Hammond, D. L., Gogas, K., Levine, J. & Basbaum, A. (1989). Morphine and U-50488H suppress noxious visceral stimulation-evoked expression of c-fos in the rat. (Vols. 15). pp. 155. Neuroscience.

Hansen, D. W., Hammond, D. L., Mazur, R. H., Bloss, J. L., Drower, E. J. & Savage, M. A. (1989). SC-39566: A new opioid dipeptide amide analgesic containing (L)2,6-dimethyltyrosine.

Drower, E. J., Hammond, D. L. (1988). GABAergic modulation of nociceptive threshold: effects of THIP and bicuculline microinjected in the ventral medulla of the rat. Brain Research, 450(1-2), 316-24. PMID: 3401715.

Evans, C., Hammond, D. L. & Frederickson, R. C. (1988). The Opioid Peptides. In G. W. Pasternak (Eds.) The Opiate Receptors. pp. 23-71. New York, NY: Raven Press.

Hammond, D. L. (1988). Intrathecal Administration: Methodological Considerations. H. L. Fields (Eds.) pp. 313-20. Amsterdam: Progress in Brain Research. PMID: 3064174.

Drower, E. J., Hammond, D. L. (1988). The effect of pentobarbital on GABA-ergic modulation of nociceptive threshold. (Vols. 14). pp. 711. Neuroscience.

Drower, E. J., Stapelfeld, A., Mueller, R. A. & Hammond, D. L. (1987). The antinociceptive effects of prostaglandin antagonists in the rat. European Journal of Pharmacology, 133(3), 249-56. PMID: 2881791.

Bloss, J. L., Hammond, D. L. (1987). Intermittent shock titration in the rhesus monkey. (Vols. 13). pp. 111. Neuroscience.

Hammond, D. L., Ruda, M. A. (1987). Developmental alterations in thermal nociceptive threshold and the distribution of immunoreactive calcitonin gene-related peptide and substance P after neonatal administration of capsaicin in the rat. (Vols. 13). pp. 111. Neuroscience.

Egofske, P. J., Hammond, D. L. (1987). A rapid extraction and ion-pairing HPLCRC method for the quantitation of 3H-inositol phosphates in rat brain. (Vols. 13). pp. 648. Neuroscience.

Hammond, D. L., Mazur, R., Hansen, D., Pilipauskas, D., Bloss, J. & Drower, E. (1987). Analgesic activity of SC-39566. (Vols. 30). (Supplement 1), pp. S253. Pain.

Hansen, D. W., Hammond, D. L., Mazur, R. H., Pilipauskas, D. & Clare, M. (1987). Analgesic properties and SAR of structurally minimized enkephalin analogues: Dipeptide amines containing (L) 2,6-dimethyltyrosine.

Hammond, D. L. (1986). Control Systems for Nociceptive Afferent Processing: The Descending Inhibitory Pathways. In T. L. Yaksh (Eds.) Spinal Afferent Processing. pp. 363-90. New York, NY: Plenum Press.

Hammond, D. L. (1986). Biological Effects of Opiates. In G. R. Lenz , S. Evans-Radak , D. E. Walters , A. J. Hopfinger (Eds.) Opiates. pp. 29-44. San Diego, CA: Academic Press.

Bloss, J. L., Hammond, D. L. (1985). Shock titration in the rhesus monkey: effects of opiate and nonopiate analgesics. The Journal of Pharmacology and Experimental Therapeutics, 235(2), 423-30. PMID: 4057079.

Bloss, J. L., Hammond, D. L. (1985). Effects of opiate and non-opiate analgesics on shock titration in the rhesus monkey. (Vols. 44). pp. 1724. Federal Proceedings.

Hammond, D. L. (1985). Pharmacology of Central Pain Modulating Networks. In H. L. Fields , R. Dubner , F. Cervero (Eds.) Advances in Pain Research and Therapy. pp. 499-512. New York, NY: Raven Press.

Hammond, D. L., Tyce, G. M. & Yaksh, T. L. (1985). Efflux of 5-hydroxytryptamine and noradrenaline into spinal cord superfusates during stimulation of the rat medulla. The Journal of Physiology, 359, 151-62. PMID: 2582112.

Drower, E. J., Hammond, D. L. (1985). Effects on nociceptive threshold of THIP and bicuculline microinjected in the nucleus raphe magnus. (Vols. 11). pp. 1179. Neuroscience.

Barbaro, N. M., Hammond, D. L. & Fields, H. L. (1985). Effects of intrathecally administered methysergide and yohimbine on microstimulation-produced antinociception in the rat. Brain Research, 343(2), 223-9. PMID: 2996695.

Hammond, D. L., Drower, E. J. (1984). Effects of intrathecally administered THIP, baclofen and muscimol on nociceptive threshold. European Journal of Pharmacology, 103(1-2), 121-5. PMID: 6548190.

Hammond, D. L., Yaksh, T. L. & Tyce, G. M. (1984). Conjugates of dopamine and serotonin in ventriculocisternal perfusates of the cat. Journal of Neurochemistry, 42(6), 1752-7. PMID: 6726235.

Hammond, D. L., Yaksh, T. L. (1984). Antagonism of stimulation-produced antinociception by intrathecal administration of methysergide or phentolamine. Brain Research, 298(2), 329-37. PMID: 6326954.

Hammond, D. L., Drower, E. J. (1983). Failure of intrathecally administered THIP to produce analgesia. (Vols. 9). pp. 791. Neuroscience.

Barbaro, N. M., Hammond, D. L. & Fields, H. L. (1983). Antagonism of microstimulation-produced analgesia by intrathecal injection of methysergide and yohimbine. (Vols. 9). pp. 791. Neuroscience.

Bergstrom, L., Hammond, D. L., Go, V. L. & Yaksh, T. L. (1983). Concurrent measurement of substance P and serotonin in spinal superfusates: failure of capsaicin and p-chloroamphetamine to co-release. Brain Research, 270(1), 181-4. PMID: 6191841.

Hammond, D. L., Tyce, G. M. & Yaksh, T. L. (1983). Drug-induced alterations in the efflux of 5-hydroxytryptamine and of 5-hydroxyindoleacetic acid into superfusates of the rat spinal cord. European Journal of Pharmacology, 87(4), 441-8. PMID: 6189730.

Schmauss, C., Hammond, D. L., Ochi, J. W. & Yaksh, T. L. (1983). Pharmacological antagonism of the antinociceptive effects of serotonin in the rat spinal cord. European Journal of Pharmacology, 90(4), 349-57. PMID: 6688398.

Tyce, G. M., Hammond, D. L. & Yaksh, T. L. (1982). Presence of dopamine conjugate in ventriculocisternal perfusates of the cat. (Vols. 47). pp. 1706. Federal proceedings.

Hammond, D. L., Tyce, G. M. & Yaksh, T. L. (1982). Release of serotonin and norepinephrine into superfusates of rat spinal cord following electrical magnus. (Vols. 8). pp. 769. Neuroscience.

Yaksh, T. L., Hammond, D. L. (1982). Putative Transmitters of Descending Systems-Studies of Local Administration and Liberation. In B. Sjolund , A. Bjorklund (Eds.) Brain Stem Control of Spinal Mechanisms. pp. 473-92. New York, NY: Elsevier Biomedical Press.

Yaksh, T. L., Hammond, D. L. (1982). Peripheral and central substrates involved in the rostrad transmission of nociceptive information. Pain, 13(1), 1-85. PMID: 6287384.

Hammond, D. L., Yaksh, T. L. (1982). Intrathecal methysergide and phentolamine antagonize stimulation produced analgesia from the nucleus raphe. (Vols. 8). pp. 769. Neuroscience.

Hammond, D. L., Yaksh, T. L. (1981). Peripheral and central pathways in pain. Pharmacology & Therapeutics, 14(3), 459-75. PMID: 7323138.

Proudfit, H. K., Hammond, D. L. (1981). Alterations in nociceptive threshold and morphine-induced analgesia produced by intrathecally administered amine antagonists. Brain Research, 218(1-2), 393-9. PMID: 6895046.

Hammond, D. L., Yaksh, T. L. & Tyce, G. M. (1981). Presence of conjugated 5-hydroxytryptamine in in vivo superfusates of rat spinal cord. Journal of Neurochemistry, 37(4), 1068-71. PMID: 6172561.

Tyce, G. M., Hammond, D. L., Rorie, D. K. & Taksh, T. I. (1981). In Vivo and In Vitro Efflux of Conjugated Amines into Superfusates from Discrete Areas of the Central Nervous System of Cats and Rats. In M. Sandler , E. Usdin (Eds.) Phenosulfo-transferase in Mental Health. pp. 152-63. London, England: MacMillan Publishers, Inc..

Yaksh, T. L., Hammond, D. L. & Tyce, G. M. (1981). Functional aspects of bulbospinal monoaminergic projections in modulating processing of somatosensory information. Federation Proceedings, 40(13), 2786-94. PMID: 6975220.

Hammond, D. L., Tyce, G. M. & Yaksh, T. L. (1981). Stimulation of the nucleus raphe magnus. (Vols. 7). (532) Neuroscience.

Hammond, D. L., Levy, R. A. & Proudfit, H. K. (1980). Hypoalgesia induced by microinjection of a norepinephrine antagonist in the raphe magnus: reversal by intrathecal administration of a serotonin antagonist. Brain Research, 201(2), 475-9. PMID: 6893423.

Tyce, G. M., Hammond, D. L., Rorie, D. K., Sharpless, N. S. & Yaksh, T. L. (1980). In vivo and in vitro efflux of conjugated amines into superfusates from discrete areas of the central nervous system of cats and rats.

Hammond, D. L., Proudfit, H. K. (1980). Effects of locus coeruleus lesions on morphine-induced antinociception. Brain Research, 188(1), 79-91. PMID: 7370762.

Hammond, D. L., Tyce, G. M. & Yaksh, T. L. (1980). 5-HT and 5-HIAA levels in spinal superfusates. (Vols. 22). pp. 219. The Pharmacologist.

Hammond, D. L., Proudfit, H. K. (1980). Effects of intrathecally administered amine antagonists on nociceptive threshold and morphine-induced analgesia. (Vols. 6). pp. 433. Neuroscience.

Hammond, D. L., Levy, R. A. & Proudfit, H. K. (1980). Hypoalgesia following microinjection of noradrenergic antagonists in the nucleus raphe magnus. Pain, 9(1), 85-101. PMID: 7422339.

Hammond, D. L., Levy, R. A. (1979). Analgesia following microinjection of phentolamine in the nucleus raphe magnus. (Vols. 5). pp. 610. Neuroscience.

Hammond, D. L., Proudfit, H. K. (1977). Potentiation of morphine analgesia by lesions of the nucleus locus coeruleus. (Vols. 19). pp. 140. The Pharmacologist.

Sawyer, R. T., Hammond, D. L. (1973). Observations on the marine leech Calliobdella carolinensis (Hirudinea: Piscicolidae), epizootic on the Atlantic menhaden. The Biological Bulletin, 145(2), 373-88. PMID: 4799586.