Address: 2-300 BSB
Phone: (319) 353-5803
Email: sarah-sapouckey@uiowa.edu
Mentor: Justin L. Grobe, PhD
Undergraduate Institution: University of Massachusetts
Graduate Program: Molecular Medicine
Year Entered Into Program: 2016
Research Description
Leptin-Angiotensin Interaction in Hypothalamic Control of Metabolism
Obesity represents an enormous biomedical, economic and social burden worldwide, and development of new therapeutic approaches depends upon understanding the molecular mechanisms that control energy balance. Leptin is a well-known circulating hormone that contributes to energy homeostasis in part through the control of resting metabolic rate, and our team has demonstrated that the renin-angiotensin system within the arcuate nucleus of the hypothalamus mediates this control. My ongoing work is focused on understanding the molecular connections that mediate this leptin-angiotensin cross-talk within the brain.
Awards
- American Heart Association Predoctoral Fellowship (18PRE33960377), 2018-present
- Molecular Medicine Graduate Program Travel Award, 2017
Publications
- Sandgren JA, Linggonegoro DW, Zhang SY, Sapouckey SA, Claflin KE, Pearson NA, Leidiner MR, Pierce GL, Santillan MK, Gibson-Corley KN, Sigmund CD, and Grobe JL.: Angiotensin AT1A receptors expressed in vasopressin-producing cells of the supraoptic nucleus contribute to the osmotic control of vasopressin. Am J Physiol Regul Integr Comp Physiol. 314(6):R770-R780, 2018. PMCID: PMC6032302
- Sapouckey SA, Deng G, Sigmund CD, Grobe JL.: Potential mechanisms of hypothalamic renin-angiotensin system activation by leptin and DOCA-salt for the control of resting metabolism. Physiol Genomics. 49(12):722-32, 2017. PMCID: PMC5814669
- Hill CE, Sapouckey SA, Suvorov A, Vandenberg LN.: Developmental exposures to bisphenol S, a BPA replacement, alter estrogen-responsiveness of the female reproductive tract: A pilot study. Cogent Medicine. 4:1317690, 2017.