Addison Woll

Address: 2-340 BSB
Phone: (319) 335-8926
Email: addison-woll@uiowa.edu

Mentor: Curt D. Sigmund, PhD

Undergraduate Institution: Southeast Missouri State University

Graduate Program: Molecular Medicine

Year Entered Into Program: 2015

Research Description

Elucidation of the RBP7 dependent PPARg antioxidant hub in the endothelium

Peroxisome Proliferator-Activated Receptor gamma (PPARg) has been shown to regulate hypertension in animal models through regulation of nitric oxide bioavailability in the vasculature. Specifically in the endothelium we have found that a PPARg target gene, Retinol Binding Protein 7 (RBP7), is required for these effects. My project is to characterize the mechanism of RBP7 and PPARg interaction, as well as define the necessity of RBP7 expression in the endothelium in vivo in a genetic compliment study.

Awards

  • Graduate College Post-Comprehensive Research Award, 2016-2017