Anand Nair, PhD

Address: 2-340 BSB
Phone: (319) 335-8926

Mentor: Curt D. Sigmund, PhD

PhD Institution: Louisiana State University, Baton Rouge

Research Description

Role of PPARgamma in Preeclampsia


  1. Nair AR, Agbor LN, Mukohda M, Liu X, Hu C, Wu J, Sigmund CD.: Interference With Endothelial PPAR (Peroxisome Proliferator-Activated Receptor)-γ Causes Accelerated Cerebral Vascular Dysfunction in Response to Endogenous Renin-Angiotensin System Activation. Hypertension 72(5):1227-1235, 2018  PMID: 30354810
  2. Sandgren JA, Deng G, Linggonegoro DW, Scroggins SM, Perschbacher, KJ, Nair AR, Nishimura TE, Zhang SY, Agbor LN, Wu J, Keen HL, Naber MC, Pearson NA, Zimmerman KA, Weiss RM, Bowdler NC, Usachev YM, Santillan DA, Potthoff MJ, Pierce GL, Gibson-Corley KN, Sigmund CD, Santillan MK, Grobe JL: Arginine Vasopressin Infusion is Sufficient to Model Clinical Features of Preeclampsia in Mice. JCI Insight. 3(19), 2018. PMCID: PMC6237463
  3. Ebenezer PJ, Wilson CB, Wilson LD, Nair AR, JF.:  The Anti-Inflammatory Effects of Blueberries in an Animal Model of Post-Traumatic Stress Disorder (PTSD). PLoS One. 11(9):e0160923, 2016.  PMCID: PMC5014311
  4. Masson GS*, Nair AR*, Dange R, Soares PPS, Michelini LC, Francis J.:  Toll-like receptor 4 promotes autonomic dysfunction, inflammation and microglia activation in the hypothalamicparaventricular nucleus through Endoplasmic reticulum stress. PLoS One 10(3):e0122850, 2015.  PMCID: PMC4374971
  5. Masson GS, Nair AR, Silva Soares PP, Michelini LC, Francis J.:  Aerobic training normalizes autonomic dysfunction, HMGB1 content, microglia activation and inflammation in hypothalamic paraventricular nucleus of SHR. Am J Physiol Heart Circ Physiol. 309(7):H1115-22, 2015. PMID: 26254332
  6. Nair AR, Ebenezer PJ, Saini Y, Francis, J.: Angiotensin II-induced hypertensive renal inflammation is mediated through HMGB1-TLR4 signaling in rat tubulo-epithelial cells. Exp Cell Res 335(2):238-47, 2015.  PMID: 26033363
  7. Bruce E, Shenoy V, Rathinasabapathy A, Espejo A, Horowitz A, Oswalt A, Francis J, Nair A, Unger T, Raizada MK, Steckelings UM, Sumners C, Katovich MJ.:  Selective activation of AT2receptor attenuates progression of pulmonary hypertension and inhibits cardiopulmonary fibrosis.Br J Pharmacol. 2014 Dec 17. doi: 10.1111/bph.13044.
  8. Nair AR, Elks CM, Vila J, Piero FD, Paulsen DB, Francis J.:  A blueberry-enriched diet improves renal function and reduces oxidative stress in metabolic syndrome animals – Potential role of TLR4-MAPK signaling pathway. PlosOne. 9(11):e111976, 2014.  PMCID: PMC4221362
  9. Shenoy V , Kwon KC , Rathinasabapathy A , Lin S , Jin G , Song C , Shil P , Nair AR , Qi Y, LiQ, Francis J, Katovich M, Daniell H, Raizada M.:  Oral Delivery of Angiotensin ConvertingEnzyme 2 (ACE2) or Angiotensin-(1-7) Bioencapsulated in Plant Cells Attenuates PulmonaryHypertension and Associated Cardiac Dysfunction. Hypertension 64(6):1248-59, 2014.
  10. Wilson CB, McLaughlin LD, Ebenezer PJ, Nair AR, Dange R, Harre JG, Shaak TL, Diamond DM, Francis J.:  Differential effects of sertraline in a predator exposure animal model of post-traumatic stress disorder. Front. Behav. Neuroscience. 8:256, 2014.  PMCID: PMC4115632
  11. Nair AR, Masson GS, Ebenezer PJ, Piero FD, Francis J.:  Role of TLR4 in Lipopolysaccharide-induced acute kidney injury (AKI): Protection by Blueberry. Free Radic Bio Med. 71:16-25, 2014.  PMID: 24657730
  12. Wilson CB, McLaughlin LD, Ebenezer PJ, Nair AR, Francis J.:  Valproic acid effects in the Hippocampus and Prefrontal Cortex in an animal model of Post-Traumatic Stress Disorder.Behav Brain Res. 268:72-80, 2014.  PMID: 24675160
  13. Dange RB, Agarwal D, Masson GS, Vila J, Wilson B, Nair A, Francis J.:  Central blockade ofTLR4 improves cardiac function and attenuates myocardial infarction in Angiotensin II-inducedhypertension. Cardiovasc Res. 103(1):17-27, 2014.
  14. Wilson CB, McLaughlin LD, Nair AR, Ebenezer PJ, Dange R, Francis J.: Inflammation andoxidative stress in the progression of Post-Traumatic Stress Disorder in a predator exposureanimal model. PLoSOne. 8(10), 2013.
  15. Peng H, Li W, Seth DM, Nair AR, Francis J, Feng Y.: Pro-renin receptor mediates bothangiotensin II-dependent and independent oxidative stress in neuronal cells. PLoSOne.8(3):e58339, 2013.  PMCID: PMC3597628
  16. Sehgal I, Winters WD, Scott M, David A, Gillis G, Stoufflet T, Nair A, Kousoulas K.: Toxicologic assessment of a commercial decolorized whole leaf extract of aloe vera juice, lily ofthe desert filtered whole leaf juice with aloesorb. J Toxicol. 2013, 2013
  17. Freeman LR, Zhang L, Nair A, Dasuri K, Francis J, Fernandez-Kim SO, Bruce-Keller AJ, KellerJN. Obesity increases cerebrocortical reactive oxygen species and impairs brain function. FreeRadic Bio Med. 56:226-33, 2013.