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Larry Njotu Agbor, PhD

Address: 2-340 BSB
Phone: (319) 335-8926
Email: njotu-agbor@uiowa.edu

Mentor: Curt D. Sigmund, PhD

PhD Institution: University of New Mexico, 2012

Research Description

Identification and function of PPAR-γ and PPAR-γ target genes in the blood vessel

Awards

  • Ranbir K. Bhatnagar Scholar Award, Department of Pharmacology, University of Iowa, 2017
  • 1st place oral presentation, 4th Annual Abboud Cardiovascular Symposium, 2017
  • APS Minority Travel Fellowship Award, Experimental Biology, 2016
  • New Investigator Travel Award, attend High Blood Pressure Meeting, 2016
  • New Investigator Travel Award, AHA Council of Hypertension, 2015, 2016
  • NIH Research Training Grant, HL007171 (Postdoctoral T32), 2014-present

Research Interest

Role of Cullin3 in human hypertension

Publications

  1. Agbor, L.N., Ibeawuchi, S.C., Hu, C., Wu, J., Davis, D.R., Keen, H.L., Quelle, F.W. and Sigmund, C.D.: Cullin-3 mutation causes arterial stiffness and hypertension through a vascular smooth muscle mechanism. JCI Insight. 1(19):e91015, 2016.  PMCID: PMC5111503
  2. Ibeawuchi, S.R., Agbor, L.N., Quelle, F.W., Sigmund, C.D.:  Hypertension-causing Mutations in Cullin3 Protein Impair RhoA Protein Ubiquitination and Augment the Association with Substrate Adaptors.  J Biol Chem 290(31):19208-17, 2015.  PMCID: PMC4521042  
  3. Agbor, L.N., Wiest, E.F., Rothe, M., Schunck, W.H., Walker, M.K.:  Role of CYP1A1 in modulating the vascular and blood pressure benefits of omega-3 polyunsaturated fatty acids.  J Pharmacol Exp Ther. 351(3):688-98, 2014.  PMCID: PMC4244579 
  4. Bentson, L.F., Agbor, V.A., Agbor, L.N., Lopez, A.C., Nfonsam, L.E., Bornstein, S.S., Handel, M.A. and Linder, C.C.: New point mutation in Golga3 causes multiple defects in spermatogenesis. Andrology. 1(3):440-50, 2013. PMCID: PMC4134951
  5. Agbor, L.N., Walsh, M.T., Boberg, J.R. and Walker, M.K.: Elevated blood pressure in CYP1A1 knockout mice is associated with reduced vasodilation to omega-3 polyunsaturated fatty acids. Toxicol Appl Pharmacol. 264(3):351-360, 2012. PMCID: PMC3494483
  6. Agbor, L.N., Elased, K.M. and Walker, M.K.: Endothelial cell-specific aryl hydrocarbon receptor knockout mice exhibit hypotension mediated, in part, by an attenuated angiotensin II responsiveness. Biochem Pharmacol. 82(5):514-23, 2011. PMCID: PMC3148414
  7. Zhang, N., Agbor, L.N., Scott, J.A., Zalobowski, T., Elased, K.M., Trujillo, A., Duke, M.S., Wolf, V., Walsh, M.T., Born, J.L., Felton, L.A., Wang, J., Wang, W., Kanagy, N.L. and Walker, M.K.: An activated renin-angiotensin system maintains normal blood pressure in aryl hydrocarbon receptor heterozygous mice but not in null mice. Biochem Pharmacol. 80(2):197-204, 2010. PMCID: PMC2867364
  8. Kopf, P.G., Scott, J.A., Agbor, L.N., Boberg, J.R., Elased, K.M., Huwe, J.K. and Walker, M.K.: Cytochrome P4501A1 is required for vascular dysfunction and hypertension induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol Sci. 117(2):537-46, 2010. PMCID: PMC2940412
  9. Lund, A.K., Agbor, L.N., Zhang, N., Baker, A., Zhao, H., Fink, G.D., Kanagy, N.L. and Walker, M.K.: Loss of the aryl hydrocarbon receptor induces hypoxemia, endothelin-1, and systemic hypertension at modest altitude. Hypertension. 51(3):803-809, 2008. PMID: 18212270

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