Barry G. Kasson, PhD

Portrait
CCOM Course Director (20% time)
Associate Professor of Pharmacology

Contact Information

Primary Office: 2-460 BSB
51 Newton Rd.
Iowa City, IA 52242
319-335-9954

Education

BA, University of California at Los Angeles, Los Angeles, CA
MS, University of California at Los Angeles, Los Angeles, CA
PhD, Pharmacology, University of California at Los Angeles, Los Angeles, CA

Post Doctoral Fellow, University of California at San Diego, La Jolla, CA

Research Summary

Molecular Mechanisms of Hormone-Induced Cell Proliferation Research in my laboratory focuses on the cellular and molecular mechanisms of hormone-induced cell proliferation in reproductive organs. The gonadotropins, luteinizing hormone (LH) and follicle stimulating hormone (FSH), are thought to provide the main stimuli for steroidogenic and proliferative activity in gonadal cells, whereas steroids themselves are thought to be the primary stimuli for proliferation in most other reproductive organs. Recent evidence suggests that a variety of growth factors and other peptides either mediate or modulate the actions of these hormones. Our investigations are directed toward identifying factors involved in regulating proliferative and activity in prostate, uterus, and ovary, then defining the molecular pathways through which these factors act. Current studies focus on two specific areas: 1. Molecular mechanisms regulating cell proliferation in the prostate. These studies include projects on regulation of cyclin production, characterization and regulation of cyclin-dependent kinase activity, identification of cyclin-dependent kinase targets, and identification of defects in normal regulatory processes resulting in prostate cancer. 2. The actions of leukocyte secretory products (cytokines) on steroidogenic activity in ovarian cells. These studies include projects on receptor interactions, signal transduction pathways, and characterization of novel cytokines in reproductive tissues.

Publications

Hegmann, T. E., Kasson, B. G. & Stafford, H. A. (2009). Medical and physician assistant students performance in interprofessional pharmacology and clinical medicine courses. J. Phys. Assist. Ed., 20, 21-25.

Holt, K. H., Kasson, B. G. & Pessin, J. E. (1996). Insulin stimulation of a MEK-dependent but ERK-independent SOS protein kinase. Mol Cell Biol, 16(2), 577-583.

Simon, J. S., Baum, J. S., Moore, S. A. & Kasson, B. G. (1995). Arginine vasopressin stimulates protein synthesis but not proliferation of cultured vascular endothelial cells. J Cardiovasc Pharmacol, 25(3), 368-375. PMID: 7769800.

Simon, J., Kasson, B. G. (1995). Identification of vasopressin mRNA in rat aorta. Hypertension, 25(5), 1030-1033. PMID: 7737711.

Ness, J. M., Kasson, B. G. (1995). Stimulation of rat granulosa cell progesterone production but not other differentiated functions by a splenocyte-derived factor. J Reprod Fertil, 105(1), 125-133. PMID: 7490703.

Ness, J. M., Kasson, B. G. (1994). Induction of rat granulosa cell steroidogenic enzyme activities and their messenger ribonucleic acids by a splenocyte-derived factor. Mol Cell Endocrinol, 106(1-2), 163-170. PMID: 7895903.

Zhong, Y., Kasson, B. G. (1994). Pituitary adenylate cyclase-activating polypeptide stimulates steroidogenesis and adenosine 3',5'-monophosphate accumulation in cultured rat granulosa cells. Endocrinology, 135(1), 207-213. PMID: 8013355.

Kasson, B. G., Bai, S., Liu, J., Tobin, C. & Kessel, B. (1993). Characterization of a sensitive and specific enzyme immunoassay (EIA) for progesterone applied to cell culture. J. Immunoassay, 14(1-2), 33-49. PMID: 8315027.

Li, Y., Kasson, B. G. (1993). Androgens augment vasoactive intestinal peptide- and growth hormone-releasing hormone-stimulated progestin production by rat granulosa cells. Endocrinology, 132(2), 584-590. PMID: 8425478.

Simon, J. S., Brody, M. J. & Kasson, B. G. (1992). Characterization of a vasopressin-like peptide in rat and bovine blood vessels. Am J Physiol, 262(3 PT. 2), H799-H805. PMID: 1558190.

Ness, J. M., Kasson, B. G. (1992). Gonadotropin regulation of c-fos and c-jun messenger ribonucleic acids in cultured rat granulosa cells. Mol Cell Endocrinol, 90(1), 17-25. PMID: 1338729.

Kasson, B. G., Gorospe, W. C. (1989). Effects of interleukins 1, 2 and 3 on follicle-stimulating hormone-induced differentiation of rat granulosa cells. Mol. Cell Endocrinol, 62(1), 103-111. PMID: 2501121.

Kasson, B. G., Tuchel, T. L. (1989). Hormonal regulation of rat testicular arginine vasopressin receptors. Endocrinology, 124(6), 2777-2784. PMID: 2498062.

Janiak, P., Kasson, B. G. & Brody, M. J. (1989). Central vasopressin raises arterial pressure by sympathetic activation and vasopressin release. Hypertension, 13(6 pt 2), 935-940. PMID: 2737730.

Gorospe, W. C., Kasson, B. G. (1988). Lymphokines from concanavalin A-stimulated lymphocytes regulate rat granulosa cell steroidogenesis in vitro. Endocrinology, 123, 2462-2471.

Kasson, B. G., Hsueh, A. (1988). Gonadal actions of vasopressin and GnRH. In A. Negro-Vilar , P. M. Conn (Eds.) Peptide Hormones: Effects and Mechanisms of Action. pp. 205-239. CRC Press, Boca Raton, FL.

Gorospe, W. C., Tuchel, T. & Kasson, B. G. (1988). Gamma-interferon inhibits rat granulosa cell differentiation in culture. Biochem. Biophys. Res. Comm., 157(3), 891-897. PMID: 3144977.

Liu, Y., Kasson, B. G., Dahl, K. D. & Hsueh, A. (1987). Vasoactive intestinal peptide stimulates plasminogen activator activity by cultured rat granulosa cells and cumulus-oocyte complexes. Peptides., 8, 29-33.

Kasson, B. G., Hsueh, A. (1987). Insulin-like growth factor-I augments gonadotropin-stimulated androgen biosynthesis by cultured rat testicular cells. Lymphokines from concanavalin A-stimulated lymphocytes regulate rat granulosa cell steroidogenesis in vitro., 52, 27-34.

Kasson, B. G., Hsueh, A. (1986). Arginine vasopressin as an intragonadal hormone in Brattleboro rats: Presence of a testicular vasopressin-like peptide and functional vasopressin receptors. Endocrinology, 118, 23-31.

Kasson, B. G., Adashi, E. Y. & Hsueh, A. (1986). Arginine vasopressin in the testis: An intragonadal peptide control system. Endocr. Rev., 7, 156-168.

Welsh, Jr., T. H., Kasson, B. G. & Hsueh, A. (1986). Direct biphasic modulation of gonadotropin-stimulated testicular androgen biosynthesis by prolactin. Biol. Reprod., 34, 796-804.

Kasson, B. G., Lim, P. & Hsueh, A. (1986). Vasoactive intestinal peptide stimulates androgen biosynthesis by cultured neonatal testicular cells. Mol. Cell. Endocrinol., 48, 21-29.

dfavoren, J. B., Kasson, B. G., Li, C. H. & Hsueh, A. (1986). Specific insulin-like growth factor (IGF) I and II binding sites on rat granulosa cells: Relation to IGF action. Endocrinology, 119, 2155-2162.

Kasson, B. G., Hsueh, A. (1985). Nicotinic cholinergic agonists inhibit androgen biosynthesis by cultured rat Leydig cells. Endocrinology, 117, 1874-1880.

Kasson, B. G., Conn, P. M. & Hsueh, A. (1985). Inhibition of granulosa cell differentiation by dioctanoylglycerol - a novel activator of protein kinase C. Mol. Cell. Endocrinol., 42, 29-37.

Kasson, B. G., Meidan, R., Davoren, J. B. & Hsueh, A. (1985). Identification of subpopulations of rat granulosa cells: Sedimentation properties and hormonal responsiveness. Endocrinology, 117, 1027-1037.

Kasson, B. G., Hsueh, A. (1985). Cholinergic inhibition of follicle stimulating hormone-induced progestin production by cultured rat granulosa cells. Biol. Reprod., 33, 1158-1167.

Kasson, B. G., Meidan, R. & Hsueh, A. (1985). Identification and characterization of arginine vasopressin-like substances in the rat testis. J. Biol. Chem., 260, 5302-5307.

Conti, M., Kasson, B. G. & Hsueh, A. (1984). Hormonal regulation of adenosine-3,5-cyclic monophosphate phosphodiesterases in cultured rat granulosa cells. Endocrinology, 114, 2361-2368.

Kasson, B. G., George, R. (1984). Endocrine influences on the actions of morphine: IV. Effects of sex and strain. Endocrine influences on the actions of morphine: IV. Effects of sex and strain., 34, 1627-1634.

Kasson, B. G., George, R. (1983). Endocrine influences on the actions of morphine: III. Responses to hypothalamic hormones. Neuroendocrinology, 37, 416-420.

Kasson, B. G., George, R. (1983). Thermoregulation in hyperthyroid rats: Mechanism underlying the lack of hypothermic response to morphine in hyperthyroid ani¬mals. Life Sci., 33, 1845-1852.

Kasson, B. G., Carlson, H. E. & George, R. (1983). Endocrine influences on the actions of morphine: II. Responses to pituitary hormones. J. Pharmacol. Exp. Ther., 224, 282-288.

Kasson, B. G., George, R. (1983). Endocrine influences on the actions of morphine: I. Alteration of target gland hormones. J. Pharmacol. Exp. Ther., 224, 273-281.

Sharp, B., Kasson, B. G., marshak, D., Ross, R., George, R., Sowers, J. & Yamada, T. (1982). Domperidone elevates rat plasma ß-endorphin-immunoreactivity when administered peripherally but not intracerebroventricularly. Life Sci., 31, 981-986.

Kasson, B. G., Levin, S. R. (1981). Characterization of rat pancreatic islet Ca2+ ATPase. Biochim. Biophys. Acta, 662, 30-35.

Kasson, B. G., George, R. (1981). Effects of growth hormone and prolactin on morphine sensitivity and tolerance. Proc. West. Pharmacol. Soc., 24, 319-321.

Morley, J. E., Melmed, S., Reed, A., Kasson, B. G., Levin, S. R., Pekary, A. E. & Hershman, J. M. (1980). Effect of vitamin A on the hypothalamo-pituitary-thyroid axis. Am. J. Physiol., 238, E174-E179.

Levin, S. R., Kasson, B. G. & Driessen, J. F. (1978). Adenosine triphosphatases of rat pancreatic islets: Comparison with those of kidney. J. Clin. Invest., 62, 692-701.

Murray, G. M., Kasson, B. G., Garcia, J. A. & George, R. (1978). Neuroendocrine responses to benzomorphans (cyclazocine, ketocyclazocine and WIN 35,197-2) in the rat. Proc. West. Pharmacol. Soc., 21, 371-375.

Ulrich, R., Levy, L., Kasson, B. G., Harwick, H. j. & Brammer, G. (1977). Developmental changes of immunoglobulins in rats treated neonatally with hydrocortisone (39614). Proc. Soc. Exp. Biol. Med., 154, 107-111.