Andrew A. Pieper, MD, PhD

Portrait
Professor of Psychiatry
Professor of Neurology
Professor of Radiation Oncology
Professor of Molecular Physiology and Biophysics

Contact Information

Office: 1318 Pappajohn Biomedical Discovery Building
Iowa City, IA 52242
319-353-5781

Education

BA, Biology, Chemistry, Earlham College, Richmond, IN
MD, Johns Hopkins University School of Medicine, Baltimore, MD
PhD, Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD

Internship, Internal Medicine, Johns Hopkins University School of Medicine
Resident, Psychiatry, Johns Hopkins University School of Medicine
Resident, Psychiatry Research, University of Texas Southwestern Medical Center
Fellow, Psychiatry and Biochemistry, University of Texas Southwestern Medical Center

Licensure and Certifications

Psychiatry Certification - American Board of Psychiatry and Neurology

Publications

Michaelson, J. J., Shin, M. K., Koh, J. Y., Brueggerman, L., Zhang, A., Katzman, A., McDaniel, L., Fang, M., Pufall, M. & Pieper, A. A. (2017). Neuronal PAS domain proteins 1 and 3 are master regulators of neuropsychiatric risk genes. Biol Pshychiatry.

Loris, Z. B., Pieper, A. A. & Dietrich, W. D. (2017). The neuroprotective compound P7C3-A20 promotes neurogenesis and improves cognitive function after ischemic stroke. Experimental Neurology, 290, 63-73.

Voorhees, J., Rohlam, D., Lein, P. & Pieper, A. A. (2017). Neurotoxicity in preclinical models of occupational exposure to organophosphorus compounds. Frontiers in Neuroscience, 10, 590.

Voorhees, J. R., Remy, M. T., Cintrón-Pérez, C. J., El Rassi, E., Khan, M. Z., Dutca, L. M., Yin, T. C., McDaniel, L. N., Williams, N. S., Brat, D. J. & Pieper, A. A. (2017). (-)-P7C3-S243 Protects a Rat Model of Alzheimer's Disease From Neuropsychiatric Deficits and Neurodegeneration Without Altering Amyloid Deposition or Reactive Glia. Biological psychiatry. PMID: 29246437.

Pieper, A. A., Baraban, J. M. (2017). Moving beyond serendipity to mechanism driven psychiatric therapeutics. Neurotherapeutics. PMID: 28653277.

Lee, A. S., De Jesus-Cortes, H., Kabir, Z. D., Knobbe, W., Orr, M., Burgdorf, C., Huntington, P., McDaniel, L., Britt, J. K., Hoffman, F., Brat, D. J., Rajadhyaksha, A. M. & Pieper, A. A. (2016). The neuropsychiatric disease-associated gene cacna1c mediates survival of young hippocampal neurons. eNeuro. DOI: 10.1523/ENEURO.0006-16.2016.

Lutter, M., Khan, M. Z., Satio, K., Davis, K. C., Kidder, I. J., McDaniel, L., Darbro, B. W., Pieper, A. A. & Cui, H. (2016). The eating-disorder associated HDAC4-A778T mutation alters feeding behaviors in female mice. Biological Psychiatry, 81, 770-777.

De Jesus-Cortes, H., Lu, Y., Anderson, R. M., Khan, M. Z., Nath, V., McDaniel, L. M., Lutter, M., Radley, J. J., Pieper, A. A. & Cui, H. (2016). Loss of estrogen-related receptor alpha disrupts ventral-striatal synaptic function in female mice. (Vols. 329). pp. 66-73. Neuroscience.

von Holstein-Rathlou, S., BonDurant, L. D., Peltekian, L., Naber, M. C., Yin, T. C., Claflin, K. E., Urizar, A. I., Madsen, A. N., Ratner, C., Holst, B., Karstoft, K., Vandenbeuch, A., Anderson, C. B., Cassell, M. D., Thompson, A. P., Solomon, T. P., Rahmouni, K., Kinnamon, S. C., Pieper, A. A., Gillum, M. P. & Potthoff, M. J. (2016). FGF21 Mediates Endocrine Control of Simple Sugar Intake and Sweet Taste Preference by the Liver. Cell Metab, 23(2), 335-43. DOI: 10.1016/j.cmet.2015.12.003.

Yin, T. C., Voorhees, J. R., Genova, R. M., Davis, K., Madison, A., Britt, J. K., Cintron, C., McDaniel, L. M., Harper, M. M. & Pieper, A. A. (2016). Acute axonal degeneration drives development of cognitive, motor and visual deficits after blast-mediated traumatic brain injury in mice. eNEURO.

De Jesus-Cortes, H., Rajadhyaksha, A. M. & Pieper, A. A. (2016). Cacna1c: protecting young hippocampal neurons in the adult brain. Neurogenesis. DOI: 10.1080/23262133.2016.1231160.

Kemp, S. W., Szynkaruk, M., Stanoulis, K. N., Wood, M. D., Liu, E. H., Willand, M. P., Morlock, L., Naidoo, J., Williams, N. S., Ready, J. M., Mangano, T. J., Beggs, S., Salter, M. W., Gordon, T., Pieper, A. A. & Borschel, G. H. (2015). Pharmacologic rescue of motor and sensory function by the neuroprotective compound P7C3 following neonatal nerve injury. Neuroscience, 284, 202-16. DOI: 10.1016/j.neuroscience.2014.10.005.

De Jesús-Cortés, H., Miller, A. D., Britt, J. K., DeMarco, A. J., De Jesús-Cortés, M., Stuebing, E., Naidoo, J., Vázquez-Rosa, E., Morlock, L., Williams, N. S. & Ready, J. M. (2015). Protective efficacy of P7C3-S243 in the 6-hydroxydopamine model of Parkinson's disease. npj Parkinson's Disease, 1.

Wang, J., Wegener, J. E., Huang, T. W., Sripathy, S., De Jesus-Cortes, H., Xu, P., Tran, S., Knobbe, W., Leko, V., Britt, J., Starwalt, R., McDaniel, L., Ward, C. S., Parra, D., Newcomb, B., Lao, U., Nourigat, C., Flowers, D. A., Cullen, S., Jorstad, N. L., Yang, Y., Glaskova, L., Vigneau, S., Kozlitina, J., Yetman, M. J., Jankowsky, J. L., Reichardt, S. D., Reichardt, H. M., Gartner, J., Bartolomei, M. S., Fang, M., Loeb, K., Keene, C. D., Bernstein, I., Goodell, M., Brat, D. J., Huppke, P., Neul, J. L., Bedalov, A. & Pieper, A. A. (2015). Corrigendum: Wild-type microglia do not reverse pathology in mouse models of Rett syndrome. Nature, 525(7570), 552. DOI: 10.1038/nature14671.

Leira, E. C., Zaheer, A., Schnell, T., Torner, J. C., Olalde, H. M., Pieper, A. A., Ortega-Gutierrez, S., Nagaraja, N., Marks, N. L. & Adams, Jr., H. P. (2015). Effect of helicopter transport on neurological outcomes in a mouse model of embolic stroke with reperfusion: AIR-MICE pilot study. Int J Stroke, 10 Suppl A100, 119-24. DOI: 10.1111/ijs.12619.

Wang, J., Wegener, J. E., Huang, T. W., Sripathy, S., De Jesus-Cortes, H., Xu, P., Tran, S., Knobbe, W., Leko, V., Britt, J., Starwalt, R., McDaniel, L., Ward, C. S., Parra, D., Newcomb, B., Lao, U., Nourigat, C., Flowers, D. A., Cullen, S., Jorstad, N. L., Yang, Y., Glaskova, L., Vingeau, S., Kozlitina, J., Yetman, M. J., Jankowsky, J. L., Reichardt, S. D., Reichardt, H. M., Gartner, J., Bartolomei, M. S., Fang, M., Loeb, K., Keene, C. D., Bernstein, I., Goodell, M., Brat, D. J., Huppke, P., Neul, J. L., Bedalov, A. & Pieper, A. A. (2015). Wild-type microglia do not reverse pathology in mouse models of Rett syndrome. Nature, 521(7552), E1-4. DOI: 10.1038/nature14444.

Cui, H., Lu, Y., Khan, M. Z., Anderson, R. M., McDaniel, L., Wilson, H. E., Yin, T. C., Radley, J. J., Pieper, A. A. & Lutter, M. (2015). Behavioral disturbances in estrogen-related receptor alpha-null mice. Cell Rep, 11(3), 344-50. DOI: 10.1016/j.celrep.2015.03.032.

Walker, A. K., Rivera, P. D., Wang, Q., Chuang, J. C., Tran, S., Osborne-Lawrence, S., Estill, S. J., Starwalt, R., Huntington, P., Morlock, L., Naidoo, J., Williams, N. S., Ready, J. M., Eisch, A. J., Pieper, A. A. & Zigman, J. M. (2015). The P7C3 class of neuroprotective compounds exerts antidepressant efficacy in mice by increasing hippocampal neurogenesis. Molecular Psychiatry, 20(4), 500-8. PMID: 24751964.

Pieper, A. A., McKnight, S. L. & Ready, J. M. (2014). P7C3 and an unbiased approach to drug discovery for neurodegenerative diseases. Chemical Society Reviews, 43(19), 6716-26. PMID: 24514864.

Stanco, A., Pla, R., Vogt, D., Chen, Y., Mandal, S., Walker, J., Hunt, R. F., Lindtner, S., Erdman, C. A., Pieper, A. A., Hamilton, S. P., Xu, D., Baraban, S. C. & Rubenstein, J. L. (2014). NPAS1 represses the generation of specific subtypes of cortical interneurons. Neuron, 84(5), 940-53. DOI: 10.1016/j.neuron.2014.10.040.

Blaya, M. O., Bramlett, H. M., Naidoo, J., Pieper, A. A. & Dietrich, W. D. (2014). Neuroprotective efficacy of a proneurogenic compound after traumatic brain injury. Journal of Neurotrauma, 31(5), 476-86. PMID: 24070637.

Yin, T. C., Britt, J. K., Jesus-Cortes, H., Lu, Y., Genova, R. M., Khan, M. Z., Voorhees, J. R., Shao, J., Katzman, A. C., Wassink, C., McDaniel, L., Newell, E. A., Dutca, L. M., Naidoo, J., Cui, H., Bassuk, A. G., Harper, M. M., McKnight, S. L., Ready, J. M. & Pieper, A. A. (2014). P7C3 Neuroprotective chemicals block axonal degeneration and preserve function after traumatic brain injury. Cell Rep, 8(6), 1731-40. PMID: 25220467.

Wang, G., Han, T., Nijhawan, D., Theodoropoulos, P., Naidoo, J., Yadavalli, S., Mirzaei, H., Pieper, A. A., Ready, J. M. & McKnight, S. L. (2014). P7C3 Neuroprotective chemicals function by activating the rate-limiting enzyme in NAD salvage. Cell, 158(6), 1324-34. PMID: 25215490.

Dutca, L. M., Stasheff, S. F., Hedberg-Buenz, A., Rudd, D., Batra, N., Blodi, F. R., Yorek, M. S., Yin, T., Shankar, M., Herlein, J. A., Naidoo, J., Morlock, L., Williams, N., Kardon, R. H., Pieper, A. A. & Harper, M. M. (2014). Early detection of subclinical visual damage after blast-mediated TBI enables prevention of chronic visual deficit by treatment with P7C3-S243. Invest Ophthalmol Vis Sci, 55(12), 8330-41. PMID: 25468886.

Naidoo, J., Jesus-Cortes, H., Huntington, P., Estill, S. H., Starwalt, R., Morlock, L., Mangano, T., Williams, N., Pieper, A. A. & Ready, J. (2014). Discovery of a neuroprotective chemical, (S)-N-(3-(3,6-dibromo-9H-carbazol-9-yl)-2-fluoropropyl)-6-methoxypyridin-2-amine [(-)-P7C3-S243], with improved druglike properties. J Med Chem, 57(9), 3746-54. PMID: 24697290.

Cui, H., Moore, J., Ashimi, S. S., Mason, B. L., Drawbridge, J. N., Han, S., Hing, B., Matthews, A., McAdams, C. J., Darbro, B. W., Pieper, A. A., Waller, D. A., Xing, C. & Lutter, M. (2013). Eating disorder predisposition is associated with ESRRA and HDAC4 mutations. J Clin Invest, 123(11), 4706-13. DOI: 10.1172/jci71400.

Caldera-Alvarado, G., Khan, D. A., Defina, L. F., Pieper, A. & Brown, E. S. (2013). Relationship between asthma and cognition: the Cooper Center Longitudinal Study. Allergy, 68(4), 545-8. PMID: 23409872.

Xu, P., Grueter, B. A., Britt, J. K., McDaniel, L., Huntington, P. J., Hodge, R., Tran, S., Mason, B. L., Lee, C., Vong, L., Lowell, B. B., Malenka, R. C., Lutter, M. & Pieper, A. A. (2013). Double deletion of melanocortin 4 receptors and SAPAP3 corrects compulsive behavior and obesity in mice. Proc Natl Acad Sci U S A, 110(26), 10759-64. PMID: 23754400.

Buchovecky, C. M., Brown, H. M., McDonald, J. G., Lui, B., Kyle, S., Pieper, A. A., Huang, W., Katz, D. M., Turley, S. D., Russell, D. W., Shendure, J. & Justice, M. J. (2013). A suppressor screen in Mecp2 mutant mice implicates cholesterol metabolism in Rett syndrome. Nat Genet, 45(9), 1013-20. PMID: 23892605.

Paemka, L., Mahajan, V. B., Skeie, J. M., Sowers, L. P., Ehaideb, S. N., Gonzalez-Alegre, P., Sasaoka, T., Tao, H., Miyagi, A., Ueno, N., Takao, K., Miyakawa, T., Wu, S., Darbo, B. W., Ferguson, P. J., Pieper, A. A., Britt, J. K., Wemmie, J. A., Wassink, T., Rudd, D. S., El-Shanti, H., Mefford, H. C., Carvill, G. L., Manak, J. R. & Bassuk, A. G. (2013). PRICKLE1 interaction with SYNAPSIN I reveals a role in autism spectrum disorders. PloS one, 8(12), e80737. PMID: 24312498.

Lee, A. S., Gonzales, K. L., Lee, A., Moosmang, S., Hofmann, F., Pieper, A. A. & Rajadhyaksha, A. M. (2012). Selective genetic deletion of cacna1c in the mouse prefrontal cortex. Mol psychiatry, 17(11), 1051. PMID: 23096954.

De Jesús-Cortés, H., Xu, P., Drawbridge, J., Estill, S. J., Huntington, P., Tran, S., Britt, J., Tesla, R., Morlock, L., Naidoo, J., Melito, L. M., Wang, G., Williams, N. S., Ready, J. M., McKnight, S. L. & Pieper, A. A. (2012). Neuroprotective efficacy of aminopropyl carbazoles in a mouse model of Parkinson disease. Proceedings of the National Academy of Sciences of the United States of America, 109(42), 17010-5. PMID: 23027934.

Lee, A. S., Ra, S., Rajadhyaksha, A. M., Britt, J. K., De Jesus-Cortes, H., Gonzales, K. L., Lee, A., Moosmang, S., Hofmann, F., Pieper, A. A. & Rajadhyaksha, A. M. (2012). Forebrain elimination of cacna1c mediates anxiety-like behavior in mice. Mol Psychiatry, 17(11), 1054-5. PMID: 22665262.

Tesla, R., Wolf, H. P., Xu, P., Drawbridge, J., Estill, S. J., Huntington, P., McDaniel, L., Knobbe, W., Burket, A., Tran, S., Starwalt, R., Morlock, L., Naidoo, J., Williams, N. S., Ready, J. M., McKnight, S. L. & Pieper, A. A. (2012). Neuroprotective efficacy of aminopropyl carbazoles in a mouse model of amyotrophic lateral sclerosis. Proc Natl Acad Sci U S A, 109(42), 17016-21. PMID: 23027932.

Aqul, A., Liu, B., Ramirez, C. M., Pieper, A. A., Estill, S. J., Burns, D. K., Liu, B., Repa, J. J., Turley, S. D. & Dietschy, J. M. (2011). Unesterified cholesterol accumulation in late endosomes/lysosomes causes neurodegeneration and is prevented by driving cholesterol export from this compartment. The Journal of neuroscience : the official journal of the Society for Neuroscience, 31(25), 9404-13. PMID: 21697390.

Watkins, C. C., Pieper, A. A. & Treisman, G. J. (2011). Safety considerations in drug treatment of depression in HIV-positive patients: an updated review. Drug safety : an international journal of medical toxicology and drug experience, 34(8), 623-39. PMID: 21751824.

MacMillan, K. S., Naidoo, J., Liang, J., Melito, L., Williams, N. S., Morlock, L., Huntington, P. J., Estill, S. J., Longgood, J., Becker, G. L., McKnight, S. L., Pieper, A. A., De Brabander, J. K. & Ready, J. M. (2011). Development of proneurogenic, neuroprotective small molecules. Journal of the American Chemical Society, 133(5), 1428-37. PMID: 21210688.

Pieper, A. A., Xie, S., Capota, E., Estill, S. J., Zhong, J., Long, J. M., Becker, G. L., Huntington, P., Goldman, S. E., Shen, C. H., Capota, M., Britt, J. K., Kotti, T., Ure, K., Brat, D. J., Williams, N. S., MacMillan, K. S., Naidoo, J., Melito, L., Hsieh, J., De Brabander, J., Ready, J. M. & McKnight, S. L. (2010). Discovery of a proneurogenic, neuroprotective chemical. Cell, 142(1), 39-51. PMID: 20603013.

Zhao, H., Negash, L., Wei, Q., LaCour, T. G., Estill, S. J., Capota, E., Pieper, A. A. & Harran, P. G. (2008). Acid promoted cinnamyl ion mobility within peptide derived macrocycles. Journal of the American Chemical Society, 130(42), 13864-6. PMID: 18811162.

Pickard, B. S., Pieper, A. A., Porteous, D. J., Blackwood, D. H. & Muir, W. J. (2006). The NPAS3 gene--emerging evidence for a role in psychiatric illness. Annals of medicine, 38(6), 439-48. PMID: 17008307.

Pieper, A. A., Rush, A. J., John, A., Choate, L., Gibson, A., Ayacannoo, S., Noack, K. R., Han, T. W., Quinn, C., Ihara, T., Probst, B. & McKnight, S. L. (2006). Polymorphic variation in human circadian genes in mental illness. www.mcknightlab.com.

Pieper, A. A., Wu, X., Han, T. W., Estill, S. J., Dang, Q., Wu, L. C., Reece-Fincanon, S., Dudley, C. A., Richardson, J. A., Brat, D. J. & McKnight, S. L. (2005). The neuronal PAS domain protein 3 transcription factor controls FGF-mediated adult hippocampal neurogenesis in mice. Proceedings of the National Academy of Sciences of the United States of America, 102(39), 14052-7. PMID: 16172381.

Pieper, A. A., Treisman, G. J. (2005). Drug treatment of depression in HIV-positive patients: Safety considerations. Drug Saf, 28(9), 753-762. PMID: 16119970.

Pieper, A. A., Treisman, G. J. (2004). Depression, mania, and schizophrenia in HIV-infected patients. UpToDate www.uptodate.com.

Pieper, A. A., Treisman, G. J. (2004). Overview of the neuropsychiatric aspects of HIV infection and AIDS. UpToDate www.uptodate.com.

Pieper, A. A., Treisman, G. J. (2004). Dementia and delirium in HIV-infected patients. UpToDate www.uptodate.com.

Pieper, A. A., Treisman, G. J. (2004). Substance abuse and addiction in HIV-infected patients. UpToDate www.uptodate.com.

Pieper, A. A., Brat, D. J., O'Hearn, E., Krug, D. K., Kaplin, A. I., Takahashi, K., Greenberg, J. H., Ginty, D., Molliver, M. E. & Snyder, S. H. (2001). Differential neuronal localizations and dynamics of phosphorylated and unphosphorylated type 1 inositol 1,4,5-trisphosphate receptors. Neuroscience, 102(2), 433-44. PMID: 11166129.

Pieper, A. A., Walles, T., Wei, G., Clements, E. E., Verma, A., Snyder, S. H. & Zweier, J. L. (2000). Myocardial postischemic injury is reduced by polyADPripose polymerase-1 gene disruption. Molecular medicine (Cambridge, Mass.), 6(4), 271-82. PMID: 10949908.

Pieper, A. A., Blackshaw, S., Clements, E. E., Brat, D. J., Krug, D. K., White, A. J., Pinto-Garcia, P., Favit, A., Conover, J. R., Snyder, S. H. & Verma, A. (2000). Poly(ADP-ribosyl)ation basally activated by DNA strand breaks reflects glutamate-nitric oxide neurotransmission. Proceedings of the National Academy of Sciences of the United States of America, 97(4), 1845-50. PMID: 10677544.

LaPlaca, M. C., Raghupathi, R., Verma, A., Pieper, A. A., Saatman, K. E., Snyder, S. H. & McIntosh, T. K. (1999). Temporal patterns of poly(ADP-ribose) polymerase activation in the cortex following experimental brain injury in the rat. Journal of neurochemistry, 73(1), 205-13. PMID: 10386972.

Takahashi, K., Pieper, A. A., Croul, S. E., Zhang, J., Snyder, S. H. & Greenberg, J. H. (1999). Post-treatment with an inhibitor of poly(ADP-ribose) polymerase attenuates cerebral damage in focal ischemia. Brain research, 829(2-Jan), 46-54. PMID: 10350529.

Pieper, A. A., Brat, D. J., Krug, D. K., Watkins, C. C., Gupta, A., Blackshaw, S., Verma, A., Wang, Z. Q. & Snyder, S. H. (1999). Poly(ADP-ribose) polymerase-deficient mice are protected from streptozotocin-induced diabetes. Proceedings of the National Academy of Sciences of the United States of America, 96(6), 3059-64. PMID: 10077636.

Pieper, A. A., Verma, A., Zhang, J. & Snyder, S. H. (1999). Poly (ADP-ribose) polymerase, nitric oxide and cell death. Trends in pharmacological sciences, 20(4), 171-81. PMID: 10322503.

Eliasson, M. J., Sampei, K., Mandir, A. S., Hurn, P. D., Traystman, R. J., Bao, J., Pieper, A., Wang, Z. Q., Dawson, T. M., Snyder, S. H. & Dawson, V. L. (1997). Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia. Nature medicine, 3(10), 1089-95. PMID: 9334719.

Zhang, J., Pieper, A. & Snyder, S. H. (1995). Poly(ADP-ribose) synthetase activation: an early indicator of neurotoxic DNA damage. Journal of neurochemistry, 65(3), 1411-4. PMID: 7643121.