Logo for University of Iowa Health Care This logo represents the University of Iowa Health Care

Subhash Gupta

Postdoctoral Research Scholar 
Address: 1314 PBDB
Phone: 319-384-1760
Email: subhash-gupta@uiowa.edu

Mentor: John Wemmie, MD, PhD

Undergraduate Institution: Dr. RML Awadh University, India

PhD Institution: Barkatullah University/CIMAP-CSIR, India

Research Description

I am working on role of acid sensing ion channel 1a (ASIC1a) in cocaine addiction. As this is known cocaine modulate the synaptic plasticity in mesolimbic circuit, ASIC1a is expressed in nucleus accumbens which mainly plays role in cocaine addiction and reward related behaviors. We are addressing the role of ASIC1a using behavior, electrophysiology and optogenetic approach.

Publication(s)

Gupta SC, Yadav R, Pavuluri R, Morley B, Stairs DJ, Dravid SM. Essential role of GluD1 in dendritic spine development and GluN2B to GluN2A NMDAR subunit switch in the cortex and hippocampus reveals ability of GluN2B inhibition in correcting hyperconnectivity. Neuropharmacology. 2015 June. 93: 273-84.

Gupta SC, Hillman BG, Prakash A, Stairs DJ, Dravid SM. Role of D-cycloserine in conjunction with fear extinction training on extracellular signal-regulated kinase activation in the medial prefrontal cortex and amygdala in rat. European Journal of Neuroscience. 2013 June. 37(11): 1811-22.

Yadav R, Hillman BG, Gupta SC, Suryavanshi P, Bhatt JM, Pavuluri R, Stairs DJ, Dravid SM. Deletion of Glutamate Delta-1 Receptor in Mouse Leads to Enhanced Working Memory and Deficit in Fear Conditioning. PLoS ONE. 2013. 8(4): e60785.

Yadav R, Gupta SC, Hillman BG, Bhatt JM, Stairs DJ, Dravid SM. Deletion of glutamate delta-1 receptor results in deficits in social interaction and abnormal synaptic proteins. PLoS ONE. 2012. 7(3): e32969.

Pal A, Bawankule DU, Darokar MP, Gupta SC, Arya JS, Shanker K, Mohangupta M, Yadav NP, Singh Khanuja SP. Influence of Moringa oleifera on pharmacokinetic disposition of rifampicin using HPLC-PDA method: a pre-clinical study. Biomed Chromatogr. 2011 June. 25(6):641-5.

Hillman BG, Gupta SC, Stairs DJ, Buonanno A, Dravid SM. Behavioral analysis of NR2C knockout mouse reveals deficit in acquisition of conditioned fear and working memory. Neurobiol Learn Mem. 2011 May. 95(4):404-14.

Bhardwaj V, Ankola DD, Gupta SC, Schneider M, C.-M. Lehr & M.N.V. Ravi Kumar. PLGA nanoparticles stabilized with cationic surfactant: Safety studies and application in oral delivery of paclitaxel to treat chemical induced breast cancer in rat. Pharmaceutical Research. 2009 November. 26(11):2495-503.

Saikia D, Khanuja SPS, Kahol AP, Gupta SC, Kumar S. Comparative antifungal activity of essential oils and constituents from three distinct genotype of Cymbopogon spp. Current Science. 2001. 80(10):1264-66.