Prabhat Goswami, PhD

Portrait
Professor of Radiation Oncology

Contact Information

Iowa City, IA 52242
+319-384-4666

Education

BS, Chemistry, St. Anthony's College, Shillong, India
MS, Chmistry, Gauhati University, India
PhD, Chemistry, Gauhati University, India

Fellow, Regional Research Laboratory
Postdoctoral Fellow, Department of Microbiology, University of Miami

Education/Training Program Affiliations

Biomedical Science Program, Free Radical and Radiation Biology Graduate Program, Interdisciplinary Graduate Program in Human Toxicology, Interdisciplinary Graduate Program in Molecular Medicine, Interdisciplinary Graduate Program in Translational Biomedicine, Medical Scientist Training Program

Research Summary

Dr. Goswami's laboratory is pursuing mechanistic understanding of the role intracellular redox-state plays in regulating the mammalian cell cycle, and the establishment of a link between ROS-signaling and other aspects of intracellular signaling networks. Research efforts are concentrated in identifying the molecular mechanisms involved in the regulation of the redox-sensitive G1-checkpoint following mitogenic stimuli and in asynchronously growing exponential cells. The possible role of ROS and thiol-redox reactions in regulating expression and activities of cyclins, CDKs, CKIs, CDC25, Rb, thioredoxin, and glutaredoxin are of immediate interest. Research efforts are also ongoing identifying the cellular effects of environmental pollutants, polychlorinated biphenyls. The possible role of oxidative stress in PCB-induced DNA damage, perturbation in cellular proliferation, and cell death is currently being investigated. Additional research interest includes investigating the possible role of intracellular redox environment in wound healing, radiosensitivity, radiation-induced cell cycle checkpoint pathways, and post-transcriptional gene regulation. The knowledge gained from these research projects may provide novel insights into the regulation of the mammalian cell cycle both in physiological as well as pathological states. This knowledge may allow us to devise better treatment protocols based on redox control of the cell cycle.

Publications

Son, J. M., Sarsour, E. H., Kakkerla Balaraju, A., Fussell, J., Kalen, A. L., Wagner, B. A., Buettner, G. R. & Goswami, P. C. (2017). Mitofusin 1 and optic atrophy 1 shift metabolism to mitochondrial respiration during aging. Aging cell, 16(5), 1136-1145. PMID: 28758339.

Mapuskar, K. A., Flippo, K. H., Schoenfeld, J. D., Riley, D. P., Strack, S., Hejleh, T. A., Furqan, M., Monga, V., Domann, F. E., Buatti, J. M., Goswami, P. C., Spitz, D. R. & Allen, B. G. (2017). Mitochondrial Superoxide Increases Age-Associated Susceptibility of Human Dermal Fibroblasts to Radiation and Chemotherapy. Cancer research, 77(18), 5054-5067. PMID: 28765155.

Kalen, A. L., Ahmad, I. M., Abdalla, M. Y., O'Malley, Y. Q., Goswami, P. C. & Sarsour, E. H. (2017). MnSOD and Cyclin B1 Coordinate a Mito-Checkpoint during Cell Cycle Response to Oxidative Stress. Antioxidants (Basel, Switzerland), 6(4). PMID: 29149089.

Mao, G., Goswami, M., Kalen, A. L., Goswami, P. C. & Sarsour, E. H. (2016). N-acetyl-L-cysteine increases MnSOD activity and enhances the recruitment of quiescent human fibroblasts to the proliferation cycle during wound healing. Molecular biology reports, 43(1), 31-9. PMID: 26671656.

Xiao, W., Sarsour, E. H., Wagner, B. A., Doskey, C. M., Buettner, G. R., Domann, F. E. & Goswami, P. C. (2016). Succinate dehydrogenase activity regulates PCB3-quinone-induced metabolic oxidative stress and toxicity in HaCaT human keratinocytes. Archives of toxicology, 90(2), 319-32. PMID: 25417049.

Xiao, W., Goswami, P. C. (2015). Down-regulation of peroxisome proliferator activatedreceptor ? coactivator 1a induces oxidative stress and toxicity of1-(4-Chlorophenyl)-benzo-2,5-quinone in HaCaT human keratinocytes. Toxicol InVitro., 29(7), 1332-1338. PMID: 26004620.

Xiao, W., Son, J., Vorrink, S. U. & Goswami, P. C. (2015). Ligand-independentactivation of aryl hydrocarbon receptor signaling in PCB3-quinone treated HaCaThuman keratinocytes. Toxicol Lett., 233(3), 258-66. PMID: 25668756.

Rybakova, Y. S., Kalen, A. L., Eckers, J. C., Fedorova, T. N., Goswami, P. C. & Sarsour, E. H. (2015). [Increased manganese superoxide dismutase and cyclin B1 expression in carnosine-induced inhibition of glioblastoma cell proliferation]. Biomeditsinskaia khimiia, 61(4), 510-8. PMID: 26350743.

DU, J., Cieslak, 3rd, J. A., Welsh, J. L., Allen, B. G., Wagner, B. A., Kalen, A. L., Doskey, C. M., Strother, R. K., Button, A. M., Mott, S. L., Smith, B., Tsai, S., Mezhir, J., Goswami, P. C., Spitz, D. R., Buettner, G. R. & Cullen, J. J. (2015). Pharmacological Ascorbate RadiosensitizesPancreatic Cancer. Cancer Res., pii: canres.1707.2014.. PMID: 26081808.

Sibenaller, Z. A., Welsh, J. L., Du, C., Witmer, J. R., Schrock, H. E., Du, J., Buettner, G. R., Goswami, P. C., Cieslak, J. A. & Cullen, J. J. (2014). Extracellular superoxide dismutase suppresses hypoxia-inducible factor-1a in pancreatic cancer. Free Radical Biology and Medicine, 69, 357-366. PMID: 24509158.

Sarsour, E. H., Goswami, M., Kalen, A. L., Lafin, J. T. & Goswami, P. C. (2014). Hydroxytyrosol inhibits chemokine C-C motif ligand 5 mediated aged quiescent fibroblast-induced stimulation of breast cancer cell proliferation. Age (Dordr)., 36(3), 9645. PMID: PMID: 24691968.

Vorrink, S. U., Sarsour, E. H., Olivier, A. K., Robertson, L. W., Goswami, P. C. & Domann, F. E. (2014). PCB 126 perturbs hypoxia-induced HIF-1a activity and glucose consumption in human HepG2 cells. Exp Toxicol Pathol., pii: S0940-2993(14), 00071-2. PMID: PMID: 24916446.

Eckers, J. C., Kalen, A. L., Sarsour, E. H., Tompkins, V. S., Janz, S., Son, J. M., Doskey, C. M., Buettner, G. R. & Goswami, P. C. (2014). Forkhead box M1 regulates quiescence-associatedradioresistance of human head and neck squamous carcinoma cells. Radiat Res., 182(4), 420-249. PMID: 25229973.

Xiao, W., Sarsour, E. H., Wagner, B. A., Doskey, C. M., Buettner, G. R., Domann, F. E. & Goswami, P. C. (2014). Succinate dehydrogenase activity regulates PCB3-quinone-induced metabolicoxidative stress and toxicity in HaCaT human keratinocytes. Arch Toxicol, Epub ahead of print. PMID: 25417049.

Vorrink, S. U., Sarsour, E. H., Olivier, A. K., Robertson, L. W., Goswami, P. C. & Domann, F. E. (2014). PCB 126 perturbs hypoxia-induced HIF-1a activity and glucose consumption in humanHepG2 cells. Exp Toxicol Pathol., 66(8), 377-382. PMID: 24916446.

Sarsour, E. H., Kalen, A. L. & Goswami, P. C. (2013). Manganese Superoxide Dismutase Regulates a Redox Cycle Within the Cell Cycle. Antioxidants & redox signaling. PMID: 23590434.

Xiao, W., Sarsour, E. H., Kalen, A. L., Aykin-Burns, N., Spitz, D. R. & Goswami, P. C. (2013). Selenoprotein P regulates 1-(4-Chlorophenyl)-benzo-2,5-quinone-induced oxidative stress and toxicity in human keratinocytes. Free Radic Biol Med., 65C, 70-77. PMID: PMID:23770201.

Eckers, J. C., Kalen, A. L., Xiao, W., Sarsour, E. H. & Goswami, P. C. (2013). Selenoprotein p inhibits radiation-induced late reactive oxygen species accumulation and normal cell injury. Int J Radiat Oncol Biol Phys., 87(3), 619-25. PMID: PMID:24074935.

Sarsour, E. H., Kumar, M. G., Kalen, A. L., Goswami, M., Buettner, G. R. & Goswami, P. C. (2012). MnSOD activity regulates hydroxytyrosol-induced extension of chronological lifespan. Age (Dordrecht, Netherlands), 34(1), 95-109. PMID: 21384152.

Sarsour, E. H., Kalen, A. L., Xiao, Z., Veenstra, T. D., Chaudhuri, L., Venkataraman, S., Reigan, P., Buettner, G. R. & Goswami, P. C. (2012). Manganese superoxide dismutase regulates a metabolic switch during the mammalian cell cycle. Cancer research, 72(15), 3807-16. PMID: 22710435.

Chaudhuri, L., Nicholson, A. M., Kalen, A. L. & Goswami, P. C. (2012). Preferential selection of MnSOD transcripts in proliferating normal and cancer cells. Oncogene, 31(10), 1207-16. PMID: 21804600.

Kumar, M. G., Patel, N. M., Nicholson, A. M., Kalen, A. L., Sarsour, E. H. & Goswami, P. C. (2012). Reactive oxygen species mediate microRNA-302 regulation of AT-rich interacting domain 4a and C-C motif ligand 5 expression during transitions between quiescence and proliferation. Free radical biology & medicine, 53(4), 974-82. PMID: 22732186.

Sarsour, E. H., Goswami, M., Kalen, A. L. & Goswami, P. C. (2010). MnSOD activity protects mitochondrial morphology of quiescent fibroblasts from age associated abnormalities. Mitochondrion, 10(4), 342-9. PMID: 20206302.

Venkatesha, V. A., Kalen, A. L., Sarsour, E. H. & Goswami, P. C. (2010). PCB-153 exposure coordinates cell cycle progression and cellular metabolism in human mammary epithelial cells. Toxicology letters, 196(2), 110-6. PMID: 20394812.

Chaudhuri, L., Sarsour, E. H., Kalen, A. L., Aykin-Burns, N., Spitz, D. R. & Goswami, P. C. (2010). Polychlorinated biphenyl induced ROS signaling delays the entry of quiescent human breast epithelial cells into the proliferative cycle. Free radical biology & medicine, 49(1), 40-9. PMID: 20307652.

Chaudhuri, L., Sarsour, E. H. & Goswami, P. C. (2010). 2-(4-Chlorophenyl)benzo-1,4-quinone induced ROS-signaling inhibits proliferation in human non-malignant prostate epithelial cells. Environment international, 36(8), 924-30. PMID: 20163859.

Cloos, C. R., Daniels, D. H., Kalen, A., Matthews, K., Du, J., Goswami, P. C. & Cullen, J. J. (2009). Mitochondrial DNA depletion induces radioresistance by suppressing G2 checkpoint activation in human pancreatic cancer cells. Radiation research, 171(5), 581-7. PMID: 19580493.

Yu, L., Hitchler, M. J., Sun, W., Sarsour, E. H., Goswami, P. C., Klingelhutz, A. J. & Domann, F. E. (2009). AP-2alpha Inhibits c-MYC Induced Oxidative Stress and Apoptosis in HaCaT Human Keratinocytes. Journal of oncology, 2009, 780874. PMID: 20066163.

Itani, H., Liu, X., Sarsour, E. H., Goswami, P. C., Born, E., Keen, H. L. & Sigmund, C. D. (2009). Regulation of renin gene expression by oxidative stress. Hypertension, 53(6), 1070-6. PMID: 19433777.

Goswami, P. C. (2009). Mutant mitochondria and cancer cell metastasis: quest for a mechanism. Cancer biology & therapy, 8(14), 1386-8. PMID: 19823013.

Du, C., Gao, Z., Venkatesha, V. A., Kalen, A. L., Chaudhuri, L., Spitz, D. R., Cullen, J. J., Oberley, L. W. & Goswami, P. C. (2009). Mitochondrial ROS and radiation induced transformation in mouse embryonic fibroblasts. Cancer biology & therapy, 8(20), 1962-71. PMID: 19738419.

Dayal, D., Martin, S. M., Owens, K. M., Aykin-Burns, N., Zhu, Y., Boominathan, A., Pain, D., Limoli, C. L., Goswami, P. C., Domann, F. E. & Spitz, D. R. (2009). Mitochondrial complex II dysfunction can contribute significantly to genomic instability after exposure to ionizing radiation. Radiation research, 172(6), 737-45. PMID: 19929420.

Zhu, Y., Kalen, A. L., Li, L., Lehmler, H. J., Robertson, L. W., Goswami, P. C., Spitz, D. R. & Aykin-Burns, N. (2009). Polychlorinated-biphenyl-induced oxidative stress and cytotoxicity can be mitigated by antioxidants after exposure. Free radical biology & medicine, 47(12), 1762-71. PMID: 19796678.

Sarsour, E. H., Kumar, M. G., Chaudhuri, L., Kalen, A. L. & Goswami, P. C. (2009). Redox control of the cell cycle in health and disease. Antioxidants & redox signaling, 11(12), 2985-3011. PMID: 19505186.

Morrissey, J. J., Higashikubo, R., Goswami, P. C. & Dixon, P. (2009). Mild hyperthermia as a potential mechanism to locally enhance cell growth kinetics. Journal of drug targeting, 17(9), 719-23. PMID: 19845488.

Sarsour, E. H., Venkataraman, S., Kalen, A. L., Oberley, L. W. & Goswami, P. C. (2008). Manganese superoxide dismutase activity regulates transitions between quiescent and proliferative growth. Aging cell, 7(3), 405-17. PMID: 18331617.

Hansen, M. R., Clark, J. J., Gantz, B. J. & Goswami, P. C. (2008). Effects of ErbB2 signaling on the response of vestibular schwannoma cells to gamma-irradiation. The Laryngoscope, 118(6), 1023-30. PMID: 18520822.

Gao, Z., Sarsour, E. H., Kalen, A. L., Li, L., Kumar, M. G. & Goswami, P. C. (2008). Late ROS accumulation and radiosensitivity in SOD1-overexpressing human glioma cells. Free radical biology & medicine, 45(11), 1501-9. PMID: 18790046.

Fisher, C. J., Goswami, P. C. (2008). Mitochondria-targeted antioxidant enzyme activity regulates radioresistance in human pancreatic cancer cells. Cancer biology & therapy, 7(8), 1271-9. PMID: 18497575.

Venkatesha, V. A., Venkataraman, S., Sarsour, E. H., Kalen, A. L., Buettner, G. R., Robertson, L. W., Lehmler, H. J. & Goswami, P. C. (2008). Catalase ameliorates polychlorinated biphenyl-induced cytotoxicity in nonmalignant human breast epithelial cells. Free radical biology & medicine, 45(8), 1094-102. PMID: 18691649.

Menon, S. G., Goswami, P. C. (2007). A redox cycle within the cell cycle: ring in the old with the new. Oncogene, 26(8), 1101-9. PMID: 16924237.

Bock, J. M., Menon, S. G., Sinclair, L. L., Bedford, N. S., Goswami, P. C., Domann, F. E. & Trask, D. K. (2007). Celecoxib toxicity is cell cycle phase specific. Cancer research, 67(8), 3801-8. PMID: 17440094.

Menon, S. G., Sarsour, E. H., Kalen, A. L., Venkataraman, S., Hitchler, M. J., Domann, F. E., Oberley, L. W. & Goswami, P. C. (2007). Superoxide signaling mediates N-acetyl-L-cysteine-induced G1 arrest: regulatory role of cyclin D1 and manganese superoxide dismutase. Cancer research, 67(13), 6392-9. PMID: 17616699.

Bock, J. M., Menon, S. G., Goswami, P. C., Sinclair, L. L., Bedford, N. S., Domann, F. E. & Trask, D. K. (2007). Relative non-steroidal anti-inflammatory drug (NSAID) antiproliferative activity is mediated through p21-induced G1 arrest and E2F inhibition. Molecular carcinogenesis, 46(10), 857-64. PMID: 17415779.

Bock, J. M., Menon, S. G., Goswami, P. C., Sinclair, L. L., Bedford, N. S., Jackson, R. E. & Trask, D. K. (2007). Differential activity of sulindac metabolites against squamous cell carcinoma of the head and neck is mediated by p21waf1/cip1 induction and cell cycle inhibition. Cancer biology & therapy, 6(1), 30-9. PMID: 17172818.

Slane, B. G., Aykin-Burns, N., Smith, B. J., Kalen, A. L., Goswami, P. C., Domann, F. E. & Spitz, D. R. (2006). Mutation of succinate dehydrogenase subunit C results in increased O2.-, oxidative stress, and genomic instability. Cancer research, 66(15), 7615-20. PMID: 16885361.

Goswami, P., Singh, K. K. (2006). Oxidative Stress and Multistage Carcinogenesis. In K. K. Singh (Eds.) in Oxidative Stress, Disease and Cancer. pp. Chapter 24, p 705-731. Imperial College Press London.

Kalen, A. L., Sarsour, E. H., Venkataraman, S. & Goswami, P. C. (2006). Mn-superoxide dismutase overexpression enhances G2 accumulation and radioresistance in human oral squamous carcinoma cells. Antioxidants & redox signaling, 8(8-Jul), 1273-81. PMID: 16910775.

Li, H., Goswami, P. C. & Domann, F. E. (2006). AP-2gamma induces p21 expression, arrests cell cycle, and inhibits the tumor growth of human carcinoma cells. Neoplasia (New York, N.Y.), 8(7), 568-77. PMID: 16867219.

Venkataraman, S., Jiang, X., Weydert, C., Zhang, Y., Zhang, H. J., Goswami, P. C., Ritchie, J. M., Oberley, L. W. & Buettner, G. R. (2005). Manganese superoxide dismutase overexpression inhibits the growth of androgen-independent prostate cancer cells. Oncogene, 24(1), 77-89. PMID: 15543233.

Ridnour, L. A., Sim, J. E., Choi, J., Dickinson, D. A., Forman, H. J., Ahmad, I. M., Coleman, M. C., Hunt, C. R., Goswami, P. C. & Spitz, D. R. (2005). Nitric oxide-induced resistance to hydrogen peroxide stress is a glutamate cysteine ligase activity-dependent process. Free radical biology & medicine, 38(10), 1361-71. PMID: 15855054.

Menon, S. G., Coleman, M. C., Walsh, S. A., Spitz, D. R. & Goswami, P. C. (2005). Differential susceptibility of nonmalignant human breast epithelial cells and breast cancer cells to thiol antioxidant-induced G(1)-delay. Antioxidants & redox signaling, 7(6-May), 711-8. PMID: 15890017.

Sarsour, E. H., Agarwal, M., Pandita, T. K., Oberley, L. W. & Goswami, P. C. (2005). Manganese superoxide dismutase protects the proliferative capacity of confluent normal human fibroblasts. The Journal of biological chemistry, 280(18), 18033-41. PMID: 15743756.

Zhao, W., Goswami, P. C. & Robbins, M. E. (2004). Radiation-induced up-regulation of Mmp2 involves increased mRNA stability, redox modulation, and MAPK activation. Radiation research, 161(4), 418-29. PMID: 15038770.

Wang, H. P., Schafer, F. Q., Goswami, P. C., Oberley, L. W. & Buettner, G. R. (2003). Phospholipid hydroperoxide glutathione peroxidase induces a delay in G1 of the cell cycle. Free radical research, 37(6), 621-30. PMID: 12868489.

Menon, S. G., Sarsour, E. H., Spitz, D. R., Higashikubo, R., Sturm, M., Zhang, H. & Goswami, P. C. (2003). Redox regulation of the G1 to S phase transition in the mouse embryo fibroblast cell cycle. Cancer research, 63(9), 2109-17. PMID: 12727827.

He, T., Weintraub, N. L., Goswami, P. C., Chatterjee, P., Flaherty, D. M., Domann, F. E. & Oberley, L. W. (2003). Redox factor-1 contributes to the regulation of progression from G0/G1 to S by PDGF in vascular smooth muscle cells. American journal of physiology. Heart and circulatory physiology, 285(2), H804-12. PMID: 12730053.

Delsite, R. L., Rasmussen, L. J., Rasmussen, A. K., Kalen, A., Goswami, P. C. & Singh, K. K. (2003). Mitochondrial impairment is accompanied by impaired oxidative DNA repair in the nucleus. Mutagenesis, 18(6), 497-503. PMID: 14614184.

Goswami, P., Higashikubo, R. & Spitz, D. R. (2002). Redox control of cell cycle coupled topoisomerase II alpha gene expression.

Goswami, P. C., Higashikubo, R. & Spitz, D. R. (2002). Redox control of cell cycle-coupled topoisomerase II alpha gene expression. Methods in enzymology, 353, 448-59. PMID: 12078518.

Zoberi, I., Bradbury, C. M., Curry, H. A., Bisht, K. S., Goswami, P. C., Roti Roti, J. L. & Gius, D. (2002). Radiosensitizing and anti-proliferative effects of resveratrol in two human cervical tumor cell lines. Cancer letters, 175(2), 165-73. PMID: 11741744.

Karimpour, S., Lou, J., Lin, L. L., Rene, L. M., Lagunas, L., Ma, X., Karra, S., Bradbury, C. M., Markovina, S., Goswami, P. C., Spitz, D. R., Hirota, K., Kalvakolanu, D. V., Yodoi, J. & Gius, D. (2002). Thioredoxin reductase regulates AP-1 activity as well as thioredoxin nuclear localization via active cysteines in response to ionizing radiation. Oncogene, 21(41), 6317-27. PMID: 12214272.

Chen, M. S., Goswami, P. C. & Laszlo, A. (2002). Differential accumulation of U14 snoRNA and hsc70 mRNA in Chinese hamster cells after exposure to various stress conditions. Cell stress & chaperones, 7(1), 65-72. PMID: 11892989.

Parsian, A. J., Sheren, J. E., Tao, T. Y., Goswami, P. C., Malyapa, R., Van Rheeden, R., Watson, M. S. & Hunt, C. R. (2000). The human Hsp70B gene at the HSPA7 locus of chromosome 1 is transcribed but non-functional. Biochimica et biophysica acta, 1494(2-Jan), 201-5. PMID: 11072087.

Wei, S. J., Botero, A., Hirota, K., Bradbury, C. M., Markovina, S., Laszlo, A., Spitz, D. R., Goswami, P. C., Yodoi, J. & Gius, D. (2000). Thioredoxin nuclear translocation and interaction with redox factor-1 activates the activator protein-1 transcription factor in response to ionizing radiation. Cancer research, 60(23), 6688-95. PMID: 11118054.

Goswami, P. C., Sheren, J., Albee, L. D., Parsian, A., Sim, J. E., Ridnour, L. A., Higashikubo, R., Gius, D., Hunt, C. R. & Spitz, D. R. (2000). Cell cycle-coupled variation in topoisomerase IIalpha mRNA is regulated by the 3'-untranslated region. Possible role of redox-sensitive protein binding in mRNA accumulation. The Journal of biological chemistry, 275(49), 38384-92. PMID: 10986283.

Goswami, P. C., Albee, L. D., Parsian, A. J., Baty, J. D., Moros, E. G., Pickard, W. F., Roti Roti, J. L. & Hunt, C. R. (1999). Proto-oncogene mRNA levels and activities of multiple transcription factors in C3H 10T 1/2 murine embryonic fibroblasts exposed to 835.62 and 847.74 MHz cellular phone communication frequency radiation. Radiation research, 151(3), 300-9. PMID: 10073668.

Hunt, C. R., Parsian, A. J., Goswami, P. C. & Kozak, C. A. (1999). Characterization and expression of the mouse Hsc70 gene. Biochimica et biophysica acta, 1444(3), 315-25. PMID: 10095055.

Diamond, D. A., Parsian, A., Hunt, C. R., Lofgren, S., Spitz, D. R., Goswami, P. C. & Gius, D. (1999). Redox factor-1 (Ref-1) mediates the activation of AP-1 in HeLa and NIH 3T3 cells in response to heat shock. The Journal of biological chemistry, 274(24), 16959-64. PMID: 10358044.

Curry, H. A., Clemens, R. A., Shah, S., Bradbury, C. M., Botero, A., Goswami, P. & Gius, D. (1999). Heat shock inhibits radiation-induced activation of NF-kappaB via inhibition of I-kappaB kinase. The Journal of biological chemistry, 274(33), 23061-7. PMID: 10438474.

Goswami, P. C., Albee, L. D., Spitz, D. R. & Ridnour, L. A. (1997). A polymerase chain reaction assay for simultaneous detection and quantitation of proto-oncogene and GAPD mRNAs in different cell growth rates. Cell proliferation, 30(7-Jun), 271-82. PMID: 9451418.

Hunt, C. R., Goswami, P. C. & Kozak, C. A. (1997). Assignment of the mouse Hsp25 and Hsp105 genes to the distal region of chromosome 5 by linkage analysis. Genomics, 45(2), 462-3. PMID: 9344682.

Goswami, P. C., Roti Roti, J. L. & Hunt, C. R. (1996). The cell cycle-coupled expression of topoisomerase IIalpha during S phase is regulated by mRNA stability and is disrupted by heat shock or ionizing radiation. Molecular and cellular biology, 16(4), 1500-8. PMID: 8657123.

Goswami, P. C., He, W., Higashikubo, R. & Roti Roti, J. L. (1994). Accelerated G1-transit following transient inhibition of DNA replication is dependent on two processes. Experimental cell research, 214(1), 198-208. PMID: 8082722.

Higashikubo, R., Goswami, P. & Roti Roti, J. L. (1994). A comparison of time-lapse cinemicrography and flow cytometry for the study of accelerated cell-cycle transit. Cell Proliferation, 27, 697-709.

Goswami, P. C., Hill, M., Higashikubo, R., Wright, W. D. & Roti Roti, J. L. (1992). The suppression of the synthesis of a nuclear protein in cells blocked in G2 phase: identification of NP-170 as topoisomerase II. Radiation research, 132(2), 162-7. PMID: 1332112.

Goswami, P. C., Higashikubo, R., Tolmach, L. J. & Roti Roti, J. L. (1992). G1 shortening following unbalanced growth: a specific v. nonspecific effect. Cell proliferation, 25(3), 251-60. PMID: 1596538.

Goswami, P. C., Vretou, E. & Bose, S. K. (1991). Host passage-dependent wheat germ agglutinin-binding proteins of Chlamydia trachomatis. FEMS microbiology letters, 65(1), 53-6. PMID: 1874403.

Goswami, P. C., Vretou, E. & Bose, S. K. (1990). Extensive heterogeneity of the protein composition of Chlamydia trachomatis following serial passage in two different cell lines. Journal of general microbiology, 136(8), 1623-9. PMID: 2262794.

Vretou, E., Goswami, P. C. & Bose, S. K. (1989). Adherence of multiple serovars of Chlamydia trachomatis to a common receptor on HeLa and McCoy cells is mediated by thermolabile protein(s). Journal of general microbiology, 135(12), 3229-37. PMID: 2636258.

Goswami, P., Goldenberg, C. J. (1988). Intron sequences and the length of the downstream second exon affect the binding of hnRNP C proteins in an in vitro splicing reaction. Nucleic acids research, 16(11), 4995-5011. PMID: 3290845.

Wollenzien, P. L., Goswami, P., Teare, J., Szeberenyi, J. & Goldenberg, C. J. (1987). The secondary structure of a messenger RNA precursor probed with psoralen is melted in an in vitro splicing reaction. Nucleic acids research, 15(22), 9279-98. PMID: 3317279.

Bose, S. K., Goswami, P. (1986). Chlamydial adherence to glycosylation defective mutants of Chinese hamster cell lines. In Chlamydial Infections (Oriel, Ridgway, Schacter, Taylor-Robinson, and Ward, eds.),. pp. 31-34. Cambridge University Press,.

Bose, S. K., Goswami, P. C. (1986). Host modification of the adherence properties of Chlamydia trachomatis. Journal of general microbiology, 132(6), 1631-9. PMID: 3806051.

Bose, S. K., Goswami, P. C. (1986). Enhancement of adherence and growth of Chlamydia trachomatis by estrogen treatment of HeLa cells. Infection and immunity, 53(3), 646-50. PMID: 3744558.

Goswami, P., Singh, H. D. (1984). Isolation of phytosterols from sugar cane pressed mud and microbial conversion of the phytosterols to 17-ketosteroids. Current Science, 53, 917-919.

Goswami, P. C., Singh, H. D. & Baruah, J. N. (1984). Factors limiting the microbial conversion of sterols to 17-ketosteroids in the presence of metal chelate inhibitors. Folia microbiologica, 29(3), 209-16. PMID: 6745816.

Goswami, P. C., Singh, H. D., Bhagat, S. D. & Baruah, J. N. (1983). Mode of uptake of insoluble solid substrates by microorganisms. I: Sterol uptake by an arthrobacter species. Biotechnology and bioengineering, 25(12), 2929-43. PMID: 18548628.

Goswami, P. C., Singh, H. D., Hazarika, A. K. & Baruah, J. N. (1982). Isolation and characterisation of sterol metabolites formed by an Arthrobacter species. Indian journal of biochemistry & biophysics, 19(5), 367-9. PMID: 7184854.

Mishra, P. K., Gupta, R. K., Goswami, P. C., Venkatasubramanian, P. N. & Nath, A. (1981). 31p nuclear relaxation studies of para- and diamagnetic cobalamins in their two isomeric forms. Biochimica et biophysica acta, 668(3), 406-12. PMID: 7236717.