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Stanley J. Kruger, PhD

Portrait
Research Assistant Professor of Radiology - Division of Neuroradiology

Contact Information

Primary Office
L341 PBDB
195-207 Newton Rd
Iowa City, IA 52246
319-335-5161

Education

BS, Physics / Mathematics, University of Wisconsin
PhD, Medical Physics, University of Wisconsin

Research Summary

I am interested in MRI as a tool for thoracic imaging applications generally. Specifically, I have two primary areas of thoracic interest. The first is investigating lung structure and function in order to better assess regional ventilation and perfusion, especially as it relates to disease and therapy. In pursuit of this aim, I am interested in the use of hyperpolarized gas contrast agents (He-3 or Xe-129), Flourine Imaging, and Oxygen-Enhanced Proton MRI. My second area of interest is to collaborate on development of an MR-only radiation oncology suite for tumor treatment in the chest. Ultimately, I am interested in overcoming the challenges of respiratory motion, as well as the removal of the need for multi-modal acquisitions in treatment planning.

Publications

Zha, W., Kruger, S. J., Johnson, K. M., Cadman, R. V., Bell, L. C., Liu, F., Hahn, A. D., Evans, M. D., Nagle, S. K. & Fain, S. B. (2018). Pulmonary ventilation imaging in asthma and cystic fibrosis using oxygen-enhanced 3D radial ultrashort echo time MRI. Journal of magnetic resonance imaging : JMRI, 47(5), 1287-1297. PMID: 29086454.

Mummy, D. G., Kruger, S. J., Zha, W., Sorkness, R. L., Jarjour, N. N., Schiebler, M. L., Denlinger, L. C., Evans, M. D. & Fain, S. B. (2018). Ventilation defect percent in helium-3 magnetic resonance imaging as a biomarker of severe outcomes in asthma. The Journal of allergy and clinical immunology, 141(3), 1140-1141.e4. PMID: 29129582.

Zha, W., Kruger, S. J., Cadman, R. V., Mummy, D. G., Evans, M. D., Nagle, S. K., Denlinger, L. C., Jarjour, N. N., Sorkness, R. L. & Fain, S. B. (2018). Regional Heterogeneity of Lobar Ventilation in Asthma Using Hyperpolarized Helium-3 MRI. Academic radiology, 25(2), 169-178. PMID: 29174189.

Zha, W., Niles, D. J., Kruger, S. J., Dardzinski, B. J., Cadman, R. V., Mummy, D. G., Nagle, S. K. & Fain, S. B. (2016). Semiautomated Ventilation Defect Quantification in Exercise-induced Bronchoconstriction Using Hyperpolarized Helium-3 Magnetic Resonance Imaging: A Repeatability Study. Academic radiology, 23(9), 1104-14. PMID: 27263987.

Kruger, S. J., Nagle, S. K., Couch, M. J., Ohno, Y., Albert, M. & Fain, S. B. (2016). Functional imaging of the lungs with gas agents. Journal of magnetic resonance imaging : JMRI, 43(2), 295-315. PMID: 26218920.

Kruger, S. J., Fain, S. B., Johnson, K. M., Cadman, R. V. & Nagle, S. K. (2014). Oxygen-enhanced 3D radial ultrashort echo time magnetic resonance imaging in the healthy human lung. NMR in biomedicine, 27(12), 1535-41. PMID: 24984695.

Kruger, S. J., Niles, D. J., Dardzinski, B., Harman, A., Jarjour, N. N., Ruddy, M., Nagle, S. K., Francois, C. J., Sorkness, R. L., Burton, R. M., del Munoz Rio, A. & Fain, S. B. (2014). Hyperpolarized Helium-3 MRI of exercise-induced bronchoconstriction during challenge and therapy. Journal of magnetic resonance imaging : JMRI, 39(5), 1230-7. PMID: 24006239.

Johansson, M. W., Kruger, S. J., Schiebler, M. L., Evans, M. D., Sorkness, R. L., Denlinger, L. C., Busse, W. W., Jarjour, N. N., Montgomery, R. R., Mosher, D. F. & Fain, S. B. (2013). Markers of vascular perturbation correlate with airway structural change in asthma. American journal of respiratory and critical care medicine, 188(2), 167-78. PMID: 23855693.

Niles, D. J., Kruger, S. J., Dardzinski, B. J., Harman, A. B., Jarjour, N. N., Ruddy, M. K., Nagle, S. K., Francois, C. J. & Fain, S. B. (2013). Exercise-induced Bronchoconstriction: Reproducibility of Hyperpolarized 3He MR Imaging. Radiology, 266(2), 618-625.