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Vincent A. Magnotta, PhD

Professor of and Carl Gillies Chair in Radiology - Division of Neuroradiology

Introduction

I am interested in the development of novel imaging approaches and analysis strategies to better understand psychiatric and neurological brain disorders. My work in image acquisition focuses on diffusion tensor imaging and chemical shift imaging. I am also working on methods to automate the analysis of brain morphology and incorporating these tools into diffusion tensor and chemical shift imaging.

Current Positions

  • Professor of Radiology - Division of Neuroradiology
  • Professor of Biomedical Engineering
  • Professor of Psychiatry

Education

  • BA in Mathematics, Physics, Albion College, Albion, Michigan, United States
  • MS in Biomedical Engineering, University of Iowa, Iowa City, Iowa, United States
  • PhD in Biomedical Engineering, University of Iowa, Iowa City, Iowa, United States
  • Fellow in Mental Health Clinical Research Center, University of Iowa, Iowa City, IA

Graduate Program Affiliations

Center, Program and Institute Affiliations

Selected Publications

  • Petronek, M. S., Bodeker, K. L., Lee, C. Y., Teferi, N., Eschbacher, K. L., Jones, K. A., Loeffler B. T., Smith B. J., Buatti J. M., Magnotta V. A. et al. (2024) Iron-based biomarkers for personalizing pharmacological ascorbate therapy in glioblastoma: insights from a phase 2 clinical trial. Journal of neuro-oncology 166 493-501. DOI: 10.1007/s11060-024-04571-z
  • Petronek, M. S., Teferi, N., Lee, C., Magnotta, V. A., & Allen, B. G. (2024) MRI Detection and Therapeutic Enhancement of Ferumoxytol Internalization in Glioblastoma Cells. Nanomaterials 14 (2). DOI: 10.3390/nano14020189
  • Harmata GIS, Barsotti EJ, Casten LG, Fiedorowicz JG, Williams A, Shaffer JJ, Richards JG, Sathyaputri L, Schmitz SL, Christensen GE, Long JD, Gaine ME, Xu J, Michaelson JJ, Wemmie JA, Magnotta VA. Cerebellar morphological differences and associations with extrinsic factors in bipolar disorder type I. J Affect Disord. 2023 Nov 1;340:269-279. doi: 10.1016/j.jad.2023.08.018. Epub 2023 Aug 8. PMID: 37562560; PMCID: PMC10529949.
  • Wijeakumar S, Forbes SH, Magnotta VA, Deoni S, Jackson K, Singh VP, Tiwari M, Kumar A, Spencer JP. Stunting in infancy is associated with atypical activation of working memory and attention networks. Nat Hum Behav. 2023 Oct 26. doi: 10.1038/s41562-023-01725-3. Epub ahead of print. PMID: 37884677.
  • Zhu X, Kim Y, Ravid O, He X, Suarez-Jimenez B, Zilcha-Mano S, Lazarov A, Lee S, Abdallah CG, Angstadt M, Averill CL, Baird CL, Baugh LA, Blackford JU, Bomyea J, Bruce SE, Bryant RA, Cao Z, Choi K, Cisler J, Cotton AS, Daniels JK, Davenport ND, Davidson RJ, DeBellis MD, Dennis EL, Densmore M, deRoon-Cassini T, Disner SG, Hage WE, Etkin A, Fani N, Fercho KA, Fitzgerald J, Forster GL, Frijling JL, Geuze E, Gonenc A, Gordon EM, Gruber S, Grupe DW, Guenette JP, Haswell CC, Herringa RJ, Herzog J, Hofmann DB, Hosseini B, Hudson AR, Huggins AA, Ipser JC, Jahanshad N, Jia-Richards M, Jovanovic T, Kaufman ML, Kennis M, King A, Kinzel P, Koch SBJ, Koerte IK, Koopowitz SM, Korgaonkar MS, Krystal JH, Lanius R, Larson CL, Lebois LAM, Li G, Liberzon I, Lu GM, Luo Y, Magnotta VA, Manthey A, Maron-Katz A, May G, McLaughlin K, Mueller SC, Nawijn L, Nelson SM, Neufeld RWJ, Nitschke JB, O'Leary EM, Olatunji BO, Olff M, Peverill M, Phan KL, Qi R, Quidé Y, Rektor I, Ressler K, Riha P, Ross M, Rosso IM, Salminen LE, Sambrook K, Schmahl C, Shenton ME, Sheridan M, Shih C, Sicorello M, Sierk A, Simmons AN, Simons RM, Simons JS, Sponheim SR, Stein MB, Stein DJ, Stevens JS, Straube T, Sun D, Théberge J, Thompson PM, Thomopoulos SI, van der Wee NJA, van der Werff SJA, van Erp TGM, van Rooij SJH, van Zuiden M, Varkevisser T, Veltman DJ, Vermeiren RRJM, Walter H, Wang L, Wang X, Weis C, Winternitz S, Xie H, Zhu Y, Wall M, Neria Y, Morey RA. Neuroimaging-based classification of PTSD using data-driven computational approaches: A multisite big data study from the ENIGMA-PGC PTSD consortium. Neuroimage. 2023 Oct 18;283:120412. doi: 10.1016/j.neuroimage.2023.120412. Epub ahead of print. PMID: 37858907.
  • Mawla I, Schrepf A, Kutch JJ, Helmuth ME, Smith AR, Ichesco E, Yang CC, Andreev VP, Kreder KJ, Bradley CS, Magnotta VA, Kirkali Z, Harris RE, Lai HH, Harte SE. Reply By Authors. J Urol. 2023 Oct 5:101097JU000000000000369902. doi: 10.1097/JU.0000000000003699.02. Epub ahead of print. PMID: 37796787.
  • Mawla I, Schrepf A, Kutch JJ, Helmuth ME, Smith AR, Ichesco E, Yang CC, Andreev VP, Kreder KJ, Bradley CS, Magnotta VA, Kirkali Z, Harris RE, Lai HH, Harte SE. Naturalistic Bladder Filling Reveals Subtypes in Overactive Bladder Syndrome That Differentially Engages Urinary Urgency-Related Brain Circuits: Results From the Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN). J Urol. 2023 Oct 5:101097JU0000000000003699. doi: 10.1097/JU.0000000000003699. Epub ahead of print. PMID: 37796776.
  • Petronek MS, Monga V, Bodeker KL, Kwofie M, Lee CY, Mapuskar KA, Stolwijk JM, Zaher A, Wagner BA, Smith MC, Vollstedt S, Brown H, Chandler ML, Lorack AC, Wulfekuhle JS, Sarkaria JN, Flynn RT, Greenlee JDW, Howard MA, Smith BJ, Jones KA, Buettner GR, Cullen JJ, St-Aubin J, Buatti JM, Magnotta VA, Spitz DR, Allen BG. Magnetic resonance imaging of iron metabolism with T2* mapping predicts an enhanced clinical response to pharmacological ascorbate in patients with GBM. Clin Cancer Res. 2023 Sep 29. doi: 10.1158/1078-0432.CCR-22-3952. Epub ahead of print. PMID: 37773633.
  • Mirza S, de Carvalho Lima CN, Del Favero-Campbell A, Rubinstein A, Topolski N, Cabrera-Mendoza B, Kovács EHC, Blumberg HP, Richards JG, Williams AJ, Wemmie JA, Magnotta VA, Fiedorowicz JG, Gaine ME, Walss-Bass C, Quevedo J, Soares JC, Fries GR. Blood epigenome-wide association studies of suicide attempt in adults with bipolar disorder. medRxiv [Preprint]. 2023 Jul 24:2023.07.20.23292968. doi: 10.1101/2023.07.20.23292968. PMID: 37546994; PMCID: PMC10402220.
  • Müller Ewald VA, Trapp NT, Sarrett ME, Pace BD, Wendt L, Richards JG, Gala IK, Miller JN, Wessel JR, Magnotta VA, Wemmie JA, Boes AD, Parker KL. Supra-second interval timing in bipolar disorder: examining the role of disorder sub-type, mood, and medication status. Res Sq [Preprint]. 2023 Jun 2:rs.3.rs-3006203. doi: 10.21203/rs.3.rs-3006203/v1. Update in: Int J Bipolar Disord. 2023 Oct 1;11(1):32. PMID: 37398216; PMCID: PMC10312933.