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Selected Publications

CURRENT STUDENTS:

 

Gavin McGivney

Distinct Tumor Microenvironments Are a Defining Feature of Strain-Specific CRISPR/Cas9-Induced MPNSTs. Scherer A, Stephens VR, McGivney GR, Gutierrez WR, Laverty EA, Knepper-Adrian V, Dodd RD. Genes (Basel). 2020 May 23;11(5):583. doi: 10.3390/genes11050583.PMID: 32456131 

Tumor subtype determines therapeutic response to chimeric polypeptide nanoparticle-based chemotherapy in Pten-deleted mouse models of sarcoma. Dodd RD, Scherer A, Huang W,  McGivney GR, Gutierrez WR, Laverty E, Ashcraft KA, Stephens VR, Yousefpour P, Saha S, Knepper-Adrian VL, Floyd W, Chen M, Ma Y, Mastria EM, Cardona DM, Eward WC, Chilkoti A, Kirsch DG. Clin Cancer Res.  2020 Jul 27:clincanres.2597.2019. doi: 10.1158/1078-0432.CCR-19-2597. Online ahead of print.PMID: 32718998

 

Wade Gutierrez

Distinct Tumor Microenvironments Are a Defining Feature of Strain-Specific CRISPR/Cas9-Induced MPNSTs. Scherer A, Stephens VR, McGivney GR, Gutierrez WR, Laverty EA, Knepper-Adrian V, Dodd RD.Genes (Basel). 2020 May 23;11(5):583. doi: 10.3390/genes11050583.PMID: 32456131 

Tumor subtype determines therapeutic response to chimeric polypeptide nanoparticle-based chemotherapy in Pten-deleted mouse models of sarcoma. Dodd RD, Scherer A, Huang W, McGivney GR, Gutierrez WR, Laverty E, Ashcraft KA, Stephens VR, Yousefpour P, Saha S, Knepper-Adrian VL, Floyd W, Chen M, Ma Y, Mastria EM, Cardona DM, Eward WC, Chilkoti A, Kirsch DG. Clin Cancer Res. 2020 Jul 27:clincanres.2597.2019. doi: 10.1158/1078-0432.CCR-19-2597. Online ahead of print. PMID: 32718998

RNA inhibitors of nuclear proteins responsible for multiple organ dysfunction syndrome. Urak K, Blanco GN, Shubham S, Lin LH, Dassie JP, Thiel WH, Chen Y, Sonkar VK, Lei B, Murthy S, Gutierrez WR, Wilson ME, Stilber JA, Klesney-Tait J, Dayal S, Miller FJ Jr, Giangrande PH. Nat Commun 2019 Jan 10; 10(1) doi: 10.1038/s41467-018-08030y. PMID: 30631065 PMC6328615

 

Devon Moose

Cancer Cells Resist Mechanical Destruction in Circulation via RhoA/Actomyosin-Dependent Mechano-Adaptation. Moose DL, Krog BL, Kim TH, Zhao L, Williams-Perez S, Burke G, Rhodes L, Vanneste M, Breheny P, Milhem M, Stipp CS, Rowat AC, Henry MD.  Cell Rep. 2020 Mar 17;30(11):3864-3874.e6. doi:10.1016/j.celrep.2020.02.080. PMID: 32187555. PMC7219793 

High content screening identifies monensin as an EMT-selective cytotoxic compound. Vanneste M, Huang Q, Li M, Moose D, Zhao L, Stamnes MA, Schultz M, Wu M, Henry MD.Sci Rep. 2019 Feb 4;9(1):1200. doi: 10.1038/s41598-018-38019-y.PMID: 30718715 PMC6361972

A model for the detection of pancreatic ductal adenocarcinoma circulating tumor cells. Alexander MS, O'Leary BR, Moose D, Du J, Henry MD, Cullen JJ. J Biol Methods. 2018 Sep 5;5(3):e97. doi: 10.14440/jbm.2018.250. eCollection 2018. PMID: 31453247 PMC6706145

The Narrow Abdomen Ion Channel Complex Is Highly Stable and Persists from Development into Adult Stages to Promote Behavioral Rhythmicity. Moose DL, Haase SJ, Aldrich BT, Lear BC.  Front Cell Neurosci. 2017 Jun 6;11:159. doi: 10.3389/fncel.2017.00159. eCollection 2017. PMID: 28634443 PMC5459923.

A Trp53fl/flPtenfl/fl mouse model of undifferentiated pleomorphic sarcoma mediated by adeno-Cre injection and in vivo bioluminescence imaging. Buchakjian MR, Merritt NM, Moose DL, Dupuy AJ, Tanas MR, Henry MD.PLoS One. 2017 Aug 25;12(8):e0183469. doi: 10.1371/journal.pone.0183469. eCollection 2017.PMID: 28841687 PMC5571905

 

Eliot Zhu

Functional Genomic Screening Independently Identifies CUL3 as a Mediator of Vemurafenib Resistance via Src-Rac1 Signaling Axis. Vanneste M, Feddersen CR, Varzavand A, Zhu EY, Foley T, Zhao L, Holt KH, Milhem M, Piper R, Stipp CS, Dupuy AJ, Henry MD. Front Oncol. 2020 Apr 3;10:442. doi: 10.3389/fonc.2020.00442. eCollection 2020. PMID: 32346533

A simplified transposon mutagenesis method to perform phenotypic forward genetic screens in cultured cells. Feddersen CR, Wadsworth LS, Zhu EY, Vaughn HR, Voigt AP, Riordan JD, Dupuy AJ.BMC Genomics. 2019 Jun 17;20(1):497. doi: 10.1186/s12864-019-5888-6.PMID: 31208320. PMC6580595 

Src-Dependent DBL Family Members Drive Resistance to Vemurafenib in Human Melanoma. ​Feddersen CR, Schillo JL, Varzavand A, Vaughn HR, Wadsworth LS, Voigt AP, Zhu EY, Jennings BM, Mullen SA, Bobera J, Riordan JD, Stipp CS, Dupuy AJ. Cancer Res. 2019 Oct 1;79(19):5074-5087. PMID: 31416844

 

 

PAST STUDENTS:

 

Nick Borcherding

Mapping the immune environment in clear cell renal carcinoma by single-cell genomics. Borcherding, N*, Vishwakarma, A*, Voigt, A.P. et al.  Commun Biol 4, 122 (2021). doi: 10.1038/s42003-020-01625-6. PMID: 33504936.

Metadherin enhances vulnerability of cancer cells to ferroptosis. Bi J, Yang S, Li L, Dai Q, Borcherding N, Wagner BA, Buettner GR, Spitz DR, Leslie KK, Zhang J, Meng X. Cell Death Dis. 2019 Sep 17;10(10):682. doi: 10.1038/s41419-019-1897-2. PMID:  31527591 PMC6746770

Single-Cell Profiling of Cutaneous T-Cell Lymphoma Reveals Underlying Heterogeneity Associated with Disease Progression. Borcherding N, Voigt AP, Liu V, Link BK, Zhang W, Jabbari A. Clin Cancer Res. 2019 May 15;25(10):2996-3005. doi: 10.1158/1078-0432.CCR-18-3309. Epub 2019 Feb 4.PMID: 30718356. PMC6659117.  

Obesity-associated inflammation promotes angiogenesis and breast cancer via angiopoietin-like 4. Kolb R, Kluz P, Tan ZW, Borcherding N, Bormann N, Vishwakarma A, Balcziak L, Zhu P, Davies BS, Gourronc F, Liu LZ, Ge X, Jiang BH, Gibson-Corley K, Klingelhutz A, Tan NS, Zhu Y, Sutterwala FS, Shen X, Zhang W. Oncogene. 2019 Mar;38(13):2351-2363. doi: 10.1038/s41388-018-0592-6. Epub 2018 Dec 5. PMID: 30518876 

The clinical promise of immunotherapy in triple-negative breast cancer. Vikas P, Borcherding N, Zhang W. Cancer Manag Res. 2018 Dec 10;10:6823-6833. doi: 10.2147/CMAR.S185176. eCollection 2018.PMID: 30573992. PMC6292225

Obesity-associated NLRC4 inflammasome activation drives breast cancer progression. Kolb R, Phan L, Borcherding N, Liu Y, Yuan F, Janowski AM, Xie Q, Markan KR, Li W, Potthoff MJ, Fuentes-Mattei E, Ellies LG, Knudson CM, Lee MH, Yeung SJ, Cassel SL, Sutterwala FS, Zhang W. Nat Commun. 2016 Oct 6;7:13007. PMID: 27708283 PMC5059727

 

Ajaykumar Vishwakarma

Direct and indirect immune effects of CMP-001, a virus-like particle containing a TLR9 agonist.Sabree SA, Voigt AP, Blackwell SE, Vishwakarma A, Chimenti MS, Salem AK, Weiner GJ.   Journal for ImmunoTherapy of Cancer 9 (2021). PMID: 34083419. PMC8183212

Mapping the immune environment in clear cell renal carcinoma by single-cell genomics.    Borcherding N*, Vishwakarma A*, Voigt AP. et al. Commun Biol 4, 122 (2021). doi: 10.1038/s42003-020-01625-6. PMID: 33504936.

Obesity-associated inflammation promotes angiogenesis and breast cancer via angiopoietin-like 4. Kolb R, Kluz P, Tan ZW, Borcherding N, Bormann N, Vishwakarma A, Balcziak L, Zhu P, Davies BS, Gourronc F, Liu LZ, Ge X, Jiang BH, Gibson-Corley K, Klingelhutz A, Tan NS, Zhu Y, Sutterwala FS, Shen X, Zhang W. Oncogene. 2019 Mar;38(13):2351-2363. doi: 10.1038/s41388-018-0592-6. Epub 2018 Dec 5. PMID: 30518876 

Vishwakarma, Ajaykumar and Karp, Jeffrey, eds. Biology and Engineering of Stem Cell Niches. Elsevier Academic Press, 2017.

 

Zhaoming Wang

T cells, particularly activated CD4+ cells, maintain anti-CD20-mediated NK cell viability and antibody dependent cellular cytotoxicity. Wang Z, Chimenti MS, Strouse C, Wiener GJ. Cancer Immunol Immunother. 2021 Jun 10. doi: 10.1007/s00262-021-02976-7. 

A genetic screen to identify gain- and loss-of-function modifications that enhance T-cell infiltration into tumors.Rogers LM, Wang Z, Mott SL, Dupuy AJ, Weiner GJ.  Cancer Immunol Res. 2020 Jul 1:canimm.0056.2020. doi: 10.1158/2326-6066.CIR-20-0056. Online ahead of print. PMID: 32611665

Immune checkpoint markers and anti-CD20-mediated NK cell activation.  Wang Z, Weiner GJ.  J Leukoc Biol. 2020 Dec 8;10.1002/JLB.5A0620-365R.  doi: 10.1002/JLB.5A0620-365R

In situ immunization of a TLR9 agonist virus-like particle enhances anti-PD1 therapy.  Cheng Y, Lemke-Miltner CD, Wongpattaraworkul W, Wang Z, Chan CHF, Salem AK, Weiner GJ, Simons AL. J Immunother Cancer. 2020 Oct;8(2):e000940.  doi: 10.1136/jitc-2020-000940.

Provisional intellectual patent No. 63/159,276; Inventors: George Weiner, Zhaoming Wang