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Lokesh Lab

  • Protein production and purification
  • Physical protein purity analysis by dynamic light scattering (DLS)
  • Molecular weight determination by static light scattering (SLS and MALS)
  • Protein stability analysis using thermal shift assays by differential scanning fluorimetry (DSF)
  • Protein-protein, protein-DNA, protein-small molecule interaction analysis by biolayer interferometry (BLI)
  • Set-up of crystallization screens using commercial and facility-made conditions
  • Screening of crystals and diffraction data collection at synchrotrons
  • Diffraction data processing and structure determination
  • Small angle x-ray scattering (SAXS) data collection, processing and modeling
  • Negative stain electron microscopy
  • Homology modeling and docking