Mohamad Mokadem, MD

Contact Information

Office: 4570 JCP
Phone: 319-384-6178
Faculty Profile


Brief desctiption of current research:

My Laboratory focuses on body weight and metabolism regulation after bariatric surgery in rodents, specifically Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG). We have developed a reproducible model of RYGB and SG in mice that recapitulate most of the effects of those surgeries on body weight, body composition, fecal calories, glucose homeostasis and lipid metabolism of human subjects. We have applied this surgical technique to genetic muose models in order to investigate molecular mechanisms of those bariatric surgeries.

3 most influential diabetes/obesity/metabolism publications:

  • Mokadem M, Zechner JF, Margolskee RF, Drucker DJ, Aguirre V. Effects of Roux-en-Y gastric bypass on energy and glucose homeostasis are preserved in two mouse models of functional glucagon-like peptide-1 deficiency. Mol Metab. 2013 Dec 11;3(2):191-201. doi: 10.1016/j.molmet.2013.11.010. eCollection 2014.
  • Li H, Chan L, Bartuzi P, Melton SD, Weber A, Ben-Shlomo S, Varol C, Raetz M, Mao X, Starokadomskyy P, van Sommeren S, Mokadem M, Schneider H, Weisberg R, Westra HJ, Esko T, Metspalu A, Kumar V, Faubion WA, Yarovinsky F, Hofker M, Wijmenga C, Kracht M, Franke L, Aguirre V, Weersma RK, Gluck N, van de Sluis B, Burstein E. Copper metabolism domain-containing 1 represses genes that promote inflammation and protects mice from colitis and colitis-associated cancer. Gastroenterology. 2014 Jul;147(1):184-195.e3. doi: 10.1053/j.gastro.2014.04.007. Epub 2014 Apr 13.
  • Barada K, Bitar A, Mokadem MA, Hashash JG, Green P. Celiac disease in Middle Eastern and North African countries: a new burden? World J Gastroenterol. 2010 Mar 28;16(12):1449-57.

Quote:

We believe that understanding the mechanism behind the beneficial effects of bariatric procedures (the most effective treatment available for obesity and diabetes) is of paramount importance given the implications for developing less invasive alternatives to surgical therapy for weight loss, diabetes and other related metabolic conditions.