François M. Abboud, M.D.

Contact Information

Office: 616 MRC
Phone: 319-353-3057
Faculty Profile


Brief description of research:

Autonomic Regulation in Cardiovascular Diseases
Specific studies examine molecular mechanisms of sensory neuronal signals and ion channel activation in baroreceptors, chemoreceptors, and vagal afferents in response to hypoxia, acidosis, and dysautonomic states such as heart failure, hypertension, diabetes and obesity. More recent emphasis is on neuro-immune mechanisms, and on ion channel modulation of neuronal ischemic preconditioning and post-prandial satiety signaling. The work is done in isolated neurons, glomus cells, immune cells and systems in genetically modified mice. Integrated control of sympathetic nerve activity during sleep apnea and hypertension has been the focus of studies in humans.

3 most influential diabetes/obesity/metabolism publications:

  • Abboud, F.M., McKenna, J.L., and Pisciotta, A.V.: Erythrocyte Reduced Glutathione (GSH) in Diabetic Ketosis. Clin. Res., 8:253, 1960.
  • Pereda, S.A., Eckstein, J.W., and Abboud, F.M.: Cardiovascular Responses to Insulin in the Absence of Hypoglycemia. Amer. J. Physiol., 202(2):249-252, 1962.
  • Abboud, F.M., and Huston, J.H.: Measurement of Arterial Aging in Hypertensive Patients. J. Clin. Invest., 40(10):1915-1921, 1961.
    Huston, J.H., and Abboud, F.M.: Measurement of Arterial Aging in Relation to Diabetes Mellitus. Circulation, 25:938-946, 1962.
  • McDowell, T.S., Chapleau, M.W., Hajduczok, G., and Abboud, F.M.: Baroreflex Dysfunction in Diabetes Mellitus. I. Selective Impairment of Parasympathetic Control of Heart Rate. Am. J. Physiol. 266 (Heart Circ. Physiol. 35):H235-243,1994.
  • McDowell, T.S., Hajduczok, G., Abboud, F.M., and Chapleau, M.W.: Baroreflex Dysfunction in Diabetes Mellitus. II. Site of Baroreflex Impairment in Diabetic Rabbits. Am. J. Physiol. 266(Heart Circ. Physiol. 35):H244-H249, 1994.
  • Wang, R., Lu, Y., Cicha, M.Z., Rahmouni, K., Chapleau, M.W., Benson, C.J., Abboud, F.M.: Cholecystokinin Activates a Ca2+-dependent Cl- Conductance in Intestinal Nodose Neurons that is Inhibited in Diet Induced Obesity and May Suppress Satiety. Experimental Biology 2014, April 26-30, 2014, San Diego, CA (Submitted November 2013.)

Quote:

The deadly links between diabetes and vascular, renal and immunological diseases as well as autonomic and somatic neural damage, make it essential to mobilize experts from multiple disciplines to galvanize their creative efforts into an integrated force for discovery and management.

Hence a Diabetes Center.