Ethan Anderson, PhD

Contact Information

Phone: 319-335-8157
Office: S425 PHAR
Faculty Profile  

Brief description of current research:

Dr. Anderson is unabashedly a ‘mitochondriac.’ Work in his lab is directed toward understanding how mitochondria (energy factory of the cell) become unhealthy in the heart and liver, and the mechanisms by which mitochondria communicate within and between cells. Much of the research is focused on cardiovascular complications of diabetes, heart/liver inflammation and fibrosis, and towards development of novel therapeutics and biomarkers of cardiometabolic disease risk. To see the work that goes on in his lab, go to 

3 most influential diabetes/obesity/metabolism publications:

  • Katunga LA, Gudimella P, Efird JT, Abernathy SM, Mattox TA, Beatty C, Darden TM, Thayne KA, Alwair H, Kypson AP, Virag J, andAnderson EJ. Obesity in a model of gpx4 haploinsufficiency uncovers a causal role for lipid-derived aldehydes in human metabolic disease and cardiomyopathy. Molecular Metabolism. (2015) Apr 21;4(6):493-506. doi: 10.1016/j.molmet.2015.04.001. PMID: 26042203
  • Fisher-Wellman KH*, Mattox TA*, Thayne K, Katunga LA, La Favor JD, Neufer PD, Hickner RC, Wingard CJ and Anderson EJ. Novel Role for Thioredoxin Reductase-2 in Mitochondrial Redox Adaptations to Obesogenic Diet and Exercise in Heart and Skeletal Muscle. J Physiol 2013 591(Pt 14):3471-86. doi: 10.1113/jphysiol.2013.254193. Epub 2013 Apr 22. * denotes co-first authors
  • Anderson EJ, Lustig ME, Boyle KE, Woodlief TL, Kane DA, Lin CT, Price III JW, Kang L, Rabinovitch PS, Szeto HH, Houmard JA, Cortright RN, Wasserman DW, and Neufer PD. Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans. J Clin Invest, 119(3): 573-581 (2009) E pub Feb 2, 2009, PMCID 19188683


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