Featured 2018 Publications of FOEDRC Members

E. Dale Abel, MD, PhD:

  • Ock S, Lee WS, Kim HM, Park KS, Kim YK, Kook H, Park WJ, Lee TJ, Abel ED, Kim J. Connexin43 and zonula occludens-1 are targets of Akt in cardiomyocytes that correlate with cardiac contractile dysfunction in Akt deficient hearts. Biochim Biophys Acta. 2018 Jan 31;1864(4 Pt A):1183-1191. doi: 10.1016/j.bbadis.2018.01.022. [Epub ahead of print] PubMed PMID: 29378301.

Michael Abramoff, MD, PhD:

  • van der Heijden AA, Abramoff MD, Verbraak F, van Hecke MV, Liem A, Nijpels G. Validation of automated screening for referable diabetic retinopathy with the IDx-DR device in the Hoorn Diabetes Care System. Acta Ophthalmol. 2018 Feb;96(1):63-68. doi: 10.1111/aos.13613. Epub 2017 Nov 27. PubMed PMID: 29178249.

Michael Anderson, MD, PhD:

  • Anderson MG, Meyer KJ, Hedberg-Buenz A, Fingert JH. Update on Animal Models of Exfoliation Syndrome. J Glaucoma. 2018 Feb 6. doi: 10.1097/IJG.0000000000000911. [Epub ahead of print] PubMed PMID: 29419647.

James Ankrum, PhD:

  • Klingelhutz AJ, Gourronc FA, Chaly A, Wadkins DA, Burand AJ, Markan KR, Idiga SO, Wu M, Potthoff MJ, Ankrum JA. Scaffold-free generation of uniform adipose spheroids for metabolism research and drug discovery. Sci Rep. 2018 Jan 11;8(1):523. doi: 10.1038/s41598-017-19024-z. PubMed PMID: 29323267.

Wei Bao, MD, PhD:

  • Liu B, Sun Y, Snetselaar LG, Sun Q, Yang Q, Zhang Z, Liu L, Hu FB, Bao W. Association between Plasma trans-Fatty Acid Concentrations and Diabetes in a Nationally Representative Sample of U.S. Adults. J Diabetes. 2018 Feb 15. doi: 10.1111/1753-0407.12652. [Epub ahead of print] PubMed PMID: 29446544.

Gail Bishop, PhD: 

  • Wallis AM, Bishop GA. TRAF3 regulation of inhibitory signaling pathways in B and T lymphocytes by kinase and phosphatase localization. J Leukoc Biol. 2018 Jan 17. doi: 10.1002/JLB.2MIR0817-339RR. [Epub ahead of print] Review. PubMed PMID: 29345428.

Sue Bodine, PhD:

  • Miller BF, Bodine SC. A New Cover and Updated Scope for JAPPL. J Appl Physiol  (1985). 2018 Jan 4. doi: 10.1152/japplphysiol.00004.2018. [Epub ahead of print] PubMed PMID: 29357484.

Ryan Boudreau, PhD:

  • Zhang X, Yoon JY, Morley M, McLendon JM, Mapuskar KA, Gutmann R, Mehdi H, Bloom HL, Dudley SC, Ellinor PT, Shalaby AA, Weiss R, Tang WHW, Moravec CS, Singh M, Taylor AL, Yancy CW, Feldman AM, McNamara DM, Irani K, Spitz DR, Breheny P, Margulies KB, London B, Boudreau RL. A common variant alters SCN5A-miR-24 interaction and associates with heart failure mortality. J Clin Invest. 2018 Feb 19. pii: 95710. doi: 10.1172/JCI95710. [Epub ahead of print] PubMed PMID: 29457789.

Trudy Burns, MPH, PhD, FAHA:

  • Chen C, Zhang X, Guo J, Jin D, Letuchy EM, Burns TL, Levy SM, Hoffman EA, Saha PK. Quantitative imaging of peripheral trabecular bone microarchitecture using MDCT. Med Phys. 2018 Jan;45(1):236 249. doi: 10.1002/mp.12632. Epub 2017 Nov 23. PubMed PMID: 29064579.

Darren Casey, PhD:

  • Iwamoto E, Bock JM, Casey DP. Blunted shear-mediated dilation of the internal but not common carotid artery in response to lower body negative pressure. J Appl Physiol (1985). 2018 Feb 15. doi: 10.1152/japplphysiol.01011.2017. [Epub ahead of print] PubMed PMID: 29446714.

Mark Chapleau, PhD:

  • Sabharwal R, Mason BN, Kuburas A, Abboud FM, Russo AF, Chapleau MW. Increased receptor activity-modifying protein 1 in the nervous system is sufficient to protect against autonomic dysregulation and hypertension. J Cereb Blood Flow Metab. 2018 Jan 1:271678X17751352. doi: 10.1177/0271678X17751352. [Epub ahead of print] PubMed PMID: 29297736.

John Engelhardt, PhD:

  • Rosen BH, Evans TIA, Moll SR, Gray JS, Liang B, Sun X, Zhang Y, Jensen-Cody CW, Swatek AM, Zhou W, He N, Rotti PG, Tyler SR, Keiser NW, Anderson PJ, Brooks L, Li Y, Pope RM, Rajput M, Hoffman EA, Wang K, Harris JK, Parekh KR, Gibson-Corley KN, Engelhardt JF. Infection is Not Required for Mucoinflammatory Lung Disease in CFTR-knockout Ferrets. Am J Respir Crit Care Med. 2018 Jan 12. doi: 10.1164/rccm.201708-1616OC. [Epub ahead of print] PubMed PMID: 29327941.

David Frisvold, PhD:

  • Cawley J, Willage B, Frisvold D. Pass-Through of a Tax on Sugar-Sweetened Beverages at the Philadelphia International Airport. JAMA. 2018 Jan 16;319(3):305-306. doi: 10.1001/jama.2017.16903. PubMed PMID: 29071342.

Katherine Gibson-Corley, DVM, PhD:

  • Gibbins KJ, Gibson-Corley KN, Brown AS, Wieben M, Law RC, Fung CM. Effects of excess thromboxane A2 on placental development and nutrient transporters in a Mus musculus model of fetal growth restriction. Biol Reprod. 2018 Jan 17. doi: 10.1093/biolre/ioy006. [Epub ahead of print] PubMed PMID: 29351577.
  • Rotti PG, Xie W, Poudel A, Yi Y, Sun X, Tyler SR, Uc A, Norris AW, Hara M, Engelhardt JF, Gibson-Corley KN. Pancreatic and Islet Remodeling in Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Knockout Ferrets. Am J Pathol. 2018 Jan 20. pii: S0002-9440(17)30728-9. doi: 10.1016/j.ajpath.2017.12.015. [Epub ahead of print] PubMed PMID: 29366680.
  • Fricke EM, Elgin TG, Gong H, Reese J, Gibson-Corley KN, Weiss RM, Zimmerman K, Bowdler NC, Kalantera KM, Mills DA, Underwood MA, McElroy SJ. Lipopolysaccharide-induced maternal inflammation induces direct placental injury without alteration in placental blood flow and induces a secondary fetal intestinal injury that persists into adulthood. Am J Reprod Immunol. 2018 Jan 25. doi: 10.1111/aji.12816. [Epub ahead of print] PubMed PMID: 29369434.
  • Wilkes JG, O'Leary BR, Du J, Klinger AR, Sibenaller ZA, Doskey CM, Gibson-Corley KN, Alexander MS, Tsai S, Buettner GR, Cullen JJ. Pharmacologic ascorbate (P-AscH(-)) suppresses hypoxia-inducible Factor-1α (HIF-1α) in pancreatic adenocarcinoma. Clin Exp Metastasis. 2018 Feb 2. doi: 10.1007/s10585-018-9876 z. [Epub ahead of print] PubMed PMID: 29396728.
  • Gadupudi GS, Elser BA, Sandgruber FA, Li X, Gibson-Corley KN, Robertson LW. PCB126 inhibits the activation of AMPK-CREB signal transduction required for energy sensing in liver. Toxicol Sci. 2018 Feb 20. doi: 10.1093/toxsci/kfy041. [Epub ahead of print] PubMed PMID: 29474705.

Justin Grobe, PhD:

  • Scroggins SM, Santillan DA, Lund JM, Sandgren JA, Krotz LK, Hamilton WS, Devor EJ, Davis HA, Pierce GL, Gibson-Corley KN, Sigmund CD, Grobe JL, Santillan MK. Elevated Vasopressin in Pregnant Mice Induces T Helper Subset Alterations Consistent with Human Preeclampsia. Clin Sci (Lond). 2018 Jan 25. pii: CS20171059. doi: 10.1042/CS20171059. [Epub ahead of print] PubMed PMID: 29371289.
  • Sandgren JA, Linggonegoro DW, Zhang SY, Sapouckey SA, Claflin KE, Pearson NA, Leidinger MR, Pierce GL, Santillan MK, Gibson-Corley KN, Sigmund CD, Grobe JL. Angiotensin AT(1A) Receptors Expressed in Vasopressin-Producing Cells of the Supraoptic Nucleus Contribute to the Osmotic Control of Vasopressin. Am J Physiol Regul Integr Comp Physiol. 2018 Jan 24. doi: 10.1152/ajpregu.00435.2017. [Epub ahead of print] PubMed PMID: 29364700.

Isabella Grumbach, MD, PhD:

  • Dogan MV, Grumbach IM, Michaelson JJ, Philibert RA. Integrated genetic and epigenetic prediction of coronary heart disease in the Framingham Heart Study. PLoS One. 2018 Jan 2;13(1):e0190549. doi: 10.1371/journal.pone.0190549. eCollection 2018. PubMed PMID: 29293675.

Kaikobad Irani, MD:

  • Piao S, Lee JW, Nagar H, Jung SB, Choi S, Kim S, Lee I, Kim SM, Shin N, Lee YR, Lee SD, Park JB, Irani K, Won M, Hur GM, Jeon BH, Kim DW, Kim CS. CR6 interacting factor 1 deficiency promotes endothelial inflammation by SIRT1 downregulation. PLoS One. 2018 Feb 23;13(2):e0192693. doi: 10.1371/journal.pone.0192693. eCollection 2018. PubMed PMID: 29474366.

Kathleen Janz, EdD:

  • Janz KF, Baptista F. Bone Strength and Exercise During Youth-The Year That Was 2017. Pediatr Exerc Sci. 2018 Feb 19:1-4. doi: 10.1123/pes.2017-0295. [Epub ahead of print] PubMed PMID: 29457753.

Alan Johnson, PhD:

  • Zhang YP, Huo YL, Fang ZQ, Wang XF, Li JD, Wang HP, Peng W, Johnson AK, Xue B. Maternal High Fat Diet Acts on the Brain to Induce Baroreflex Dysfunction and Sensitization of Angiotensin II-Induced Hypertension in Adult Offspring. Am J Physiol Heart Circ Physiol. 2018 Jan 26. doi: 10.1152/ajpheart.00698.2017. [Epub ahead of print] PubMed PMID: 29373045.

Linnea Polgreen, PhD:

  • Kennelty KA, Polgreen LA, Carter BL. Team-Based Care with Pharmacists to Improve Blood Pressure: a Review of Recent Literature. Curr Hypertens Rep. 2018 Jan 18;20(1):1. doi: 10.1007/s11906-018-0803-0. Review. PubMed PMID: 29349522.

Philip Polgreen, MD, MPH:

  • Simmering JE, Cavanaugh JE, Polgreen LA, Polgreen PM. Warmer weather as a risk factor for hospitalisations due to urinary tract infections. Epidemiol Infect. 2018 Jan 8:1-8. doi: 10.1017/S0950268817002965. [Epub ahead of print] PubMed PMID: 29307331.

Kamal Rahmouni, PhD:

  • Schmidt EA, Despas F, Pavy-Le Traon A, Czosnyka Z, Pickard JD, Rahmouni K, Pathak A, Senard JM. Intracranial Pressure Is a Determinant of Sympathetic Activity. Front Physiol. 2018 Feb 8;9:11. doi: 10.3389/fphys.2018.00011. eCollection 2018. PubMed PMID: 29472865; PubMed Central PMCID: PMC5809772.

Thomas Rutkowski, PhD:

  • Rutkowski DT. Liver function and dysfunction - a unique window into the physiological reach of ER stress and the unfolded protein response. FEBS J. 2018 Jan 23. doi: 10.1111/febs.14389. [Epub ahead of print] Review. PubMed PMID: 29360258.

Rajan Sah, MD, PhD:

  • Kang C, Xie L, Gunasekar SK, Mishra A, Zhang Y, Pai S, Gao Y, Kumar A, Norris AW, Stephens SB, Sah R. SWELL1 is a glucose sensor regulating β-cell excitability and systemic glycaemia. Nat Commun. 2018 Jan 25;9(1):367. doi: 10.1038/s41467-017-02664-0. PubMed PMID: 29371604; PubMed Central PMCID: PMC5785485.

Elliott Sohn, MD:

  • Abramoff MD, Fort PE, Han IC, Jayasundera KT, Sohn EH, Gardner TW. Approach for a Clinically Useful Comprehensive Classification of Vascular and Neural Aspects of Diabetic Retinal Disease. Invest Ophthalmol Vis Sci. 2018 Jan 1;59(1):519-527. doi: 10.1167/iovs.17-21873. PubMed PMID: 29372250; PubMed Central PMCID: PMC5786342.

Long Sheng-Song, MD, MS:

  • Guo A, Chen R, Wang Y, Huang CK, Chen B, Kutschke W, Hong J, Song LS. Transient activation of PKC results in long-lasting detrimental effects on systolic [Ca(2+)](i) in cardiomyocytes by altering actin cytoskeletal dynamics and T-tubule integrity. J Mol Cell Cardiol. 2018 Jan 4. pii: S0022-2828(18)30012-9. doi: 10.1016/j.yjmcc.2018.01.003. [Epub ahead of print] PubMed PMID: 29307535.
  • Yan J, Zhao W, Thomson JK, Gao X, DeMarco DM, Carrillo E, Chen B, Wu X, Ginsburg KS, Bakhos M, Bers DM, Anderson ME, Song LS, Fill M, Ai X. Stress Signaling JNK2 Crosstalk with CaMKII Underlies Enhanced Atrial Arrhythmogenesis. Circ Res. 2018 Jan 19. pii: CIRCRESAHA.117.312536. doi: 10.1161/CIRCRESAHA.117.312536. [Epub ahead of print] PubMed PMID: 29352041.
  • Chiamvimonvat N, Song LS. LRRC10 (Leucine-Rich Repeat Containing Protein 10) and REEP5 (Receptor Accessory Protein 5) as Novel Regulators of Cardiac Excitation-Contraction Coupling Structure and Function. J Am Heart Assoc. 2018 Feb 3;7(3). pii: e008260. doi: 10.1161/JAHA.117.008260. PubMed PMID: 29431105.

Douglas Spitz, PhD:

  • Heer CD, Davis AB, Riffe DB, Wagner BA, Falls KC, Allen BG, Buettner GR, Beardsley RA, Riley DP, Spitz DR. Superoxide Dismutase Mimetic GC4419 Enhances the Oxidation of Pharmacological Ascorbate and Its Anticancer Effects in an H₂O₂-Dependent Manner. Antioxidants (Basel). 2018 Jan 19;7(1). pii: E18. doi: 10.3390/antiox7010018. PubMed PMID: 29351198.
  • Rashmi R, Huang X, Floberg JM, Elhammali A, McCormick ML, Patti GJ, Spitz DR, Schwarz JK. Radio-resistant Cervical Cancers Are Sensitive to Inhibition of Glycolysis and Redox Metabolism. Cancer Res. 2018 Jan 16. pii: canres.2367.2017. doi: 10.1158/0008-5472.CAN-17-2367. [Epub ahead of print] PubMed PMID: 29339540.

Aliya Uc, MD:

  • Abu-El-Haija M, Kumar S, Quiros JA, Balakrishnan K, Barth B, Bitton S, Eisses JF, Foglio EJ, Fox V, Francis D, Freeman AJ, Gonska T, Grover AS, Husain SZ, Kumar R, Lapsia S, Lin T, Liu QY, Maqbool A, Sellers ZM, Szabo F, Uc A, Werlin SL, Morinville VD. Management of Acute Pancreatitis in the Pediatric Population: A Clinical Report From the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition Pancreas Committee. J Pediatr Gastroenterol Nutr. 2018 Jan;66(1):159-176. doi: 10.1097/MPG.0000000000001715. PubMed PMID: 29280782.
  • Párniczky A, Abu-El-Haija M, Husain S, Lowe M, Oracz G, Sahin-Tóth M, Szabó FK, Uc A, Wilschanski M, Witt H, Czakó L, Grammatikopoulos T, Rasmussen IC, Sutton R, Hegyi P. EPC/HPSG evidence-based guidelines for the management of pediatric pancreatitis. Pancreatology. 2018 Jan 4. pii: S1424-3903(18)30001-2. doi: 10.1016/j.pan.2018.01.001. [Epub ahead of print] Review. PubMed PMID: 29398347.

Michael Welsh, MD:

  • Mao S, Shah AS, Moninger TO, Ostedgaard LS, Lu L, Tang XX, Thornell IM, Reznikov LR, Ernst SE, Karp PH, Tan P, Keshavjee S, Abou Alaiwa MH, Welsh MJ. Motile cilia of human airway epithelia contain hedgehog signaling components that mediate noncanonical hedgehog signaling. Proc Natl Acad Sci U S A. 2018 Jan 22. pii: 201719177. doi: 10.1073/pnas.1719177115. [Epub ahead of print] PubMed PMID: 29358407.
  • Meyerholz DK, Stoltz DA, Gansemer ND, Ernst SE, Cook DP, Strub MD, LeClair EN, Barker CK, Adam RJ, Leidinger MR, Gibson-Corley KN, Karp PH, Welsh MJ, McCray PB  Jr. Lack of cystic fibrosis transmembrane conductance regulator disrupts fetal airway development in pigs. Lab Invest. 2018 Feb 21. doi: 10.1038/s41374-018-0026-7. [Epub ahead of print] PubMed PMID: 29467455.