Charles Brenner, PhD

Contact Information

Office: 4-403 BSB 
Phone: 319-335-7934 
Faculty Profile


Brief description of current research:

The Brenner laboratory discovered nicotinamide riboside as a novel vitamin precursor of NAD and has been a leading group in identification and characterization of NAD biosynthetic genes, enzymes and transporters.  Current work makes extensive use of NAD metabolomics, NAD chemical biological tools, and animal experiments that probe how elevating NAD biosynthesis can ameliorate diseases and conditions.  Nicotinamide riboside has shown promise as an agent to oppose weight gain on high fat diet and as an agent that blocks particular diabetic complications.  Ongoing experiments are both mechanistic and translational.

3 most influential diabetes/obesity/metabolism publications:

  • K.L. Bogan & C. Brenner, "Nicotinic Acid, Nicotinamide, and Nicotinamide Riboside: A Molecular Evaluation of NAD+ Precursor Vitamins in Human Nutrition," Ann Review Nutrition, v. 28, pp. 115-130 (2008). 
  • S.A.J. Trammell & C. Brenner, "Targeted, LCMC-Based Metabolomics for Quantitative Measurement of NAD+ Metabolites," Computational and Structural Biotechnology Journal, v. 4, e201301012 (2013). DOI: 10.5936/csbj.201301012.
  • S. Ghanta, R.E. Grossmann & C. Brenner, "Mitochondrial protein acetylation as a cell-intrinsic, evolutionary driver of fat storage: chemical and metabolic logic of acetyl-lysine modifications"Critical Rev Biochem & Mol Biol, v. 48, in press, 2013. DOI: 10.3109/10409238.2013.838204. 

Quote:

The interface between the Obesity Research and Education Initiative and the Fraternal Order of Eagles Diabetes Research Center is a powerful one.   I am thrilled that we have been able to coalesce, organize and expand research in obesity and diabetes so dramatically in the last 3 years.  The best is yet to come as we reach a critical mass and begin to be able to deliver improved preventative and therapeutic approaches to the problems of obesity and diabetes, which threaten the health of people worldwide.