Frank Faraci, PhD

Contact Information

Office: 340F EMRB 
Phone: 319-335-7640
Faculty Profile

Brief description of current research:

Vascular disease is a major cause of death in patients with diabetes. Dr. Faraci’s research deals with mechanisms that underlie vascular disease, particularly in the cerebral circulation. His laboratory uses varied approaches to study the impact of cardiovascular risk factors on large and small vessel disease in brain. Current studies focus on interacting oxidant- and immune-related signaling pathways and the role of peroxisome proliferator activated receptor-γ (PPARγ), a molecule that is particularly important in diabetes. This work involves examination of cell-specific effects of PPARγ in the cerebral vasculature. A better understanding of such mechanisms may lead to more specific therapeutic approaches for cerebrovascular disease that cause stroke and contribute to the vascular component of dementia and cognitive decline.

3 most influential diabetes/obesity/metabolism publications:

  • Beyer AM, GL Baumbach, CM Halabi, ML Modrick, CM Lynch, TD Gerhold, SM Ghoneim, W de Lange, HL Keen, Y-S. Tsai, N Maeda, CD Sigmund, FM Faraci. Interference with PPARγ signaling causes cerebral vascular dysfunction, hypertrophy, and remodeling. Hypertension 51:867-871, 2008.
  • Faraci FM. Protecting against vascular disease in brain. The Robert M. Berne distinguished lecture. Am J Physiol 300:H1566-H1582, 2011.
  • Johnson AW, Kinzenbaw DA, Modrick ML, Faraci FM. Small molecule inhibitors of STAT3 protect against angiotensin II-induced vascular dysfunction and hypertension. Hypertension 61:437-442, 2013.