Riehle C, Wende AR, Zhu Y, Oliveira KJ, Pereira RO, Jaishy BP, Bevins J, Valdez S, Noh J, Kim BJ, Moreira AB, Weatherford ET, Manivel R, Rawlings TA, Rech M, White MF, Abel ED. Insulin receptor substrates are essential for the bioenergetic and hypertrophic response of the heart to exercise training. Mol Cell Biol. 2014 Sep 15;34(18):3450-60. doi: 10.1128/MCB.00426-14. Epub 2014 Jul 7.
Pereira RO, Wende AR, Crum A, Hunter D, Olsen CD, Rawlings T, Riehle C, Ward WF, Abel ED. Maintaining PGC-1α expression following pressure overload-induced cardiac hypertrophy preserves angiogenesis but not contractile or mitochondrial function. FASEB J. 2014 Aug;28(8):3691-702. doi: 10.1096/fj.14-253823. Epub 2014 Apr 28.
Fu Q, Xu B, Liu Y, Parikh D, Li J, Li Y, Zhang Y, Riehle C, Zhu Y, Rawlings T, Shi Q, Clark RB, Chen X, Abel ED, Xiang YK. Insulin inhibits cardiac contractility by inducing a Gi-biased β2-adrenergic signaling in hearts. Diabetes. 2014 Aug;63(8):2676-89. doi: 10.2337/db13-1763. Epub 2014 Mar 27.
Bugger H, Abel ED. Molecular mechanisms of diabetic cardiomyopathy. Diabetologia. 2014 Apr;57(4):660-71. doi: 10.1007/s00125-014-3171-6. Epub 2014 Jan 30.
Mark Arnold, BS, PhD:
Qiu J, Arnold MA, Murhammer DW. On-line near infrared bioreactor monitoring of cell density and concentrations of glucose and lactate during insect cell cultivation. J Biotechnol. 2014 Mar 10;173:106-11. doi: 10.1016/j.jbiotec.2014.01.009. Epub 2014 Jan 19.
Trudy Burns, MPH, PhD, FAHA:
Calarge CA, Nicol G, Schlechte JA, Burns TL. Cardiometabolic outcomes in children and adolescents following discontinuation of long-term risperidone treatment. J Child Adolesc Psychopharmacol. 2014 Apr;24(3):120-9. doi: 10.1089/cap.2013.0126.
Lucas Carr, PhD:
Manini TM, Carr LJ, King AC, Marshall S, Robinson TN, Jack Rejeski W. Interventions to Reduce Sedentary Behavior. Med Sci Sports Exerc. 2014 Sep 12. [Epub ahead of print
Maeda H, Quartiroli A, Vos PW, Carr LJ, Mahar MT. Feasibility of retrofitting a university library with active workstations to reduce sedentary behavior. Am J Prev Med. 2014 May;46(5):525-8. doi: 10.1016/j.amepre.2014.01.024.
John Engelhardt, PhD:
Sui H, Yi Y, Yao J, Liang B, Sun X, Hu S, Uc A, Nelson DJ, Ode KL, Philipson LH, Engelhardt JF, Norris AW. Quantifying insulin sensitivity and entero-insular responsiveness to hyper- and hypoglycemia in ferrets. PLoS One. 2014 Mar 3;9(3):e90519. doi: 10.1371/journal.pone.0090519. eCollection 2014.
Justin Grobe, PhD:
Fink BD, Herlein JA, Guo DF, Kulkarni C, Weidemann BJ, Yu L, Grobe JL, Rahmouni K, Kerns RJ, Sivitz WI. A Mitochondrial-Targeted Coenzyme Q Analog Prevents Weight Gain and Ameliorates Hepatic Dysfunction in High Fat-Fed Mice. J Pharmacol Exp Ther. 2014 Oct 9. pii: jpet.114.219329. [Epub ahead of print]
Burnett CM, Grobe JL. Dietary effects on resting metabolic rate in C57BL/6 mice are differentially detected by indirect (O2/CO2 respirometry) and direct calorimetry. Mol Metab. 2014 Mar 21;3(4):460-4. doi: 10.1016/j.molmet.2014.03.003. eCollection 2014.
Isabella Grumbach, MD, PhD:
Zhu LJ, Klutho PJ, Scott JA, Xie L, Luczak ED, Dibbern ME, Prasad AM, Jaffer OA, Venema AN, Nguyen EK, Guan X, Anderson ME, Grumbach IM. Oxidative activation of the Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) regulates vascular smooth muscle migration and apoptosis. Vascul Pharmacol. 2014 Feb;60(2):75-83. doi: 10.1016/j.vph.2014.01.001. Epub 2014 Jan 10.
Kaikobad Irani, MD:
Vikram A, Kim YR, Kumar S, Naqvi A, Hoffman TA, Kumar A, Miller FJ Jr, Kim CS, Irani K. Canonical Wnt Signaling Induces Vascular Endothelial Dysfunction via p66Shc-Regulated Reactive Oxygen Species. Arterioscler Thromb Vasc Biol. 2014 Oct;34(10):2301-9. doi: 10.1161/ATVBAHA.114.304338. Epub 2014 Aug 21.
Wang JM, Tao J, Chen DD, Cai JJ, Irani K, Wang Q, Yuan H, Chen AF. MicroRNA miR-27b rescues bone marrow-derived angiogenic cell function and accelerates wound healing in type 2 diabetes mellitus. Arterioscler Thromb Vasc Biol. 2014 Jan;34(1):99-109. doi: 10.1161/ATVBAHA.113.302104. Epub 2013 Oct 31.
Kathleen Janz, EdD:
Metcalf KM, Singhvi A, Tsalikian E, Tansey MJ, Zimmerman MB, Esliger DW, Janz KF. Effects of moderate-to-vigorous intensity physical activity on overnight and next-day hypoglycemia in active adolescents with type 1 diabetes. Diabetes Care. 2014 May;37(5):1272-8. doi: 10.2337/dc13-1973. Epub 2014 Feb 26.
Randy Kardon, MD, PhD:
Davidson EP, Coppey LJ, Kardon RH, Yorek MA. Differences and similarities in development of corneal nerve damage and peripheral neuropathy and in diet-induced obesity and type 2 diabetic rats. Invest Ophthalmol Vis Sci. 2014 Mar 3;55(3):1222-30. doi: 10.1167/iovs.13-13794.
Aloysius Klingelhutz, PhD:
Gadupudi G, Gourronc FA, Ludewig G, Robertson LW, Klingelhutz AJ. PCB126 inhibits adipogenesis of human preadipocytes. Toxicol In Vitro. 2014 Oct 7. pii: S0887-2333(14)00188-X. doi: 10.1016/j.tiv.2014.09.015. [Epub ahead of print]
Anne Kwitek, PhD:
Ma MC, Atanur SS, Aitman TJ, Kwitek AE. Genomic structure of nucleotide diversity among Lyon rat models of metabolic syndrome. BMC Genomics. 2014 Mar 14;15:197. doi: 10.1186/1471-2164-15-197.
Laroche HH, Ford C, Hansen K Formerly, Cai X, Just DR, Hanks AS, Wansink B. Concession stand makeovers: a pilot study of offering healthy foods at high school concession stands. J Public Health (Oxf). 2014 Mar 12. [Epub ahead of print]
Allyn Mark, MD:
Mark AL, Norris AW, Rahmouni K. Sympathetic inhibition after bariatric surgery. Hypertension. 2014 Aug;64(2):235-6. doi: 10.1161/HYPERTENSIONAHA.114.03183.
Lyse Norian, PhD:
Chehval V, Norian LA. Effects of obesity on immune responses to renal tumors. Immunol Res. 2014 Aug;59(1-3):211-9. doi: 10.1007/s12026-014-8533-0.
Andrew Norris, MD, PhD:
Baack ML, Wang C, Hu S, Segar JL, Norris AW. Hyperglycemia induces embryopathy, even in the absence of systemic maternal diabetes: an in vivo test of the fuel mediated teratogenesis hypothesis. Reprod Toxicol. 2014 Jul;46:129-36. doi: 10.1016/j.reprotox.2014.03.013. Epub 2014 Apr 8.
Christine Oltman, PhD:
Kleinschmidt TL, Oltman CL. Progression and reversal of coronary and mesenteric vascular dysfunction associated with obesity. Obesity (Silver Spring). 2014 Oct;22(10):2193-200. doi: 10.1002/oby.20837. Epub 2014 Jul 9.
Matthew Potthoff, PhD:
Markan KR, Naber MC, Ameka MK, Anderegg MD, Mangelsdorf DJ, Kliewer SA, Mohammadi M, Potthoff MJ. Circulating FGF21 is Liver Derived and Enhances Glucose Uptake During Refeeding and Overfeeding. Diabetes. 2014 Jul 9. pii: DB_140595. [Epub ahead of print]
Kamal Rahmouni, PhD:
Contreras C, González-García I, Martínez-Sánchez N, Seoane-Collazo P, Jacas J, Morgan DA, Serra D, Gallego R, Gonzalez F, Casals N, Nogueiras R, Rahmouni K, Diéguez C, López M. Central Ceramide-Induced Hypothalamic Lipotoxicity and ER Stress Regulate Energy Balance. Cell Rep. 2014 Oct 9;9(1):366-77. doi: 10.1016/j.celrep.2014.08.057. Epub 2014 Oct 2.
Tillman EJ, Morgan DA, Rahmouni K, Swoap SJ. Three months of high-fructose feeding fails to induce excessive weight gain or leptin resistance in mice. PLoS One. 2014 Sep 11;9(9):e107206. doi: 10.1371/journal.pone.0107206. eCollection 2014.
Owen BM, Ding X, Morgan DA, Coate KC, Bookout AL, Rahmouni K, Kliewer SA, Mangelsdorf DJ. FGF21 Acts Centrally to Induce Sympathetic Nerve Activity, Energy Expenditure, and Weight Loss. Cell Metab. 2014 Oct 7;20(4):670-7. doi: 10.1016/j.cmet.2014.07.012. Epub 2014 Aug 14.
Martínez de Morentin PB, González-García I, Martins L, Lage R, Fernández-Mallo D, Martínez-Sánchez N, Ruíz-Pino F, Liu J, Morgan DA, Pinilla L, Gallego R, Saha AK, Kalsbeek A, Fliers E, Bisschop PH, Diéguez C, Nogueiras R, Rahmouni K, Tena-Sempere M, López M. Estradiol regulates brown adipose tissue thermogenesis via hypothalamic AMPK. Cell Metab. 2014 Jul 1;20(1):41-53. doi: 10.1016/j.cmet.2014.03.031. Epub 2014 May 22.
Jennifer Robinson, MD, MPH:
Swerdlow DI, Preiss D, Kuchenbaecker KB, Holmes MV, Engmann JE, Shah T, Sofat R, Stender S, Johnson PC, Scott RA, Leusink M, Verweij N, Sharp SJ, Guo Y, Giambartolomei C, Chung C, Peasey A, Amuzu A, Li K, Palmen J, Howard P, Cooper JA, Drenos F, Li YR, Lowe G, Gallacher J, Stewart MC, Tzoulaki I, Buxbaum SG, van der A DL, Forouhi NG, Onland-Moret NC, van der Schouw YT, Schnabel RB, Hubacek JA, Kubinova R, Baceviciene M, Tamosiunas A, Pajak A, Topor-Madry R, Stepaniak U, Malyutina S, Baldassarre D, Sennblad B, Tremoli E, de Faire U, Veglia F, Ford I, Jukema JW, Westendorp RG, de Borst GJ, de Jong PA, Algra A, Spiering W, der Zee AH, Klungel OH, de Boer A, Doevendans PA, Eaton CB, Robinson JG, Duggan D; DIAGRAM Consortium, MAGIC Consortium, InterAct Consortium, Kjekshus J, Downs JR, Gotto AM, Keech AC, Marchioli R, Tognoni G, Sever PS, Poulter NR, Waters DD, Pedersen TR, Amarenco P, Nakamura H, McMurray JJ, Lewsey JD, Chasman DI, Ridker PM, Maggioni AP, Tavazzi L, Ray KK, Seshasai SR, Manson JE, Price JF, Whincup PH, Morris RW, Lawlor DA, Smith GD, Ben-Shlomo Y, Schreiner PJ, Fornage M, Siscovick DS, Cushman M, Kumari M, Wareham NJ, Verschuren WM, Redline S, Patel SR, Whittaker JC, Hamsten A, Delaney JA, Dale C, Gaunt TR, Wong A, Kuh D, Hardy R, Kathiresan S, Castillo BA, van der Harst P, Brunner EJ, Tybjaerg-Hansen A, Marmot MG, Krauss RM, Tsai M, Coresh J, Hoogeveen RC, Psaty BM, Lange LA, Hakonarson H, Dudbridge F, Humphries SE, Talmud PJ, Kivimäki M, Timpson NJ, Langenberg C, Asselbergs FW, Voevoda M, Bobak M, Pikhart H, Wilson JG, Reiner AP, Keating BJ, Hingorani AD, Sattar N. HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials. Lancet. 2014 Sep 24. pii: S0140-6736(14)61183-1. doi: 10.1016/S0140-6736(14)61183-1. [Epub ahead of print]
Robert Roghair, MD:
Meyer LR, Zhu V, Miller A, Roghair RD. Growth restriction, leptin, and the programming of adult behavior in mice. Behav Brain Res. 2014 Sep 6;275C:131-135. doi: 10.1016/j.bbr.2014.08.054. [Epub ahead of print]
Dexter BC, Rahmouni K, Cushman T, Hermann GM1, Ni C, Nopoulos PC, Thedens DL, Roghair RD. Neonatal leptin deficiency reduces frontal cortex volumes and programs adult hyperactivity in mice. Behav Brain Res. 2014 Apr 15;263:115-21. doi: 10.1016/j.bbr.2014.01.021. Epub 2014 Jan 25.
Curt Sigmund, PhD:
Carrillo-Sepulveda MA, Keen HL, Davis DR, Grobe JL, Sigmund CD. Role of vascular smooth muscle PPARγ in regulating AT1 receptor signaling and angiotensin II-dependent hypertension. PLoS One. 2014 Aug 14;9(8):e103786. doi: 10.1371/journal.pone.0103786. eCollection 2014.
William Sivitz, MD:
Fink BD, Herlein JA, Guo DF, Kulkarni C, Weidemann BJ, Yu L, Grobe JL, Rahmouni K, Kerns RJ, Sivitz WI. A Mitochondrial-Targeted Coenzyme Q Analog Prevents Weight Gain and Ameliorates Hepatic Dysfunction in High Fat-Fed Mice. J Pharmacol Exp Ther. 2014 Oct 9. pii: jpet.114.219329. [Epub ahead of print]
Linda Snetselaar, RD, PhD:
Jones JA, Hartman TJ, Klifa CS, Coffman DL, Mitchell DC, Vernarelli JA, Snetselaar LG, Van Horn L, Stevens VJ, Robson AM, Himes JH, Shepherd JA, Dorgan JF. Dietary Energy Density Is Positively Associated with Breast Density among Young Women. J Acad Nutr Diet. 2014 Oct 6. pii: S2212-2672(14)01315-X. doi: 10.1016/j.jand.2014.08.015. [Epub ahead of print]
Spracklen CN, Wallace RB, Sealy-Jefferson S, Robinson JG, Freudenheim JL, Wellons MF, Saftlas AF, Snetselaar LG, Manson JE, Hou L, Qi L, Chlebowski RT, Ryckman KK. Birth weight and subsequent risk of cancer. Cancer Epidemiol. 2014 Oct;38(5):538-43. doi: 10.1016/j.canep.2014.07.004. Epub 2014 Aug 3.
Milian Sonka, PhD:
Gerendas BS, Waldstein SM, Simader C, Deak G, Hajnajeeb B, Zhang L, Bogunovic H, Abramoff MD, Kundi M, Sonka M, Schmidt-Erfurth U. Three-Dimensional Automated Choroidal Volume Assessment on Standard Spectral-Domain Optical Coherence Tomography and Correlation With the Level of Diabetic Macular Edema. Am J Ophthalmol. 2014 Aug 12. pii: S0002-9394(14)00481-4. doi: 10.1016/j.ajo.2014.08.001. [Epub ahead of print]
David Stoltz, MD, PhD:
Uc A, Olivier AK, Griffin MA, Meyerholz DK, Yao J, Abu-El-Haija M, Buchanan KM, Vanegas Calderón OG, Abu-El-Haija M, Pezzulo AA, Reznikov LR, Hoegger MJ, Rector MV, Ostedgaard LS, Taft PJ, Gansemer ND, Ludwig PS, Hornick EE, Stoltz DA, Ode KL, Welsh MJ, Engelhardt JF, Norris AW. Glycaemic regulation and insulin secretion are abnormal in cystic fibrosis pigs despite sparing of islet cell mass. Clin Sci (Lond). 2015 Jan 1;128(2):131-42. doi: 10.1042/CS20140059.
Stefan Strack, PhD:
Merrill RA, Strack S. Mitochondria: a kinase anchoring protein 1, a signaling platform for mitochondrial form and function. Int J Biochem Cell Biol. 2014 Mar;48:92-6. doi: 10.1016/j.biocel.2013.12.012. Epub 2014 Jan 8.
Michael Tansey, MD:
Singhvi A, Tansey MJ, Janz K, Zimmerman MB, Tsalikian E. Aerobic fitness and glycemic variability in adolescents with type 1 diabetes. Endocr Pract. 2014 Jun 1;20(6):566-70. doi: 10.4158/EP13211.OR.
Eric Taylor, PhD:
Gray LR, Tompkins SC, Taylor EB. Regulation of pyruvate metabolism and human disease. Cell Mol Life Sci. 2014 Jul;71(14):2577-604. doi: 10.1007/s00018-013-1539-2. Epub 2013 Dec 21.
Eva Tsalikian, MD:
Sherr J, Tsalikian E, Fox L, Buckingham B, Weinzimer S, Tamborlane WV, White NH, Arbelaez AM, Kollman C, Ruedy KJ, Cheng P, Beck RW; Diabetes Research in Children Network. Evolution of abnormal plasma glucagon responses to mixed-meal feedings in youth with type 1 diabetes during the first 2 years after diagnosis. Diabetes Care. 2014 Jun;37(6):1741-4. doi: 10.2337/dc13-2612. Epub 2014 Apr 2.
Mauras N, Mazaika P, Buckingham B, Weinzimer S, White NH, Tsalikian E, Hershey T, Cato A, Cheng P, Kollman C, Beck RW, Ruedy K, Aye T, Fox L, Arbelaez AM, Wilson D, Tansey M, Tamborlane W, Peng D, Marzelli M, Winer KK, Reiss AL; for the Diabetes Research in Children Network (DirecNet). Longitudinal Assessment of Neuroanatomical and Cognitive Differences in Young Children with Type 1 Diabetes: Association with Hyperglycemia. Diabetes. 2014 Dec 8. pii: DB_141445. [Epub ahead of print]PMID: 25488901.
Rigby MR, DiMeglio LA, Rendell MS, Felner EI, Dostou JM, Gitelman SE, Patel CM, Griffin KJ, Tsalikian E, Gottlieb PA, Greenbaum CJ, Sherry NA, Moore WV, Monzavi R, Willi SM, Raskin P, Moran A, Russell WE, Pinckney A, Keyes-Elstein L, Howell M, Aggarwal S, Lim N, Phippard D, Nepom GT, McNamara J, Ehlers MR; T1DAL Study Team. Targeting of memory T cells with alefacept in new-onset type 1 diabetes (T1DAL study): 12 month results of a randomised, double-blind, placebo-controlled phase 2 trial. Lancet Diabetes Endocrinol. 2013 Dec;1(4):284-94. doi: 10.1016/S2213-8587(13)70111-6. Epub 2013 Sep 23. PMID: 24622414
Metcalf KM, Singhvi A, Tsalikian E, Tansey MJ, Zimmerman MB, Esliger DW, Janz KF. Effects of moderate-to-vigorous intensity physical activity on overnight and next-day hypoglycemia in active adolescents with type 1 diabetes. Diabetes Care. 2014 May;37(5):1272-8. doi: 10.2337/dc13-1973. Epub 2014 Feb 26. PMID: 24574352.
Marzelli MJ, Mazaika PK, Barnea-Goraly N, Hershey T, Tsalikian E, Tamborlane W, Mauras N, White NH, Buckingham B, Beck RW, Ruedy KJ, Kollman C, Cheng P, Reiss AL; Diabetes Research in Children Network (DirecNet). Neuroanatomical correlates of dysglycemia in young children with type 1 diabetes. Diabetes. 2014 Jan;63(1):343-53. doi: 10.2337/db13-0179. Epub 2013 Oct 29. PMID: 24170697.
Barnea-Goraly N, Weinzimer SA, Ruedy KJ, Mauras N, Beck RW, Marzelli MJ, Mazaika PK, Aye T, White NH, Tsalikian E, Fox L, Kollman C, Cheng P, Reiss AL; Diabetes Research in Children Network (DirecNet). High success rates of sedation-free brain MRI scanning in young children using simple subject preparation protocols with and without a commercial mock scanner--the Diabetes Research in Children Network (DirecNet) experience. Pediatr Radiol. 2014 Feb;44(2):181-6. doi: 10.1007/s00247-013-2798-7. Epub 2013 Oct 6. PMID: 24096802.
Arbelaez AM, Xing D, Cryer PE, Kollman C, Beck RW, Sherr J, Ruedy KJ, Tamborlane WV, Mauras N, Tsalikian E, Wilson DM, White NH; Diabetes Research in Children Network (DirecNet) Study Group. Blunted glucagon but not epinephrine responses to hypoglycemia occurs in youth with less than 1 yr duration of type 1 diabetes mellitus. Pediatr Diabetes. 2014 Mar;15(2):127-34. doi: 10.1111/pedi.12070. Epub 2013 Aug 28. PMID: 23992543.
Yuriy Usachev, PhD:
Kim MS, Shutov LP, Gnanasekaran A, Lin Z, Rysted JE, Ulrich JD, Usachev YM. Nerve Growth Factor (NGF) Regulates Activity of the Transcription Factor NFAT in Neurons via the Phosphatidylinositol-3-Kinase (PI3K)-Akt-Glycogen Synthase Kinase 3β (GSK3β) Pathway.J Biol Chem. 2014 Sep 17. pii: jbc.M114.587188. [Epub ahead of print]
Wu J, Prole DL, Shen Y, Lin Z, Gnanasekaran A, Liu Y, Chen L, Zhou H, Chen SR, Usachev YM, Taylor CW, Campbell RE. Red fluorescent genetically encoded Ca2+ indicators for use in mitochondria and endoplasmic reticulum. Biochem J. 2014 Aug 28. [Epub ahead of print]
Mark Yorek, PhD:
Dominguez JM 2nd, Yorek MA, Grant MB. Combination therapies prevent the neuropathic, pro-inflammatory characteristics of the bone marrow in streptozotocin-induced diabetic rats. Diabetes. 2014 Sep 9. pii: DB_140433. [Epub ahead of print]
Stavniichuk R, Shevalye H, Lupachyk S, Obrosov A, Groves JT, Obrosova IG, Yorek MA. Peroxynitrite and protein nitration in the pathogenesis of diabetic peripheral neuropathy. Diabetes Metab Res Rev. 2014 Mar 28. doi: 10.1002/dmrr.2549. [Epub ahead of print]
Davidson EP, Coppey LJ, Kardon RH, Yorek MA. Differences and similarities in development of corneal nerve damage and peripheral neuropathy and in diet-induced obesity and type 2 diabetic rats. Invest Ophthalmol Vis Sci. 2014 Mar 3;55(3):1222-30. doi: 10.1167/iovs.13-13794.
Nicholas Zavazava, MD, PhD:
Manzar GS, Kim EM, Rotti P, Zavazava N. Skin deep: from dermal fibroblasts to pancreatic beta cells. Immunol Res. 2014 Aug;59(1-3):279-86. doi: 10.1007/s12026-014-8546-8.
Kim EM, Miyake B, Aggarwal M, Voetlause R, Griffith M, Zavazava N. Embryonic stem cell-derived haematopoietic progenitor cells down-regulate the CD3 ξ chain on T cells, abrogating alloreactive T cells. Immunology. 2014 Jul;142(3):421-30. doi: 10.1111/imm.12268.
Leonid Zingman, MD:
Zhu Z, Sierra A, Burnett CM, Chen B, Subbotina E, Koganti SR, Gao Z, Wu Y, Anderson ME, Song LS, Goldhamer DJ, Coetzee WA, Hodgson-Zingman DM, Zingman LV. Sarcolemmal ATP-sensitive potassium channels modulate skeletal muscle function under low-intensity workloads. J Gen Physiol. 2014 Jan;143(1):119-34. doi: 10.1085/jgp.201311063. Epub 2013 Dec 16.