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Winkler EA, Nishida Y, Sagare AP, Rege SV, Bell RD, Perlmutter D, Sengillo JD, Hillman S, Kong P, Nelson AR, Sullivan JS, Zhao Z, Meiselman HJ, Wenby RB, Soto J, Abel ED, Makshanoff J, Zuniga E, De Vivo DC, Zlokovic BV. GLUT1 reductions exacerbate Alzheimer's disease vasculo-neuronal dysfunction and degeneration. Nat Neurosci. 2015 Mar 2. doi: 10.1038/nn.3966. [Epub ahead of print] PMID: 25730668
Jaishy B, Zhang Q, Chung HS, Riehle C, Soto J, Jenkins S, Abel P, Cowart LA, Van Eyk JE, Abel ED. Lipid-induced NOX2 activation inhibits autophagic flux by impairing lysosomal enzyme activity. J Lipid Res. 2015 Mar;56(3):546-61. doi: 10.1194/jlr.M055152. Epub 2014 Dec 21.PMID: 25529920
Ilkun O, Wilde N, Tuinei J, Pires KM, Zhu Y, Bugger H, Soto J, Wayment B, Olsen C, Litwin SE, Abel ED. Antioxidant treatment normalizes mitochondrial energetics and myocardial insulin sensitivity independently of changes in systemic metabolic homeostasis in a mouse model of the metabolic syndrome. J Mol Cell Cardiol. 2015 May 22;85:104-116. doi: 10.1016/j.yjmcc.2015.05.012. [Epub ahead of print]
Koentges C, Konig A, Pfeil K, Holscher ME, Schnick T, Wende AR, Schrepper A, Cimolai MC, Kersting S, Hoffmann MM, Asal J, Osterholt M, Odening KE, Doenst T, Hein L, Abel ED, Bode C, Bugger H. Myocardial mitochondrial dysfunction in mice lacking adiponectin receptor 1. Basic Res Cardiol. 2015 Jul;110(4):495. doi: 10.1007/s00395-015-0495-4. Epub 2015 May 16.
Ping-Chih Ho, Jessica Dauz Bihuniak, Andrew N. Macintyre, Matthew Staron, Xiaojing Liu, Robert Amezquita, Yao-Chen Tsui, Guoliang Cui, Goran Micevic, Jose C. Perales, Steven H. Kleinstein, E. Dale Abel, Karl L. Insogna, Stefan Feske, Jason W. Locasale, Marcus W. Bosenberg, Jeffrey C. Rathmell, Susan M. Kaech. Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses. Cell. 2015 Aug. doi:10.1016/j.cell.2015.08.012
Liao X, Zhang R, Lu Y, Prosdocimo DA, Sangwung P, Zhang L, Zhou G, Anand P, Lai L, Leone TC, Fujioka H, Ye F, Rosca MG, Hoppel CL, Schulze PC, Abel ED, Stamler JS, Kelly DP, Jain MK. Kruppel-like factor 4 is critical for transcriptional control of cardiac mitochondrial homeostasis. J Clin Invest. 2015
Bharath LP, Ruan T, Li Y, Ravindran A, Wan X, Nhan JK, Walker ML, Deeter L, Goodrich R, Johnson E, Munday D, Mueller R, Kunz D, Jones D, Reese V, Summers SA, Anandh Babu PV, Holland WL, Zhang QJ, Abel ED, Symons JD.Sep 1;125(9):3461-76. doi: 10.1172/JCI79964. Epub 2015 Aug 4. Ceramide initiated protein phosphatase 2A activation contributes to arterial dysfunction in vivo. Diabetes. 2015 Aug 7. pii: db150244. [Epub ahead of print]
Ho PC, Bihuniak JD, Macintyre AN, Staron M, Liu X, Amezquita R, Tsui YC, Cui G, Micevic G, Perales JC, Kleinstein SH, Abel ED, Insogna KL, Feske S, Locasale JW, Bosenberg MW, Rathmell JC, Kaech SM. Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses. Cell. 2015 Sep 10;162(6):1217-28. doi: 10.1016/j.cell.2015.08.012. Epub 2015 Aug 27.
Ni R, Zheng D, Xiong S, Hill DJ, Sun T, Gardiner RB, Fan G-C, Lu Y, Abel ED, Greer PA, Peng T. Mitochondrial calpain-1 disrupts ATP synthase and induces superoxide generation in type-1 diabetic hearts: a novel mechanism contributing to diabetic cardiomyopathy. Diabetes. 2015. In Press.
Ock S, Lee WS, Ahn J, Kim HM, Kang H, Kim H-S, Jo D, Abel ED, Lee TJ, Kim J. Deletion of IGF-1 Receptors in Cardiomyocytes Attenuates Cardiac Aging in Male Mice. Endocrinology. 2015. In Press.
Noh J, Wende AR, Olsen CD, Kim B, Bevins J, Zhu Y, Zhang QJ, Riehle C, Abel ED. Phosphoinositide Dependent Protein Kinase 1 is Required for Exercise-induced Cardiac Hypertrophy but not the Associated Mitochondrial Adaptations. J. Molecular and Cellular Cardiology. 2015: In Press.
Michael Abramoff, MD, PhD:
Kafieh R, Rabbani H, Hajizadeh F, Abramoff MD, Sonka M. Thickness mapping of eleven retinal layers segmented using the diffusion maps method in normal eyes. J Ophthalmol. 2015;2015:259123. doi: 10.1155/2015/259123. Epub 2015 Apr 19.
Xu X, Lee K, Zhang L, Sonka M, Abramoff M. Stratified Sampling Voxel Classification for Segmentation of Intraretinal and Subretinal Fluid in Longitudinal Clinical OCT Data. IEEE Trans Med Imaging. 2015 Mar 6. [Epub ahead of print]
Antony BJ, Stetson PF, Abramoff MD, Lee K, Colijn JM, Buitendijk GH, Klaver CC, Roorda A, Lujan BJ. Characterizing the Impact of Off-Axis Scan Acquisition on the Reproducibility of Total Retinal Thickness Measurements in SDOCT Volumes. Transl Vis Sci Technol. 2015 Jul 31;4(4):3. eCollection 2015.
Hedberg-Buenz A, Christopher MA, Lewis CJ, Meyer KJ, Rudd DS, Dutca LM, Wang K, Scheetz TE, Abramoff MD, Harper MM, Anderson MG. RetFM-J, an ImageJ-based module for automated counting and quantifying features of nuclei in retinal whole-mounts. Exp Eye Res. 2015 Aug 14. pii: S0014-4835(15)00253-5. doi: 10.1016/j.exer.2015.07.020. [Epub ahead of print]
Miri MS, Abramoff MD, Lee K, Niemeijer M, Wang JK, Kwon YH, Garvin MK. Multimodal Segmentation of Optic Disc and Cup From SD-OCT and Color Fundus Photographs Using a Machine-Learning Graph-Based Approach. IEEE Trans Med Imaging. 2015 Sep;34(9):1854-66. doi: 10.1109/TMI.2015.2412881. Epub 2015 Mar 13.
Hu Q, Abràmoff MD, Garvin MK. Automated construction of arterial and venous trees in retinal images. J Med Imaging (Bellingham). 2015 Oct;2(4):044001. doi: 10.1117/1.JMI.2.4.044001. Epub 2015 Nov 19.
Hedberg-Buenz A, Christopher MA, Lewis CJ, Fernandes KA, Dutca LM, Wang K, Scheetz TE, Abràmoff MD, Libby RT, Garvin MK, Anderson MG. Quantitative measurement of retinal ganglion cell populations via histology-based random forest classification. Exp Eye Res. 2015 Oct 22. pii: S0014-4835(15)30032-4. doi: 10.1016/j.exer.2015.09.011. [Epub ahead of print]
Hansen MB, Abràmoff MD, Folk JC, Mathenge W, Bastawrous A, Peto T. Results of Automated Retinal Image Analysis for Detection of Diabetic Retinopathy from the Nakuru Study, Kenya. PLoS One. 2015 Oct 1;10(10):e0139148. doi: 10.1371/journal.pone.0139148. eCollection 2015.
Christopher M, Abràmoff MD, Tang L, Gordon MO, Kass MA, Budenz DL, Fingert JH, Scheetz TE. Stereo Photo Measured ONH Shape Predicts Development of POAG in Subjects With Ocular Hypertension. Invest Ophthalmol Vis Sci. 2015 Jul;56(8):4470-9. doi: 10.1167/iovs.14-16142.
Zhang L, Buitendijk GH, Lee K, Sonka M, Springelkamp H, Hofman A, Vingerling JR, Mullins RF, Klaver CC, Abràmoff MD. Validity of Automated Choroidal Segmentation in SS-OCT and SD-OCT. Invest Ophthalmol Vis Sci. 2015 May;56(5):3202-11. doi: 10.1167/iovs.14-15669.
Darma S, Kok PH, van den Berg TJ, Abràmoff MD, Faber DJ, Hulsman CA, Zantvoord F, Mourits MP, Schlingemann RO, Verbraak FD. Optical density filters modeling media opacities cause decreased SD-OCT retinal layer thickness measurements with inter- and intra-individual variation. Acta Ophthalmol. 2015 Jun;93(4):355-61. doi: 10.1111/aos.12596. Epub 2014 Dec 8.
Christopher Adams, MD, PhD:
Adams CM, Ebert SM, Dyle MC. Use of mRNA expression signatures to discover small molecule inhibitors of skeletal muscle atrophy. Curr Opin Clin Nutr Metab Care. 2015 May;18(3):263-8. doi: 10.1097/MCO.0000000000000159.
Bongers KS, Fox DK, Kunkel SD, Stebounova LV, Murry DJ, Pufall MA, Ebert SM, Dyle MC, Bullard SA, Dierdorff JM, Adams CM. Spermine oxidase maintains basal skeletal muscle gene expression and fiber size and is strongly repressed by conditions that cause skeletal muscle atrophy. Am J Physiol Endocrinol Metab. 2015 Jan 15;308(2):E144-58. doi:
Suneja M, Fox DK, Fink BD, Herlein JA, Adams CM, Sivitz WI. Evidence for metabolic aberrations in asymptomatic persons with type 2 diabetes after initiation of simvastatin therapy. Transl Res. 2015 Aug;166(2):176-87. doi: 10.1016/j.trsl.2015.01.007. Epub 2015 Jan 28.
Michael Anderson, MD, PhD:
Gramlich OW, Ding QJ, Zhu W, Cook A, Anderson MG, Kuehn MH. Adoptive transfer of immune cells from glaucomatous mice provokes retinal ganglion cell loss in recipients. Acta Neuropathol Commun. 2015 Sep 15;3:56. doi: 10.1186/s40478-015-0234-y.
Koehn DR, Meyer KJ, Anderson MG. Genetic Evidence for Differential Regulation of Corneal Epithelial and Stromal Thickness. Invest Ophthalmol Vis Sci. 2015 Aug 1;56(9):5599-607. doi: 10.1167/iovs.15-17179.
Fernandes KA, Harder JM, Williams PA, Rausch RL, Kiernan AE, Nair KS, Anderson MG, John SW, Howell GR, Libby RT. Using genetic mouse models to gain insight into glaucoma: Past results and future possibilities. Exp Eye Res. 2015 Jun 24. pii: S0014-4835(15)00207-9. doi: 10.1016/j.exer.2015.06.019. [Epub ahead of print]
Mark Arnold, BS, PhD:
Smith RM, Arnold MA. Selectivity of Terahertz Gas-Phase Spectroscopy. Anal Chem. 2015 Nov 3;87(21):10679-83. doi: 10.1021/acs.analchem.5b03028. Epub 2015 Oct 15.
Wei Bao, MD, PhD:
Bao W, Li S, Chavarro JE, Tobias DK, Zhu Y, Hu FB, Zhang C. Low Carbohydrate-Diet Scores and Long-term Risk of Type 2 Diabetes Among Women With a History of Gestational Diabetes Mellitus: A Prospective Cohort Study. Diabetes Care. 2016 Jan;39(1):43-9. doi: 10.2337/dc15-1642. Epub 2015 Nov 17.
Gary Baumbach, MD:
Chan SL, Umesalma S, Baumbach GL. Epidermal growth factor receptor is critical for angiotensin II-mediated hypertrophy in cerebral arterioles. Hypertension. 2015 Apr;65(4):806-12. doi: 10.1161/HYPERTENSIONAHA.114.04794. Epub 2015 Mar 2.
Christopher Benson, MD:
Gibbons DD, Kutschke WJ, Weiss RM, Benson CJ. Heart failure induces changes in acid-sensing ion channels in sensory neurons innervating skeletal muscle. J Physiol. 2015 Oct 15;593(20):4575-87. doi: 10.1113/JP270690. Epub 2015 Sep 23.
Gail Bishop, PhD:
Yi Z, Bishop GA. Regulatory role of CD40 in obesity-induced insulin resistance. Adipocyte. 2014 Oct 30;4(1):65-9. doi: 10.4161/adip.32214.
Bankert KC, Oxley KL, Smith SM, Graham JP, de Boer M, Thewissen M, Simons PJ, Bishop GA. Induction of an altered CD40 signaling complex by an antagonistic human monoclonal antibody to CD40. J Immunol. 2015 May 1;194(9):4319-27. doi: 10.4049/jimmunol.1402903. Epub 2015 Mar 20.
Lin WW, Yi Z, Stunz LL, Maine CJ, Sherman LA, Bishop GA. The adaptor protein TRAF3 inhibits interleukin-6 receptor signaling in B cells to limit plasma cell development. Sci Signal. 2015 Sep 1;8(392):ra88. doi: 10.1126/scisignal.aaa5157.
Lin WW, Hostager BS, Bishop GA. TRAF3, ubiquitination, and B-lymphocyte regulation. Immunol Rev. 2015 Jul;266(1):46-55. doi: 10.1111/imr.12299.
Satpathy S, Wagner SA, Beli P, Gupta R, Kristiansen TA, Malinova D, Francavilla C, Tolar P, Bishop GA, Hostager BS,Choudhary C. Systems-wide analysis of BCR signalosomes and downstream phosphorylation and ubiquitylation. Mol Syst Biol. 2015 Jun 2;11(6):810. doi: 10.15252/msb.20145880.
Charles Brenner, PhD:
Trammell SA, Brenner C. NNMT: A Bad Actor in Fat Makes Good in Liver. Cell Metab. 2015 Aug 4;22(2):200-1. doi: 10.1016/j.cmet.2015.07.017.
Trudy Burns, MPH, PhD, FAHA:
Worden NE, Lindower PD, Burns TL, Chatterjee K, Weiss RM. A second look with prone SPECT myocardial perfusion imaging reduces the need for angiography in patients at low risk for cardiac death or MI. J Nucl Cardiol. 2015 Feb;22(1):115-22. doi: 10.1007/s12350-014-9934-0. Epub 2014 Jul 1.
Coryell WH, Butcher BD, Burns TL, Dindo LN, Schlechte JA, Calarge CA. Fat distribution and major depressive disorder in late adolescence. J Clin Psychiatry. 2015 Oct 27. [Epub ahead of print]
Kwon S, Janz KF, Letuchy EM, Burns TL, Levy SM. Active lifestyle in childhood and adolescence prevents obesity development in young adulthood. Obesity (Silver Spring). 2015 Nov 5. doi: 10.1002/oby.21262. [Epub ahead of print]
Bahr SM, Tyler BC, Wooldridge N, Butcher BD, Burns TL, Teesch LM, Oltman CL, Azcarate-Peril MA, Kirby JR, Calarge CA. Use of the second-generation antipsychotic, risperidone, and secondary weight gain are associated with an altered gut microbiota in children. Transl Psychiatry. 2015 Oct 6;5:e652. doi: 10.1038/tp.2015.135.
Lucas Carr, PhD:
Carr LJ, Leonhard C, Tucker S, Fethke N, Benzo R, Gerr F. Total Worker Health Intervention Increases Activity of Sedentary Workers. American Journal of Preventive Medicine August 07, 2015
Manini TM, Carr LJ, King AC, Marshall S, Robinson TN, Rejeski WJ. Interventions to reduce sedentary behavior. Med Sci Sports Exerc. 2015 Jun;47(6):1306-10. doi: 10.1249/MSS.0000000000000519.
Carr LJ, Swift M, Ferrer A, Benzo R. Cross-sectional Examination of Long-term Access to Sit-Stand Desks in a Professional Office Setting. Am J Prev Med. 2016 Jan;50(1):96-100. doi: 10.1016/j.amepre.2015.07.013. Epub 2015 Oct 1.
Darren Casey, PhD:
Joyner MJ, Casey DP. Regulation of Increased Blood Flow (Hyperemia) to Muscles During Exercise: A Hierarchy of Competing Physiological Needs. Physiol Rev. 2015 Apr;95(2):549-601.
Casey DP, Treichler DP, Ganger CT 4th, Schneider AC, Ueda K. Acute dietary nitrate supplementation enhances compensatory vasodilation during hypoxic exercise in older adults. J Appl Physiol (1985). 2015 Jan 15;118(2):178-86. doi: 10.1152/japplphysiol.00662.2014. Epub 2014 Nov 20.
Hughes WE, Ueda K, Treichler DP, Casey DP. Rapid onset vasodilation with single muscle contractions in the leg: influence of age. Physiol Rep. 2015 Aug;3(8). pii: e12516. doi: 10.14814/phy2.12516.
Casey DP, Ranadive SM, Joyner MJ. Aging is associated with altered vasodilator kinetics in dynamically contracting muscle: role of nitric oxide. J Appl Physiol (1985). 2015 Aug 1;119(3):232-41. doi: 10.1152/japplphysiol.00787.2014. Epub 2015 May 28.
Mark Chapleau, PhD:
Sabharwal R, Rasmussen L, Sluka KA, Chapleau MW. EXERCISE PREVENTS DEVELOPMENT OF AUTONOMIC DYSREGULATION AND HYPERALGESIA IN A MOUSE MODEL OF CHRONIC MUSCLE PAIN. Pain. 2015 Aug 13. [Epub ahead of print]
Singh MV, Cicha MZ, Meyerholz DK, Chapleau MW, Abboud FM. Dual Activation of TRIF and MyD88 Adaptor Proteins by Angiotensin II Evokes Opposing Effects on Pressure, Cardiac Hypertrophy, and Inflammatory Gene Expression. Hypertension. 2015 Sep;66(3):647-56. doi: 10.1161/HYPERTENSIONAHA.115.06011. Epub 2015 Jul 20.
Prasad AM, Morgan DA, Nuno DW, Ketsawatsomkron P, Bair TB, Venema AN, Dibbern ME, Kutschke WJ, Weiss RM, Lamping KG, Chapleau MW, Sigmund CD, Rahmouni K, Grumbach IM. Calcium/calmodulin-dependent kinase II inhibition in smooth muscle reduces angiotensin II-induced hypertension by controlling aortic remodeling and baroreceptor function. J Am Heart Assoc. 2015 Jun 15;4(6):e001949. doi: 10.1161/JAHA.115.001949.
Sandra Daack-Hirsch, PhD, RN:
Conley YP, Heitkemper M, McCarthy D, Anderson CM, Corwin EJ, Daack-Hirsch S, Dorsey SG, Gregory KE, Groer MW, Henly SJ, Landers T, Lyon DE, Taylor JY, Voss J. Educating future nursing scientists: Recommendations for integrating omics content in PhD programs. Nurs Outlook. 2015 Jul-Aug;63(4):417-27. doi: 10.1016/j.outlook.2015.06.006. Epub 2015 Jun 12.
Brandon Davies, PhD:
Chi X, Shetty SK, Shows HW, Hjelmaas AJ, Malcolm EK, Davies BS. Angiopoietin-like 4 Modifies the Interactions between Lipoprotein Lipase and Its Endothelial Cell Transporter GPIHBP1. J Biol Chem. 2015 May 8;290(19):11865-77. doi: 10.1074/jbc.M114.623769. Epub 2015 Mar 25.
Beigneux AP, Fong LG, Bensadoun A, Davies BS, Oberer M, Gårdsvoll H, Ploug M, Young SG. GPIHBP1 missense mutations often cause multimerization of GPIHBP1 and thereby prevent lipoprotein lipase binding. Circ Res. 2015 Feb 13;116(4):624-32. doi: 10.1161/CIRCRESAHA.116.305085. Epub 2014 Nov 11.
John Engelhardt, PhD:
Uc A, Olivier AK, Griffin MA, Meyerholz DK, Yao J, Abu-El-Haija M, Buchanan KM, Vanegas Calderón OG, Abu-El-Haija M, Pezzulo AA, Reznikov LR, Hoegger MJ, Rector MV, Ostedgaard LS, Taft PJ, Gansemer ND, Ludwig PS, Hornick EE, Stoltz DA, Ode KL, Welsh MJ, Engelhardt JF, Norris AW. Glycaemic regulation and insulin secretion are abnormal in cystic fibrosis pigs despite sparing of islet cell mass. Clin Sci (Lond). 2015 Jan;128(2):131-42. doi: 10.1042/CS20140059.
Yan Z, Sun X, Feng Z, Li G, Fisher JT, Stewart ZA, Engelhardt JF. Optimization of Recombinant Adeno-Associated Virus-Mediated Expression for Large Transgenes, Using a Synthetic Promoter and Tandem Array Enhancers. Hum Gene Ther. 2015 Apr 20. [Epub ahead of print]
Xie W, Fisher JT, Lynch TJ, Luo M, Evans TI, Neff TL, Zhou W, Zhang Y, Ou Y, Bunnett NW, Russo AF, Goodheart MJ, Parekh KR, Liu X, Engelhardt JF. CGRP induction in cystic fibrosis airways alters the submucosal gland progenitor cell niche in mice. J Clin Invest. 2015 May;125(5):2179. doi: 10.1172/JCI82138. Epub 2015 May 1.
Yan Z, Stewart ZA, Sinn PL, Olsen JC, Hu J, McCray PB Jr, Engelhardt JF. Ferret and pig models of cystic fibrosis: prospects and promise for gene therapy. Hum Gene Ther Clin Dev. 2015 Mar;26(1):38-49. doi: 10.1089/humc.2014.154. Epub 2015 Feb 12.
Spencer NY, Yan Z, Cong L, Zhang Y, Engelhardt JF, Stanton RC. Definitive localization of intracellular proteins: Novel approach using CRISPR-Cas9 genome editing, with glucose 6-phosphate dehydrogenase as a model. Anal Biochem. 2016 Feb 1;494:55-67. doi: 10.1016/j.ab.2015.11.002. Epub 2015 Nov 11.
Evans TI, Joo NS, Keiser NW, Yan Z, Tyler SR, Xie W, Zhang Y, Hsiao JJ, Cho HJ, Wright ME, Wine JJ, Engelhardt JF. Glandular Proteome Identifies Antiprotease Cystatin C as a Critical Modulator of Airway Hydration and Clearance. Am J Respir Cell Mol Biol. 2015 Sep 3. [Epub ahead of print]
Wisely SM, Ryder OA, Santymire RM, Engelhardt JF, Novak BJ. A Road Map for 21st Century Genetic Restoration: Gene Pool Enrichment of the Black-Footed Ferret. J Hered. 2015 Sep-Oct;106(5):581-92. doi: 10.1093/jhered/esv041. Epub 2015 Aug 24.
Shen W, Deng X, Zou W, Cheng F, Engelhardt JF, Yan Z, Qiu J. Identification and Functional Analysis of Novel Nonstructural Proteins of Human Bocavirus 1. J Virol. 2015 Oct;89(19):10097-109. doi: 10.1128/JVI.01374-15. Epub 2015 Jul 29.
Keiser NW, Birket SE, Evans IA, Tyler SR, Crooke AK, Sun X, Zhou W, Nellis JR, Stroebele EK, Chu KK, Tearney GJ, Stevens MJ, Harris JK, Rowe SM, Engelhardt JF. Defective innate immunity and hyperinflammation in newborn cystic fibrosis transmembrane conductance regulator-knockout ferret lungs. Am J Respir Cell Mol Biol. 2015 Jun;52(6):683-94. doi: 10.1165/rcmb.2014-0250OC.
Frank Faraci, PhD:
Hasan DM, Starke RM, Gu H, Wilson K, Chu Y, Chalouhi N, Heistad DD, Faraci FM, Sigmund CD. Smooth Muscle Peroxisome Proliferator-Activated Receptor γ Plays a Critical Role in Formation and Rupture of Cerebral Aneurysms in Mice In Vivo. Hypertension. 2015 Jul;66(1):211-20. doi: 10.1161/HYPERTENSIONAHA.115.05332. Epub 2015 Apr 27.
De Silva TM, Ketsawatsomkron P, Pelham C, Sigmund CD, Faraci FM. Genetic Interference With Peroxisome Proliferator-Activated Receptor γ in Smooth Muscle Enhances Myogenic Tone in the Cerebrovasculature via A Rho Kinase-Dependent Mechanism. Hypertension. 2015 Feb;65(2):345-51. doi: 10.1161/HYPERTENSIONAHA.114.04541. Epub 2014 Nov 10.
James Folk, MD:
Chin EK, Almeida DR, Grant LW, Niles PI, Folk JC. Letter to the Editor: Outer Retinal Tubulations and Age-Related Macular Degeneration. Ophthalmic Surg Lasers Imaging Retina. 2015 Jun;46(6):604-5. doi: 10.3928/23258160-20150610-01.
Almeida DR, Chin EK, Tarantola RM, Folk JC, Boldt HC, Skeie JM, Mullins RF, Russell SR, Mahajan VB. Effect of internal limiting membrane abrasion on retinal tissues in macular holes. Invest Ophthalmol Vis Sci. 2015 May;56(5):2783-9. doi: 10.1167/iovs.14-16355.
David Frisvold, PhD:
Frisvold DE. Nutrition and Cognitive Achievement: An Evaluation of the School Breakfast Program. J Public Econ. 2015 Apr 1;124:91-104.
Gazmararian JA, Frisvold D, Zhang K, Koplan JP. Obesity is associated with an increase in pharmaceutical expenses among university employees. J Obes. 2015;2015:298698. doi: 10.1155/2015/298698. Epub 2015 Feb 8.
Matthew Gillum, PhD:
McGlashon JM, Gorecki MC, Kozlowski AE, Thirnbeck CK, Markan KR, Leslie KL, Kotas ME, Potthoff MJ, Richerson GB, Gillum MP. Central serotonergic neurons activate and recruit thermogenic brown and beige fat and regulate glucose and lipid homeostasis. Cell Metab. 2015 May 5;21(5):692-705. doi: 10.1016/j.cmet.2015.04.008.
Darryl Granner, MD:
Granner DK. In the Pursuit of Genes of Glucose Metabolism. Journal of Biological Chemistry
Granner DK, Wang JC, Yamamoto KR. Regulatory Actions of Glucocorticoid Hormones: From Organisms to Mechanisms. Adv Exp Med Biol. 2015;872:3-31. doi: 10.1007/978-1-4939-2895-8_1.
Justin Grobe, PhD:
Claflin KE, Grobe JL. Control of energy balance by the brain Renin-Angiotensin system. Curr Hypertens Rep. 2015 May;17(5):549. doi: 10.1007/s11906-015-0549-x.
Sandgren JA, Scroggins SM, Santillan DA, Devor EJ, Gibson-Corley KN, Pierce GL, Sigmund CD, Santillan MK, Grobe JL. Vasopressin: The Missing Link for Preeclampsia? Am J Physiol Regul Integr Comp Physiol. 2015 Mar 25:ajpregu.00073.2015. doi: 10.1152/ajpregu.00073.2015. [Epub ahead of print]
Weidemann BJ, Voong S, Morales-Santiago FI, Kahn MZ, Ni J, Littlejohn NK, Claflin KE, Burnett CM, Pearson NA, Lutter ML, Grobe JL. Dietary Sodium Suppresses Digestive Efficiency via the Renin-Angiotensin System. Sci Rep. 2015 Jun 11;5:11123. doi: 10.1038/srep11123. PMID: 26068176
Santillan MK, Pelham CJ, Ketsawatsomkron P, Santillan DA, Davis DR, Devor EJ, Gibson-Corley KN, Scroggins SM, Grobe JL, Yang B, Hunter SK, Sigmund CD. Pregnant mice lacking indoleamine 2,3-dioxygenase exhibit preeclampsia phenotypes. Physiol Rep. 2015 Jan 19;3(1). pii: e12257. doi: 10.14814/phy2.12257. Print 2015 Jan 1.
Coble JP, Grobe JL, Johnson AK, Sigmund CD. Mechanisms of brain renin angiotensin system-induced drinking and blood pressure: importance of the subfornical organ. Am J Physiol Regul Integr Comp Physiol. 2015 Feb 15;308(4):R238-49. doi: 10.1152/ajpregu.00486.2014. Epub 2014 Dec 17.
Littlejohn NK, Grobe JL. Opposing tissue-specific roles of angiotensin in the pathogenesis of obesity, and implications for obesity-related hypertension. Am J Physiol Regul Integr Comp Physiol. 2015 Dec 15;309(12):R1463-73. doi: 10.1152/ajpregu.00224.2015. Epub 2015 Oct 21.
Chad Grueter, PhD:
Guo A, Hall D, Zhang C, Peng T, Miller JD, Kutschke W, Grueter CE, Johnson FL, Lin RZ, Song LS. Molecular Determinants of Calpain-dependent Cleavage of Junctophilin-2 Protein in Cardiomyocytes. J Biol Chem. 2015 Jul 17;290(29):17946-55. doi: 10.1074/jbc.M115.652396. Epub 2015 Jun 10.
Isabella Grumbach, MD, PhD:
Prasad AM, Morgan DA, Nuno DW, Ketsawatsomkron P, Bair TB, Venema AN, Dibbern ME, Kutschke WJ, Weiss RM, Lamping KG, Chapleau MW, Sigmund CD, Rahmouni K, Grumbach IM. Calcium/Calmodulin-Dependent Kinase II Inhibition in Smooth Muscle Reduces Angiotensin II-Induced Hypertension by Controlling Aortic Remodeling and Baroreceptor Function. J Am Heart Assoc. 2015 Jun 15;4(6). pii: e001949. doi: 10.1161/JAHA.115.001949.
Klutho PJ, Pennington SM, Scott JA, Wilson KM, Gu SX, Doddapattar P, Xie L, Venema AN, Zhu LJ, Chauhan AK, Lentz SR, Grumbach IM. Deletion of Methionine Sulfoxide Reductase A Does Not Affect Atherothrombosis but Promotes Neointimal Hyperplasia and Extracellular Signal-Regulated Kinase 1/2 Signaling. Arterioscler Thromb Vasc Biol. 2015 Dec;35(12):2594-604. doi: 10.1161/ATVBAHA.115.305857. Epub 2015 Oct 8.
Doddapattar P, Gandhi C, Prakash P, Dhanesha N, Grumbach IM, Dailey ME, Lentz SR, Chauhan AK. Fibronectin Splicing Variants Containing Extra Domain A Promote Atherosclerosis in Mice Through Toll-Like Receptor 4. Arterioscler Thromb Vasc Biol. 2015 Nov;35(11):2391-400. doi: 10.1161/ATVBAHA.115.306474. Epub 2015 Oct 1.
Lawrence Hunsicker, MD:
Bansal N, Carpenter MA, Weiner DE, Levey AS, Pfeffer M, Kusek JW, Cai J, Hunsicker LG, Park M, Bennett M, Liu KD, Hsu CY. Urine Injury Biomarkers and Risk of Adverse Outcomes in Recipients of Prevalent Kidney Transplants: The Folic Acid for Vascular Outcome Reduction in Transplantation Trial. J Am Soc Nephrol. 2015 Nov 4. pii: ASN.2015030292. [Epub ahead of print]
Kathleen Janz, EdD:
Singh B, Yack HJ, Francis SL, Janz KF. Biomechanical loads during common rehabilitation exercises in obese individuals. Int J Sports Phys Ther. 2015 Apr;10(2):189-96.
Brazendale K, Beets MW, Bornstein DB, Moore JB, Pate RR, Weaver RG, Falck RS, Chandler JL, Andersen LB, Anderssen SA, Cardon G, Cooper A, Davey R, Froberg K, Hallal PC, Janz KF, Kordas K, Kriemler S, Puder JJ, Reilly JJ, Salmon J, Sardinha LB, Timperio A, van Sluijs EM; On behalf of the International Children's Accelerometry Database (ICAD) Collaborators. Equating accelerometer estimates among youth: The Rosetta Stone 2. J Sci Med Sport. 2015 Feb 23. pii: S1440-2440(15)00050-X. doi: 10.1016/j.jsams.2015.02.006. [Epub ahead of print]
Janz KF, Thomas DQ, Ford MA, Williams SM. Top 10 research questions related to physical activity and bone health in children and adolescents. Res Q Exerc Sport. 2015 Mar;86(1):5-12. doi: 10.1080/02701367.2014.995019.
Aitaoto N, Campo S, Snetselaar LG, Janz KF, Farris KB, Parker E, Belyeu-Camacho T, Jimenez RP. Formative Research to Inform Nutrition Interventions in Chuuk and the US Pacific. J Acad Nutr Diet. 2015 Jan 26. pii: S2212-2672(14)01765-1. doi: 10.1016/j.jand.2014.11.018. [Epub ahead of print]
Piercy KL, Dorn JM, Fulton JE, Janz KF, Lee SM, McKinnon RA, Pate RR, Pfeiffer KA, Young DR, Troiano RP, Lavizzo-Mourey R. Opportunities for public health to increase physical activity among youths. Am J Public Health. 2015 Mar;105(3):421-6. doi: 10.2105/AJPH.2014.302325. Epub 2015 Jan 20.
Cooper AR, Goodman A, Page AS, Sherar LB, Esliger DW, van Sluijs EM, Andersen LB, Anderssen S, Cardon G, Davey R, Froberg K, Hallal P, Janz KF, Kordas K, Kreimler S, Pate RR, Puder JJ, Reilly JJ, Salmon J, Sardinha LB, Timperio A, Ekelund U. Objectively measured physical activity and sedentary time in youth: the International children's accelerometry database (ICAD). Int J Behav Nutr Phys Act. 2015 Sep 17;12:113. doi: 10.1186/s12966-015-0274-5.
Morrissey JL, Janz KF, Letuchy EM, Francis SL, Levy SM. The effect of family and friend support on physical activity through adolescence: a longitudinal study. Int J Behav Nutr Phys Act. 2015 Aug 20;12(1):103. doi: 10.1186/s12966-015-0265-6.
Zhang N, Campo S, Yang J, Janz KF, Snetselaar LG, Eckler P. Effects of Social Support About Physical Activity on Social Networking Sites: Applying the Theory of Planned Behavior. Health Commun. 2015 Dec;30(12):1277-85. doi: 10.1080/10410236.2014.940669. Epub 2015 Jun 18.
Kwon S, Janz KF, Letuchy EM, Burns TL, Levy SM. Developmental Trajectories of Physical Activity, Sports, and Television Viewing During Childhood to Young Adulthood: Iowa Bone Development Study. JAMA Pediatr. 2015 Jul;169(7):666-72. doi: 10.1001/jamapediatrics.2015.0327.
Francis SL, Singhvi A, Tsalikian E, Tansey MJ, Janz KF. Cross-Validation of Single-Stage Treadmill Tests for Predicting Aerobic Fitness in Adolescents with Type I Diabetes. Pediatr Exerc Sci. 2015 Aug;27(3):396-403. doi: 10.1123/pes.2014-0146. Epub 2015 Jul 17.
Kim Johnson, BS, MA, BA, PhD:
Johnson AK, Zhang Z, Clayton SC, Beltz TG, Hurley SW, Thunhorst RL, Xue B. The Roles of Sensitization and Neuroplasticity in the Long-Term Regulation of Blood Pressure and Hypertension. Am J Physiol Regul Integr Comp Physiol. 2015 Aug 19:ajpregu.00037.2015. doi: 10.1152/ajpregu.00037.2015. [Epub ahead of print]
Randy Kardon, MD, PhD:
Greiner MA, Burckart KA, Wagoner MD, Schmidt GA, Reed CR, Liaboe CA, Flamme-Wiese MJ, Zimmerman MB, Mullins RF, Kardon RH, Goins KM, Aldrich BT. Regional assessment of energy-producing metabolic activity in the endothelium of donor corneas. Invest Ophthalmol Vis Sci. 2015 May;56(5):2803-10. doi: 10.1167/iovs.15-16442.
Vu BG, Stach CS, Kulhankova K, Salgado-Pabón W, Klingelhutz AJ, Schlievert PM. Chronic superantigen exposure induces systemic inflammation, elevated bloodstream endotoxin, and abnormal glucose tolerance in rabbits: possible role in diabetes. MBio. 2015 Feb 24;6(2):e02554. doi: 10.1128/mBio.02554-14.
Gadupudi G, Gourronc FA, Ludewig G, Robertson LW, Klingelhutz AJ. PCB126 inhibits adipogenesis of human preadipocytes. Toxicol In Vitro. 2015 Feb;29(1):132-41. doi: 10.1016/j.tiv.2014.09.015. Epub 2014 Oct 7.
Gadupudi GS, Klaren WD, Olivier AK, Klingelhutz AJ, Robertson LW. PCB126-induced disruption in gluconeogenesis and fatty acid oxidation precedes fatty liver in male rats. Toxicol Sci. 2015 Sep 22. pii: kfv215. [Epub ahead of print]
Schlievert PM, Salgado-Pabón W, Klingelhutz AJ. Does Staphylococcus aureus have a role in the development of Type 2 diabetes mellitus? Future Microbiol. 2015 Oct;10:1549-52. doi: 10.2217/fmb.15.95. Epub 2015 Oct 6.
Ulla Kopp, PhD:
Kopp UC. Role of renal sensory nerves in physiological and pathophysiological conditions. Am J Physiol Regul Integr Comp Physiol. 2015 Jan 15;308(2):R79-95. doi: 10.1152/ajpregu.00351.2014. Epub 2014 Nov 19.
Anne Kwitek, PhD:
Wang J, Ma MC, Mennie AK, Pettus JM, Xu Y, Lin L, Traxler MG, Jakoubek J, Atanur SS, Aitman TJ, Xing Y, Kwitek AE. Systems Biology with High-Throughput Sequencing Reveals Genetic Mechanisms Underlying the Metabolic Syndrome in the Lyon Hypertensive Rat. Circ Cardiovasc Genet. 2015 Jan 8. pii: CIRCGENETICS.114.000520. [Epub ahead of print]
Helena Laroche, MD, MS:
Laroche HH, Ford C, Hansen K, Cai X, Just DR, Hanks AS, Wansink B. Concession stand makeovers: a pilot study of offering healthy foods at high school concession stands. J Public Health (Oxf). 2015 Mar;37(1):116-24. doi: 10.1093/pubmed/fdu015. Epub 2014 Mar 12.
Boone-Heinonen J, Howard AG, Meyer K, Lewis CE, Kiefe CI, Laroche HH, Gunderson EP, Gordon-Larsen P. Marriage and parenthood in relation to obesogenic neighborhood trajectories: The CARDIA study. Health Place. 2015 Jul;34:229-40. doi: 10.1016/j.healthplace.2015.05.005. Epub 2015 Jun 18.
Vitor Lira, PhD:
Ebert SM, Dyle MC, Bullard SA, Dierdorff JM, Murry DJ, Fox DK, Bongers KS, Lira VA, Meyerholz DK, Talley JJ, Adams CM. Identification and Small Molecule Inhibition of an ATF4-dependent Pathway to Age-related Skeletal Muscle Weakness and Atrophy. J Biol Chem. 2015 Sep 3. pii: jbc.M115.681445. [Epub ahead of print]
Michael Lutter, MD, PhD:
Morgan DA, McDaniel LN, Yin T, Khan M, Jiang J, Acevedo MR, Walsh SA, Boles Ponto LL, Norris AW, Lutter M, Rahmouni K, Cui H. Regulation of Glucose Tolerance and Sympathetic Activity by MC4R Signaling in the Lateral Hypothalamus. Diabetes. 2015 Jan 20. pii: db141257. [Epub ahead of print] PMID: 25605803.
Cui H, Lu Y, Khan MZ Anderson RM, McDaniel L, Wilson HE, Yin TC, Radley JJ, Pieper AA, Lutter M. Behavioral Distubances in Estrogen-Related Receptor alpha-Null Mice. Cell Reports. 2015 Apr.
Weidemann BJ, Voong S, Morales-Santiago FI, Kahn MZ, Ni J, Littlejohn NK, Claflin KE, Burnett CM, Pearson NA, Lutter ML, Grobe JL. Dietary Sodium Suppresses Digestive Efficiency via the Renin-Angiotensin System. Sci Rep. 2015 Jun 11;5:11123. doi: 10.1038/srep11123. PMID: 26068176
Acevedo SF, Valencia C, Lutter M, McAdams CJ. Severity of eating disorder symptoms related to oxytocin receptor polymorphisms in anorexia nervosa. Psychiatry Res. 2015 Aug 30;228(3):641-8. doi: 10.1016/j.psychres.2015.05.040. Epub 2015 Jun 11.
Allyn Mark, MD:
Young CN, Morgan DA, Butler SD, Rahmouni K, Gurley SB, Coffman TM, Mark AL, Davisson RL. Angiotensin type 1a receptors in the forebrain subfornical organ facilitate leptin-induced weight loss through brown adipose tissue thermogenesis. Mol Metab. 2015 Jan 31;4(4):337-43. doi: 10.1016/j.molmet.2015.01.007. eCollection 2015.
Francis Miller, MD:
Miller FJ Jr. Nox4 NADPH oxidase: emerging from the veil of darkness. Eur Heart J. 2015 Dec 21;36(48):3457-9. doi: 10.1093/eurheartj/ehv518. Epub 2015 Oct 1.
Pagano PJ, Griendling KK, Miller FJ, Laurindo FR, Touyz RM. Chemiluminescence and the Nox1-Nox2-Nox4 Triple Knockout. Antioxid Redox Signal. 2015 Nov 20;23(15):1246-7. doi: 10.1089/ars.2015.6382. Epub 2015 Jul 14.
Mohamad Mokadem, MD:
Mokadem M, Zechner JF, Uchida A, Aguirre V. Leptin Is Required for Glucose Homeostasis after Roux-en-Y Gastric Bypass in Mice. PLoS One. 2015 Oct 7;10(10):e0139960. doi: 10.1371/journal.pone.0139960. eCollection 2015.
Andrew Norris, MD, PhD:
Uc A, Olivier AK, Griffin MA, Meyerholz DK, Yao J, Abu-El-Haija M, Buchanan KM, Vanegas Calderón OG, Abu-El-Haija M, Pezzulo AA, Reznikov LR, Hoegger MJ, Rector MV, Ostedgaard LS, Taft PJ, Gansemer ND, Ludwig PS, Hornick EE, Stoltz DA, Ode KL, Welsh MJ, Engelhardt JF, Norris AW. Glycaemic regulation and insulin secretion are abnormal in cystic fibrosis pigs despite sparing of islet cell mass. Clin Sci (Lond). 2015 Jan;128(2):131-42. doi: 10.1042/CS20140059.
Gordon EE, Reinking BE, Hu S, Yao J, Kua KL, Younes AK, Wang C, Segar JL, Norris AW. Maternal Hyperglycemia Directly and Rapidly Induces Cardiac Septal Overgrowth in Fetal Rats. J Diabetes Res. 2015;2015:479565. doi: 10.1155/2015/479565. Epub 2015 May 7.
Sawatzke AB, Norris AW, Spyropoulos F, Walsh SA, Acevedo MR, Hu S, Yao J, Wang C, Sunderland JJ, Boles Ponto LL. PET/CT imaging reveals unrivaled placental avidity for glucose compared to other tissues. Placenta. 2015 Feb;36(2):115-20. doi: 10.1016/j.placenta.2014.12.009. Epub 2014 Dec 23.
Christine Oltman, PhD:
Dake BL, Oltman CL. Cardiovascular, metabolic, and coronary dysfunction in high-fat-fed obesity-resistant/prone rats. Obesity (Silver Spring). 2015 Mar;23(3):623-9. doi: 10.1002/oby.21009. Epub 2015 Feb 3.
Ibrahim Ozbolat, PhD:
Zhang Y, Yu Y, Akkouch A, Dababneh A, Dolati F, Ozbolat IT. In Vitro Study of Directly Bioprinted Perfusable Vasculature Conduits. Biomater Sci. 2015 Jan 1;3(1):134-143.
Akkouch A, Yu Y, Ozbolat IT. Microfabrication of scaffold-free tissue strands for three-dimensional tissue engineering. Biofabrication. 2015 Sep 16;7(3):031002. doi: 10.1088/1758-5090/7/3/031002.
Ozbolat IT. Bioprinting scale-up tissue and organ constructs for transplantation. Trends Biotechnol. 2015 Jul;33(7):395-400. doi: 10.1016/j.tibtech.2015.04.005. Epub 2015 May 12.
Gary Pierce, PhD:
Sandgren JA, Scroggins SM, Santillan DA, Devor EJ, Gibson-Corley KN, Pierce GL, Sigmund CD, Santillan MK, Grobe JL. Vasopressin: The Missing Link for Preeclampsia? Am J Physiol Regul Integr Comp Physiol. 2015 Mar 25:ajpregu.00073.2015. doi: 10.1152/ajpregu.00073.2015. [Epub ahead of print]
Montero D, Pierce GL, Stehouwer CD, Padilla J, Thijssen DH. The impact of age on vascular smooth muscle function in humans. J Hypertens. 2015 Mar;33(3):445-53; discussion 453. doi: 10.1097/HJH.0000000000000446.
Weng TB, Pierce GL, Darling WG, Voss MW. Differential Effects of Acute Exercise on Distinct Aspects of Executive Function. Med Sci Sports Exerc. 2015 Jul;47(7):1460-9. doi: 10.1249/MSS.0000000000000542.
Chu Y, Wilson K, Gu H, Wegman-Points L, Dooley SA, Pierce GL, Cheng G, Pena Silva RA, Heistad DD, Hasan D. Myeloperoxidase is increased in human cerebral aneurysms and increases formation and rupture of cerebral aneurysms in mice. Stroke. 2015 Jun;46(6):1651-6. doi: 10.1161/STROKEAHA.114.008589. Epub 2015 Apr 28.
Robert Piper, PhD:
MacDonald C, Payne JA, Aboian M, Smith W, Katzmann DJ, Piper RC. A family of tetraspans organizes cargo for sorting into multivesicular bodies. Dev Cell. 2015 May 4;33(3):328-42. doi: 10.1016/j.devcel.2015.03.007.
Peterson TA, Yu L, Piper RC. Backbone and side-chain NMR assignments for the C-terminal domain of mammalian Vps28. Biomol NMR Assign. 2015 Apr;9(1):21-4. doi: 10.1007/s12104-013-9537-8. Epub 2013 Dec 24.
Carter BL, Levy BT, Gryzlak B, Chrischilles EA, Vander Weg MW, Christensen AJ, James PA, Moss CA, Parker CP, Gums T, Finkelstein RJ, Xu Y, Dawson JD, Polgreen LA. A centralized cardiovascular risk service to improve guideline adherence in private primary care offices. Contemp Clin Trials. 2015 May 4. pii: S1551-7144(15)00085-3. doi: 10.1016/j.cct.2015.04.014. [Epub ahead of print]
Carter BL, Coffey CS, Chrischilles EA, Ardery G, Ecklund D, Gryzlak B, Vander Weg MW, James PA, Christensen AJ, Parker CP, Gums T, Finkelstein RJ, Uribe L, Polgreen LA; MEDication Focused Outpatient Care for Underutilization of Secondary Prevention Trial Investigators. A Cluster-Randomized Trial of a Centralized Clinical Pharmacy Cardiovascular Risk Service to Improve Guideline Adherence. Pharmacotherapy. 2015 Jul;35(7):653-62. doi: 10.1002/phar.1603. Epub 2015 Jun 25.
Anthony CA, Polgreen LA, Chounramany J, Foster ED, Goerdt CJ, Miller ML, Suneja M, Segre AM, Carter BL, Polgreen PM. Outpatient blood pressure monitoring using bi-directional text messaging. J Am Soc Hypertens. 2015 May;9(5):375-81. doi: 10.1016/j.jash.2015.01.008. Epub 2015 Jan 21.
Polgreen LA, Han J, Carter BL, Ardery GP, Coffey CS, Chrischilles EA, James PA. Cost-Effectiveness of a Physician-Pharmacist Collaboration Intervention to Improve Blood Pressure Control. Hypertension. 2015 Dec;66(6):1145-51. doi: 10.1161/HYPERTENSIONAHA.115.06023. Epub 2015 Nov 2.
Philip Polgreen, MD, MPH:
Anthony CA, Polgreen LA, Chounramany J, Foster ED, Goerdt CJ, Miller ML, Suneja M, Segre AM, Carter BL, Polgreen PM. Outpatient blood pressure monitoring using bi-directional text messaging. J Am Soc Hypertens. 2015 Jan 21. pii: S1933-1711(15)00009-1. doi: 10.1016/j.jash.2015.01.008.
Matthew Potthoff, PhD:
Markan KR, Potthoff MJ. Metabolic fibroblast growth factors (FGFs): Mediators of energy homeostasis. Semin Cell Dev Biol. 2015 Sep 30. pii: S1084-9521(15)00181-0. doi: 10.1016/j.semcdb.2015.09.021. [Epub ahead of print]
Kamal Rahmouni, PhD:
Kenjiro Muta, Donald A. Morgan, and Kamal Rahmouni. The role of hypothalamic mTORC1 signaling in insulin regulation of food intake, body weight and sympathetic nerve activity in male mice. Endocrinology. 2015 Jan 9:en20141660. [Epub ahead of print]
Morgan DA, McDaniel LN, Yin T, Khan M, Jiang J, Acevedo MR, Walsh SA, Boles Ponto LL, Norris AW, Lutter M, Rahmouni K, Cui H. Regulation of Glucose Tolerance and Sympathetic Activity by MC4R Signaling in the Lateral Hypothalamus. Diabetes. 2015 Jan 20. pii: db141257. [Epub ahead of print] PMID: 25605803.
Young CN, Morgan DA, Butler SD, Rahmouni K, Gurley SB, Coffman TM, Mark AL, Davisson RL. Angiotensin type 1a receptors in the forebrain subfornical organ facilitate leptin-induced weight loss through brown adipose tissue thermogenesis. Mol Metab. 2015 Jan 31;4(4):337-43. doi: 10.1016/j.molmet.2015.01.007. eCollection 2015.
Tanida M, Yamamoto N, Morgan DA, Kurata Y, Shibamoto T, Rahmouni K. Leptin receptor signaling in the hypothalamus regulates hepatic autonomic nerve activity via phosphatidylinositol 3-kinase and AMP-activated protein kinase. J Neurosci. 2015 Jan 14;35(2):474-84. doi: 10.1523/JNEUROSCI.1828-14.2015
Starks RD, Beyer AM, Guo DF, Boland L, Zhang Q, Sheffield VC, Rahmouni K. Regulation of Insulin Receptor Trafficking by Bardet Biedl Syndrome Proteins. PLoS Genet. 2015 Jun 23;11(6):e1005311. doi: 10.1371/journal.pgen.1005311. eCollection 2015 Jun.
Morgan DA, Despas F, Rahmouni K. Effects of leptin on sympathetic nerve activity in conscious mice. Physiol Rep. 2015 Sep;3(9). pii: e12554. doi: 10.14814/phy2.12554.
Muta K, Morgan DA, Rahmouni K. The role of hypothalamic mTORC1 signaling in insulin regulation of food intake, body weight, and sympathetic nerve activity in male mice. Endocrinology. 2015 Apr;156(4):1398-407. doi: 10.1210/en.2014-1660. Epub 2015 Jan 9.
Jennifer Robinson, MD, MPH:
Joseph L, Robinson JG. Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Inhibition and the Future of Lipid Lowering Therapy. Prog Cardiovasc Dis. 2015 May 1. pii: S0033-0620(15)00029-8. doi: 10.1016/j.pcad.2015.04.004. [Epub ahead of print]
Schmiegelow MD, Hedlin H, Stefanick ML, Mackey RH, Allison M, Martin LW, Robinson JG, Hlatky MA. Insulin Resistance and Risk of Cardiovascular Disease in Postmenopausal Women: A Cohort Study From the Women's Health Initiative. Circ Cardiovasc Qual Outcomes. 2015 May 5. pii: CIRCOUTCOMES.114.001563. [Epub ahead of print]
Robinson JG. Statins and diabetes risk: how real is it and what are the mechanisms? Curr Opin Lipidol. 2015 Jun;26(3):228-35. doi: 10.1097/MOL.0000000000000172.
Robinson JG, Farnier M, Krempf M, Bergeron J, Luc G, Averna M, Stroes ES, Langslet G, Raal FJ, El Shahawy M, Koren MJ, Lepor NE, Lorenzato C, Pordy R, Chaudhari U, Kastelein JJ; ODYSSEY LONG TERM Investigators. Efficacy and safety of alirocumab in reducing lipids and cardiovascular events. N Engl J Med. 2015 Apr 16;372(16):1489-99. doi: 10.1056/NEJMoa1501031. Epub 2015 Mar 15.
Ryckman KK, Spracklen CN, Smith CJ, Robinson JG, Saftlas AF. Maternal lipid levels during pregnancy and gestational diabetes: a systematic review and meta-analysis. BJOG. 2015 Apr;122(5):643-51. doi: 10.1111/1471-0528.13261. Epub 2015 Jan 22.
Robinson JG. Statins for Primary Prevention in Adults Aged 75 Years or Older. Ann Intern Med. 2015 Sep 15;163(6):481. doi: 10.7326/L15-5135.
Kereiakes DJ, Robinson JG, Cannon CP, Lorenzato C, Pordy R, Chaudhari U, Colhoun HM. Efficacy and safety of the proprotein convertase subtilisin/kexin type 9 inhibitor alirocumab among high cardiovascular risk patients on maximally tolerated statin therapy: The ODYSSEY COMBO I study. Am Heart J. 2015 Jun;169(6):906-915.e13. doi: 10.1016/j.ahj.2015.03.004. Epub 2015 Mar 13.
Robinson JG, Stone NJ. The 2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular disease risk: a new paradigm supported by more evidence. Eur Heart J. 2015 Aug 14;36(31):2110-2118. Epub 2015 May 20.
Spracklen CN, Saftlas AF, Triche EW, Bjonnes A, Keating B, Saxena R, Breheny PJ, Dewan AT, Robinson JG, Hoh J, Ryckman KK. Genetic Predisposition to Dyslipidemia and Risk of Preeclampsia. Am J Hypertens. 2015 Jul;28(7):915-23. doi: 10.1093/ajh/hpu242. Epub 2014 Dec 17.
Swerdlow DI, Preiss D, Kuchenbaecker KB, Holmes MV, Engmann JE, Shah T, Sofat R, Stender S, Johnson PC, Scott RA, Leusink M, Verweij N, Sharp SJ, Guo Y, Giambartolomei C, Chung C, Peasey A, Amuzu A, Li K, Palmen J, Howard P, Cooper JA, Drenos F, Li YR, Lowe G, Gallacher J, Stewart MC, Tzoulaki I, Buxbaum SG, van der A DL, Forouhi NG, Onland-Moret NC, van der Schouw YT, Schnabel RB, Hubacek JA, Kubinova R, Baceviciene M, Tamosiunas A, Pajak A, Topor-Madry R, Stepaniak U, Malyutina S, Baldassarre D, Sennblad B, Tremoli E, de Faire U, Veglia F, Ford I, Jukema JW, Westendorp RG, de Borst GJ, de Jong PA, Algra A, Spiering W, Maitland-van der Zee AH, Klungel OH, de Boer A, Doevendans PA, Eaton CB, Robinson JG, Duggan D; DIAGRAM Consortium; MAGIC Consortium; InterAct Consortium, Kjekshus J, Downs JR, Gotto AM, Keech AC, Marchioli R, Tognoni G, Sever PS, Poulter NR, Waters DD, Pedersen TR, Amarenco P, Nakamura H, McMurray JJ, Lewsey JD, Chasman DI, Ridker PM, Maggioni AP, Tavazzi L, Ray KK, Seshasai SR, Manson JE, Price JF, Whincup PH, Morris RW, Lawlor DA, Smith GD, Ben-Shlomo Y, Schreiner PJ, Fornage M, Siscovick DS, Cushman M, Kumari M, Wareham NJ, Verschuren WM, Redline S, Patel SR, Whittaker JC, Hamsten A, Delaney JA, Dale C, Gaunt TR, Wong A, Kuh D, Hardy R, Kathiresan S, Castillo BA, van der Harst P, Brunner EJ, Tybjaerg-Hansen A, Marmot MG, Krauss RM, Tsai M, Coresh J, Hoogeveen RC, Psaty BM, Lange LA, Hakonarson H, Dudbridge F, Humphries SE, Talmud PJ, Kivimäki M, Timpson NJ, Langenberg C, Asselbergs FW, Voevoda M, Bobak M, Pikhart H, Wilson JG, Reiner AP, Keating BJ, Hingorani AD, Sattar N. HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials. Lancet. 2015 Jan 24;385(9965):351-61. doi: 10.1016/S0140-6736(14)61183-1. Epub 2014 Sep 24.
Smith CJ, Ryckman KK, Barnabei VM, Howard BV, Isasi CR, Sarto GE, Tom SE, Van Horn LV, Wallace RB, Robinson JG. The impact of birth weight on cardiovascular disease risk in the Women's Health Initiative. Nutr Metab Cardiovasc Dis. 2015 Nov 18. pii: S0939-4753(15)30006-5. doi: 10.1016/j.numecd.2015.10.015. [Epub ahead of print]
Newman AB, Avilés-Santa ML, Anderson G, Heiss G, Howard WJ, Krucoff M, Kuller LH, Lewis CE, Robinson JG, Taylor H, Treviño RP, Weintraub W. Embedding clinical interventions into observational studies. Contemp Clin Trials. 2016 Jan;46:100-5. doi: 10.1016/j.cct.2015.11.017. Epub 2015 Dec 2.
Robinson JG, Heistad DD, Fox KA. Atherosclerosis stabilization with PCSK-9 inhibition: An evolving concept for cardiovascular prevention. Atherosclerosis. 2015 Dec;243(2):593-7. doi: 10.1016/j.atherosclerosis.2015.10.023. Epub 2015 Oct 23.
Navar AM, Wang TY, Goldberg AC, Robinson JG, Roger VL, Wilson PF, Virani SS, Elassal J, Lee LV, Webb LE, Peterson E. Design and rationale for the Patient and Provider Assessment of Lipid Management (PALM) registry. Am Heart J. 2015 Nov;170(5):865-71. doi: 10.1016/j.ahj.2015.08.002. Epub 2015 Aug 7.
Shantha GP, Robinson JG. Emerging innovative therapeutic approaches targeting PCSK9 to lower lipids. Clin Pharmacol Ther. 2015 Oct 22. doi: 10.1002/cpt.281. [Epub ahead of print]
Foraker RE, Abdel-Rasoul M, Kuller LH, Jackson RD, Van Horn L, Seguin RA, Safford MM, Wallace RB, Kucharska-Newton AM, Robinson JG, Martin LW, Agha G, Hou L, Allen NB, Tindle HA. Cardiovascular Health and Incident Cardiovascular Disease and Cancer: The Women's Health Initiative. Am J Prev Med. 2015 Oct 8. pii: S0749-3797(15)00482-1. doi: 10.1016/j.amepre.2015.07.039. [Epub ahead of print]
Millen AE, Meyers KJ, Liu Z, Engelman CD, Wallace RB, LeBlanc ES, Tinker LF, Iyengar SK, Robinson JG, Sarto GE, Mares JA. Association Between Vitamin D Status and Age-Related Macular Degeneration by Genetic Risk. JAMA Ophthalmol. 2015 Oct 1;133(10):1171-9. doi: 10.1001/jamaophthalmol.2015.2715.
Robinson JG, Kastelein JJ. PCSK9 Inhibitors and Cardiovascular Events. N Engl J Med. 2015 Aug 20;373(8):774. doi: 10.1056/NEJMc1508222.
Smith CJ, Saftlas AF, Spracklen CN, Triche EW, Bjonnes A, Keating B, Saxena R, Breheny PJ, Dewan AT, Robinson JG, Hoh J, Ryckman KK. Genetic Risk Score for Essential Hypertension and Risk of Preeclampsia. Am J Hypertens. 2016 Jan;29(1):17-24. doi: 10.1093/ajh/hpv069. Epub 2015 May 23.
Isaac Samuel, MD:
Saurabh S, Smith JK, Pedersen M, Jose P, Nau P, Samuel I. Scheduled intravenous acetaminophen reduces postoperative narcotic analgesic demand and requirement after laparoscopic Roux-en-Y gastric bypass. Surg Obes Relat Dis. 2015 Mar-Apr;11(2):424-30. doi: 10.1016/j.soard.2014.09.017. Epub 2014 Sep 30.
Patrick Schlievert, PhD:
Merriman JA, Klingelhutz AJ, Diekema DJ, Leung DY, Schlievert PM. Novel Staphylococcus aureus Secreted Protein Alters Keratinocyte Proliferation and Elicits a Proinflammatory Response In Vitro and In Vivo. Biochemistry. 2015 Aug 11;54(31):4855-62. doi: 10.1021/acs.biochem.5b00523. Epub 2015 Jul 28
Stach CS, Vu BG, Schlievert PM. Determining the Presence of Superantigens in Coagulase Negative Staphylococci from Humans. PLoS One. 2015 Nov 23;10(11):e0143341. doi: 10.1371/journal.pone.0143341. eCollection 2015.
Mueller EA, Schlievert PM. Non-aqueous glycerol monolaurate gel exhibits antibacterial and anti-biofilm activity against Gram-positive and Gram-negative pathogens. PLoS One. 2015 Mar 23;10(3):e0120280. doi: 10.1371/journal.pone.0120280. eCollection 2015.
Thomas Scholz, MD:
Sandgren J, Scholz TD, Segar JL. ANGIOTENSIN II MODULATION OF CARDIAC GROWTH AND REMODELING IN IMMATURE FETAL SHEEP. Am J Physiol Regul Integr Comp Physiol. 2015 Mar 25:ajpregu.00034.2015. doi: 10.1152/ajpregu.00034.2015. [Epub ahead of print]
Val Sheffield, MD, PhD:
Haziza S, Magnani R, Lan D, Keinan O, Saada A, Hershkovitz E, Yanay N, Cohen Y, Nevo Y, Houtz RL, Sheffield VC, Golan H, Parvari R. Calmodulin Methyltransferase Is Required for Growth, Muscle Strength, Somatosensory Development and Brain Function. PLoS Genet. 2015 Aug 6;11(8):e1005388. doi: 10.1371/journal.pgen.1005388. eCollection 2015.
Goodman CW, Major HJ, Walls WD, Sheffield VC, Casavant TL, Darbro BW. CNV-ROC: A cost effective, computer-aided analytical performance evaluator of chromosomal microarrays. J Biomed Inform. 2015 Apr;54:106-13. doi: 10.1016/j.jbi.2015.01.001. Epub 2015 Jan 13.
Muhammad E, Levitas A, Singh SR, Braiman A, Ofir R, Etzion S, Sheffield VC, Etzion Y, Carrier L, Parvari R. PLEKHM2 mutation leads to abnormal localization of lysosomes, impaired autophagy flux and associates with recessive dilated cardiomyopathy and left ventricular noncompaction. Hum Mol Genet. 2015 Dec 20;24(25):7227-40. doi: 10.1093/hmg/ddv423. Epub 2015 Oct 12.
Datta P, Allamargot C, Hudson JS, Andersen EK, Bhattarai S, Drack AV, Sheffield VC, Seo S. Accumulation of non-outer segment proteins in the outer segment underlies photoreceptor degeneration in Bardet-Biedl syndrome. Proc Natl Acad Sci U S A. 2015 Aug 11;112(32):E4400-9. doi: 10.1073/pnas.1510111112. Epub 2015 Jul 27.
Curt Sigmund, PhD:
Jo F, Jo H, Hilzendeger AM, Thompson AP, Cassell MD, Rutkowski DT, Davisson RL, Grobe JL, Sigmund CD. Brain Endoplasmic Reticulum Stress Mechanistically Distinguishes the Saline-Intake and Hypertensive Response to Deoxycorticosterone Acetate-Salt. Hypertension. 2015 Apr 20. pii: HYPERTENSIONAHA.115.05377.
David M. Hasan, Robert M. Starke, He Gu, Katina Wilson, Yi Chu, Nohra Chalouhi, Donald D. Heistad, Frank M. Faraci, Curt D. Sigmund. Smooth Muscle Peroxisome Proliferator-Activated Receptor ү Plays a Critical Role in Formation and Rupture of Cerebral Aneurysms in Mice In Vivo. Hypertension, Published online before print, April 27, 2015
Jin H, Gebska MA, Blokhin IO, Wilson KM, Ketsawatsomkron P, Chauhan AK, Keen HL, Sigmund CD, Lentz SR. Endothelial PPAR-γ Protects Against Vascular Thrombosis by Downregulating P-Selectin Expression. Arterioscler Thromb Vasc Biol. 2015 Apr;35(4):838-44. doi: 10.1161/ATVBAHA.115.305378. Epub 2015 Feb 12.
De Silva TM, Ketsawatsomkron P, Pelham C, Sigmund CD, Faraci FM. Genetic interference with peroxisome proliferator-activated receptor γ in smooth muscle enhances myogenic tone in the cerebrovasculature via A Rho kinase-dependent mechanism. Hypertension. 2015 Feb;65(2):345-51. doi: 10.1161/HYPERTENSIONAHA.114.04541. Epub 2014 Nov 10.
Sequeira-Lopez ML, Nagalakshmi VK, Li M, Sigmund CD, Gomez RA. Vascular versus tubular renin: role in kidney development. Am J Physiol Regul Integr Comp Physiol. 2015 Sep 15;309(6):R650-7. doi: 10.1152/ajpregu.00313.2015. Epub 2015 Aug 5.
Ibeawuchi SR, Agbor LN, Quelle FW, Sigmund CD. Hypertension-causing Mutations in Cullin3 Protein Impair RhoA Protein Ubiquitination and Augment the Association with Substrate Adaptors. J Biol Chem. 2015 Jul 31;290(31):19208-17. doi: 10.1074/jbc.M115.645358. Epub 2015 Jun 22.
Santillan MK, Pelham CJ, Ketsawatsomkron P, Santillan DA, Davis DR, Devor EJ, Gibson-Corley KN, Scroggins SM, Grobe JL, Yang B, Hunter SK, Sigmund CD. Pregnant mice lacking indoleamine 2,3-dioxygenase exhibit preeclampsia phenotypes. Physiol Rep. 2015 Jan 19;3(1). pii: e12257. doi: 10.14814/phy2.12257. Print 2015 Jan 1.
Coble JP, Grobe JL, Johnson AK, Sigmund CD. Mechanisms of brain renin angiotensin system-induced drinking and blood pressure: importance of the subfornical organ. Am J Physiol Regul Integr Comp Physiol. 2015 Feb 15;308(4):R238-49. doi: 10.1152/ajpregu.00486.2014. Epub 2014 Dec 17.
Ketsawatsomkron P, Keen HL, Davis DR, Lu KT, Stump M, De Silva TM, Hilzendeger AM, Grobe JL, Faraci FM, Sigmund CD. Protective Role for Tissue Inhibitor of Metalloproteinase-4, a Novel Peroxisome Proliferator-Activated Receptor-γ Target Gene, in Smooth Muscle in Deoxycorticosterone Acetate-Salt Hypertension. Hypertension. 2016 Jan;67(1):214-22. doi: 10.1161/HYPERTENSIONAHA.115.06391. Epub 2015 Nov 23.
Hu C, Lu KT, Mukohda M, Davis DR, Faraci FM, Sigmund CD. Interference with PPARγ in Endothelium Accelerates Angiotensin II-induced Endothelial Dysfunction. Physiol Genomics. 2015 Nov 3:physiolgenomics.00087.2015. doi: 10.1152/physiolgenomics.00087.2015. [Epub ahead of print]
Mukohda M, Stump M, Ketsawatsomkron P, Hu C, Quelle FW, Sigmund CD. Endothelial PPARγ Provides Vascular Protection from IL-1β-Induced Oxidative Stress. Am J Physiol Heart Circ Physiol. 2015 Nov 13:ajpheart.00490.2015. doi: 10.1152/ajpheart.00490.2015. [Epub ahead of print]
Stump M, Mukohda M, Hu C, Sigmund CD. PPARγ Regulation in Hypertension and Metabolic Syndrome. Curr Hypertens Rep. 2015 Dec;17(12):89. doi: 10.1007/s11906-015-0601-x.
William Sivitz, MD:
Suneja M, Fox DK, Herlein JA, Adams CM, Sivitz WI. Evidence for metabolic aberrations in asymptomatic persons with type 2 diabetes after initiation of simvastatin therapy. Translational Research, Available online 27 January 2015 In Press, Accepted Manuscript.
Yu L, Fink BD, Sivitz WI. Simultaneous quantification of mitochondrial ATP and ROS production. Methods Mol Biol. 2015;1264:149-59. doi: 10.1007/978-1-4939-2257-4_14.
Linda Snetselaar, RD, PhD:
Resnicow K, McMaster F, Bocian A, Harris D, Zhou Y, Snetselaar L, Schwartz R, Myers E, Gotlieb J, Foster J, Hollinger D, Smith K, Woolford S, Mueller D, Wasserman RC. Motivational Interviewing and Dietary Counseling for Obesity in Primary Care: An RCT. Pediatrics. 2015 Apr;135(4):649-57. doi: 10.1542/peds.2014-1880.
Aitaoto N, Campo S, Snetselaar LG, Janz KF, Farris KB, Parker E, Belyeu-Camacho T, Jimenez RP. Formative Research to Inform Nutrition Interventions in Chuuk and the US Pacific. J Acad Nutr Diet. 2015 Jan 26. pii: S2212-2672(14)01765-1. doi: 10.1016/j.jand.2014.11.018. [Epub ahead of print]
Vyas A, Rubenstein L, Robinson J, Seguin RA, Vitolins MZ, Kazlauskaite R, Shikany JM, Johnson KC, Snetselaar L, Wallace R. Diet drink consumption and the risk of cardiovascular events: a report from the Women's Health Initiative. J Gen Intern Med. 2015 Apr;30(4):462-8. doi: 10.1007/s11606-014-3098-0. Epub 2014 Dec 17.
Jones JA, Hartman TJ, Klifa CS, Coffman DL, Mitchell DC, Vernarelli JA, Snetselaar LG, Van Horn L, Stevens VJ, Robson AM, Himes JH, Shepherd JA, Dorgan JF. Dietary energy density is positively associated with breast density among young women. J Acad Nutr Diet. 2015 Mar;115(3):353-9. doi: 10.1016/j.jand.2014.08.015. Epub 2014 Oct 7.
Zhang N, Campo S, Yang J, Janz KF, Snetselaar LG, Eckler P. Effects of Social Support About Physical Activity on Social Networking Sites: Applying the Theory of Planned Behavior. Health Commun. 2015;30(12):1277-85. doi: 10.1080/10410236.2014.940669. Epub 2015 Jun 18.
Peter Snyder, MD:
Butler PL, Staruschenko A, Snyder PM. Acetylation Stimulates the Epithelial Sodium Channel by Reducing Its Ubiquitination and Degradation. J Biol Chem. 2015 Mar 18. pii: jbc.M114.635540. [Epub ahead of print]
Elliott Sohn, MD:
Zeng S, Whitmore SS, Sohn EH, Riker MJ, Wiley LA, Scheetz TE, Stone EM, Tucker BA, Mullins RF. Molecular Response of Chorioretinal Endothelial Cells to Complement Injury: Implications for Macular Degeneration. J Pathol. 2015 Nov 13. doi: 10.1002/path.4669. [Epub ahead of print]
Chin EK, Almeida DR, Sohn EH. Sustained and expedited resolution of diabetic papillopathy with combined PRP and bevacizumab. Can J Ophthalmol. 2015 Oct;50(5):e88-91. doi: 10.1016/j.jcjo.2015.05.020.
Sohn EH, Jiao C, Kaalberg E, Cranston C, Mullins RF, Stone EM, Tucker BA. Allogenic iPSC-derived RPE cell transplants induce immune response in pigs: a pilot study. Sci Rep. 2015 Jul 3;5:11791. doi: 10.1038/srep11791.
Long-Sheng Song, MD:
Takeshima H, Hoshijima M, Song LS. Ca2+ microdomains organized by junctophilins. Cell Calcium. 2015 Jan 25. pii: S0143-4160(15)00018-4. doi: 10.1016/j.ceca.2015.01.007. [Epub ahead of print]
Wu Y, Rasmussen TP, Koval OM, Joiner ML, Hall DD, Chen B, Luczak ED, Wang Q, Rokita AG, Wehrens XH, Song LS, Anderson ME. The mitochondrial uniporter controls fight or flight heart rate increases. Nat Commun. 2015 Jan 20;6:6081. doi: 10.1038/ncomms7081.
Zhang W, Qu X, Chen B, Snyder M, Wang M, Li B, Tang Y, Chen H, Zhu W, Zhan L, Yin N, Li D, Li X, Liu Y, Zhang JJ, Fu XY, Rubart M, Song LS, Huang XY, Shou W. Critical Roles of STAT3 in β-Adrenergic Functions in the Heart. Circulation. 2015 Dec 1. pii: CIRCULATIONAHA.115.017472. [Epub ahead of print]
Chen B, Zhang C, Guo A, Song LS. In situ single photon confocal imaging of cardiomyocyte T-tubule system from Langendorff-perfused hearts. Front Physiol. 2015 May 6;6:134. doi: 10.3389/fphys.2015.00134. eCollection 2015.
Milan Sonka, PhD:
Shi F, Chen X, Zhao H, Zhu W, Xiang D, Gao E, Sonka M, Chen H. Automated 3-D retinal layer segmentation of macular optical coherence tomography images with serous pigment epithelial detachments. IEEE Trans Med Imaging. 2015 Feb;34(2):441-52. doi: 10.1109/TMI.2014.2359980. Epub 2014 Sep 24.
Chen H, Chen X, Qiu Z, Xiang D, Chen W, Shi F, Zheng J, Zhu W, Sonka M. Quantitative analysis of retinal layers' optical intensities on 3D optical coherence tomography for central retinal artery occlusion. Sci Rep. 2015 Mar 18;5:9269. doi: 10.1038/srep09269.
Almeida DR, Zhang L, Chin EK, Mullins RF, Kucukevcilioglu M, Critser DB, Sonka M, Stone EM, Folk JC, Abràmoff MD, Russell SR. Comparison of retinal and choriocapillaris thicknesses following sitting to supine transition in healthy individuals and patients with age-related macular degeneration. JAMA Ophthalmol. 2015 Mar;133(3):297-303. doi: 10.1001/jamaophthalmol.2014.5168.
Douglas Spitz, PhD:
Li L, Fath MA, Scarbrough PM, Watson WH, Spitz DR. Combined inhibition of glycolysis, the pentose cycle, and thioredoxin metabolism selectively increases cytotoxicity and oxidative stress in human breast and prostate cancer. Redox Biol. 2015;4:127-35. doi: 10.1016/j.redox.2014.12.001. Epub 2014 Dec 10.
Du J, Cieslak JA 3rd, Welsh JL, Sibenaller ZA, Allen BG, Wagner BA, Kalen AL, Doskey CM, Strother RK, Button AM, Mott SL, Smith B, Tsai S, Mezhir J, Goswami PC, Spitz DR, Buettner GR, Cullen JJ. Pharmacological Ascorbate Radiosensitizes Pancreatic Cancer. Cancer Res. 2015 Aug 15;75(16):3314-26. doi: 10.1158/0008-5472.CAN-14-1707. Epub 2015 Jun 16.
Stefan Strack, PhD:
Jin Z, Chung JW, Mei W, Strack S, He C, Lau GW, Yang J. Regulation of nuclear-cytoplasmic shuttling and function of Family with sequence similarity 13, member A (Fam13a), by B56-containing PP2As and Akt. Mol Biol Cell. 2015 Mar 15;26(6):1160-73. doi: 10.1091/mbc.E14-08-1276. Epub 2015 Jan 21.
Michael Tansey, MD:
Mauras N, Mazaika P, Buckingham B, Weinzimer S, White NH, Tsalikian E, Hershey T, Cato A, Cheng P, Kollman C, Beck RW, Ruedy K, Aye T, Fox L, Arbelaez AM, Wilson D, Tansey M, Tamborlane W, Peng D, Marzelli M, Winer KK, Reiss AL; Diabetes Research in Children Network (DirecNet). Longitudinal assessment of neuroanatomical and cognitive differences in young children with type 1 diabetes: association with hyperglycemia. Diabetes. 2015 May;64(5):1770-9. doi: 10.2337/db14-1445. Epub 2014 Dec 8.
Mazaika PK, Weinzimer SA, Mauras N, Buckingham B, White NH, Tsalikian E, Hershey T, Cato A, Aye T, Fox L, Wilson DM, Tansey M, Tamborlane W, Peng D, Raman M, Marzelli M, Reiss AL; Diabetes Research in Children Network. Variations in brain volume and growth in young children with type 1 diabetes. Diabetes. 2015 Oct 28. pii: db151242. [Epub ahead of print]
Eva Tsalikian, MD:
Mauras N, Mazaika P, Buckingham B, Weinzimer S, White NH, Tsalikian E, Hershey T, Cato A, Cheng P, Kollman C, Beck RW, Ruedy K, Aye T, Fox L, Arbelaez AM, Wilson D, Tansey M, Tamborlane W, Peng D, Marzelli M, Winer KK, Reiss AL; Diabetes Research in Children Network (DirecNet). Longitudinal assessment of neuroanatomical and cognitive differences in young children with type 1 diabetes: association with hyperglycemia. Diabetes. 2015 May;64(5):1770-9. doi: 10.2337/db14-1445. Epub 2014 Dec 8.
Francis SL, Singhvi A, Tsalikian E, Tansey MJ, Janz KF. Cross-Validation of Single-Stage Treadmill Tests for Predicting Aerobic Fitness in Adolescents with Type I Diabetes. Pediatr Exerc Sci. 2015 Aug;27(3):396-403. doi: 10.1123/pes.2014-0146. Epub 2015 Jul 17.
Clements MA, Foster NC, Maahs DM, Schatz DA, Olson BA, Tsalikian E, Lee JM, Burt-Solorzano CM, Tamborlane WV, Chen V, Miller KM, Beck RW; T1D Exchange Clinic Network. Hemoglobin A1c (HbA1c) changes over time among adolescent and young adult participants in the T1D exchange clinic registry. Pediatr Diabetes. 2015 Jul 8. doi: 10.1111/pedi.12295. [Epub ahead of print]
Andrea Wallace, PhD, RN:
Wallace AS, Driessnack M, Bohr N, Tripp-Reimer T. Diabetes self-management: using the Colored Eco-Genetic Relationship Map to assess social support. Nurs Res. 2015 Mar-Apr;64(2):111-6. doi: 10.1097/NNR.0000000000000074.
Michael Welsh, MD:
Seaman WE, Locksley RM, Welsh MJ. New blood: Creative funding of disease-specific research. Sci Transl Med. 2015 May 20;7(288):288ed5. doi: 10.1126/scitranslmed.aaa9513
Ling Yang, PhD:
Yang L, Calay ES, Fan J, Arduini A, Kunz RC, Gygi SP, Yalcin A, Fu S, Hotamisligil GS. S-Nitrosylation links obesity-associated inflammation to endoplasmic reticulum dysfunction. Science. 2015 Jul 31;349(6247):500-506.
Mark Yorek, PhD:
Shevalye H, Yorek MS, Coppey LJ, Holmes A, Harper MM, Kardon RH, Yorek MA. Effect of enriching the diet with menhaden oil or daily treatment with resolvin D1 on neuropathy in a mouse model of type 2 diabetes. J Neurophysiol. 2015 Apr 29:jn.00224.2015. doi: 10.1152/jn.00224.2015. [Epub ahead of print]
Yorek MS, Obrosov A, Shevalye H, Holmes A, Harper MM, Kardon RH, Yorek MA. Effect of diet induced obesity or type 1 or type 2 diabetes on corneal nerves and peripheral neuropathy in C57Bl/6J mice. J Peripher Nerv Syst. 2015 Apr 10. doi: 10.1111/jns.12111. [Epub ahead of print]
Coppey LJ, Davidson EP, Obrosov A, Yorek MA. Enriching the diet with menhaden oil improves peripheral neuropathy in streptozotocin-induced type 1 diabetic rats. J Neurophysiol. 2015 Feb 1;113(3):701-8. doi: 10.1152/jn.00718.2014. Epub 2014 Nov 5.
Dominguez JM 2nd, Yorek MA, Grant MB. Combination therapies prevent the neuropathic, proinflammatory characteristics of bone marrow in streptozotocin-induced diabetic rats. Diabetes. 2015 Feb;64(2):643-53. doi: 10.2337/db14-0433. Epub 2014 Sep 9.
Eric P. Davidson, Lawrence J. Coppey, Amey Holmes, Sergey Lupachyk, Brian L. Dake, Christine L. Oltman, Richard G. Peterson, and Mark A. Yorek. Characterization of Diabetic Neuropathy in the Zucker Diabetic Sprague-Dawley Rat: A New Animal Model for Type 2 Diabetes. J Diabetes Res. 2014; 2014: 714273.
Davidson EP, Holmes A, Coppey LJ, Yorek MA. Effect of combination therapy consisting of enalapril, α-lipoic acid, and menhaden oil on diabetic neuropathy in a high fat/low dose streptozotocin treated rat. Eur J Pharmacol. 2015 Aug 18;765:258-267. doi: 10.1016/j.ejphar.2015.08.015. [Epub ahead of print]
Holmes A, Coppey LJ, Davidson EP, Yorek MA. Rat Models of Diet-Induced Obesity and High Fat/Low Dose Streptozotocin Type 2 Diabetes: Effect of Reversal of High Fat Diet Compared to Treatment with Enalapril or Menhaden Oil on Glucose Utilization and Neuropathic Endpoints. J Diabetes Res. 2015;2015:307285. doi: 10.1155/2015/307285. Epub 2015 Jul 2.
Yorek MA. Vascular Impairment of Epineurial Arterioles of the Sciatic Nerve: Implications for Diabetic Peripheral Neuropathy. Rev Diabet Stud. 2015 Spring-Summer;12(1-2):13-28. doi: 10.1900/RDS.2015.12.13. Epub 2015 Aug 10.
Joseph Zabner, MD:
Chang EH, Zabner J. Precision Genomic Medicine in Cystic Fibrosis. Clin Transl Sci. 2015 Oct;8(5):606-10. doi: 10.1111/cts.12292. Epub 2015 Jun 15.
Nicholas Zavazava, MD, PhD:
Raikwar SP, Kim EM, Sivitz WI, Allamargot C, Thedens DR, Zavazava N. Human iPS Cell-Derived Insulin Producing Cells Form Vascularized Organoids under the Kidney Capsules of Diabetic Mice. PLoS One. 2015 Jan 28;10(1):e0116582. doi: 10.1371/journal.pone.0116582. eCollection 2015.
Gray LR, Sultana MR, Rauckhorst AJ, Oonthonpan L, Tompkins SC, Sharma A, Fu X, Miao R, Pewa AD, Brown KS, Lane EE, Dohlman A, Zepeda-Orozco D, Xie J, Rutter J, Norris AW, Cox JE, Burgess SC, Potthoff MJ, Taylor EB. Hepatic Mitochondrial Pyruvate Carrier 1 Is Required for Efficient Regulation of Gluconeogenesis and Whole-Body Glucose Homeostasis. Cell Metab. 2015 Sep 2. pii: S1550-4131(15)00390-3. doi: 10.1016/j.cmet.2015.07.027. [Epub ahead of print]
Zepeda-Orozco D, Kong M, Scheuermann RH. Molecular Profile of Mitochondrial Dysfunction in Kidney Transplant Biopsies Is Associated With Poor Allograft Outcome. Transplant Proc. 2015 Jul-Aug;47(6):1675-82. doi: 10.1016/j.transproceed.2015.04.086.
Rauhauser AA, Ren C, Lu D, Li B, Zhu J, McEnery K, Vadnagara K, Zepeda-Orozco D, Zhou XJ, Lin F, Jetten AM, Attanasio M. Hedgehog signaling indirectly affects tubular cell survival after obstructive kidney injury. Am J Physiol Renal Physiol. 2015 Nov 1;309(9):F770-8. doi: 10.1152/ajprenal.00232.2015. Epub 2015 Aug 19.
Denice Zingman, MD:
Koganti SR, Zhu Z, Subbotina E, Gao Z, Sierra A, Proenza M, Yang L, Alekseev A, Hodgson-Zingman D, Zingman L. Disruption of KATP channel expression in skeletal muscle by targeted oligonucleotide delivery promotes activity-linked thermogenesis. Mol Ther. 2015 Feb 4. doi: 10.1038/mt.2015.21. [Epub ahead of print]
Leonid Zingman, MD:
Koganti SR, Zhu Z, Subbotina E, Gao Z, Sierra A, Proenza M, Yang L, Alekseev A, Hodgson-Zingman D, Zingman L. Disruption of KATP channel expression in skeletal muscle by targeted oligonucleotide delivery promotes activity-linked thermogenesis. Mol Ther. 2015 Feb 4. doi: 10.1038/mt.2015.21. [Epub ahead of print]
Rasmussen TP, Wu Y, Joiner MA, Koval OM, Wilson NR, Luczak ED, Wang Q, Chen B, Gao Z, Zhu Z, Wagner BA, Soto J, McCormick ML, Kutschke W, Weiss RM, Yu L, Boudreau RL, Abel ED, Zhan F, Spitz DR, Buettner GR, Song LS, Zingman LV, Anderson ME. Inhibition of MCU forces extramitochondrial adaptations governing physiological and pathological stress responses in heart. Proc Natl Acad Sci U S A. 2015 Jul 7. pii: 201504705. [Epub ahead of print]
Subbotina E, Sierra A, Zhu Z, Gao Z, Koganti SR, Reyes S, Stepniak E, Walsh SA, Acevedo MR, Perez-Terzic CM, Hodgson-Zingman DM, Zingman LV. Musclin is an activity-stimulated myokine that enhances physical endurance. Proc Natl Acad Sci U S A. 2015 Dec 29;112(52):16042-7. doi: 10.1073/pnas.1514250112. Epub 2015 Dec 14.
Subbotina E, Koganti SR, Hodgson-Zingman D, Zingman LV. Morpholino-driven gene editing: A new horizon for disease treatment and prevention. Clin Pharmacol Ther. 2015 Oct 16. doi: 10.1002/cpt.276. [Epub ahead of print]