Kaikobad Irani, MD

Contact Information

Office: 2256 CBRB
Phone: 319-335-3861
Faculty Profile  

Brief description of current research:

One of the principal manifestations of diabetes is micro- and macrovascular dysfunction. The endothelium, which is crucial for a healthy vasculature, is “damaged” in diabetes. Our laboratory tries to understand the molecular bases for this damage.

3 most influential diabetes/obesity/metabolism publications:

  • Mattagaiasingh I, Kim CD, Naqvi A, Yamamori T, Hoffman TA, Jung SB, DeRicco J, Kasuno K, Irani K. SIRT1 promotes endothelium-dependent vascular relaxation by activating endothelial nitric oxide synthase. Proc Natl Acad Sci USA 2007 Sep 11:104(37):14855-60. Epub 2007 Sep 4.
  •  Jung SB, Kim CS, Naqvi A, Yamamori T, Mattagajasingh I, Hoffman TA, Cole MP, Kumar A, Dericco JS, Jeon BH, Irani K. Histone deacetylase 3 antagonizes aspirin-stimulated endothelial nitric oxide production by reversing aspirin-induced lysine acetylation of endothelial nitric oxide synthase. Cir Res 2010 Oct 1:107(7):877-87. Doi: 10.1161/CIRCRESAHA 110.222968. Epub 2010 Aug 12.
  •  Wang JM, Tao J, Chen DD, Cai JJ, Irani K, Wang Q, Yuan H, Chen AF. MicroRNA miR-27b rescues bone marrow-derived angiogenic cell function and accelerates wound healing in type 2 diabetes mellitus. Arterioscler Thromb Vasc Biol. 2014 Jan:34(1):99-109. Doe: 10.1161/ATVBAHA. 113.302104 Epub 2013.