Logo for University of Iowa Health Care This logo represents the University of Iowa Health Care

Allyn Mark, MD

Contact Information

Faculty Profile

Brief description of current research:

Dr. Mark's research has addressed brain control of the sympathetic nervous system and its role in physiologic and pathologic states, including obesity and the metabolic syndrome.  His research has focused on mechanisms of obesity-induced hypertension, including the sympathetic actions of leptin and the concept introduced in his laboratory of selective leptin resistance in obese states.  In 2017, Dr. Mark received the Excellence Award in Hypertension Research from the American Heart Association Council on Hypertension.  In 2011, Dr. Mark and Dr. Charles Brenner founded and now co-direct the UI Obesity Research and Education Initiative that interacts and partners extensively with the FOEDRC.

3 most influential diabetes/obesity/metabolism publications:

  • Ribeiro AC, Ceccarini G, Dupre C, Friedman JM, Pfaff DW, Mark AL.  Contrasting Effects of Leptin on Food Anticipatory and Total Locomotor Activity.  PLoS One 6: e23364, 2011.  (*Ribeiro and Ceccarini are co-first authors). PMC3154408
  • Hilzendeger AM, Morgan DA, Brooks L, Dellsperger D, Liu X, GrobeJL, Rahmouni K, Sigmund CD, Mark AL.  A Brain Leptin-Renin Angiotensin System Interaction in the Regulation of Sympathetic Nerve Activity.  Am J Physiol: Heart Circ Physiol, 303:H197-H206,2012. (Featured article in this issue.)  PMC3404702
  • Mark AL. Selective Leptin Resistance Revisited.  Carl Ludwig Distinguished Lectureship Award 2011. Am J Physiol: Regul Integr Comp Physiol. 2013; 305: R566-R581.