FOEDRC Member Justin Grobe Publishes Work Linking Blood Pressure Regulation with Metabolism and Obesity

FOEDRC Member Dr. Justin Grobe New recently published research findings explaining how a hormone system involved in high blood pressure and cardiovascular disease can also lower metabolism and promote obesity.

The renin-angiotensin system (RAS) controls blood pressure and is important for cardiovascular health. Many of the drugs used to treat hypertension and heart failure block or inhibit the RAS. Increasing evidence suggests the RAS also plays a role in controlling energy balance and metabolic rate and therefore may be important in obesity. But, depending on where in the body this hormone system is operating, it can have opposing effects on weight gain. When the RAS is elevated in the brain, it increases energy expenditure by increasing resting metabolism, resulting in weight loss. However, increased activity of the RAS circulating in the body (the peripheral RAS)—which occurs during obesity in humans and experimental animals—has the opposite effect, decreasing resting metabolism and increasing weight gain. The study adds another piece to the puzzle regarding why many individuals with high blood pressure might also be obese. The insights from these studies have the potential to target therapies simultaneously to both conditions. The work was published in the Journal Cell Reports.

Monday, August 8, 2016