Full proposals should be submitted electronically as a single PDF to jonathan-t-thomas@uiowa.edu by the above deadline. Full proposal content differs for catalyst versus seed grants, as follows.

1. Cover Page. File Please use this template, and include a title, PI(s) and Co-PI(s), contact information and the total budget requested. Budgets for Catalyst Grants are limited to up to $100,000 for up to two years ($50,000/year). Budgets for Seed Grants are limited to a single, nonrenewable award of up to $5,000.

2. Abstract. This section should provide a summary of the project. Not to exceed 1/2 page.

3. Biosketch. Current NIH biosketch for the PI(s).

4. Response to review of prior P&F submission, if applicable. Up to one paragraph.

5. Research Plan. This section should include a full description of the study, including Background, Hypothesis/Specific Aims, Prior Work Summary (previous work on this project), Experimental Plan (including sex as a biological variable), Timeline (describing when project goals will be completed), and References. Not to exceed 6 pages

6. Current and Pending funding for the PI(s)

7. Budget. Budgets should be framed within NIH guidelines and allowances. Indirect costs will not be allowed. Direct costs that are eligible include all allowable NIH costs, with the exception that faculty salary requests will not be supported. All other

calculations for equipment, patient care costs, supplies, animal costs etc., should be handled consistent with NIH policies.

8. Letter of support (1 page maximum per letter) if needed to signify availability of core services or resources.

1. Abstract. This section should provide a summary of the project. Not to exceed 1/2 page.

2. Biosketch. Current NIH biosketch for the PI(s).

3. Proposal, Outcomes, and Importance: a description of the new objective proposed, the expected outcomes, and overall importance. Not to not exceed 1 page.

4. Timeline and Budget. This section should describe the goals to be completed within 6 months. Note that Seed Grants are not designed to support ongoing projects, therefore no salary support is allowed. Not to not exceed 1 page.

P&F applications should present a testable hypothesis, clearly delineate the question being asked, detail the procedures to be followed, and discuss how the data will be analyzed and lead to future studies. Emphasis is placed on how the research might lead to new research ideas or research funding. For junior investigators, additional considerations include how this award will impact their career and the potential of the applicant to compete for independent research funding in the future. Research track faculty MUST include a letter from their laboratory director or departmental chair describing how this award will serve in developing an independent research program and external research funding.

· Applications in all areas of diabetes and obesity research are eligible. Must advance the understanding or evaluate the natural history/mechanism, prevention, diagnosis or treatment of diabetes or obesity.

· A proposal may be resubmitted once. A description of the changes made from a prior application should be included as part of the application.

· Catalyst Grants are expected to result in a successful NIH application (e.g., R, P or U series) within two years of completion.

· Note that it is NOT necessary for the application to go through the Office of Sponsored Research prior to submission.

· Principal investigator(s) of funded projects will be required to provide a final report and an accounting of all funds expended at the completion of the project. A progress report will be required at the end of the first fiscal year. Further information about how to submit this information will follow upon receipt of award.

· Awarded funds from this mechanism cannot be transferred or spent at other institutions.

· A faculty member may apply for only one grant per cycle on which they would be a PI. There is no limitation to the number of grants on which a faculty member can participate as a collaborator.

· All applicants must be a member of the University of Iowa faculty.

· Past recipients are ineligible for five years from the completion of their P&F funding (7 years from start date of a two year P&F grant), and only applications in directions/areas distinct from their prior award will be considered. Seed grants, however, do not preclude subsequent Pilot and Feasibility awards in the same area in any time frame, provided strong progress has been made.

· FOEDRC faculty recruits are not eligible during the period of their receipt of FOEDRC startup support.

· P&F support is usually intended for early-stage faculty investigators, for investigators from other fields intending to bring their research expertise to a diabetes-relevant research area, for investigators currently working in the diabetes area whose proposed research would constitute a significantly new direction, and for clinical and basic researchers who propose a joint research project.