Robert Roghair, MD

Contact Information

Office: 1270 CBRB 
Phone: 319-335-9895 
Faculty Profile


Brief description of current research:

Over the past decade, my collaborators and I have investigated the developmental origins of adult disease. Epidemiological studies and animal models have shown individuals born in the face of nutritional deficiency reprogram their development to thrive in the face of adversity and are born small, but thrifty. When environmental conditions change, this early life adaptation becomes maladaptive, and abundant caloric intake leads to accelerated weight gain, obesity and diabetes. Unfortunately, attempts to constrain early growth recovery may be associated with impaired brain and kidney development, predisposing to a different set of adult diseases, including psychopathology and hypertension. We seek the identification of trophic factors that facilitate organ development without subjecting the individual to the harmful effects of global overnutrition.

3 most influential diabetes/obesity/metabolism publications:

  • Katkhuda R, Peterson ES, Roghair RD, Norris AW, Scholz TD, Segar JL. Sex-specific programming of hypertension in offspring of late-gestation diabetic rats. Pediatr Res. 2012;72:352-61. PMID:22805998
  • Kummet GJ, Haskell SE, Hermann GM, Ni C, Volk KA, Younes AK, Miller AK, Roghair RD. Neonatal SSRI Exposure Programs a Hypermetabolic State in Adult Mice. J Nutr Metab. 2012;2012:431574. PMID:22570769
  • Hermann GM, Dallas LM, Haskell SE, Roghair RD. Neonatal macrosomia is an independent risk factor for adult metabolic syndrome. Neonatology. 2010;98(3):238-44. PMID:20389129
  • Hermann GM, Miller RL, Erkonen GE, Dallas LM, Hsu E, Zhu V, Roghair RD. Neonatal catch up growth increases diabetes susceptibility but improves behavioral and cardiovascular outcomes of low birth weight male mice. Pediatr Res. 2009; 66:53-8. PMID:19342983
  • Segar EM, Norris AW, Yao JR, Hu S, Koppenhafer SL, Roghair RD, Segar JL, Scholz TD. Programming of growth, insulin resistance and vascular dysfunction in offspring of late gestation diabetic rats. Clin Sci (Lond). 2009 ;117:129-38. PMID:19203348

Quote:

“As we uncover ways to prevent the development of diabetes and obesity, we improve the health and happiness of our global community.”