Douglas Spitz, PhD

Contact Information

Office: B180-E ML 
Faculty Profile

Brief description of current research:

My lab continues to have interest in the role that metabolic oxidative stress plays in the pathogenesis of diabetes and obesity, insulin growth factor signaling and cancer biology, and the relationship of these phenomena to aging as well as radiation-induced normal tissue injury.

3 most influential diabetes/obesity/metabolism publications:

  • Superoxide Mediates Acute Liver Injury in Irradiated Mice Lacking Sirtuin 3. Coleman MC, Olivier AK, Jacobus JA, Mapuskar KA, Mao G, Martin SM, Riley DP, Gius D, Spitz DR. Antioxid Redox Signal. 2013 Sep 28. [Epub ahead of print] PMID:23919724[PubMed - as supplied by publisher]
  • Ketogenic diets enhance oxidative stress and radio-chemo-therapy responses in lung cancer xenografts. Allen BG, Bhatia SK, Buatti JM, Brandt KE, Lindholm KE, Button AM, Szweda LI, Smith BJ, Spitz DR, Fath MA. Clin Cancer Res. 2013 Jul 15;19(14):3905-13. doi: 10.1158/1078-0432.CCR-12-0287. Epub 2013 Jun 6. PMID:23743570[PubMed - in process]
  • Sirt3-mediated deacetylation of evolutionarily conserved lysine 122 regulates MnSOD activity in response to stress. Tao R, Coleman MC, Pennington JD, Ozden O, Park SH, Jiang H, Kim HS, Flynn CR, Hill S, Hayes McDonald W, Olivier AK, Spitz DR, Gius D. Mol Cell. 2010 Dec 22;40(6):893-904. doi: 10.1016/j.molcel.2010.12.013. PMID:21172655[PubMed - indexed for MEDLINE] Free PMC Article