Michael Welsh, MD

Contact Information:

Office: 6332 PBDB
Phone: 319-335-7619
Faculty Profile 

Brief description of current research:

My lab focuses on the biology of cystic fibrosis (CF) and the development of new treatments for the disease. I am interested in the actions of cystic fibrosis transmembrane conductance regulator (CFTR), the anion channel that is disrupted in CF, and how its loss influences the pathogenesis of CF. By middle age, over 50% of people with CF develop diabetes mellitus. Thus, CF provides significant opportunity for insight into diabetes pathogenesis.  


3 most influential diabetes/obesity/metabolism publications:

  • Rogan MP, Reznikov LR, Pezzulo AA, Gansemer ND, Samuel M, Prather RS, Zabner J, Fredericks DC, McCray PB Jr, Welsh MJ, and Stoltz DA. Pigs and Humans with Cystic Fibrosis have Reduced IGF-1 Levels at Birth. Proc. Natl. Acad. Sci. USA, 107(47):20576-20581, 2010. PMCID: PMC2996661.
  • Stoltz DA, Meyerholz DK, and Welsh MJ. Origins of Cystic Fibrosis Lung Disease. Review Article. New Eng. J. Med. 372:351-362, 2015. PMCID: 4916857.
  • Uc A, Olivier AK, Griffin MA, Meyerholz DK, Yao J, Abu-El-Haija M, Buchanan K, Vanegas Calderón OG, Abu-El-Jaija M, Pezzulo AA, Reznikov LR, Hoegger MJ, Rector MV, Ostedgaard LS, Taft PJ, Gansemer ND, Ludwig PS, Hornick EE, Stoltz DA, Ode KL, Welsh MJ, Engelhardt JF, and Norris AW. Glycemic Regulation and Insulin Secretion are Abnormal in Cystic Fibrosis Pigs Despite Sparing of Islet Cell Mass. Clin. Sci. 128(2):131-142, 2015. PMCID: PMC4346161.