Current Grants

Current Grants:

Larson-Ode, Katie, M.D.  Glucose Profile in the Home Setting in Young Children with Cystic Fibrosis

Li, Xiaopeng, Ph.D.  Role of disrupted ASL pH regulation in small airways in CF lung disease pathogenesis

Rosen, Bradley, D.O.  Mucin subtype regulation of epithelial inflammation in mucoobstructive lung disease

Voynow, Judith, M.D.  The Alarmin and RAGE axis: A Novel Therapeutic Target for CF

 


Past Grants: 

Banfi, Botond, Ph.D. Long Term Gene Expression by Epidermal Stem Cells

Cheng, Pi-Wan, Ph.D. Ciliated Cell-Specific Gene Transfer

Cornell, Robert, Ph.D. Generation of a Transgenic Zebrafish for Optimization of Gene Correction Methodologies

Davidson, Beverly, Ph.D. Retroviral Gene Transfer to Airway Epithelia with MMLV-based Vectors

Dagle, John M., Ph.D. Modified Antisense Oligonucleotides as Pseudomonas Antimicrobials

Duan, Dongsheng, Ph.D. Analysis of rAAV Integration Specificity

Dunnwald, Martine, Ph.D. Epidermal Stem Cells as a Gene Delivery System

Engelhardt, John F., Ph.D. Circular Intermediates of rAAV as Novel Gene Transfer Vectors

Fiegel, Jennifer, Ph.D. Development of LOS-Modified Nanoparticles for Improved Airway Epithelial Uptake

Grangrande, Paloma, Ph.D. RNA Aptamers for Cytoplasmic Delivery of Nucleic Acids

Green, Steven H., Ph.D. Gene Transfer into Spiral Ganglion Neurons in vivo

Harper, Scott, Ph.D. Autoregulated AAV Vectors for Inducible RNA Interference

Henry, Michael, Ph.D. Cellular Uptake and in vivo Pharmacodynamics of Cholesterol-siRNAs

Johnson, Alan, Ph.D. Targeted Modulation of Vasopressin in Brain Magnocellular Neurons by Adenovirus-Mediated Gene Therapy

Jones, Bradley, Ph.D. Gene Therapy for Phenylketonuria using an Adherent Bacterial Vector

Kang, Yubin, Ph.D. Hematopoietic Stem Cell Gene Transfer for Hemophilia A

Keiser, Nicholas, Ph.D. Inflammation in the Neonatal CFTR-knockout Ferret Lung

Keshavje, Shaf, M.D. Repair of Damaged Lungs for Transplantation Using and Ex-vivo Gene Therapeutic Surgery

Klingelhutz, Aloysius J., Ph.D. Reversibly Immortal Human Airway Epithelium

Kline, Joel, M.D. Role of CPG Motifs in Plasmid DNA as a Barrier to Gene Transfer

Krieg, Arthur, M.D. Development of Non-Immune Activating Gene Therapy Vectors for Cystic Fibrosis

Lamb, Fred, S., M.D., Ph.D. Site-Directed Mutation of ES Cells by Oligonucleotides

Liang, Luchuan, Ph.D. A Study of Epidermal Stem Cells in the Airway

Liu, Xiaoming, Ph.D. High-Level Ectopic Expression of CFTR Imposes a Selective Disadvantage to Airway Epithelial Stem/Progenitor Cells

Look, Dwight C., M.D. Adenoviral Mechanisms for Inhibition of Interferon Signal Transduction

Lotery, Andrew, M.D. Development of Gene Therapy for Batten Disease

McCaffrey, Anton, Ph.D. Zinc Finger Nucleases Targeting Hepatitis B Virus DNAs

McCray, Paul, M.D. Optimization of Retroviral Vectors for Mucosal Delivery

McLennan, Geoffrey, Ph.D. Evaluating Gene Therapy Using a Fluorescent Marker

Mallampalli, Rama, M.D. The CCT Promoter to Drive High-Level Expression of CFTR

Maury, Wendy, Ph.D. Development of Highly Transducing Glycoproteins for Transgene Delivery Into Airway Epithelial Cells

Messerle, Louis, Ph.D. AAV-Associated Cluster Contrast Agents for MR/CT Imaging of Vector Biodistribution

Norris, Andrew, M.D., Ph.D. The Role of CFTR in Hepatic Insulin Action

Ostedgaard, Lynda S., Ph.D. Optimization of the CFTR Coding Sequence for Efficient Packaging into the AAV Vector

Parekh, Kalpaj, M.D. Epithelial Stem Cells in a Lung Transplant Model

Raikwar, Sudhanshu, Ph.D. Deviation of Insulin-Producing Cells from ES Cells

Rice, Kevin, Ph.D. Reversibly PEGylated Gene Delivery Particles for Treating Cystic Fibrosis

Roller, Richard, Ph.D. Cell-Specific Targeting of Herpes Simplex Virus in Gene Therapy for Cystic Fibrosis

Sanders, David A, Ph.D. Direct Gene Transfer to Intact Airway Epithelia for CF

Singh, Pradeep, M.D. CFTR-Mediatred Gene Correction of Biofilm Formation in the CF Airway

Sinn, Patrick, Ph.D. Targeted Integration of a Lentiviral Vector

Stapleton, Jack, M.D. A GBV-C Gene Therapy Vector for Cystic Fibrosis

Stecenko, Arlene, M.D. Delivery of CFTR Protein Using membrane Translocating Sequences

Stein, Colleen S., Ph.D. Transgene Tolerance: a Role for Apoptosis

Stipp, Christopher, Ph.D. Enhancing the Neurite Outgrowth Potential of Neuronal Precursor Cells

Uc, Aliye, M.D. Delivery of AAV9 Vector to Wild-Type and Cystic Fibrosis Pig Pancreas and Lungs

Vermeer, Paola, Ph.D. Goblet Cell Hyperplasia and Gene Transfer in CF

Weeks, Daniel, Ph.D. Site Directed Mutagenesis Using Triplex Target Sites

Wiemer, David, Ph.D. & Welsh, Michael, M.D., Co-PI, Modification of the Cell Surface to Aid Gene Transfer

Wine, Jeffrey, Ph.D. Mucus Secretion by CFTR Deficient Ferret Submucosal Glands

Wu, Chun-Fang, Ph.D. Harmful Effects of Integrating AAV Vectors

Yan, Ziying, Ph.D. Hybrid rAAV Genomes for Gene Therapy of Cystic Fibrosis

Xing, Yi, Ph.D. Deep Survey of the Cystic Fibrosis Transcriptome by mRNA Sequencing

Zabner, Joseph, M.D. Study of Chimera Recombinant Adenovirus