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New in 2015.  We now offer CRISPR/Cas9 nuclease services for production of mutant mice by pronuclear and/or cytoplasmic injection.  This technology allows production of genetically modified mice in as little as 3-4 months.  Many kinds of mutations can be introduced, including point mutations such as SNPs, LoxP sites, reporter genes, protein tags, deletions, etc.  Genetic modification can eliminte the need for manipulation in ES cells.  Contact the core director to see if CRISPR/Cas9 technology can be used for your project. Learn more