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Behcet's Syndrome (Neuro-Behçet) Rhythmic Myoclonus Laryngeal - Pharyngeal

see also: Laryngeal Myoclonus (Palatal-Pharyngeal-Laryngeal Myoclonus) or (Palato-Pharyngo-Laryngeal Myoclonus)


Multiple organ systems involved with Behcets included initial presentation with oral ulceration as well as genital ulcers, skin lesions and neuropsychiatric difficulties - with involvement of brainstme and spinal cord initially treated with infliximab and methotrexate (Kothari et al 2022) requiring G-tube and effective use of CPAP to improve nocturnal breathing - successul in avoiding a tracheotomy.  Recurrent aspiration pneumonia were addressed both by the gastrostomy feeding tube and methods to diminish saliva production including botulinum toxin injection to the parotid glands. 


Saeed RR, Mohammed ZA. Essential rhythmic palatal myoclonus in a 51-year-old man. Oxf Med Case Reports. 2016 Aug 29;2016(8):omw056. doi: 10.1093/omcr/omw056. PMID: 29497553; PMCID: PMC5782482.

Sakurai N, Koike Y, Kaneoke Y, Yasuda T, Takahashi A. Sleep apnea and palatal myoclonus in a patient with neuro-Behçet syndrome. Intern Med. 1993 Apr;32(4):336-9. doi: 10.2169/internalmedicine.32.336. PMID: 8358127.

Kothari DS, Tanenbaum ZG, Abdel-Wahed L, Cho TA, Hoffman HT. Palato-Pharyngo-Laryngeal Rhythmic Myoclonus in Neuro-Bechet Syndrome: A Case Report. Ann Otol Rhinol Laryngol. 2022 Aug 23:34894221120124. doi: 10.1177/00034894221120124. Epub ahead of print. PMID: 35997329.