Sialosis
return to:Salivary Swelling
see also: Sialosis or Sialadenosis of the Salivary Glands
and Sialosis or sialadenosis Case example of surgical treatment
- Diffuse, bilateral swelling of the major salivary glands
- Non-neoplastic, non-inflammatory, non-tender or tender enlargement of glands with insidious onset
- Often occurs in the setting of endocrine disorders (diabetes), nutritional disorders (anorexia/bulemia), or drugs (alcohol, antihypertensives)
- Predominantly in females with peak incidence in 5th and 6th decades
- Histopathology shows acinar cell hypertrophy, atrophy of striated ducts and edema of interstitial connective tissue. Advanced disease shows widespread replacement of acini with fatty tissue