Upcoming Events
The Dystroglycanopathies: 2023 Iowa Wellstone Center Patient & Family Conference
Friday & Saturday, June 23-24 at The Graduate Hotel in Iowa City, IA
2023 Wellstone Conference Agenda
Questions? Contact Carrie Stephan at 1-319-356-2673 or carrie-stephan@uiowa.edu
Latest News
New Publications
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The Iowa Wellstone MDSRC is excited to share the latest research from Dr. Kevin Campbell's laboratory: Cell surface glycan engineering reveals that matriglycan alone can recapitulate dystroglycan binding and function, recently published in Nature Communications and Structure and mechanism of LARGE1 matriglycan polymerase, recently posted as a pre-print on bioRxiv.
Awards and Lectures
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Dr. Steven Moore, Co-Director of the Iowa Wellstone MDSRC, was invited to give the 2022 Saul R. Korey Lectureship at the American Association of Neuropathologists (AANP) Annual Meeting. The Korey Lectureship was established in 1989 by Dr. Robert D. Terry, a pioneer in Alzheimer’s disease research, to honor Dr. Korey, the founder and first chair of the Department of Neurology at Albert Einstein College of Medicine. As described by Dr. Terry, the Korey Lectureship recognizes someone who has "been an active member of the Association...a working Neuropathologist...responsible for diagnostic work as well as teaching and research.” Or, as the AANP states, someone who has “done it all and done it well.” Dr. Moore's lecture was titled "Adventures in Muscular Dystrophy: the DGC, LAMA2, and Other Sticky Relationships." Dr. Moore was also awarded the AANP 2022 Award for Meritorious Contributions. Congratulations Dr. Moore!
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Dr. Katherine Mathews, who leads the clinical research project at the Iowa MDSRC, received the second annual "Pioneer for LGMD2i" award from the CureLGMD2i committee. The award was announced at the CureLGMD2i's 11th annual casino event, a fundraising event held with a virtual component on October 2, 2021. Lacey Woods, the first annual "Pioneer for LGMD2i" award recipient, created a video to present the award to Dr. Mathews, who also accepted the honor through a video shown at the event. Congratulations Dr. Mathews!
Recent Publications
Basic Science Research
Basic science research in Project 1 investigates the cellular and molecular mechanisms that underlie the dystroglycanopathies to provide a scientific foundation for the development of diagnostic and therapeutic strategies, as well as approaches to monitoring the efficacy of potential therapies.
- Cell surface glycan engineering reveals that matriglycan alone can recapitulate dystroglycan binding and function
- Large1 Gene Transfer in Older myd Mice with Severe Muscular Dystrophy Restores Muscle Function and Greatly Improves Survival
- POMK regulates dystroglycan function via LARGE1-mediated elongation of matriglycan
Clinical Research
Data collected from Wellstone study patients in Project 2 is analyzed and published in order to inform researchers and clinicians about disease progression and improve patient care.
- Diagnostic delay in patients with FKRP-related muscular dystrophy
- Cardiomyopathy in limb girdle muscular dystrophy R9, FKRP related
- Motor outcome measures in patients with FKRP mutations, longitudinal follow-up
- The outcomes and experience of pregnancy in limb girdle muscular dystrophy type R9
Diagnostics Research
Diagnostics research draws on the broad spectrum of skeletal muscle biopsies available in Core B to investigate and develop novel diagnostic testing procedures for muscular dystrophy and to expand the toolbox of evaluation techniques for muscle biopsies and cell cultures from dystroglycanopathy patients.
- The inflammatory pathology of dysferlinopathy is distinct from calpainopathy, Becker muscular dystrophy, and inflammatory myopathies
- CLIA laboratory testing for facioscapulohumeral dystrophy: a retrospective analysis
- Validation of optical genome mapping for the molecular diagnosis of facioscapulohumeral muscular dystrophy
- Cross-sectional, neuromuscular phenotyping study of arhinia patients with SMCHD1 variants
- Lysosomes and the pathogenesis of merosin-deficient congenital muscular dystrophy
More Publications from Wellstone Center Investigators
- Dr. Kevin Campbell’s Publications
- Dr. Katherine Mathews' Publications
- Dr. Steven Moore’s Publications
Recent Invited Lectures and Talks by Wellstone Center Investigators
Dr. Kevin Campbell
2021
- Regeneron Seminar Series, Tarrytown, New York, Virtual
- Albert Einstein College of Medicine, Cell Biology Outside Speaker Seminar Series, Bronx, New York, Virtual
- San Diego Glycobiology Symposium, San Diego, California, Virtual
- ASBMB Herbert Tabor Award Lecture, San Diego, California, Virtual (Voted one of the "Most Favorited" sessions and presentations, Experimental Biology 2021 conference)
- Joint Glycobiology Meeting, Heidelberg, Germany, Virtual
- Tamio Yamakawa Award Lecture, Osaka, Japan, Virtual
2020
- 12th International GlycoT Conference, San Diego, California, Virtual
- University of Iowa Neuromuscular-Neurogenetics Symposium, Iowa City, Iowa, Virtual
- Congenital Disorders of Glycosylation Pre-Meeting Course, Guadalajara Jalisco, Mexico, Virtual
2019
- International Workshop for Glycosylation Defects in Muscular Dystrophies, Charlotte, North Carolina
- 100 Years of Neurology at the University of Iowa Centennial Symposium, Iowa City, Iowa
- University of Iowa Neuromuscular-Neurogenetics Symposium, Iowa City, Iowa
- 5th Ottawa International Conference on Neuromuscular Disease & Biology, Ottawa Canada
- University of Iowa First-Generation Student Awards and Recognition Ceremony, Iowa City, Iowa
- Wellstone Centers Network Meeting, Rochester, New York
Dr. Steven Moore
2021
- 2021 Academy of Clinical Laboratory Physicians and Scientists (ACLPS) Meeting, Virtual
2019
- American Association of Neuropathologists Meeting, Atlanta, Georgia