Faculty Publications - 2016

Ted Abel

Altered resonance properties of somatosensory responses in mice deficient for the schizophrenia risk gene Neuregulin 1. Barz, C. S., Bessaih, T., Abel, T., Feldmeyer, D. and Contreras, D. (2016). Brain Structure and Function 221(9):4383-98.. PMCID: PMC5040624.


Characterization of a novel chromatin sorting tool reveals importance of histone variant H3.3 in contextual fear memory and motor learning. McNally, A. G., Poplawski, S. G., Mayweather, B. A., White, K. M. and Abel, T. (2016). Frontiers in Molecular Neuroscience 9:11. PMCID: PMC4746260.


Sleep deprivation impairs memory by attenuating mTORC1-dependent protein synthesis. Tudor, J. C., Davis, E. J., Peixoto, L., Wimmer, M., van Tilborg, E., Park, A. J., Poplawski, S. G., Chung, C. W., Havekes, R., Huang, J., Gatti, E., Pierre, P. and Abel, T. (2016). Science Signaling 9: ra41. PMCID: PMC4890572.


Sociability deficits and altered amygdala circuits in mice lacking Pcdh10, an autism associated gene. Schoch, H., Kreibich, A. S., Ferri, S., White, R. S., Bohorquez, D., Banerjee, A., Port, R. G., Dow, H. C., Cordero, L., Pallathra, A. A., Kim, H., Li, H., Bilker, W. B., Hirano, S., Schultz, R. T., Borgmann-Winter, K., Hahn, C.-G., Feldmeyer, D., Carlson, G. C., Abel, T. and Brodkin, E. S. (2016). Biological Psychiatry 81(3):193-202. PMCID: PMC5161717.


Compartmentalized PDE4A5 signaling impairs hippocampal synaptic plasticity and long-term memory. Havekes, R., Park, A. J., Tolentino, R. E., Bruinenberg, V. M., Tudor, J. C., Lee, Y., Hansen, R. T., Guercio, L. A., Linton, E., Neves-Zaph, S. R., Meerlo, P., Baillie, G. S., Houslay, M. D. and Abel, T. (2016). Journal of Neuroscience 36: 8936-8946. PMCID: PMC4995304.


The role of k opioid receptor in brain ischemia. Chen, C., Xi, C., Liang, X., Ma, J., Su, D., Abel, T. and Liu, R. (2016). Critical Care Medicine 44(12):e1219-e1225. PMCID: PMC5203937.


Adenosine differentially modulates synaptic transmission in layer 4 barrel cortical microcircuitry. Qi, G., van Aerde, K., Abel, T. and Feldmeyer, D. (2016). Cerebral Cortex, in press. PMCID: In Process.


Activation of basolateral amygdala in juvenile C57BL/6J mice during social approach behavior. Ferri, S. L., Kreibich, A. S., Torre, M., Piccoli, C. T., Dow, H., Pallathra, A., Li, H., Gur, R. C., Abel, T. and Brodkin, E. S. (2016). Neuroscience, 29;335:184-94. PMCID: PMC5056014.


Contextual fear conditioning induces differential alternative splicing. Poplawski, S. G., Peixoto, L., Porcari, G. S., Wimmer, M. E., McNally, A. G., Mizuno, K., Giese, K. P., Risso, D., Speed, T. P. and Abel, T. (2016). Neurobiology of Learning and Memory, 134 Pt B:221-35. PMCID: PMC5028328.


Sleep deprivation causes memory deficits by negatively impacting neuronal connectivity in hippocampal area CA1. Havekes, R., Park, A. J., Ferri, S. L., Tudor, J. C., Bruinenberg, V. M., Poplawski, S. G., Day, J. P., Aton, S. J., Radwanska K., Meerlo P., Houslay M.D., Baillie G.S. and Abel, T. (2016). eLife,5. PMCID: PMC4996653.


To Stay Happy, Keep Your SIRT1 Active. Chatterjee S, Abel T. (2016) Biological Psychiatry, 80(11):808-9. PMCID: In Process.


Christopher Ahern

A hitchhikers guide to the sodium channel galaxy.  Ahern, C.A, Payandeh, J., Bosmans, F., and Chanda, B. (2016) Journal of General Physiology. 147(1):1-24. doi: 10.1085/jgp.201511492. Review. PMID: 26712848.


Atomic mutagenesis in ion channels with engineered stoichiometry. Lueck, JD, Mackey, AL., Infield, DT., Li, J., Roux, B., & Ahern, CA  (2016) eLife Oct 6;5. pii: e18976. doi: 10.7554/eLife.18976. PMID: 27710770


Atomic determinants of BK channel activation by polyunsaturated fatty acids. Tian,Y., Aursnes, M., Hansen, TV., Tungen, JE., Galpin, JG., , Leisle, L.,  Ahern, CA. #, Xua, R., Heinemann, SH., and Toshinori Hoshi.  (2016).  Proc. Natl. Acad. Sci. (accepted Oct 19, 2016). #-Provided chemical reagents for the project.


Cellular encoding of Cy dyes for single-molecule imaging. Leisle, L., Chadda, R., Lueck, JD., Infield, DT., Galpin, JD., Krishnamani, V., Robertson, JL. & Ahern, CA (2016) eLife. (Dec 12;5. pii: e19088. doi: 10.7554/eLife.19088)


Michael Anderson

RetFM-J, an ImageJ-based module for automated counting and quantifying features of nuclei in retinal whole-mounts.  A. Hedberg-Buenz, M.A. Christopher, C.J. Lewis, K.J. Meyer, D.S. Rudd, L.M. Dutca, M.K. Garvin, K. Wang, T.E. Scheetz, M.D. Abramoff, M.M. Harper, and M.G. Anderson*. (2016). Experimental Eye Research 146: 386-392.  PMID: 26283021.


Nikolai Artemyev

Luteinizing Hormone Causes Phosphorylation and Activation of the cGMP Phosphodiesterase PDE5 in Rat Ovarian Follicles, Contributing, Together with PDE1 Activity, to the Resumption of Meiosis. Egbert JR, Uliasz TF, Shuhaibar LC, Geerts A, Wunder F, Kleiman RJ, Humphrey JM, Lampe PD, Artemyev NO, Rybalkin SD, Beavo JA, Movsesian MA, Jaffe LA. Biol Reprod. 94(5):110, 2016


Aryl hydrocarbon receptor interacting protein-like 1 is an obligate chaperone of phosphodiesterase 6 and is assisted by theγ-subunit of its client. Gopalakrishna KN, Boyd K, Yadav RP and Artemyev NO. J. Biol. Chem. 291(31):16282-91, 2016


Kevin Campbell

The Functional O-Mannose Glycan on α-Dystroglycan Contains a Phospho-ribitol Primed for Matriglycan Addition. Praissman, J.L., Willer, T., Sheikh, M. O., Toi, A, Chitayat, D, Lin, Y, Lee, H, Stalnkaker, S, Wang, S, Prabhakar, P, Nelson, SF, Stemple, D.L., Moore, S.A., Moremen, K.W., Campbell, K.P., Wells, L.  eLife 2016, 29;5:e14473.  doi:http://dx.doi.org/10.7554/eLife.14473 PMID: 27130732 PMCID: PMC4924997


Molecular Dissection of Membrane Protein Complexes Associated with Muscular Dystrophy.  Turk R., Hsiao J.J., Smits, M.M., Ng, B.H., Pospisil, T.C., Jones, K.S., Campbell, K.P., Wright, M.E. Mol Cell Proteomics 2016 Jun;15(6):2169-85.  doi:10.1074/mcp.M116.059188 PMID: 27099343 PMCID: PMC5083101


Structural Basis of Laminin Binding to the LARGE Glycans on Dystroglycan.  Briggs, D., Yoshida-Moriguchi, T., Zheng, T., Venzke, D., Anderson, M., Strazzulli, A., Moracci, M., Yu, L., Hohenester, E., Campbell, K.P.  Nat Chem Biol. 2016 Oct; 12(10):810-814.  doi:10.1038/nchembio.2146 PMID: 27526028 PMCID: PMC5030134


LARGE2-dependent Glycosylation Confers Laminin-Binding Ability on Proteoglycans.  Inamori, K., Beedle, A.M., Beltrán-Valero de Bernabé, D., Wright, M.E., Campbell, K.P. Glycobiology, 2016, 26(12): 1284-1296.  doi: 10.1093/glycob/cww075. PMID: 27496765 PMCID: PMC5137251


Role of dystroglycan in limiting contraction-induced injury to the sarcomeric cytoskeleton of mature skeletal muscle. Rader, E., Turk, R., Willer, T., Beltrán, D., Inamori, K., Peterson, T.A., Engle, J., Prouty, S., Matsumura, K., Saito, F., Anderson, M.E., Campbell, K.P.  Proc Natl Acad Sci U S A. 2016 Sep 27;113(39):10992-7.  doi:10.1073/pnas.1605265113 PMID: 27625424 PMCID: PMC5047148


Neuronal Dystroglycan is Necessary for Formation and Maintenance of Functional CCK-Positive Basket Cell Terminals on Pyramidal Cells. Frϋh, S., Romanos, J., Panzanelli, P., Bϋrgisser, D., Tyagaragan, S.K., Campbell, K.P., Santello, M., Fritschy, JM.  The Journal of Neuroscience, 5 October 2016, 36(40): 10296-10313.  doi:10.1523/JNEUROSCI.1823-16.2016 PMID: 27707967


Biallelic Mutations in TMTC3, Encoding a Transmembrane and TPR-Containing Protein, Lead to Cobblestone Lissencephaly.  Jerber, J., Zaki, M.S., Al-Aama, J.Y., Ozgur Rosti, R., Ben-Omran, T., Dikoglu, E., Silhavy, J. L., Caglar, C., Musaev, D., Albrecht, B., Campbell, K.P., Willer, T., Almuriekhi, M., Okay Çağlayan, A., Vajsar, J., Bilgϋvar, K., Ogur, G., Abou Jamra, R., Gϋnel, M., Gleeson, J.G.  Am. J. Hum. Genet, 3 November 2016; 99(5): 1181–1189.  doi:10.1016/j.ajhg.2016.09.007 PMID: 27773428 PMCID: PMC5097947


Structure of Protein O-Mannose Kinase Reveals a Unique Active Site Architecture. Zhu, Q., Venzke, D., Walimbe, A.S., Anderson, M.E., Fu, Q., Kinch, L., Wang,W., Chen, X., Grishin, N., Huang, N., Yu, L., Dixon, J.E., Campbell, K.P., Xiao, J. eLife 2016;10.7554/eLife.22238. doi:http://dx.doi.org/10.7554/eLife.22238 PMID: 27879205 PMCID: PMC5142810


N. Charles Harata

Disruption of protein processing in the endoplasmic reticulum of DYT1 knock-in mice implicates novel pathways in dystonia pathogenesis. Beauvais G, Bode N, Watson JL, Wen H, Glenn KA, Kawano H, Harata NC, Ehrlich ME, Gonzalez-Alegre P. J Neurosci, 36: 10245-10256, 2016.


Michael Henry

α3β1 Integrin Suppresses Prostate Cancer Metastasis via Regulation of the Hippo Pathway. Varzavand A, Hacker W, Ma D, Gibson-Corley K, Hawayek M, Tayh OJ, Brown JA, Henry MD, Stipp CS.  Cancer Res. 2016 Nov 15;76(22):6577-6587. doi: 10.1158/0008-5472.CAN-16-1483. PubMed PMID: 27680681; PubMed Central PMCID: PMC5290210.


Individualization of Adjuvant Therapy After Radical Prostatectomy for Clinically Localized Prostate Cancer: Current Status and Future Directions. Mitchell DL, Tracy CR, Buatti JM, Smith MC, Snow AN, Henry MD, Vaena DA, Tewfik HH, Watkins JM. Clin Genitourin Cancer. 2016 Feb;14(1):12-21. doi: 10.1016/j.clgc.2015.07.022. Review. PubMed PMID: 26341039.


Amy Lee

Expression and localization of CaBP Ca2+ Binding Proteins in the mouse cochlea. Yang, T., Scholl, E.S., Pan, N., Fritzsch, B., Haeseleer, F. and A. Lee. (2016) PLoS One 25: e0147495


Characterization of C-terminal splice variants of Cav1.4 Ca2+ Channels in human retina. Haeseleer, F., Williams, B., and A. Lee. (2016) J. Biol. Chem., 291(30):15663-73


A novel mouse model of the aged brain: Over-expression of the L-type voltage-gated calcium channel CaV1.3. Krueger, J.N., Moore, S.J., Parent, R., Lee, A., and G.G. Murphy. (2016) Behav. Brain Res., pii: S0166-4328(16)30418-1


Splice variants of the Cav1.3 L-type calcium channel regulate dendritic spine morphology. Stanika, R., Campiglio, M., Pinggera, A., Lee, A., Striessnig, J., Flucher, B., and G. Obermair. (2016) Sci. Reports 6:34528


Lack of CaBP1/caldendrin or CaBP2 leads to altered ganglion cell responses. Sinha, R., Lee, A., Rieke, F., and F. Haeseleer. (2016) eNeuro 3(5). pii: ENEURO.0099-16.2016


Scott Moye-Rowley

A Novel Zn2-Cys6 Transcription Factor AtrR Plays a Key Role in an Azole Resistance Mechanism of Aspergillus fumigatus by Co-regulating cyp51A and cdr1B Expressions.  Hagiwara, D., Miura, D., Shimizu, K., Paul, S., Ohba, A., Gonoi, T., Watanabe, A., Kamei, K., Shintani, T., Moye-Rowley, W.S., Kawamoto, S. and Gomi, K.  PLoS Pathog. 2017 Jan 4;13(1):e1006096. doi: 10.1371/journal.ppat.1006096.


Robert Piper

DEEPN as an Approach for Batch Processing of Yeast 2-Hybrid Interactions. Pashkova N., Peterson, TA, Krishnamani V., Breheny P., Stamnes, MA., Piper RC Cell Rep. 2016 Sep 27;17(1):303-15. doi: 10.1016/j.celrep.2016.08.095. PMID: 27681439 Similar articles Select item 27068957


Cell surface recycling in yeast: mechanisms and machineries. MacDonald C, Piper PC. Biochem Soc Trans. 2016 April 15;44(2):474-8. doi: 10.1042/BST20150263


Janice Robertson

The dimerization equilibrium of a ClC Cl-/H+ antiporter in lipid bilayers. Chadda R, Krishnamani V, Mersch K, Wong J, Brimberry M, Chadda A, Kolmakova-Partensky L, Friedman LJ, Gelles J & Robertson JL (2016). eLife 2016; 10.7554/eLife.174382016.


Measuring Membrane Protein Dimerization Equilibrium in Lipid Bilayers by Single-Molecule Fluorescence Microscopy.  Chadda R, Robertson JL. Methods Enzymol. (2016); 581:53-82.


Cellular encoding of Cy dyes for single-molecule imaging. Leisle L, Chadda R, Lueck JD, Infield DT, Galpin JD, Krishnamani V, Robertson JL & Ahern CA (2016). eLife 2016; 10.7554/eLife.19088.


Andrew Russo

Induction of migraine-like photophobic behavior in mice by both peripheral and central CGRP mechanisms. Mason BN, Kaiser EA, Kuburas A, Loomis MM, Latham JA, Garcia-Martinez LF, Russo AF. J Neurosci. 2016 Dec 1;PubMed PMID: 27909097. [Highlighted at Society for Neuroscience Press Room; Innate Neuropeptide May Act in Brain and Body to Cause Migraine Symptoms; https://www.sfn.org/Press-Room/News-Release-Archives/2016/JNeurosci-Highlights-From-the-January-4-Issue]


Anti-CGRP antibodies block CGRP-induced diarrhea in mice. Kaiser EA, Rea BJ, Kuburas A, Kovacevich BR, Garcia-Martinez LF, Recober A, Russo AF. Neuropeptides. 2016 Nov 14;PubMed PMID: 27865545.


Induction of calcitonin gene-related peptide expression in rats by cortical spreading depression. Wang Y, Tye AE, Zhao J, Ma D, Raddant AC, Bu F, Spector BL, Winslow NK, Wang M, Russo AF. Cephalalgia. 2016 Nov 9;PubMed PMID: 27919019.


Julien Sebag

The Melanocortin ReceptorAccessory Protein 2 promotes food intake through inhibition of the prokineticin receptor-1. Chaly A.L., Srisai D, Gardner E.E. and Sebag J.A.  Elife. 2016 Feb 1;5. pii: e12397. doi: 10.7554/eLife.12397.


Deborah Segaloff

Differential Regulation of Human and Mouse Myometrial Contractile Activity by FSH as a Function of FSH Receptor Density. Stilley JA, Guan R, Santillan DA, Mitchell BF, Lamping KG, Segaloff DL. Biol Reprod. 2016 Aug;95(2):36. doi: 10.1095/biolreprod.116.141648. PubMed PMID: 27335068; PubMed Central PMCID: PMC5029472.


Misfolding Ectodomain Mutations of the Lutropin Receptor Increase Efficacy of Hormone Stimulation. Charmandari E, Guan R, Zhang M, Silveira LG, Fan QR, Chrousos GP, Sertedaki AC, Latronico AC, Segaloff DL. Mol Endocrinol. 2016 Jan;30(1):62-76. doi: 10.1210/me.2015-1205. PubMed PMID: 26554443; PubMed Central PMCID: PMC4695626.


Mark Stamnes

DEEPN as an Approach for Batch Processing of Yeast 2-Hybrid Interactions. Pashkova N, Peterson TA, Krishnamani V, Breheny P, Stamnes M, Piper RC. Cell Rep. 2016 Sep 27;17(1):303-15. doi: 10.1016/j.celrep.2016.08.095. PubMed PMID: 27681439.


Michael Wright

Glandular Proteome Identifies Antiprotease Cystatin C as a Critical Modulator of Airway Hydration and Clearance. Evans, T. I., Joo, N. S., Keiser, N. W., Yan, Z., Tyler, S. R., Xie, W., Zhang, Y., Hsiao, J. J., Cho, H. J., Wright, M. E., Wine, J. J., and Engelhardt, J. F. (2016) American journal of respiratory cell and molecular biology 54, 469-481


Discovery Proteomics Identifies a Molecular Link between the Coatomer Protein Complex I and Androgen Receptor-dependent Transcription. Hsiao, J. J., Smits, M. M., Ng, B. H., Lee, J., and Wright, M. E. (2016) The Journal of biological chemistry. 291(36):18818-42.


LARGE2-dependent glycosylation confers laminin-binding ability on proteoglycans. Inamori, K. I., Beedle, A. M., de Bernabe, D. B., Wright, M. E., and Campbell, K. P. (2016) Glycobiology. 26(12):1284-1296.


Molecular Signatures of Membrane Protein Complexes Underlying Muscular Dystrophy. Turk, R., Hsiao, J. J., Smits, M. M., Ng, B. H., Pospisil, T. C., Jones, K. S., Campbell, K. P., and Wright, M. E. (2016) Molecular & cellular proteomics : MCP 15, 2169-2185


BKCa channel regulates calcium oscillations induced by alpha-2-macroglobulin in human myometrial smooth muscle cells. Wakle-Prabagaran, M., Lorca, R. A., Ma, X., Stamnes, S. J., Amazu, C., Hsiao, J. J., Karch, C. M., Hyrc, K. L., Wright, M. E., and England, S. K. (2016) Proceedings of the National Academy of Sciences of the United States of America 113, E2335-2344