Darren P. Casey, PhD

Portrait
Assistant Professor of Physical Therapy and Rehabilitation Science

Contact Information

Office
1-252 MEB
Iowa City, IA 52242
319-384-1009

Education

BS, Health & Exercise Science, Syracuse University
MS, Exercise Science, Specialization: Clinical Exercise Physiology, Syracuse University
PhD, Applied Physiology, University of Florida

Publications

Kruse, N. T., Ueda, K., Hughes, W. E. & Casey, D. P. (2018). Eight weeks of nitrate supplementation improves blood flow and reduces the exaggerated pressor response during forearm exercise in peripheral artery disease. American journal of physiology. Heart and circulatory physiology, 315(1), H101-H108. PMID: 29522355.

Kruse, N. T., Hughes, W. E., Ueda, K., Hanada, S., Feider, A. J., Iwamoto, E., Bock, J. M. & Casey, D. P. (2018). Impaired modulation of postjunctional a1 - but not a2 -adrenergic vasoconstriction in contracting forearm muscle of postmenopausal women. The Journal of physiology, 596(13), 2507-2519. PMID: 29708589.

Hughes, W. E., Kruse, N. T., Ueda, K. & Casey, D. P. (2018). Habitual exercise training in older adults offsets the age-related prolongation in leg vasodilator kinetics during single limb lower body exercise. Journal of applied physiology (Bethesda, Md. : 1985). PMID: 29856264.

Schneider, A. C., Hughes, W. E., Ueda, K., Bock, J. M. & Casey, D. P. (2018). Reduced blood pressure responsiveness to skeletal muscle metaboreflex activation in older adults following inorganic nitrate supplementation. Nitric oxide : biology and chemistry, 78, 81-88. PMID: 29864505.

Kruse, N. T., Hughes, W. E. & Casey, D. P. (2018). Mechanistic insights into the modulatory role of the mechanoreflex on central hemodynamics using passive leg movement in humans. Journal of applied physiology (Bethesda, Md. : 1985). PMID: 29771607.

Hughes, W. E., Kruse, N. T. & Casey, D. P. (2018). Age-associated impairments in contraction-induced rapid-onset vasodilatation within the forearm are independent of mechanical factors. Experimental physiology, 103(5), 728-737. PMID: 29528524.

Iwamoto, E., Bock, J. M. & Casey, D. P. (2018). Blunted shear-mediated dilation of the internal but not common carotid artery in response to lower body negative pressure. Journal of applied physiology (Bethesda, Md. : 1985), 124(5), 1326-1332. PMID: 29446714.

Benzo, R. M., Kruse, N. T., Hughes, W. E., Casey, D. P. & Carr, L. J. (2018). Acute Effects of Interrupting Sitting on Discomfort and Alertness of Office Workers. Journal of occupational and environmental medicine. PMID: 29608539.

Iwamoto, E., Bock, J. M. & Casey, D. P. (2018). High-Intensity Exercise Enhances Conduit Artery Vascular Function in Older Adults. Medicine and science in sports and exercise, 50(1), 124-130. PMID: 28817509.

Bock, J. M., Ueda, K., Schneider, A. C., Hughes, W. E., Limberg, J. K., Bryan, N. S. & Casey, D. P. (2018). Inorganic nitrate supplementation attenuates peripheral chemoreflex sensitivity but does not improve cardiovagal baroreflex sensitivity in older adults. American journal of physiology. Heart and circulatory physiology, 314(1), H45-H51. PMID: 28971842.

Kruse, N. T., Hughes, W. E., Benzo, R. M., Carr, L. J. & Casey, D. P. (2017). Workplace Strategies to Prevent Sitting-induced Endothelial Dysfunction. Medicine and science in sports and exercise. PMID: 29117072.

Casey, D. P., Ueda, K., Wegman-Points, L. & Pierce, G. L. (2017). Muscle contraction induced arterial shear stress increases endothelial nitric oxide synthase phosphorylation in humans. American journal of physiology. Heart and circulatory physiology, 313(4), H854-H859. PMID: 28801524.

Kruse, N. T., Hughes, W. E., Hanada, S., Ueda, K., Bock, J. M., Iwamoto, E. & Casey, D. P. (2017). Evidence of a greater functional sympatholysis in habitually aerobic trained postmenopausal women. Journal of applied physiology (Bethesda, Md. : 1985), jap004112017. PMID: 28970201.

Kruse, N. T., Hughes, W. E., Ueda, K. & Casey, D. P. (2017). Vasoconstrictor responsiveness in contracting human muscle: influence of contraction frequency, contractile work, and metabolic rate. European journal of applied physiology, 117(8), 1697-1706. PMID: 28624852.

Hughes, W. E., Kruse, N. T. & Casey, D. P. (2017). Sympathetic nervous system activation reduces contraction-induced rapid vasodilation in the leg of humans independent of age. Journal of applied physiology (Bethesda, Md. : 1985), 123(1), 106-115. PMID: 28385914.

Hughes, W. E., Casey, D. P. (2017). Aortic Wave Reflection During Orthostatic Challenges: Influence of Body Position and Venous Pooling. American journal of hypertension, 30(2), 166-172. PMID: 28077421.

Harvey, R. E., Barnes, J. N., Hart, E. C., Nicholson, W. T., Joyner, M. J. & Casey, D. P. (2017). Influence of sympathetic nerve activity on aortic hemodynamics and pulse wave velocity in women. American journal of physiology. Heart and circulatory physiology, 312(2), H340-H346. PMID: 27923789.

Casey, D. P., Schneider, A. C. & Ueda, K. (2016). Influence of chronic endurance exercise training on conduit artery retrograde and oscillatory shear in older adults. European journal of applied physiology, 116(10), 1931-40. PMID: 27497720.

Hughes, W. E., Ueda, K., Treichler, D. P. & Casey, D. P. (2016). Effects of acute dietary nitrate supplementation on aortic blood pressure and aortic augmentation index in young and older adults. Nitric oxide : biology and chemistry, 59, 21-7. PMID: 27373229.

Pierce, G. L., Harris, S. A., Seals, D. R., Casey, D. P., Barlow, P. B. & Stauss, H. M. (2016). Estimated aortic stiffness is independently associated with cardiac baroreflex sensitivity in humans: role of ageing and habitual endurance exercise. Journal of human hypertension, 30(9), 513-20. PMID: 26911535.

Hughes, W. E., Ueda, K. & Casey, D. P. (2016). Chronic endurance exercise training offsets the age-related attenuation in contraction-induced rapid vasodilation. Journal of applied physiology (Bethesda, Md. : 1985), 120(11), 1335-42. PMID: 27032899.

Hughes, W. E., Ueda, K., Treichler, D. P. & Casey, D. P. (2015). Rapid onset vasodilation with single muscle contractions in the leg: influence of age. Physiological reports, 3(8). PMID: 26320213.

Casey, D. P., Treichler, D. P., Ganger 4th, C. T., Schneider, A. C. & Ueda, K. (2015). Acute dietary nitrate supplementation enhances compensatory vasodilation during hypoxic exercise in older adults. J Appl Physiol (Bethesda, Md: 1985), 118(2), 178-186. PMID: 25414241.

Casey, D. P., Ranadive, S. M. & Joyner, M. J. (2015). Aging is associated with altered vasodilator kinetics in dynamically contracting muscle: role of nitric oxide. Journal of applied physiology (Bethesda, Md: 1985), 119(3), 232-241. PMID: 26023230.

Beck, D. T., Casey, D. P., Martin, J. S., Sardina, P. D. & Braith, R. W. (2015). Enhanced external counterpulsation reduces indices of central blood pressure and myocardial oxygen demand in patients with left ventricular dysfunction. Clinical and experimental pharmacology & physiology, 42(4), 315-320. PMID: 25676084.

Joyner, M. J., Casey, D. P. (2015). Regulation of increased blood flow (hyperemia) to muscles during exercise: a hierarchy of competing physiological needs. Physiol Rev, 95(2), 549-601. PMID: 25834232.

Taylor, J. L., Curry, T. B., Matzek, L. J., Joyner, M. J. & Casey, D. P. (2014). Acute effects of a mixed meal on arterial stiffness and central hemodynamics in healthy adults. Am J Hypertens, 27(3), 331-337. PMID: 24242825.

Ranadive, S. M., Joyner, M. J., Walker, B. G., Taylor, J. L. & Casey, D. P. (2014). Effect of vitamin C on hyperoxia-induced vasoconstriction in exercising skeletal muscle. Journal of applied physiology (Bethesda, Md: 1985), 117(10), 1207-1211. PMID: 25237186.

Beck, D. T., Martin, J. S., Casey, D. P., Avery, J. C., Sardina, P. D. & Braith, R. W. (2014). Enhanced external counterpulsation improves endothelial function and exercise capacity in patients with ischemic left ventricular dysfunction. Clinical and experimental pharmacology & physiology, 41(9), 628-636. PMID: 24862172.

Avery, J. C., Beck, D. T., Casey, D. P., Sardina, P. D. & Braith, R. W. (2014). Enhanced external counterpulsation improves peripheral resistance artery blood flow in patients with coronary artery disease. Appl Physiol Nutr Metab, 39(3), 405-408. PMID: 24552391.

Beck, D. T., Martin, J. S., Casey, D. P. & Braith, R. W. (2014). Exercise training improves endothelial function in resistance arteries of young prehypertensives. J Hum Hypertens, 28(5), 303-309. PMID: 24172292.

Joyner, M. J., Casey, D. P. (2014). Muscle blood flow, hypoxia, and hypoperfusion. Journal of applied physiology (Bethesda, Md.: 1985), 116(7), 852-857. PMID: 23887898.

Casey, D. P., Shepherd, J. R. & Joyner, M. J. (2014). Sex and Vasodilator Responses to Hypoxia at Rest and during Exercise. J Appl Physiol, 116(7), 927-936. PMID: 23823148.

Heffernan, K. S., Kasprowicz, A. G., Tarzia, B. J., Davies, J. E. & Casey, D. P. (2014). Sex differences in peripheral augmentation index and arterial reservoir pressure during upper limb postural shifts. Physiology Journal, 971906.

Pierce, G. L., Casey, D. P., Fiedorowicz, J. G., Searls, D. R., Curry, T. B., Barnes, J. N., Wilson, D. R. & Strauss, H. M. (2013). Aortic pulse wave velocity and reflecting distance estimation from peripheral waveforms in humans: detection of age- and exercise training-related differences. Am J Physiol Heart Circ Physiol, 305(1), H135-142. PMID: 23624628.

Casey, D. P., Walker, B. G., Ranadive, S. M., Taylor, J. L. & Joyner, M. J. (2013). Contribution of nitric oxide in the contraction-induced rapid vasodilation in young and older adults. J Appl Physiol, 115(4), 446-455. PMID: 23788575.

Beck, D. T., Casey, D. P., Martin, J. S., Emerson, B. D. & Braith, R. W. (2013). Exercise training improves endothelial function in young prehypertensives. Exp Biol Med (Maywood), 238(4), 433-441. PMID: 23760009.

Beck, D. T., Martin, J. S., Casey, D. P. & Braith, R. W. (2013). Exercise Training Reduces Peripheral Arterial Stiffness and Myocardial Oxygen Demand in Young Prehypertensive Subjects. Am J Hypertens, 26(9), 1093-1102. PMID: 23736111.

Hart, E. C., Charkoudian, N., Joyner, M. J., Barnes, J. N., Curry, T. B. & Casey, D. P. (2013). Relationship between sympathetic nerve activity and aortic wave reflection characteristics in postmenopausal women. Menopause, 20(9), 967-972. PMID: 23531685.

Lopez, M. G., Silva, B. M., Joyner, M. J. & Casey, D. P. (2013). Roles of nitric oxide and prostaglandins in the hyperemic response to a maximal metabolic stimulus: redundancy prevails. Eur J Appl Physiol, 113(6), 1449-1456. PMID: 23250568.

Casey, D. P., Curry, T. B., Charkoudian, N., Joyner, M. J. & Hart, E. C. (2013). The effects of acute beta-adrenergic blockade on aortic wave reflection in postmenopausal women. Am J Hypertens, 26(4), 503-510. PMID: 23467206.

Casey, D. P., Joyner, M. J., Claus, P. L. & Curry, T. B. (2013). Vasoconstrictor responsiveness during hyperbaric hyperoxia in contracting human muscle. J Appl Physiol, 114(2), 217-224. PMID: 23154993.

Casey, D. P., Curry, T. B., Joyner, M. J., Charkoudian, N. & Hart, E. C. (2012). Acute ß-adrenergic blockade increases aortic wave reflection in young men and women: differing mechanisms between sexes. Hypertension, 59(1), 145-150. PMID: 22106401.

Casey, D. P., Joyner, M. J. (2012). Compensatory vasodilatation during hypoxic exercise: Mechanisms responsible for matching oxygen supply to demand. J Physiol, 590(Pt 24), 6321-6. PMID: 22988134.

Barnes, J. N., Casey, D. P., Hines, C. N., Nicholson, W. T. & Joyner, M. J. (2012). Cyclooxygenase inhibition augments central blood pressure and aortic wave reflection in aging humans. Am J Physiol Heart Circ Physiol, 302(12), H2629-2634. PMID: 22505642.

Braith, R. W., Casey, D. P. & Beck, D. T. (2012). Enhanced External Counterpulsation for Ischemic Heart Disease: A Look behind the curtain. Exerc Sport Sci Rev., 40(3), 145-52. PMID: 22407185.

Casey, D. P., Joyner, M. J. (2012). Influence of a-adrenergic vasoconstriction on the blunted skeletal muscle contraction-induced rapid vasodilation with aging. J Appl Physiol, 113(8), 1201-1212. PMID: 22961267.

Casey, D. P., Mohamed, E. A. & Joyner, M. J. (2012). Role of nitric oxide and adenosine in the onset of vasodilation during dynamic forearm exercise. Eur J Appl Physiol, 113(2), 295-303. PMID: 22692759.

Casey, D. P., Joyner, M. J. (2012). a-Adrenergic Blockade Unmasks a Greater Compensatory Vasodilation in Hypoperfused Contracting Muscle. Front Physiol, 3(271). PMID: 22934025.

Casey, D. P., Padilla, J. & Joyner, M. J. (2012). a-adrenergic vasoconstriction contributes to the age-related increase in conduit artery retrograde and oscillatory shear. Hypertension, 60(4), 1016-1022. PMID: 22949528.

Casey, D. P., Walker, B. G., Curry, T. B. & Joyner, M. J. (2011). Ageing reduces the compensatory vasodilatation during hypoxic exercise: the role of nitric oxide. J Physiol, 15(589), 1477-1488. PMID: 21282292.

Martin, J. S., Casey, D. P., Gurovich, A. N., Beck, D. T. & Braith, R. W. (2011). Association of age with timing and amplitude of reflected pressure waves during exercise in men. Am J Hypertens, 24(4), 415-420. PMID: 21233799.

Casey, D. P., Joyner, M. J. (2011). Contribution of adenosine to compensatory dilation in hypoperfused contracting human muscles is independent of nitric oxide. J Appl Physiol, 110(5), 1181-1189. PMID: 21292838.

Casey, D. P., Beck, D. T., Nichols, W. W., Conti, C. R., Choi, C. Y., Khuddus, M. A. & Braith, R. W. (2011). Effects of enhanced external counterpulsation on arterial stiffness and myocardial oxygen demand in patients with chronic angina pectoris. Am J Cardiol, 107(10), 1466-1472. PMID: 21420062.

Casey, D. P., Joyner, M. J., Claus, P. L. & Curry, T. B. (2011). Hyperbaric hyperoxia reduces exercising forearm blood flow in humans. Am J Physiol Heart Circ Physiol, 300(5), H1892-1897. PMID: 21421819.

Padilla, J., Simmons, G. H., Fadel, P. J., Laughlin, M. H., Joyner, M. J. & Casey, D. P. (2011). Impact of aging on conduit artery retrograde and oscillatory shear at rest and during exercise: role of nitric oxide. Hypertension, 57(3), 484-489. PMID: 21263118.

Casey, D. P., Joyner, M. J. (2011). Local control of skeletal muscle blood flow during exercise: Influence of available oxygen. J Appl Physiol, 111(6), 1527-1538. PMID: 21885800.

Casey, D. P., Curry, T. B., Wilkins, B. W. & Joyner, M. J. (2011). Nitric oxide-mediated vasodilation becomes independent of beta-adrenergic receptor activation with increased intensity of hypoxic exercise. J Appl Physiol, 110(3), 687-694. PMID: 21193565.

Casey, D. P., Joyner, M. J. (2011). Prostaglandins do not contribute to the nitric oxide-mediated compensatory vasodilation in hypoperfused exercising muscle. Am J Physiol Heart Circ Physiol, 301(1), H261-268. PMID: 21536852.

Casey, D. P., Curry, T. B., Joyner, M. J., Charkoudian, N. & Hart, E. C. (2011). Relationship between muscle sympathetic nerve activity and aortic wave reflection characteristics in young men and women. Hypertension, 57(3), 421-427. PMID: 21242459.

Hart, E. C., Lopez, M. G. & Casey, D. P. (2010). Altered microvascular control of exercising skeletal muscle blood flow. The unfortunate male. J Physiol, 588, 3851-3852. PMID: 20952376.

Adkisson, E. J., Casey, D. P., Beck, D. T., Gurovich, A. N., Martin, J. S. & Braith, R. W. (2010). Central, peripheral and resistance arterial reactivity: fluctuates during the phases of the menstrual cycle. Exp Biol Med (Maywood), 235(1), 111-118. PMID: 20404025.

Braith, R. W., Conti, C. R., Nichols, W. W., Choi, C. Y., Khuddus, M. A., Beck, D. T. & Casey, D. P. (2010). Enhanced external counterpulsation improves peripheral artery flow-mediated dilation in patients with chronic angina: a randomized sham-controlled study. Circulation, 122(16), 1612-1620. PMID: 20921442.

Casey, D. P., Madery, B. D., Curry, T. B., Eisenach, J. H., Wilkens, B. W. & Joyner, M. J. (2010). Nitric oxide contributes to the augmented vasodilatation during hypoxic exercise. J Physiol, 15(588), 373-385. PMID: 19948661.

Casey, D. P., Nichols, W. W., Conti, C. R. & Braith, R. W. (2010). Relationship between endogenous concentrations of vasoactive substances and measures of peripheral vasodilator function in patients with coronary artery disease. Clin Exp Pharmacol Physiol, 37(1), 24-28. PMID: 19515062.

Casey, D. P., Madery, B. D., Pike, T. L., Eisenach, J. H., Dietz, N. M., Joyner, M. J. & Wilkins, B. W. (2009). Adenosine receptor antagonist and augmented vasodilation during hypoxic exercise. J Appl Physiol, 107(4), 1128-1137. PMID: 19661449.

Casey, D. P., Joyner, M. J. (2009). NOS inhibition blunts and delays the compensatory dilation in hypoperfused contracting human muscles. J Appl Physiol, 107(6), 1685-1692. PMID: 19729589.

Casey, D. P., Joyner, M. J. (2009). Skeletal muscle blood flow responses to hypoperfusion at rest and during rhythmic exercise in humans. J Appl Physiol, 107(2), 429-437. PMID: 19520838.

Joyner, M. J., Casey, D. P. (2009). The catecholamines strike back. What NO does not do. Circ J, 73(10), 1783-1792. PMID: 19729859.

Casey, D. P. (2008). Assessment of central arterial blood pressure during exercise: is it reproducible?. Am J Hypertens, 21(10), 1073. PMID: 18806769.

Casey, D. P., Hart, E. C. (2008). Cardiovascular function in humans during exercise: role of the muscle pump. J Physiol, 5045-6. PMID: 18801838.

Casey, D. P., Braith, R. W. & Pierce, G. L. (2008). Changes in central artery blood pressure and wave reflection during a cold pressor test in young adults. Eur J Appl Physiol, 103(5), 539-543. PMID: 18431592.

Casey, D. P., Conti, C. R., Nichols, W. W., Choi, C. Y., Khuddus, M. A. & Braith, R. W. (2008). Effect of enhanced external counterpulsation on inflammatory cytokines and adhesion molecules in patients with angina pectoris and angiographic coronary artery disease. Am J Cardiol, 101(3), 300-302. PMID: 18237588.

Pierce, G. L., Schofield, R. S., Casey, D. P., Hamlin, S. A., Hill, J. A. & Braith, R. W. (2008). Effects of exercise training on forearm and calf vasodilation and proinflammatory markers in recent heart transplant recipients: a pilot study. Eur J Cardiovasc Prev Rehabil, 15(1), 10-18. PMID: 18277180.

Braith, R. W., Schofield, R. S., Hill, J. A., Casey, D. P. & Pierce, G. L. (2008). Exercise training attenuates progressive decline in brachial artery reactivity in heart transplant recipients. J Heart Lung Transplant, 27(1), 52-59. PMID: 18187087.

Casey, D. P., Nichols, W. W. & Braith, R. W. (2008). Impact of aging on central pressure wave reflection characteristics during exercise. Am J Hypertens, 21(4), 419-424. PMID: 18246057.

Casey, D. P., Curry, T. B. & Joyner, M. J. (2008). Measuring muscle blood flow: a key link between systemic and regional metabolism. Curr Opin Clin Nutr Metab Care, 11(5), 580-586. PMID: 18685453.

Braith, R. W., Connor, J. A., Fulton, M. N., Lisor, C. F., Casey, D. P., Howe, K. S. & Baz, M. A. (2007). Comparison of alendronate vs alendronate plus mechanical loading as prophylaxis for osteoporosis in lung transplant recipients: a pilot study. J Heart Lung Transplant, 26(2), 132-137. PMID: 17258146.

Casey, D. P., Pierce, G. L., Howe, K. S., Mering, M. C. & Braith, R. W. (2007). Effect of resistance training on arterial wave reflection and brachial artery reactivity in normotensive postmenopausal women. Eur J Appl Physiol, 100(4), 403-408. PMID: 17394009.

Casey, D. P., Beck, D. T. & Braith, R. W. (2007). Progressive resistance training without volume increases does not alter arterial stiffness and aortic wave reflection. Exp Biol Med, 232(9), 1228-1235. PMID: 17895531.

Casey, D. P., Beck, D. T. & Braith, R. W. (2007). Systemic plasma levels of nitrite/nitrate (NOx) reflect brachial flow-mediated dilation responses in young men and women. Clin Exp Pharmacol Physiol, 34(12), 1291-1293. PMID: 17973870.

Pierce, G. L., Casey, D. P., Nichols, W. W. & Braith, R. W. (2006). Effect of Acute Cold Pressor Test on Amplitude and Timing of Central Pressure Wave Reflection in Young Healthy Adults. (Vols. 38). (5), pp. S185. Med Sci. Sports and Exerc..

Braith, R. W., Beck, D. T. & Casey, D. P. (2006). Effects of Resistance Training on Arterial Function in Young, Healthy Men and Women. (Vols. 38). (11), pp. Supl:1:S5. Med Sci. Sports and Exerc.

Braith, R. W., Scholfield, R. S., Casey, D. P., Nichols, W. W., Hill, J. A. & Pierce, G. L. (2006). Endurance Training Improves Endothelial Function and Buffers Sympathetic Nervous System Hyperactivity in Heart Transplant Recipients. (Vols. 38). (5), pp. S20. Med Sci Sports and Exerc.

Casey, D. P., Pierce, G. L., Nichols, W. W. & Braith, R. W. (2006). Measurement of Pulse Wave Velocity and Augmentation Index is Reproducible in Young, Healthy Men. (Vols. 38). (5), pp. S185-186. Med Sci Sports and Exerc.

Collier, S. R., Casey, D. P. & Kanaley, J. A. (2005). Growth hormone responses to varying doses of oral arginine. Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society, 15(2), 136-9. PMID: 15809017.

Pierce, G. L., Scholfield, R. S., Hamlin, S. A., Casey, D. P., Hill, J. A. & Braith, R. W. (2005). Exercise training improves vasodilation of limb resistance vasculature and attenuates inflammation and asymmetric dimethylarginine in heart transplant recipients. (Vols. 112). (17), pp. II-813. Circulation.

Collier, S. R., Casey, D. P. & Kanaley, J. A. (2002). Supplemental oral arginine induces a growth hormone response. (Vols. 34). (5), pp. S70. Med Sci Sports and Exerc.