Holden Comprehensive Cancer Center Biostatistics Core

uihc.org/biostatistics-core

Leadership:

Director

Brian J. Smith, PhD

(319) 384-1587

brian-j-smith@uiowa.edu

Mission/Client Group:

The Biostatistics Core provides statistical support in the design, analysis, and reporting of cancer research projects to members of the Holden Comprehensive Cancer Center. Our goals are to enable you to:

  • use your time more efficiently
  • learn more from your research
  • increase the scientific impact of your research
  • successfully compete for grant funding
  • publish your papers more efficiently
  • smooth the approval of your protocols by the Protocol Review Committee

Services:

Assistance is available on all types of projects, ranging from clinical trials to basic science experiments. Examples include:

  • consultation on study design, selection of outcome variables and formulation of hypotheses
  • specification of appropriate methods of data analysis
  • estimation of sample size
  • development of protocols
  • generation of randomization schedules
  • analysis of data
  • assistance in the preparation of manuscripts
  • education and training

Early consultation during the design of a study may be especially beneficial, and response times are generally short.

Consulting Fees:

Service

 

Cost

Support for the development and planning of new projects:

consultations for the planning of new projects

development of study hypotheses, experimental designs, and data analysis plans

estimation of sample size and study power

 

Free

Support later stages of projects, including:

data management

analysis

interpretation

presentation of results

Short-term

Long-term

$70/hour

% Effort Basis

Support for the development and planning of new projects:

consultations for the planning of new projects

development of study hypotheses, experimental designs, and data analysis plans

estimation of sample size and study power

Free
Support later stages of projects, including:

data management

analysis

interpretation

presentation of results

Short-term projects: $70/hour

Long-term projects/grants: % effort basis

How to engage our services:

To formally request support for a new project or obtain additional information about the kind of support provided, please visit the Biostatistics Core Alliance website, and/or fill out a Biostatistical Support Request Form. After submitting this form, you will be contacted by a Core member to schedule a meeting to discuss your research and statistical needs.

Staff Bios:

Brian J Smith, PhD (Core Director)

Dr. Smith has been part of the Biostatistics Core since 2001 and Director since 2006.  He provides statistical support and oversight for the Biostatistics Core.  He is involved in the design and conduct of a broad range of research studies, including cellular studies, animal experiments, epidemiologic studies, and clinical trials.  His methodological interests include statistical computing, Bayesian methods, correlated data, and statistical modeling. 

Gideon Zamba, PhD

Dr. Zamba joined the Biostatistics Core in 2005 and provides general statistical support for the HCCC.  He is an expert in statistical design and analysis.  He has statistical research interests in the development and application of methods for recurrent event data and sequential analysis. 

Patrick Breheny, PhD

Dr. Breheny joined the Biostatistics Core in October 2013. He provides statistical consultation and analysis support for investigators carrying out studies involving genetics and/or genomics, including genome-wide association, whole exome sequencing, and copy-number variation analysis.  In addition, he has collaborated with many groups and developed novel methods for the analysis of gene expression studies, including pathway analysis. 

Sarah Bell, MS

Ms. Bell joined the Biostatistics Core in July 2013.  In general, she assists with the development of new projects, data management, statistical analysis, and preparation of statistical analysis sections for grant applications, manuscripts and presentations. Her research expertise is grant and protocol development for pre-clinical and clinical trials, survival analysis, mixed effects regression and predictive modeling,

Tim Ginader, MS

Mr. Ginader joined the Biostatistics Core in June 2015. Some of his duties include data analysis, statistical computing, and trial design.  He has provided support for many projects, focusing on diagnostic accuracy, survival analyses, and clinical trials.