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Research Associate
Requisition 70542

Samuel Young, PhD, is an R01 funded investigator moving his research laboratory to the University of Iowa from the Max Planck Florida Institute.  He holds a primary appointment in the Department of Anatomy and Cell Biology in the Carver College of Medicine as well as a secondary appointment in the Department of Otolaryngology serving as the Director of Molecular Auditory Sciences.  This Research Associate position will be largely centered on recombinant Adenoviral vector production and development for use in neuron-specific and gene therapy applications, and will provide general support for projects in the laboratory centered on molecular biology.  Requires a Bachelor’s degree in a biomedical related science field or an equivalent combination of education and professional experience in a molecular and cell biology related field.  A minimum of 2 years of relevant experience is required.  The ideal candidate will have knowledge of viral vector production techniques, advanced cloning techniques, quantitative real time PCR.  Good working knowledge of complex lab procedures and equipment. Strong background in molecular biology, including cloning, is required.   Strong organizational skills are a must as are effective interpersonal skills and written/oral communication skills. Basic computer skills, working knowledge of email, word processing, spreadsheets, etc are required.  The ability to think independently and to problem solve is highly desirable.  To apply for this position visit our website at http://jobs.uiowa.edu; requisition #70542.  Application deadline is February 16, 2017.  The University of Iowa is an Equal Opportunity/Affirmative Action Employer. All qualified applicants are encouraged to apply and will receive consideration for employment free from discrimination on the basis of race, creed, color, national origin, age, sex, pregnancy, sexual orientation, gender identity, genetic information, religion, associational preference, status as a qualified individual with a disability, or status as a protected veteran.  Applicants’ credentials are subject to verification.


Research Assistant
Requisition 70540

This position is in a well-established laboratory investigating the pathophysiology of lung disease in Cystic Fibrosis and testing new therapies in an animal model.  The major role of this research assistant will be to conduct laboratory experiments in a variety of settings (existing banked samples, cell culture, animal procedures detailed below) using innovative methods designed by research staff in a premiere CF laboratory. There is an animal model focus for this position, which is centered on the CF ferret lung and aims to identify key pathophysiologic aspects amenable for therapeutic intervention.  This professional position requires a Bachelor’s degree in a biomedical-related science or an equivalent combination of education and experience in a relevant field of study. A good working knowledge of basic laboratory techniques, including use of antibodies for assays such as ELISA, Western, immunostaining and cell culture is required. Knowledge of laboratory etiquette, strong interpersonal skills, and excellent written and verbal skills are also required. Basic computer skills including document formatting and page layout, advanced spreadsheet abilities, standard use of presentation software for communication of results during lab meetings, familiarity with various other standard applications (email, image processing, etc) also necessary for success in this position.  Desired qualifications include previous independent research experience and familiarity with basic laboratory techniques at a more advanced level (independence in performing ELISA, blots, tissue culture and immunostaining). Additional experience with larger animal models would be similarly sought after for this position, although not required at the time of application.  The ideal candidate will be able to conduct him/herself in the above matters and easily grow to take on additional responsibilities in an organized fashion. Creativity and interest in the topic matter is prized and encouraged.  To apply for this position visit our website at http://jobs.uiowa.edu; requisition #70540.  Application deadline is February 15, 2017.  The University of Iowa is an Equal Opportunity/Affirmative Action Employer. All qualified applicants are encouraged to apply and will receive consideration for employment free from discrimination on the basis of race, creed, color, national origin, age, sex, pregnancy, sexual orientation, gender identity, genetic information, religion, associational preference, status as a qualified individual with a disability, or status as a protected veteran.  Applicants’ credentials are subject to verification.


POSTDOCTORAL FELLOW
Requisition #2634

The Yeaman laboratory in the Department of Anatomy and Cell Biology at the University of Iowa is seeking a motivated, focused and skilled Postdoctoral Fellow. The Yeaman group is interested in identifying molecular mechanisms responsible for biogenesis of epithelial cell polarity (publications in Cell, Molecular Cell, Nature Cell Biology, J. Cell Biol., etc).  We study details of fundamental cellular processes, such as intercellular adhesion, cytoskeletal remodeling and membrane trafficking, that are at the foundation of tissue development and organogenesis.  Our focus is on the Exocyst, a multi-functional, allosterically regulated scaffold, and Ral GTPases, which regulate Exocyst functions by facilitating association or disassociation with additional proteins.  We utilize CRISPR/Cas9 gene editing, along with mouse models, 2D and 3D cell culture models, cutting edge cell imaging technologies and biochemical assays to understand how Exocyst protein assemblies function during cell growth and differentiation, motility and cell division.  We are performing focused structure-function studies in efforts to understand how specific mutations in genes encoding Exocyst and Ral proteins contribute to human diseases including cancers, diabetes and ciliopathies. The University of Iowa Carver College of Medicine is a highly ranked biomedical research institute. The Yeaman laboratory is located in a state-of-the-art facility that features a collaborative atmosphere to foster innovation.

Qualifications: Interested candidates should have obtained a Ph.D. or M.D. degree with a strong background in molecular biology, cell biology and biochemistry. The ideal candidate will have proven talent to work independently with excellent interpersonal and communication skills.

Desired:

  • Solid knowledge in Cell and Molecular Biology and Biochemistry;
  • Extensive experience working with mammalian cell lines and primary cells (ideally polarized epithelial cultures grown on Transwells or in Matrigel);
  • Extensive experience with PCR, RT-PCR, molecular cloning, CRISPR/Cas9;
  • Experience with TIRF, super-resolution microscopy, confocal microscopy and electron microscopy;
  • Experience in mouse handling, genotyping, mouse surgeries, tissue dissection.

To apply for this position visit our website at http://jobs.uiowa.edu; requisition #2634.  The University of Iowa is an Equal Opportunity/Affirmative Action Employer. All qualified applicants are encouraged to apply and will receive consideration for employment free from discrimination on the basis of race, creed, color, national origin, age, sex, pregnancy, sexual orientation, gender identity, genetic information, religion, associational preference, status as a qualified individual with a disability, or status as a protected veteran.  Applicants’ credentials are subject to verification.


POSTDOCTORAL FELLOW
Requisition #2617

The Yang laboratory at the Fraternal Order of Eagles Diabetes Research Center at the University of Iowa is seeking a motivated, focused and skilled Postdoctoral Fellow. The Yang group is interested in identifying the molecular components of integration between organelle stress responses that are in play in obesity and diabetes at the cellular and organismic levels (publications in Science, Cell Metabolism and Diabetes). Genetic mouse models, cellular and in vivo metabolic analysis, cell culture, cell imaging and biochemistry assays will be used in the project. The University of Iowa Carver College of Medicine is a highly ranked biomedical research institute. The Yang laboratory is located in a state-of-the-art facility that features a collaborative atmosphere to foster innovation. 

Qualifications: Interested candidates should have obtained a Ph.D. or M.D. degree with a strong background in mouse models, metabolism, molecular biology, cell biology and biochemistry. The ideal candidate will have proven talent to work independently with excellent interpersonal and communication skills.

Desired:

  • Solid knowledge in Cell biology, Biochemistry and metabolic diseases;
  • Extensive experience working with mammalian cell lines and primary cells (ideally primary hepatocyte culture);
  • Extensive experience with sub-clone, viral construction, as well as overexpression/suppression of target gene expression in mouse model;
  • Experience with flow cytometry, confocal microscopy and EM;
  • Profound experience in mouse metabolic profiling, animal handling, mouse surgeries, tissue dissection.

To apply for this position visit our website at http://jobs.uiowa.edu; requisition #2617.  The University of Iowa is an Equal Opportunity/Affirmative Action Employer. All qualified applicants are encouraged to apply and will receive consideration for employment free from discrimination on the basis of race, creed, color, national origin, age, sex, pregnancy, sexual orientation, gender identity, genetic information, religion, associational preference, status as a qualified individual with a disability, or status as a protected veteran.  Applicants’ credentials are subject to verification.  


Research Intern
Requisition #128
The duties for this Laboratory Research Internship position include basic molecular and cell biology protocols involving recombinant DNA and cloning, RT-PCR, cell fractionation, protein sample preparation, SDS-PAGE and Western blotting. This research project will also involve viral vector mediated gene transfer in experimental cell culture models of kidney disease and primary ciliopathies, as well as manipulating epithelial cells in both 2-D and 3-D culture conditions, immunocytochemistry and confocal microscopy. The ideal candidate will have strong interpersonal communication skills and will receive relevant on-site training but will be expected to work independently and keep meticulous research notes. Other duties include lab maintenance, cleaning and organization. This Post-Baccalaureate Research Internship is designed for individuals who are seeking training, experience, and mentoring in a research setting and who plan to pursue a graduate or degree in science. You must have US citizenship or permanent residency to apply. More information on the Research Internship program can be found here: http://research.uiowa.edu/post-baccalaureate-research-internship. A Bachelor’s of Science degree in Cell Biology, Molecular Biology, Biochemistry or similar is required. Required qualifications include: Laboratory and coursework experience in molecular or cell biology and basic laboratory techniques. Strong interpersonal skills along with a strong work ethic are required. Excellent written and verbal skills are also required. Desired qualifications include previous independent research experience performing molecular biology. To apply for this position visit our website at http://jobs.uiowa.edu; requisition #128. Application deadline is January 4, 2017. The University of Iowa is an Equal Opportunity/Affirmative Action Employer. All qualified applicants are encouraged to apply and will receive consideration for employment free from discrimination on the basis of race, creed, color, national origin, age, sex, pregnancy, sexual orientation, gender identity, genetic information, religion, associational preference, status as a qualified individual with a disability, or status as a protected veteran. Applicants’ credentials are subject to verification.


 The University of Iowa is an Equal Opportunity/Affirmative Action Employer. All qualified applicants are encouraged to apply and will receive consideration for employment free from discrimination on the basis of race, creed, color, national origin, age, sex, pregnancy, sexual orientation, gender identity, genetic information, religion, associational preference, status as a qualified individual with a disability, or status as a protected veteran. Applicants’ credentials are subject to verification.