Career Opportunties


Research Associate

Requisition 72323

POSITION DESCRIPTION

The position is in a well-established laboratory investigating the pathophysiology of lung disease in Cystic Fibrosis and testing new therapies in an animal model. This position is focused on a CF ferret animal model of lung disease and aims to identify key pathophysiologic aspects amenable for therapeutic intervention.  John Engelhardt is a well-funded Professor and Chair on the Department of Anatomy and Cell Biology and Director of the Center for Gene Therapy.  The major role of this research associate will be to conduct laboratory experiments in a variety of settings and areas (molecular and cellular biology, primary cell culture, use of viral vectors, and animal procedures) using methods designed by research staff in a cystic fibrosis (CF) laboratory. Research will be focused on pathophysiologic mechanisms of disease with an emphasis on lung stem cells and developing viral and non-viral mediated approaches for gene editing in isolated stem cells in culture and in vivo in animals. Animal handling experience and excellent laboratory skills in molecular genetics is paramount. This professional position requiring a Bachelor’s degree in a biomedical related science field or an equivalent combination of education and professional experience in animal science, and a molecular and cell biology related field.  Minimum of 1-3 years of relevant experience is required.  The ideal candidate will have knowledge of viral vector production techniques, advanced cloning techniques, tissue culture of primary cells, quantitative real time PCR, working with primary lung stem cells, and extensive experience in working with ferrets.  Good working knowledge of complex lab procedures and equipment. Strong background in molecular biology and genetics is required.   Strong organizational skills are a must as are effective interpersonal skills and written/oral communication skills. Basic computer skills, working knowledge of email, word processing, spreadsheets, etc are required.  Desired qualifications include experience in handling animals larger than mice, and experience with multiple forms of recombinant viruses. Highly desired qualifications include 5 years relevant experience, generation of air-liquid interface differentiated airway cultures, and performing immunologic assays such as ELISPOT.  To apply for this position visit our website at http://jobs.uiowa.edu; requisition #72323.  Application deadline is February 27, 2018.  The University of Iowa is an Equal Opportunity/Affirmative Action Employer. All qualified applicants are encouraged to apply and will receive consideration for employment free from discrimination on the basis of race, creed, color, national origin, age, sex, pregnancy, sexual orientation, gender identity, genetic information, religion, associational preference, status as a qualified individual with a disability, or status as a protected veteran.  Applicants’ credentials are subject to verification.


Post-Baccalaureate Research Intern

Requisition #162

POSITION DESCRIPTION

  • This position is in a laboratory investigating Fatty Liver Disease and its relationship to protein misfolding stress in the endoplasmic reticulum (ER). 

Responsibilities include, but are not limited to:

  • Culture of both primary and immortalized mammalian cells
  • Molecular analysis such as qRT-PCR and Western Blotting
  • Gene transfer and gene manipulation (i.e., CRISPR/Cas) in cultured cells
  • Conducting experiments in the mouse, including manipulating gene expression with recombinant viruses and procuring tissue samples for subsequent analysis

This Post-Baccalaureate Research Internship is designed for individuals who are seeking training, experience, and mentoring in a research setting and who plan to pursue an advanced graduate or degree in science (e.g. PhD, MD, DDS, etc). You must have US citizenship or permanent residency to apply. More information on the Research Internship program can be found here: http://research.uiowa.edu/post-baccalaureate-research-internship.

A Bachelor’s of Science degree in Cell Biology, Molecular Biology, Biochemistry or similar is required.  Required qualifications include: recent experience in biological sciences (course and laboratory work), knowledge of basic laboratory techniques and etiquette, strong interpersonal skills and work ethic. Highly desired qualifications include recent previous independent research experience (especially at UIowa) in the above techniques and excellent written/verbal skills.

The ideal candidate will be able to conduct him/herself in the above matters and easily grow to take on additional responsibilities in an organized fashion. Creativity and interest in the topic matter is prized and encouraged, and there is room to grow once the baseline responsibilities are fulfilled.

Qualified applicants are welcome regardless of race, national origin, sex, age, creed, religious or political affiliation, disability, sexual orientation, or gender identity.

To apply for this position visit our website at http://jobs.uiowa.edu; requisition #162.  Application deadline is July 12, 2017.  The University of Iowa is an Equal Opportunity/Affirmative Action Employer. All qualified applicants are encouraged to apply and will receive consideration for employment free from discrimination on the basis of race, creed, color, national origin, age, sex, pregnancy, sexual orientation, gender identity, genetic information, religion, associational preference, status as a qualified individual with a disability, or status as a protected veteran.  Applicants’ credentials are subject to verification.


Combined Teaching and Research Postdoctoral position in Developmental Biology

The Department of Anatomy & Cell Biology

Requisition #2855

A postdoctoral position is immediately available in the Tootle Lab at the University of Iowa, Carver College of Medicine. The position entails ~80% research and ~20% teaching. The teaching experience will entail designing an online development/human embryology course for both master’s and Ph.D. candidates, and a journal club on related material for only the Ph.D. students. Mentorship in curriculum design and instruction will be provided by Dr. Darren Hoffmann, a recipient of numerous teaching awards.

Research will be performed in the Tootle lab, which focuses on prostaglandin regulation of actin – both within the cytoskeleton and in the nucleus. The primary model used is Drosophila oogenesis. The enzymes that make prostaglandins are the targets of non-steroidal anti-inflammatory drugs (NSAIDs), such as aspirin and ibuprofen. Prostaglandins are lipid signals that play critical roles in human health and disease, including pain/inflammation, reproduction, heart health and disease, and cancer. Importantly, actin is also implicated in these processes. Therefore, the mechanisms by which prostaglandins regulate actin – both in the cytoplasm and in the nucleus – are likely conserved from flies to humans.

For more information on the Tootle lab, please see: www.tootlelab.com. The Tootle Lab is located within the Anatomy and Cell Biology Department (https://www.medicine.uiowa.edu/acb/).

The University of Iowa is located in Iowa City – a fun, college town that was ranked no. 3 for best places to live in America by Outside Magazine (2015). For more information on Iowa City, see http://livability.com/ia/iowa-city/community/why-iowa-city-iowa-top-100-....

Requirements: PhD in biological sciences and less than 3 years postdoctoral experience. Technical experience in one or more of the following areas preferred: molecular biology, basic protein biochemistry, genetics, and microscopy.  Excellent interpersonal and communication skills are required.   

To apply for this position visit our website at http://jobs.uiowa.edu requisition #2855.  Applications should include: CV, List of three references, Graduate transcript (unofficial is fine), and a cover letter. The University of Iowa is an Equal Opportunity/Affirmative Action Employer. All qualified applicants are encouraged to apply and will receive consideration for employment free from discrimination on the basis of race, creed, color, national origin, age, sex, pregnancy, sexual orientation, gender identity, genetic information, religion, associational preference, status as a qualified individual with a disability, or status as a protected veteran.  Applicants’ credentials are subject to verification.


The University of Iowa

Research Assistant Professor (non-tenure track)

Department of Anatomy and Cell Biology

Requisition #71614

The University of Iowa Department of Anatomy and Cell Biology is seeking a candidate for a non-tenure faculty position as a Research Assistant Professor. The successful candidate will be expected to contribute to the academic missions of teaching and research, interface with corporate sponsored research, and conduct research in the area of cystic fibrosis pathophysiology and molecular therapies for this disorder. The position will involve independently pursuing funding, performing research experiments and theoretical investigations, analyzing data, liaison with industrial sponsored research, and disseminating research findings. The work will require expertise in cell biology, genetics, animal models, neuroendocrine systems, and gene therapy. Key areas of responsibility include some experimentation, data/research analysis and evaluation, dissemination of research results in publication form, research proposals/grants, assist in supervising/mentoring students and other research collaborators in the laboratory.

For further information about the department see: http://www.medicine.uiowa.edu/acb/

The position requires the academic knowledge of a discipline generally associated with a Doctoral degree in Genetics. Applicants should have at least six years postdoctoral experience related to pulmonary and neuroscience research experience is required. In particular, applicant should have experience with cystic fibrosis research, gene therapy, and genetic animal models. Required technical experience includes the ability to analyze of large omics datasets, the use of primary airway cell culture systems, and experience with microRNA regulation. Molecular biology techniques that are required include experience with RNAseq platforms, molecular biology techniques, viral vectors, histological and immunohistochemical analysis, fluorescence imaging analyses using confocal microscopy on animal tissue and cell culture. Excellent written and verbal communication skills are required. Documented recent academic productivity as evidenced by primary authorship on peer reviewed research publications and review articles is required. Previous experience presenting talks at national and international scientific meetings is required. All applicants will have demonstrated experience working effectively in a diverse research environment. Desirable qualifications: The applicant’s research interests should closely align with the Dept. of Anatomy and Cell Biology and Center for Gene Therapy of Cystic Fibrosis. Experience studying the stem cell biology and CFTR functions in the lung is desirable.

To apply for this position, please visit http://jobs.uiowa.edu, requisition 71614. Review of applicants will begin immediately. Please direct questions to the search committee at mary-beckler@uiowa.edu. The University of Iowa is an Equal Opportunity/Affirmative Action Employer. All qualified applicants are encouraged to apply and will receive consideration for employment free from discrimination on the basis of race, creed, color, national origin, age, sex, pregnancy, sexual orientation, gender identity, genetic information, religion, associational preference, status as a qualified individual with a disability, or status as a protected veteran. Applicants’ credentials are subject to verification.