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John F. Engelhardt, PhD

Chair, Department of Anatomy and Cell Biology
Director, Center for Gene Therapy
Roy J. Carver Chair in Molecular Medicine
Professor of Anatomy and Cell Biology
Professor of Internal Medicine

Contact Information

Primary Office
1-100 Bowen Science Building (BSB)
Iowa City, IA 52242

51 Newton Road
Iowa City, IA 52242


BS, Biochemistry, Iowa State University
PhD, Human Genetics, Johns Hopkins University
HHMI, University of Michigan
Internal Medicine, University of Michigan

Education/Training Program Affiliations

Department of Cell and Developmental Graduate Program, Free Radical and Radiation Biology Graduate Program, Interdisciplinary Graduate Program in Informatics, Interdisciplinary Graduate Program in Molecular Medicine, Interdisciplinary Graduate Program in Translational Biomedicine, Medical Scientist Training Program

Center, Program and Institute Affiliations

Center for Gene Therapy of Cystic Fibrosis and other Genetic Diseases, Fraternal Order of Eagles Diabetes Research Center, George M. O’Brien Kidney Research Center, Helen C. Levitt Center for Viral Pathogenesis, Holden Comprehensive Cancer Center, Institute for Clinical and Translational Science

Research Summary

Research in the Engelhardt laboratory focuses on the molecular basis of cystic fibrosis disease pathologies, and on the development of gene therapies for this disorder. Included are four major research areas include the study of: 1) lung molecular and cellular biology as it relates to the pathogenesis and treatment of cystic fibrosis (CF) lung disease, 2) the development of viral vector for gene therapy and gene editing, 3) pathogenesis cystic fibrosis related diabetes, and 4) the study of airway stem cell niches, the regulatory mechanisms that control stem cell proliferation and repair in the airway, and the development of cell-based therapies for CF using stem cells.