Nathan E. Holton
Introduction
My research interest is on the evolution and development of the craniofacial complex in humans. As a biological anthropologist, I am particularly interested in understanding how evolution interacts with developmental processes to influence to produce phenotypic differences in modern and archaic humans. To this end, my work is focused primarily on understanding the determinants of variation in the nasal region and the masticatory region. Regarding the nasal region, my research is focused on developing a better understanding of early developmental interactions between bony and cartilaginous nasal components, as well as the developmental interaction between the nasal region and other parts of the craniofacial complex. I am also working to understand how the evolution and development of the nasal complex are influenced by larger systemic factors related to bioenergetics. With respect to the masticatory region, my work is focused on functional-developmental interactions in the jaws. The goal of this work is to better understand to what extent functional and behavioral inferences can be made from skeletal elements in fossil and extant primates. This includes work designed to assess which aspects of jaw form are associated with jaw function, and which aspects of jaw form are independent of function. Additionally, this includes work designed to better understand variation in skeletal responses to functional loading.
Current Positions
- Clinical Instructor of Anatomy and Cell Biology
Education
- BA in Anthropology, San Francisco State University, San Francisco, California, United States
- MA in Anthropology, Northern Illinois University, DeKalb, Illinois, United States
- PhD in Anthropology, The University of Iowa, Iowa City, Iowa, United States
Research Interests
- Masticatory function and craniofacial development
- NASAL MORPHOLOGY: One of my primary research foci is an examination of the developmental relationship between the nasal region and other aspects of the facial skeleton. This includes: a) understanding patterns of morphological integration in the nasal region; b) assessing the influence of climatic variation and energetics on nasal cavity form; and c) examining the role of the nasal septum in facial growth and development.
- MASTICATORY FUNCTION: I am currently undertaking a series of projects designed to provide a better understanding the in the influence of mastication on craniomandibular development. This includes: a) examining the role of masticatory function on bone distribution in the mandible in humans and animal models; b) studying heterogeneity of the skeletal response to variation in jaw function; and c) examining how masticatory function modulates growth allometries and influences patterns of morphological variation.
- Evolution of Neanderthal and modern human facial anatomy
- Paleoanthropology: Late Pleistocene human evolution
- Nasal morphological variation, function, and evolution
- Craniofacial biology, facial growth and development, functional anatomy
Selected Publications
- Sun, Z., da Fontoura, C. S., Moreno, M., Holton, N. E., Sweat, M., Sweat, Y., Lee, M. K., Arbon, J., Bidlack, F. B., Thedens, D. R., Nopoulos, P., Cao, H., Eliason, S., Weinberg, S. M., Martin, J. F., Moreno-Uribe, L. & Amendt, B. A. (2018). FoxO6 regulates Hippo signaling and growth of the craniofacial complex. PLoS Genetics/Public Library of Science (PLOS) 14 (10) e1007675. DOI: 10.1371/journal.pgen.1007675. PMID: 30286078. PMCID: PMC6197693.
- Bilbo, E. E., Marshall, S. D., Southard, K. A., Allareddy, V., Holton, N. E., Thames, A. M., Otsby, M. S. & Southard, T. E. (2018). Long-term skeletal effects of high-pull headgear followed by fixed appliances for treatment of Class II malocclusions. The Angle Orthodontist/Allen Press Inc. 88 (5) 530-537. DOI: 10.2319/091517-620.1. PMID: 29667470.
- Holton, N. E., Piche, A. & Yokley, T. R. (2018). Integration of the nasal complex: Implications for developmental and evolutionary change in modern humans. American Journal of Physical Anthropology/Wiley 166 (4) 791-802. DOI: 10.1002/ajpa.23466. PMID: 29566424.
- Nicholas, C. L., Kadavy, K., Holton, N. E., Marshall, T., Richter, A. & Southard, T. (2018). Childhood body mass index is associated with early dental development and eruption in a longitudinal sample from the Iowa Facial Growth Study. American Journal of Orthodontics and Dentofacial Orthopedics/Elsevier 154 (1) 72-81. DOI: 10.1016/j.ajodo.2017.10.033. PMID: 29957323.
- Ries, R. J., Yu, W., Holton, N. E. & Amendt, B. A. (2017). Inhibition of the miR-17-92 cluster separates stages of palatogenesis. Journal of Dental Research/Sage Journals 96 (11) 1257-1264. DOI: 10.1177/0022034517716915. PMID: 28662367. PMCID: PMC5613877.
- Strassman, A., Schnütgen, F., Dai, Q., Jones, J. C., Gomez, A. C., Pitstick, L., Holton, N. E., Moskal, R., Leslie, E. R., von Melchner, H., Beier, D. R. & Bjork, B. C. (2017). Generation of a multipurpose Prdm16 mouse allele by targeted gene trapping. Disease Models & Mechanisms/The Company of Biologists 10 (7) 909-922. DOI: 10.1242/dmm.029561. PMID: 28424158. PMCID: PMC5536910.
- Sousa Melo, S. L., de Faria Vasconcelos, K., Holton, N. E., Allareddy, V., Tabchoury, C., Haieter-Neto, F. & Ruprecht, A. (2017). The impact of CBCT scan mode on diagonostic yield of chemically simulated external root resportion. American Journal of Orthodontics and Dentofacial Orthopedics/Elsevier 151 (6) 1073-1082. DOI: 10.1016/j.ajodo.2016.10.041. PMID: 28554453.
- Goergen, M. J., Holton, N. E. & Grünheid, T. (2017). Morphological interaction between the nasal septum and nasofacial skeleton during human ontogeny. Journal of Anatomy/Wiley 230 (5) 689-700. DOI: 10.1111/joa.12596. PMID: 28220482. PMCID: PMC5382596.
- Weaver, C. A., Miller, S. F., da Fontura, C., Wehby, G. L., Amendt, B. A., Holton, N. E., Allareddy, V., Southard, T. E. & Moreo Uribe, L. M. (2017). Candidate gene analyses of 3D dento-alveolar phenotypes in individuals with malocclusion. American Journal of Orthodontics and Dentofacial Orthopedics/Elsevier 151 (3) 539-558. DOI: 10.1016/j.ajodo.2016.08.027. PMID: 28257739. PMCID: PMC5358674.
- Franks, E. M., Holton, N. E., Scott, J. E., McAbee, K. R., Rink, J. T., Pax, K. C., Pasquinelly, A. C., Scollan, J. P., Eastman, M. M. & Ravosa, M. J. (2016). Betwixt and between: Intracranial perspectives on zygomaxillary arch plasticity and function in mammals. The Anatomical Record/John Wiley & Sons 299 (12) 1646-1660. DOI: 10.1002/ar.23477. PMID: 27870345.