Nathan Swailes, PhD
Introduction
My research interests lie in two areas: development and repair of skeletal muscle and innovative techniques to enhance deep student learning in the anatomical sciences. In the developing embryo, muscle precursor cells, or myoblasts, develop from the somites (regions of embryonic mesoderm arranged segmentally along the length of the embryo). Some of these myoblasts will form the skeletal muscles of the axial skeleton (vertebral column, head, neck and trunk) while others will form the muscles of the appendicular skeleton (limbs).
A number of influencing factors guide the myoblasts destined to become limb muscles on a long and precise journey of migration from the somites where they developed, to their final destination in the limb. Once there, the myoblasts will elongate and form aligned groups before they fuse to form myotubes. It is these myotubes that will become the muscles that move the joints of our limbs. As the cells pass through this developmental process, there is a change in the organisation of their actin and myosin "cytoskeleton".
My interests lie in the organisation and interaction of these cytoskeletal components to determine how they are involved in the control of normal muscle development.
Current Positions
- Clinical Instructor of Anatomy and Cell Biology
- Director of Virtual Microscopy Education and Outreach
Education
- BSc (Hons) in Human Biology (with Honors), The University of Leeds, UK, Leeds, England
- PhD in Anatomy and Cell Biology, The University of Leeds, UK, Leeds, England
- Grad Cert (Higher Ed) in Graduate Certificate in College Teaching, James Cook University, QLD, Australia, Townsville, Australia
Research Interests
- Effective assessment within integrated and non-integrated curricula
- The use of technology in medical curricula.
- The effects of scatter factor on myogenesis.
- The development and implementation of integrated curricula.
Selected Publications
- Chapman, J. A., Lee LMJ & Swailes, N. T. (2020). From Scope to Screen: The Evolution of Histology Education. Advances in experimental medicine and biology 1260 75-107. DOI: 10.1007/978-3-030-47483-6_5. PMID: 33211308.
- Hoffmann, D. & Swailes, N. (2014). GRISTO: an integrated learning experience in Gross Anatomy and Histology for Dental Students, learning outcomes and student perspectives on curriculum change (532.4). The FASEB Journal 28 (1). DOI: https://doi.org/10.1096/fasebj.28.1_supplement.532.4.
- Swailes, N. T., Colgrave, M., Knight, P. J. & Peckham, M. (2006). Non-muscle myosins 2A and 2B drive changes in cell morphology that occur as myoblasts align and fuse. Journal of Cell Science 119 3561-3570. PMID: 16895968.
- Swailes, N. T., Knight, P. J. & Peckham, M. (2004). Actin filament organization in aligned pre-fusion myoblasts. Journal of Anatomy 205 (5) 381-391. PMID: 15575887.
- Swailes, N. T., Knight, P. J. & Peckham, M. (2003). Actin filament organization in aligned pre-fusion myoblasts in vitro. (Vols. 203). (1), pp. 143-154. Journal of Anatomy (Proceedings of the Anatomical Society of Great Britain & Ireland).