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David W. Kaczka, MD, PhD

Portrait
Associate Professor of Anesthesia - Critical Care Medicine
Associate Professor of Radiology
Associate Professor of Biomedical Engineering (BME)

Contact Information

Primary Office
8483 John Colloton Pavilion
200 Hawkins Drive
Iowa City, IA 52242
319-356-2633

Fax
6546-1 John Colloton Pavilion
200 Hawkins Drive
Iowa City, IA 52242
319-356-2940

Education

BS, Biomedical Engineering, Boston University
MS, Biomedical Engineering, Boston University
MD, Medicine, Boston University School of Medicine
PhD, Biomedical Engineering, Boston University College of Engineering
Resident, Anesthesiology, Johns Hopkins University
Officer Training School (OTS), United States Air Force, Air University
Fellow, Obstetrical Anesthesia, Johns Hopkins University
Correspondence Program: Squadron Officer School (SOS), United States Air Force, Air University
Fellow, Critical Care Medicine, University of Iowa, Carver College of Medicine, Department of Anesthesia

Publications

Herrmann, J., da Fonseca Cruz, A., Hawley, M. L., Branson, R. D. & Kaczka, D. W. (2020). Shared ventilation in the era of COVID-19: a theoretical consideration of the dangers and potential solutions. Respir Care. PMID: 32376612.

Herrmann, J., Gerard, S. E., Shao, W., Xin, Y., Cereda, M., Reinhardt, J. M., Christensen, G. E., Hoffmann, E. A. & Kaczka, D. W. (2020). Expiratory de-aeration occurs faster in poorly- vs. normally-aerated regions of the injured lung. (Vols. 201). pp. A4107. New York, NY: Am J Respir Crit Care Med.

Liu, Y., Comellas, A. P., Kaczka, D. W., Motahari, A., Lee, C., Gerke, A. K., Wilson, J., Salisbury, S., O'Connel-Moore, D., Philibert, R. & Hoffman, E. A. (2020). An incentive-based program coupled with sildenafil provides enhanced success of smoking cessation associated with an accelerated loss of CT assessed smoking-associated lung density (inflammation) and improved DLCO. (Vols. 201). pp. A7556. New York, NY: Am J Respir Crit Care Med.

Liu, Y., Motahari, A., Comellas, A. P., Kaczka, D. W., Lee, C., Gerke, A. K., Wilson, J., Salisbury, S., O'Connel-Moore, D. & Hoffman, E. A. (2020). Ultra-low dose CT demonstrates a role for sildenafil in facilitating resolution of lung inflammation during smoking cessation. (Vols. 201). pp. A7560. New York, NY: Am J Respir Crit Care Med.

King, G. G., Bates, J., Berger, K. I., Calverley, P., de Melo, P. L., Dellacà, R. L., Farré, R., Hall, G. L., Ioan, I., Irvin, C. G., Kaczka, D. W., Kaminsky, D. A., Kurosawa, H., Lombardi, E., Maksym, G. N., Marchal, F., Oppenheimer, B. W., Simpson, S. J., Thamrin, C., van den Berge, M. & Oostveen, E. (2020). Technical standards for respiratory oscillometry. Eur Respir J, 55(2), 1900753. PMID: 31772002.

Herrmann, J., Gerard, S. E., Shao, W., Hawley, M. L., Reinhardt, J. M., Christensen, G. E., Hoffman, E. A. & Kaczka, D. W. (2020). Quantifying regional lung deformation using four-dimensional computed tomography: a comparison of conventional and oscillatory ventilation. Front Physiol, 11, 14. PMID: 32153417.

Gerard, S. E., Herrmann, J., Kaczka, D. W., Musch, G., Fernandez-Bustamante, A. & Reinhardt, J. M. (2020). Multi-resolution convolutional neural networks for fully automated segmentation of acutely injured lungs in multiple species. Med Image Anal, 60, 101592. PMID: 31760194.

Hajdarevic, B., Herrmann, J., Fonseca da Cruz, A. & Kaczka, D. W. (2020). System identification of proportional solenoid valve dynamics. Int J Model Identif Control.

Herrmann, J., Lilitwat, W., Tawhai, M. H. & Kaczka, D. W. (2020). High-frequency oscillatory ventilation and ventilator-induced lung injury: size does matter. Crit Care Med, 48(1), e66-e73. PMID: 31634232.

Kaczka, D. W., Chitilian, H. V. & Vidal Melo, M. F. (2020). Chapter 41: Respiratory Monitoring. In M. A. Gropper , L. I. Eriksson & L. A. Fleisher , J. P. Wiener-Kronish , N. H. Cohen , K. Leslie (Eds.) Miller's Anesthesia. (9), pp. 1298-1339. New York, NY: Elsevier.

Herrmann, J., Tawhai, M. H. & Kaczka, D. W. (2019). Strain, strain rate, and mechanical power: an optimization comparison for oscillatory ventilation. Int J Numer Method Biomed Eng, 35(10), e3238. PMID: 31318162.

Cereda, M., Xin, Y., Goffi, A., Herrmann, J., Kaczka, D. W., Kavanagh, B. P., Perchiazzi, G., Yoshida, T. & Rizi, R. R. (2019). Imaging the injured lung: mechanisms of action and clinical use. Anesthesiology, 131(3), 716-749. PMID: 30664057.

Motahari-Bidgoli, A., Liu, Y., Comellas, A. P., Kaczka, D. W., Gerke, A. K., Wilson, J. S. & Hoffman, E. A. (2019). Sildenafil-Based Reduction in Sub-Acinar Pulmonary Perfusion Heterogeneity Does Not Alter Acinar-Scale Histograms of V/Q Matching Derived from Dual Energy CT. (Vols. 199). pp. A3854. Am J Respir Crit Care Med.

Liu, Y., Motahari-Bidgoli, A., Comellas, A. P., Kaczka, D. W., Gerke, A. K., Wilson, J. S. & Hoffman, E. A. (2019). Role of Sildenafil in Lowering Lung Inflammation During Smoking Cessation: A Multispectral CT Assessment of Lung Anatomy and Perfused Blood Volume. (Vols. 199). pp. A3853. Am J Respir Crit Care Med.

Herrmann, J., Gerard, S. E., Shao, W., Reinhardt, J. M., Christensen, G. E., Hoffman, E. A., Hawley, M. L. & Kaczka, D. W. (2019). Multi-Frequency Oscillatory Ventilation Minimizes Spatial Gradients of Regional Strain Using 4D CT Image Registration in Porcine Lung Injury. (Vols. 199). pp. A7246. Am J Respir Crit Care Med.

Kaczka, D. W., Nieman, G. (2019). Designing Protective Mechanical Ventilation for the Injured Lung: Opportunities for the Engineer. (Vols. 2). (2), pp. 020201-020204. New York, NY: Journal of Engineering and Science in Medical Diagnostics and Therapy. DOI: 10.1115/1.4043220.

Herrmann, J., Tawhai, M. H. & Kaczka, D. W. (2019). Computational modeling of primary blast lung injury: implications for ventilator management. Mil Med, 184(Supplement_1), 273-281. PMID: 30901433.

Gerard, S. E., Herrmann, J., Kaczka, D. W. & Reinhardt, J. M. (2018). Transfer Learning for Segmentation of Injured Lungs Using Coarse-to-Fine Convolutional Neural Networks. In D. Stoyanov , Z. Taylor , B. Kainz & G. Maicas , R. Beichel , A. Martel , L. Maier-Hein , B. Kanwal , T. Vercauteren , O. Ozan , G. Carneiro , A. P. Bradley , J. Nascimento , H. Min , M. S. Brown , C. Jacobs , B. Lassen-Schmidt , K. Mori , J. Petersen , R. San Jose Estépar , A. Schmidt-Richberg , C. Veiga (Eds.) Image Analysis for Moving Organ, Breast, and Thoracic Images. pp. 191-201. Springer International Publishing. DOI: 10.1007/978-3-030-00946-5.

Mondoñedo, J. R., McNeil, J. S., Herrmann, J., Simon, B. A. & Kaczka, D. W. (2018). Targeted versus continuous delivery of volatile anesthetics during cholinergic bronchoconstriction. J Eng Sci Med Diagn Ther, 1(3). PMID: 31106293.

Kaczka, D. W. (2018). A lesson in uncertainty: how FAER helped an engineer find his calling. (Vols. 82). (5), pp. 62-3. ASA Monitor.

Taher, H., Bauer, C., Abston, E., Kaczka, D. W., Bhatt, S. P., Zabner, J., Brower, R. G., Beichel, R. R. & Eberlein, M. (2018). Chest wall strapping increases expiratory airflow and detectable airway segments in computer tomographic scans of normal and obstructed lungs. J Appl Physiol (1985), 124(5), 1186-1193. PMID: 29357485.

Herrmann, J., Shao, W., Gerard, S. E., Reinhardt, J. M., Hoffman, E. A., Christensen, G. E. & Kaczka, D. W. (2018). Time-varying regional aeration and strain in the acutely injured lung assessed with 4-D CT image registration. (Vols. 197). pp. A7227. Am J Respir Crit Care Med.

Herrmann, J., Lilitwat, W., Tawhai, M. H. & Kaczka, D. W. (2018). Lung size and ventilation heterogeneity: a comparison of high-frequency oscillatory ventilation in neonates and adults. (Vols. 197). pp. A4663. Am J Respir Crit Care Med.

Herrmann, J., Reinhardt, J. M., Hoffmann, E. A. & Kaczka, D. W. (2018). Xenon-enhanced CT for measurement of regional gas transport during oscillatory ventilation. (Vols. 197). pp. A4477. Am J Respir Crit Care Med.

Herrmann, J., Tawhai, M. H. & Kaczka, D. W. (2018). Parenchymal strain heterogeneity during oscillatory ventilation: why two frequencies are better than one. J Appl Physiol (1985), 124(3), 653-663. PMID: 29051332.

Huhle, R., D'Antini, D., Herrmann, J., Raimondo, P., Mirabella, L., Hemmes, S. N., Schultz, M. J., Pelosi, P., Kaczka, D. W., Cinnella, G. & de Gama Abreu, M. (2018). Intratidal analysis of intraoperative respiratory system mechanics: keep it simple. (Vols. 126). (2), pp. 725-726. Anesth Analg. PMID: 29346212.

D'Antini, D., Huhle, R., Herrmann, J., Sulemanji, D. S., Oto, J., Raimondo, P., Mirabella, L., Hemmes, S. N., Schultz, M. J., Pelosi, P., Kaczka, D. W., Vidal Melo, M. F., de Gama Abreu, M. & Cinnella, G. (2018). Respiratory system mechanics during low versus high positive end-expiratory pressure in open abdominal surgery: a substudy of PROVHILO randomized controlled trial. Anesth Analg, 126(1), 143-149. PMID: 28632529.

Mondoñedo, J. R., Herrmann, J., McNeil, J. S. & Kaczka, D. W. (2017). Comparison of pneumotachography and anemometery for flow measurement during mechanical ventilation with volatile anesthetics. J Clin Monit Comput, 31(6), 1263-1271. PMID: 27844299.

Herrmann, J., Hoffman, E. A. & Kaczka, D. W. (2017). Frequency-selective computed tomography: applications during periodic thoracic motion. IEEE Trans Med Imaging, 36(8), 1722-1732. PMID: 28436852.

Herrmann, J., Hoffmann, E. A. & Kaczka, D. W. (2017). Temporally resolved CT imaging to assess high-frequency periodic deformation. (Vols. 195). pp. A6522. Am J Respir Crit Care Med.

Huhle, R., Amini, R., Herrmann, J., Guldner, A., Gama De Abreu, M. & Kaczka, D. W. (2017). Stochastic resonance versus deterministic resonance during variable controlled ventilation: a numerical investigation. (Vols. 195). pp. A4433. Am J Respir Crit Care Med.

Amini, R., Herrmann, J. & Kaczka, D. W. (2017). Intratidal overdistension and derecruitment in the injured lung: a simulation study. IEEE Trans Biomed Eng, 64(3), 681-689. PMID: 27244715.

Herrmann, J., Tawhai, M. H. & Kaczka, D. W. (2016). Regional gas transport in the heterogeneous lung during oscillatory ventilation. J Appl Physiol (1985), 121(6), 1306-1318. PMID: 27763872.

Abston, E., Herrmann, J., Taft, P., Eberlein, M., Kaczka, D. W. & Stoltz, D. A. (2016). The effects of chest wall strapping in a porcine model of ARDS. (Vols. 193). pp. A4819. Am J Respir Crit Care Med.

Herrmann, J., Tawhai, M. H. & Kaczka, D. W. (2016). Multi-frequency oscillatory ventilation (MFOV): impact on eucapnic ventilation distribution in simulated lung injury. (Vols. 193). pp. A4820. Am J Respir Crit Care Med.

Kaczka, D. W., Herrmann, J., Zonneveld, C. E., Tingay, D. G., Lavizzari, A., Noble, P. B. & Pillow, J. J. (2015). Multifrequency oscillatory ventilation in the premature lung: effects on gas exchange, mechanics, and ventilation distribution. Anesthesiology, 123(6), 1394-1403. PMID: 26495977.

Mondoñedo, J. R., McNeil, J. S., Herrmann, J. & Kaczka, D. W. (2015). Comparison of flow measurements using a pneumotachograph and hot-wire anemometer during mechanical ventilation with volatile anesthetics. (Vols. 191). pp. A3168. Am J Respir Crit Care Med.

Herrmann, J., Tawhai, M. H. & Kaczka, D. W. (2015). Computational modeling of gas transport during oscillatory ventilation. (Vols. 191). pp. A1217. Am J Respir Crit Care Med.

Mondoñedo, J. R., McNeil, J. S., Amin, S. D., Herrmann, J., Simon, B. A. & Kaczka, D. W. (2015). Volatile anesthetics and the treatment of severe bronchoconstriction: a concept of targeted delivery. Drug Discov Today Dis Models, 15, 43-50. PMID: 26744597.

Bates, J. H., Kaczka, D. W. & Prisk, G. K. (2014). Chapter 17: Measurements in Pumonology. In J. G. Webster (Eds.) The Physiological Measurement Handbook. (1), pp. 419-452. Boca Raton, FL: CRC Press.

Chitillian, H. V., Kaczka, D. W. & Vidal Melo, M. F. (2014). Chapter 51: Respiratory Monitoring. In R. D. Miller , L. I. Eriksson & L. A. Fleisher , J. P. Wiener-Kronish , N. H. Cohen , W. L. Young (Eds.) Miller's Anesthesia. (8), pp. 1541-1579. Elsevier.

Pratt, S. D., Kaczka, D. W. & Hess, P. E. (2014). In reply. (Vols. 23). (3), pp. 286-287. Int J Obstet Anesth. PMID: 24934309.

Pratt, S. D., Kaczka, D. W. & Hess, P. E. (2014). Observational study of changes in epidural pressure and elastance during epidural blood patch in obstetric patients. Int J Obstet Anesth, 23(2), 144-150. PMID: 24631062.

Kaczka, D. W., Herrmann, J., Zonneveld, C. E., Tingay, D., Lavizzari, A., Noble, P. B. & Pillow, J. J. (2014). Multi-frequency oscillation ventilation improves gas exchange and lung recruitment in preterm lambs. (Vols. 189). pp. A3567. Am J Respir Crit Care Med.

Clark, A. R., Kaczka, D. W., Thompson, B. R. & Tawhai, M. H. (2014). Ventilation-perfusion matching in large and small animals. (Vols. 189). pp. A3568. Am J Respir Crit Care Med.

Sulemanji, D. S., Oto, J., Herrmann, J., Kaczka, D. W. & Melo, M. F. (2014). High PEEP during major abdominal surgery improves intraoperative elastance and reduces lung recruitment. (Vols. 189). pp. A1179. Am J Respir Crit Care Med.

Amini, R., Kaczka, D. W. (2013). Impact of ventilation frequency and parenchymal stiffness on flow and pressure distribution in a canine lung model. Ann Biomed Eng, 41(12), 2699-2711. PMID: 23872936.

Kaczka, D. W., Mitzner, W. & Brown, R. H. (2013). Effects of lung inflation on airway heterogeneity during histaminergic bronchoconstriction. J Appl Physiol (1985), 115(5), 626-633. PMID: 23813528.

Fraser, 3rd, C. D., Brady, K. M., Rhee, C. J., Easley, R. B., Kibler, K., Smielewski, P., Czosnyka, M., Kaczka, D. W., Andropoulos, D. B. & Rusin, C. (2013). The frequency response of cerebral autoregulation. J Appl Physiol (1985), 115(1), 52-56. PMID: 23681909.

Herrmann, J., Talmor, D. S., Loring, S. H. & Kaczka, D. W. (2013). Nonlinear elastic distortion in acute lung injury: effects of ventilation strategy. (Vols. 187). pp. A1128. Am J Respir Crit Care Med.

Colletti, A. A., Amini, R. & Kaczka, D. W. (2013). Simulating gas exchange in the canine lung using computational modeling. (Vols. 187). pp. A1965. Am J Respir Crit Care Med.

Amini, R., Herrmann, J. & Kaczka, D. W. (2013). Impact of ventilation frequency and collateral ventilation on global mechanics and pressure/flow distribution in the canine lung. (Vols. 187). pp. A1966. Am J Respir Crit Care Med.

Vidal Melo, M. F., Musch, G. & Kaczka, D. W. (2012). Pulmonary pathophysiology and lung mechanics in anesthesiology: a case-based overview. Anesthesiol Clin, 30(4), 759-784. PMID: 23089508.

Brady, K. M., Easley, R. B., Kibler, K., Kaczka, D. W., Andropoulos, D., Fraser III, C. D., Smielewski, P., Czosnyka, M., Adams, G. J., Rhee, C. J. & Rusin, C. G. (2012). Positive end-expiratory pressure oscillation facilitates brain vascular reactivity monitoring. J Appl Physiol (1985), 113(9), 1362-1368. PMID: 22984248.

Kaczka, D. W., Smallwood, J. L. (2012). Constant-phase descriptions of canine lung, chest wall, and total respiratory system viscoelasticity: effects of distending pressure. Respir Physiol Neurobiol, 183(2), 75-84. PMID: 22691447.

Simon, B. A., Kaczka, D. W., Bankier, A. A. & Parraga, G. (2012). What can computed tomography and magnetic resonance imaging tell us about ventilation?. J Appl Physiol (1985), 113(4), 647-657. PMID: 22653989.

Amini, R., Amin, S. & Kaczka, D. W. (2012). Nonlinear time-dependent model of recruitment and derecruitment in canine lung injury. (Vols. 185). pp. A2047. Am J Respir Crit Care Med.

Chon, D., Yin, Y., Hoffman, E. A., Amini, R., Simon, B. A. & Kaczka, D. W. (2012). High-resolution topographic distribution of regional inflation in healthy and injured canine lungs. (Vols. 185). pp. A2066. Am J Respir Crit Care Med.

Kaczka, D. W., Herrmann, J., Crowe, M. T. & Simon, B. A. (2012). Effects of high and low tidal volume ventilation on respiratory mechanics and systemic inflammation in canine acute lung injury. (Vols. 185). pp. A2046. Am J Respir Crit Care Med.

Kaczka, D. W., Simon, B. A. & Thompson, B. T. (2012). Regional lung strain and inflammation. (Vols. 185). (2), pp. 228-229; author reply 229-30. Am J Respir Crit Care Med. PMID: 22246708.

Custer, J. W., Watson, C. M., Dwyer, J., Kaczka, D. W., Simon, B. A. & Easley, R. B. (2011). Critical evaluation of emergency stockpile ventilators in an in vitro model of pediatric lung injury. Pediatr Crit Care Med, 12(6), e357-e361. PMID: 21317679.

Colletti, A. A., Amini, R. & Kaczka, D. W. (2011). Simulating ventilation distribution in heterogenous lung injury using a binary tree data structure. Comput Biol Med, 41(10), 936-945. PMID: 21872852.

Custer, J. W., Ahmed, A., Kaczka, D. W., Mulreany, D. G., Hager, D. N., Simon, B. A. & Easley, R. B. (2011). In vitro performance comparison of the Sensormedics 3100A and B high-frequency oscillatory ventilators. Pediatr Crit Care Med, 12(4), e176-e180. PMID: 21037502.

Kaczka, D. W., Lutchen, K. R. & Hantos, Z. (2011). Emergent behavior of regional heterogeneity in the lung and its effects on respiratory impedance. J Appl Physiol (1985), 110(5), 1473-1481. PMID: 21292840.

Kaczka, D. W., Cao, K., Christensen, G. E., Bates, J. H. & Simon, B. A. (2011). Analysis of regional mechanics in canine lung injury using forced oscillations and 3D image registration. Ann Biomed Eng, 39(3), 1112-1124. PMID: 21132371.

Brown, R. H., Kaczka, D. W., Fallano, K., Shapiro, S. & Mitzner, W. (2011). Individual canine airway response variability to a deep inspiration. Clin Med Insights Circ Respir Pulm Med, 5, 7-15. PMID: 21487453.

Kaczka, D. W., Dellacá, R. L. (2011). Oscillation mechanics of the respiratory system: applications to lung disease. Crit Rev Biomed Eng, 39(4), 337-59. PMID: 22011237.

Kaczka, D. W., Bates, J. H. (2011). Preface: Pulmonary physiology. (Vols. 39). (4), pp. 261-262. Crit Rev Biomed Eng. PMID: 22011232.

Kaczka, D. W., Chon, D., Yin, Y., Hoffman, E. A. & Simon, B. A. (2011). Regional expansion in canine lungs using CT image registration: a comparison of Jacobian determinant and density methods. (Vols. 183). pp. A3585. Am J Respir Crit Care Med.

Kaczka, D. W., Colletti, A. A., Tawhai, M. H. & Simon, B. A. (2010). Chapter 10: Computational Analyses of Lung Tissue and Airway Dynamics. In K. B. Chandran , H. S. Udaykumar , J. M. Reinhardt (Eds.) Image-Based Computational Modeling in the Human Circulatory and Pulmonary Systems. (2011), pp. 375-402. Norwell, MA: Springer. DOI: 10.1007/978-1-4419-7350-4_10.

Brown, R. H., Kaczka, D. W. & Mitzner, W. (2010). Effect of parenchymal stiffness on canine airway size with lung inflation. PLoS One, 5(4), e10332. PMID: 20436667.

Amini, R., Kaczka, D. W. (2010). Effect of parenchymal stiffness on regional flow and pressure distributions in the canine lung: a simulation study. (Vols. 181). pp. A1239. Am J Respir Crit Care Med.

Smallwood, J. L., Simon, B. A. & Kaczka, D. W. (2010). Effects of distending pressure and canine lung, chest wall, and total respiratory system viscoelasticity. (Vols. 181). pp. A1238. Am J Respir Crit Care Med.

Kaczka, D. W., Brown, R. H. & Mitzner, W. (2009). Assessment of heterogeneous airway constriction in dogs: a structure-function analysis. J Appl Physiol (1985), 106(2), 520-530. PMID: 18927269.

Easley, R. B., Lancaster, C. T., Fuld, M. K., Custer, J. W., Hager, D. N., Kaczka, D. W. & Simon, B. A. (2009). Total and regional lung volume changes during high-frequency oscillatory ventilation (HFOV) of the normal lung. Respir Physiol Neurobiol, 165(1), 54-60. PMID: 18996228.

Custer, J. W., Dwyer, J., Watson, C. M., Kaczka, D. W., Simon, B. A. & Easley, R. B. (2009). Emergency ventilator performance characteristics under conditions of adult pediatric respiratory failure. (Vols. 179). pp. A3071. Am J Respir Crit Care Med.

Ahmed, A., Custer, J. W., Mulreany, D. G., Kaczka, D. W., Simon, B. A. & Easley, R. B. (2009). The effect of piston position on tidal volume delivery during high-frequency oscillatory ventilation. (Vols. 179). pp. A5814. Am J Respir Crit Care Med.

Kaczka, D. W., Cao, K., Christensen, G. E., Bates, J. H. & Simon, B. A. (2009). Regional mechanics in acute lung injury: a comparison of Function and structure. (Vols. 179). pp. A3550. Am J Respir Crit Care Med.

Bellardine Black, C. L., Hoffman, A. M., Tsai, L. W., Ingenito, E. P., Suki, B., Kaczka, D. W., Simon, B. A. & Lutchen, K. R. (2008). Impact of positive end-expiratory pressure during heterogeneous lung injury: insights from computed tomographic image functional modeling. Ann Biomed Eng, 36(6), 980-991. PMID: 18340535.

Brown, R. H., Kaczka, D. W., Fallano, K., Chen, S. & Mitzner, W. (2008). Temporal variability in the responses of individual canine airways to methacholine. J Appl Physiol (1985), 104(5), 1381-1386. PMID: 18309091.

Pauldine, R., Beck, G., Salinas, J. & Kaczka, D. W. (2008). Closed-loop strategies for patient care systems. J Trauma, 64(4 Suppl), S289-S294. PMID: 18385581.

Brown, R. H., Kaczka, D. W., Fallano, K. & Mitzner, W. (2008). Individual airway size variability. (Vols. 177). pp. A547. Am J Respir Crit Care Med.

Kaczka, D. W., Brown, R. H. & Mitzner, W. (2008). Assessment of heterogeneous airway constriction: an inverse model analysis. (Vols. 177). pp. A514. Am J Respir Crit Care Med.

Kaczka, D. W. (2007). Lung impedance measurements are/are not more useful than simpler measurements of lung function in animal models of pulmonary disease. (Vols. 103). (5), pp. 1907; author reply 1909-10. Bethesda, MD: J Appl Physiol (1985). PMID: 18098391.

Kaczka, D. W., Massa, C. B. & Simon, B. A. (2007). Reliability of estimating stochastic lung tissue heterogeneity from pulmonary impedance spectra: a forward-inverse modeling study. Ann Biomed Eng, 35(10), 1722-1738. PMID: 17558554.

Bellardine Black, C., Hoffman, A. M., Tsai, L. W., Ingenito, E. P., Suki, B., Kaczka, D. W., Simon, B. A. & Lutchen, K. R. (2007). In reply: Dynamic respiratory mechanics measurements for optimization of ventilator settings in acute lung injury. (Vols. 35). (7), pp. 1807-1808. Critical Care Medicine. DOI: 10.1097/01.CCM.0000269350.98447.E3.

Hager, D. N., Fessler, H. E., Kaczka, D. W., Shanholtz, C. B., Fuld, M. K., Simon, B. A. & Brower, R. G. (2007). Tidal volume delivery during high-frequency oscillatory ventilation in adults with acute respiratory distress syndrome. Crit Care Med, 35(6), 1522-1529. PMID: 17440422.

Bellardine Black, C. L., Hoffman, A. M., Tsai, L. W., Ingenito, E. P., Suki, B., Kaczka, D. W., Simon, B. A. & Lutchen, K. R. (2007). Relationship between dynamic respiratory mechanics and disease heterogeneity in sheep lavage injury. Crit Care Med, 35(3), 870-878. PMID: 17255854.

Hager, D. N., Fuld, M., Kaczka, D. W., Fessler, H. E., Brower, R. G. & Simon, B. A. (2006). Four methods of measuring tidal volume during high-frequency oscillatory ventilation. Crit Care Med, 34(3), 751-757. PMID: 16505661.

Kaczka, D. W., Massa, C. B. & Simon, B. A. (2006). Reliability of estimating stochastic lung tissue heterogeneity with inverse modeling. (Vols. 3). pp. A876. Proc Am Thorac Soc.

Kaczka, D. W., Kumar, D., Christensen, G. E., Massa, C. B. & Simon, B. A. (2006). Assessment of regional mechanics in acute lung injury using 3D image registration. (Vols. 3). pp. A788. Proc Am Thorac Soc.

Kaczka, D. W., Hager, D. N., Hawley, M. L. & Simon, B. A. (2005). Quantifying mechanical heterogeneity in canine acute lung injury: impact of mean airway pressure. Anesthesiology, 103(2), 306-317. PMID: 16052113.

Kaczka, D. W., Beck, G. (2004). Mechanical ventilation in orbit: emphasis on closed-loop ventilation. Respir Care Clin N Am, 10(3), 369-400, vii. PMID: 15458734.

Kaczka, D. W., Lutchen, K. R. (2004). Servo-controlled pneumatic pressure oscillator for respiratory impedance measurements and high-frequency ventilation. Ann Biomed Eng, 32(4), 596-608. PMID: 15117033.

Hager, D. N., Kaczka, D. W., Fuld, M. K., Fessler, H. E., Brower, R. G. & Simon, B. A. (2004). Tidal volume measurement during simulated high frequency oscillatory ventilation (HFOV). (Vols. 169). (7), pp. A348. Am J Respir Crit Care Med.

Kaczka, D. W., Hager, D. N. & Simon, B. A. (2004). Quantifying mechanical heterogeneity in canine acute lung injury (ALI). (Vols. 169). (7), pp. A785. Am J Respir Crit Care Med.

Lutchen, K. R., Jensen, A., Atileh, H., Kaczka, D. W., Israel, E., Suki, B. & Ingenito, E. P. (2001). Airway constriction pattern is a central component of asthma severity: the role of deep inspirations. Am J Respir Crit Care Med, 164(2), 207-215. PMID: 11463589.

Kaczka, D. W., Ingenito, E. P., Body, S. C., Duffy, S. E., Mentzer, S. J., DeCamp, M. M. & Lutchen, K. R. (2001). Inspiratory lung impedance in COPD: effects of PEEP and immediate impact of lung volume reduction surgery. J Appl Physiol (1985), 90(5), 1833-1841. PMID: 11299274.

Kaczka, D. W., Ingenito, E. P. & Lutchen, K. R. (1999). Technique to determine inspiratory impedance during mechanical ventilation: implications for flow limited patients. Ann Biomed Eng, 27(3), 340-355. PMID: 10374726.

Kaczka, D. W., Ingenito, E. P., Israel, E. & Lutchen, K. R. (1999). Airway and lung tissue mechanics in asthma. Effects of albuterol. Am J Respir Crit Care Med, 159(1), 169-178. PMID: 9872836.

Ingenito, E. P., Evans, R. B., Loring, S. H., Kaczka, D. W., Rodenhouse, J. D., Body, S. C., Sugarbaker, D. J., Mentzer, S. J., DeCamp, M. M. & Reilly, Jr, J. J. (1998). Relation between preoperative inspiratory lung resistance and the outcome of lung-volume-reduction surgery for emphysema. N Engl J Med, 338(17), 1181-1185. PMID: 9554858.

Kaczka, D. W., Ingenito, E. P., Body, S., Loring, S. H. & Lutchen, K. R. (1998). Lung resistance and elastance spectra in flow-limited, intubated patients. (Vols. 157). (3), pp. A82. Am J Respir Crit Care Med.

Lutchen, K. R., Ingenito, E. P. & Kaczka, D. W. (1998). Impact of deep inspiration on induced versus spontaneous airway constriction. (Vols. 157). (3), pp. A517. Am J Respir Crit Care Med.

Lutchen, K. R., Gillis, H., Kaczka, D. W., Israel, E. & Ingenito, E. P. (1998). Does airway inflammation enable heterogeneous airway closure that amplifies acute asthma?. (Vols. 26). (Suppl. 1), pp. S-46. Ann Biomed Eng.

Kaczka, D. W., Ingenito, E. P., Suki, B. & Lutchen, K. R. (1997). Partitioning airway and lung tissue resistances in humans: effects of bronchoconstriction. J Appl Physiol (1985), 82(5), 1531-1541. PMID: 9134903.

Lutchen, K. R., Gillis, H. & Kaczka, D. W. (1997). On the relation between heterogeneous changes in airway morphometry and important changes in lung mechanical properties. (Vols. 155). (4), pp. A744. Am J Respir Crit Care Med.

Ingenito, E. P., Evans, R. B., Loring, S. H., Kaczka, D. W., Reilly, J. J., Mentzer, S. J., DeCamp, M. M. & Sugarbaker, D. J. (1997). Preoperative inspiratory resistance: a predictor of clinical response volume reduction surgery. (Vols. 155). (4), pp. A794. Am J Respir Crit Care Med.

Kaczka, D. W., Ingenito, E. P., Israel, E., Suki, B. & Lutchen, K. R. (1997). Effect of beta agonist-induced bronchodilation airway and lung tissue resistances in asthmatic subjects. (Vols. 155). (4), pp. A859. Am J Respir Crit Care Med.

MacLeod, D., Kaczka, D. W., Krishna, M., Scott, R., Grant, L., Frew, A. (1997). Effect of short-term ozone exposure on human input impedance (Zin) behavior in healthy subjects between 5-4 Hz. (Vols. 10). (Suppl. 25), pp. 329S. Eur Respir J.

Kaczka, D. W., Ingenito, E. P., Suki, B. & Lutchen, K. R. (1996). Separation of airway and lung tissue resistance in healthy humans using an optimal ventilator waveform. (Vols. 153). (4), pp. A745. Am J Crit Care Med.

Kaczka, D. W., Ingenito, E. P., Body, S., Suki, B. & Lutchen, K. R. (1996). Partitioning airway and lung tissue resistance in unhealthy human lungs. (Vols. 24). (Suppl. 1), pp. S-12. Ann Biomed Eng.

Kaczka, D. W., Barnas, G. M., Suki, B. & Lutchen, K. R. (1995). Assessment of time-domain analyses for estimation of low-frequency respiratory mechanical properties and impedance spectra. Ann Biomed Eng, 23(2), 135-151. PMID: 7605051.

Barnas, G. M., Harinath, P., Green, M. D., Suki, B., Kaczka, D. W. & Lutchen, K. R. (1994). Influence of waveform and analysis technique on lung and chest wall properties. Respir Physiol, 96(2-3), 331-344. PMID: 8059094.

Lutchen, K. R., Suki, B., Kaczka, D. W., Zhang, O., Hantos, Z., Daroczy, B. & Petak, F. (1994). Direct use of mechanical ventilation to measure respiratory mechanics associated with physiological breathing. European Respiratory Review, 4(19), 198-202.

Lutchen, K. R., Kaczka, D. W., Suki, B., Barnas, G., Cevenini, G. & Barbini, P. (1993). Low-frequency respiratory mechanics using ventilator-driven forced oscillations. J Appl Physiol (1985), 75(6), 2549-2560. PMID: 8125874.

Lutchen, K. R., Yang, K., Kaczka, D. W. & Suki, B. (1993). Optimal ventilation waveforms for estimating low-frequency respiratory impedance. J Appl Physiol (1985), 75(1), 478-488. PMID: 8376299.

Bamas, G. M., Harinath, P., Green, M. D., Suki, B., Kaczka, D. W. & Lutchen, K. R. (1993). Measurement of respiratory system properties in the physiologic range. (Vols. 7). pp. A9. FASEB J.

Kaczka, D. W., Suki, B. & Lutchen, K. R. (1993). Time- vs. frequency-domain analysis of respiratory mechanics at low frequencies: impact of waveform. (Vols. 21). (Suppl 1), pp. 6. Ann Biomed Eng.

Yutchen, K. R., Yang, K., Kaczka, D. W. & Suki, B. (1992). Optimal ventilator waveform design for estimating respiratory impedance at low frequencies. (Vols. 6). pp. A1480. FASEB J.

Lutchen, K. R., Kaczka, D. W., Suki, B., Yang, K., Cevinini, G., Ursino, M. & Barbini, P. (1992). Estimating low frequency respiratory impedance in humans and dogs using ventilator step and optimally designed waveforms. (Vols. 5). (Suppl 15), pp. 122s. Eur Respir J.

Kaczka, D. W., Yang, K., Bamas, G. M. & Lutchen, K. R. (1991). Identification of human respiratory mechanics using ventilator-driven forced oscillations at low frequencies. (Vols. 19). (5), pp. 585. Ann Biomed Eng.

Kaczka, D. W., Yang, K., Barnas, G. M. & Lutchen, K. R. (1991). Use of ventilator driven forced oscillations for characterizing human respiratory mechanics at low frequencies. pp. 73-74. Bioengineering, Proceedings of the Northeast Conference.

Kaczka, D. W., Yang, K., Barnas, G. M. & Lutchen, K. R. (1991). Identification of human respiratory mechanics using ventilator driven forced oscillations at low frequencies. (Vols. 19). (5), pp. 585. Ann Biomed Eng.