Toshihiro Kitamoto, PhD

Portrait
Associate Professor of Anesthesia
Associate Professor of Neuroscience and Pharmacology

Contact Information

Primary Office
1-316 Bowen Science Building
51 Newton Road
Iowa City, IA 52242
319-356-2633

Fax
6546-1 John Colloton Pavilion
200 Hawkins Drive
Iowa CIty, IA 52242
319-356-2940

Education

BS, Biochemistry, University of Tokyo
MS, Biochemistry, University of Tokyo
PhD, Biochemistry, University of Tokyo
Postdoctoral Fellow, National Institute of Neuroscience
Fellow, Beckman Research, Institute of the City of Hope
Fellow, Beckman Research, Institute of the City of Hope

Education/Training Program Affiliations

Interdisciplinary Graduate Program in Genetics, Interdisciplinary Graduate Program in Neuroscience, Medical Scientist Training Program

Research Summary

Our lab is interested in understanding the genetic basis of complex behaviors or brain functions, such as learning and memory, sleep and mood. In order to elucidate fundamental mechanisms underlying the control of these behaviors, we take advantage of the power of the Drosophila (fruit fly) genetics, and study the relationship between genes and behavior at the molecular, cellular, systems and whole animal levels. Currently, our main research projects are on 1) the role of steroid hormones in the regulation of sleep and memory, and 2) the neurological pathways that are affected by the mood stabilizing drug lithium that is used for bipolar disorder. By examining the behavior of well-defined Drosophila mutants and transformants, we study the function of particular genes and their genetic interactions in fundamental aspects of behavior. Molecular and anatomical analyses are also being carried out to reveal the mechanisms employed by particular genes in the regulation of behavior. Our recent findings include 1) the insect molting hormone ecdysteroid promotes sleep and regulates long-term memory in adult flies, and 2) the Ca 2+/CaM-dependent phosphatase calcineurin is involved in the lithium's action in the nervous system and a novel SLC6 transporter plays a critical role in resistance to lithium toxicity. Our basic research is expected to provide new insights into the evolutionarily conserved mechanisms underlying higher-order brain functions that control complex behavior. PubMed link to publications: http://www.ncbi.nlm.nih.gov/pubmed?term=(((Kitamoto%20AND%20drosophila))%20OR%20(Kitamoto%20AND%20iowa))%20AND%20(%222004%22%5BDate%20-%20Publication%5D%20%3A%20%223000%22%5BDate%20-%20Publication%5D)

Publications

Petruccelli, E., Lark, A., Mrkvicka III, J. A. & Kitamoto, T. (2020). Significance of DopEcR, a G-protein coupled dopamine/ecdysteroid receptor, in physiological and behavioral response to stressors. J Neurogenet. PMID: 31955616.

Inami, S., Sato, S., Kondo, S., Tanimoto, H., Kitamoto, T. & Sakai, T. (2020). Environmental light is required for maintenance of long-term memory in Drosophila. J Neurosci. PMID: 31932417.

(2020). Environmental light triggers production of memory proteins in fruit flies. Rockville, MD: ScienceDaily.

(2020). Using light to learn: environmental light triggers production of memory proteins in fruit flies. Douglas, Isle of Man: MedicalXpress.

(2020). Fly sex study may unlock the secret to maintaining long-term memories: early-stage work suggests that it's not all about sleep. New York, NY: Inverse.

(2020). Using light to learn: environmental light triggers production of memory proteins in fruit flies. Washington, DC: EurekAlert!.

(2020). Environmental light required for maintaining long-term memories. Sydney, New South Wales: News Medical Life Sciences.

Kasuya, J., Iyengar, A., Chen, H., Lansdon, P., Wu, C. & Kitamoto, T. (2019). Milk-whey diet substantially suppresses seizure-like phenotypes of paraShu, a Drosophila voltage-gated sodium channel mutant. J Neurogenet, 33(3), 164-178. PMID: 31096839.

Hindle, S. J., Munji, R. N., Dolghih, E., Gaskins, G., Orng, S., Ishimoto, H., Soung, A., DeSalvo, M., Kitamoto, T., Keiser, M. J., Jacobson, M. P., Daneman, R. & Bainton, R. J. (2017). Evolutionarily conserved roles for blood-brain barrier xenobiotic transporters in endogenous steroid partitioning and behavior. Cell Rep, 21(5), 1304-1316. PMID: 29091768.

Lark, A., Kitamoto, T. & Martin, J. R. (2017). Modulation of neuronal activity in the Drosophila mushroom body by DopEcR, a unique dual receptor for ecdysone and dopamine. Biochim Biophys Acta Mol Cell Res, 1864(10), 1578-1588. PMID: 28554773.

Shimada, N., Inami, S., Sato, S., Kitamoto, T. & Sakai, T. (2016). Modulation of light-driven arousal by LIM-homeodomain transcription factor Apterous in large PDF-positive lateral neurons of the Drosophila brain. Sci Rep, 6, 37255. PMID: 27853240.

Kaas, G. A., Kasuya, J., Lansdon, P., Ueda, A., Iyengar, A., Wu, C. & Kitamoto, T. (2016). Lithium-responsive seizure-like hyperexcitability is caused by a mutation in the "Drosophila" voltage-gated sodium channel gene "paralytic". eNeuro, 3(5). PMID: 27844061.

Ehaideb, S. N., Wignall, E. A., Kasuya, J., Evans, W. H., Iyengar, A., Koerselman, H. L., Lilienthal, A. J., Bassuk, A. G., Kitamoto, T. & Manak, J. R. (2016). Mutation of orthologous prickle genes causes a similar epilepsy syndrome in flies and humans. Ann Clin Transl Neurol, 3(9), 695-707. PMID: 27648459.

Petruccelli, E., Li, Q., Rao, Y. & Kitamoto, T. (2016). The unique dopamine/ecdysteroid receptor DopEcR modulates ethanol-induced sedation in Drosophila. J Neurosci, 36(16), 4647-4657. PMID: 27098705.

Lark, A. R., Kitamoto, T. & Martin, J. R. (2016). In vivo functional brain imaging approach based on bioluminescent calcium indicator GFP-Aequorin. J Vis Exp,(107). PMID: 26779599.

Petruccelli, E., Lansdon, P. & Kitamoto, T. (2015). Exaggerated nighttime sleep and defective sleep homeostasis in a Drosophila knock-in model of human epilepsy. PLoS One, 10(9), e0137758. PMID: 26361221.

Sato, S., Kitamoto, T. & Sakai, T. (2014). Modulation of innate and learned sexual behaviors by the TRP channel Painless expressed in the fruit fly brain: behavioral genetic analysis and its implications. Front Behav Neurosci, 8, 400. PMID: 25520634.

Sakai, T., Watanabe, K., Ohashi, H., Sato, S., Inami, S., Shimada, N. & Kitamoto, T. (2014). Insulin-producing cells regulate the sexual receptivity through the painless TRP channel in Drosophila virgin females. PLoS One, 9(2), e88175. PMID: 24505416.

Blake, A., Kendall, N., Boppana, S., Kitamoto, T. & Lawal, H. (2014). Effects of changes in acetylcholine release on locomotion states in central synapses. Society for Neuroscience - Abstracts.

Ishimoto, H., Wang, Z., Rao, Y., Wu, C. & Kitamoto, T. (2013). A novel role for ecdysone in Drosophila conditioned behavior: linking GPCR-mediated non-canonical steroid action to cAMP signaling in the adult brain. PLoS Genet, 9(10), e1003843. PMID: 24130506.

Sakai, T., Sato, S., Ishimoto, H. & Kitamoto, T. (2012). Significance of the centrally expressed TRP channel painless in Drosophila courtship memory. Learn Mem, 20(1), 34-40. PMID: 23247253.

Sakai, T., Inami, S., Sato, S. & Kitamoto, T. (2012). Fan-shaped body neurons are involved in period-dependent regulation of long-term courtship memory in Drosophila. Learn Mem, 19(12), 571-574. PMID: 23154928.

Lark, A., Petruccelli, E. & Kitamoto, T. (2012). Drosophila DopEcR, a putative dual receptor for ecdysteroids and dopamine, is involved in behavioral response to food deprivation. Society for Neuroscience – Abstracts.

Ishimoto, H., Lark, A. & Kitamoto, T. (2012). Factors that differentially affect daytime and nighttime sleep in Drosophila melanogaster. Front Neurol, 3, 24. PMID: 22375135.

Inagaki, H. K., Ben-Tabou de-Leon, S., Wong, A. M., Jagadish, S., Ishimoto, H., Barnea, G., Kitamoto, T., Axel, R. & Anderson, D. J. (2012). Visualizing neuromodulation in vivo: TANGO-mapping of dopamine signaling reveals appetite control of sugar sensing. Cell, 148(3), 583-595. PMID: 22304923.

Soshnev, A. A., Ishimoto, H., McAllister, B. F., Li, X., Wehling, M. D., Kitamoto, T., Geyer, P. K. & Birchler, J. A. (2011). A conserved long noncoding RNA affects sleep behavior in Drosophila. Genetics, 189(2), 455-468. PMID: 21775470.

Ishimoto, H., Kitamoto, T. (2011). Beyond molting--roles of the steroid molting hormone ecdysone in regulation of memory and sleep in adult Drosophila. Fly (Austin), 5(3), 215-220. PMID: 21444997.

Iyengar, A., Ueda, A., Xing, X., Kitamoto, T. & Wu, C. (2011). A spectrum of neuronal excitability and central pattern generation phenotypes in distinct alleles of Drosophila Nav channel mutants. Society for Neuroscience – Abstracts.

Aso, Y., Siwanowicz, I., Bräcker, L., Ito, K., Kitamoto, T. & Tanimoto, H. (2010). Specific dopaminergic neurons for the formation of labile aversive memory. Curr Biol, 20(16), 1445-1451. PMID: 20637624.

Ishimoto, H., Kitamoto, T. (2010). The steroid molting hormone Ecdysone regulates sleep in adult Drosophila melanogaster. Genetics, 185(1), 269-281. PMID: 20215472.

Aldrich, B. T., Kasuya, J., Faron, M., Ishimoto, H. & Kitamoto, T. (2010). The amnesiac gene is involved in the regulation of thermal nociception in Drosophila melanogaster. J Neurogenet, 24(1), 33-41. PMID: 19995327.

Kitamoto, T., Ishimoto, H., Olsen, D., Root, C. M. & Wang, J. W. (2010). Neural development, sensory processing, and behavioral control: highlight of Cold Spring Harbor Meeting on Neurobiology of Drosophila, September 29 to October 3, 2009. J Neurogenet, 24(1), 1-4. DOI: 10.3109/01677060903552676.

Kaas, A. G., Jewell, R., Kasuya, J., Ishimoto, H. & Kitamoto, T. (2010). Shudderer, a dominant mutation in Drosophila causing lithium-responsive neurological defects, is allelic to the voltage-gated sodium channel gene paralytic. Society Neuroscience – Abstracts.

Aldrich, B. T., Frakes, E. P., Kasuya, J., Hammond, D. L. & Kitamoto, T. (2009). Changes in expression of sensory organ-specific microRNAs in rat dorsal root ganglia in association with mechanical hypersensitivity induced by spinal nerve ligation. Neuroscience, 164(2), 711-723. PMID: 19699278.

Kasuya, J., Kaas, G. A. & Kitamoto, T. (2009). A putative amino acid transporter of the solute carrier 6 family is upregulated by lithium and is required for resistance to lithium toxicity in Drosophila. Neuroscience, 163(3), 825-837. PMID: 19619614.

Kasuya, J., Ishimoto, H. & Kitamoto, T. (2009). Neuronal mechanisms of learning and memory revealed by spatial and temporal suppression of neurotransmission using shibire, a temperature-sensitive dynamin mutant gene in Drosophila melanogaster. Front Mol Neurosci, 2, 11. PMID: 19738923.

Kasuya, J., Kaas, G. & Kitamoto, T. (2009). Effects of lithium chloride on the gene expression profiles in Drosophila heads. Neurosci Res, 64(4), 413-420. PMID: 19410610.

Sakai, T., Kasuya, J., Kitamoto, T. & Aigaki, T. (2009). The Drosophila TRPA channel, Painless, regulates sexual receptivity in virgin females. Genes Brain Behav, 8(5), 546-557. PMID: 19531155.

Ishimoto, H., Sakai, T. & Kitamoto, T. (2009). Ecdysone signaling regulates the formation of long-term courtship memory in adult Drosophila melanogaster. Proc Natl Acad Sci U S A, 106(15), 6381-6386. PMID: 19342482.

Kaas, G. A., Kasuya, J. & Kitamoto, T. (2009). Possible involvement of the calcineurin A subunit gene, CanA-14F, in the neurological phenotype of the lithium-responsive Drosophila mutant, Shudderer. Society Neuroscience – Abstracts.

Sitaraman, D., Zars, M., LaFerriere, H., Chen, Y., Sable-Smith, A., Kitamoto, T., Rottinghaus, G. E. & Zars, T. (2008). Serotonin is necessary for place memory in Drosophila. Proc Natl Acad Sci U S A, 105(14), 5579-5584. PMID: 18385379.

Eberl, D. F., Kitamoto, T., Berke, B., O'Connor-Giles, K., Ueda, A., Lee, J., Ruan, H., Engel, J. E. & Ganetzky, B. (2008). Meeting report: genes, neurons, circuits, and behaviors: highlights of Cold Spring Harbor meeting on Drosophila neurobiology, October 3-7, 2007. J Neurogenet, 22(1), 3-13. PMID: 18363161.

Ishimoto, H., Sakai, T. & Kitamoto, T. (2008). The role of insect steroid hormone ecdysone in courtship memory in Drosophila. Society Neuroscience – Abstracts.

Kitamoto, T., Kaas, G., Ishimoto, H. & Kasuya, J. (2007). Calcineurin and innate immune response genes are upregulated in Shudderer, the lithium responsive neurological mutant in Drosophila. Society Neuroscience – Abstracts.

Sakai, T., Kitamoto, T. (2006). Clock, love and memory: Circadian and non-circadian regulation of Drosophila mating behavior by clock genes. Sleep and Biological Rhythms, 4(3), 255-262. DOI: 10.1111/j.1479-8425.2006.00224.x.

Sakai, T., Kitamoto, T. (2006). Differential roles of two major brain structures, mushroom bodies and central complex, for Drosophila male courtship behavior. J Neurobiol, 66(8), 821-834. PMID: 16673386.

Sakai, T., Kitamoto, T. (2006). [Recent development of research on long-term memory in Drosophila]. Seikagaku, 78(1), 38-41. PMID: 16491911.

Kitamoto, T., Ishimoto, H. & Sakai, T. (2006). Involvement of the Drosophila transient receptor potential ion channel gene painless in long-term courtship memory in Drosophila. pp. 290.18/OO68. Society Neuroscience – Abstracts.

Kaas, G. A., Ishimoto, H., Kasuya, J. & Kitamoto, T. (2006). Shudderer: a Drosophila model to study the molecular mechanisms of lithium action. pp. 813.18/T19. Society Neuroscience – Abstracts.

Sakai, T., Kitamoto, T. & Kidokoro, Y. (2005). The clock gene, period, is essential for long-term memory formation in Drosophila. Cell Technology, 24, 50-51.

Flintoft, L. (2005). Beyond the body clock. (Vols. 6). pp. 3. London, England: Nature Reviews Genetics.

Sakai, T., Tamura, T., Kitamoto, T. & Kidokoro, Y. (2004). A clock gene, period, plays a key role in long-term memory formation in Drosophila. Proc Natl Acad Sci U S A, 101(45), 16058-16063. PMID: 15522971.

Broughton, S. J., Kitamoto, T. & Greenspan, R. J. (2004). Excitatory and inhibitory switches for courtship in the brain of Drosophila melanogaster. Curr Biol, 14(7), 538-547. PMID: 15062094.

Sreenivasan, A. (2004). Fruit fly courtship puts neurons to work. Science.

Wang, Y., Chiang, A., Xia, S., Kitamoto, T., Tully, T. & Zhong, Y. (2003). Blockade of neurotransmission in Drosophila mushroom bodies impairs odor attraction, but not repulsion. Curr Biol, 13(21), 1900-1904. PMID: 14588247.

Murphey, R. K., Froggett, S. J., Caruccio, P., Shan-Crofts, X., Kitamoto, T. & Godenschwege, T. A. (2003). Targeted expression of shibire ts and semaphorin 1a reveals critical periods for synapse formation in the giant fiber of Drosophila. Development, 130(16), 3671-3682. PMID: 12835384.

Kitamoto, T. (2002). Conditional disruption of synaptic transmission induces male-male courtship behavior in Drosophila. Proc Natl Acad Sci U S A, 99(20), 13232-13237. PMID: 12239352.

Kitamoto, T. (2002). Targeted expression of temperature-sensitive dynamin to study neural mechanisms of complex behavior in Drosophila. J Neurogenet, 16(4), 205-228. PMID: 12745632.

Hall, C. T. (2002). Study finds chemical link to sex attraction. San Francisco Chronicle.

Surridge, C. (2002). Turning up the heat turns mutant male flies on to each other. Nature News.

Beckman, M. (2002). How to make a fly bi. Science Now.

Kitamoto, T. (2002). Analysis of neuronal functions using a temperature-sensitive molecular switch for synaptic transmission. Biophysics, 42, 236-241.

Choi, C. (2002). Gay flies. (Vols. 287). pp. 34. Scientific American.

Westphal, S. P. (2002). Turning up the heat makes flies fancy the same sex. (Vols. 175). pp. 15. New Scientist.

Salvaterra, P. M., Kitamoto, T. (2001). Drosophila cholinergic neurons and processes visualized with Gal4/UAS-GFP. Brain Res Gene Expr Patterns, 1(1), 73-82. PMID: 15018821.

Dubnau, J., Kitamoto, T. & Tully, T. (2001). Reversible disruption of synaptic transmission in Drosophila mushroom bodies blocks retrieval, but not acquisition or storage of olfactory memory. (Vols. 78). (Suppl. 1), pp. 12. Journal of Neurochemistry.

Menzel, R., Müller, U. (2001). Neurobiology. Learning from a fly's memory. (Vols. 411). (6836), pp. 433-434. Nature. PMID: 11373661.

Dubnau, J., Grady, L., Kitamoto, T. & Tully, T. (2001). Disruption of neurotransmission in Drosophila mushroom body blocks retrieval but not acquisition of memory. Nature, 411(6836), 476-480. PMID: 11373680.

Kitamoto, T. (2001). Conditional modification of behavior in Drosophila by targeted expression of a temperature-sensitive shibire allele in defined neurons. J Neurobiol, 47(2), 81-92. PMID: 11291099.

Waddell, S., Quinn, W. G. (2001). Learning how a fruit fly forgets. (Vols. 293). pp. 1271-1272. Science.

Wang, Y., Kitamoto, T. & Zhong, Y. (2001). Drosophila mushroom bodies in the perception of odor attractiveness. (Vols. 27). Society Neuroscience – Abstracts.

Waddell, S., Armstrong, J. D., Kitamoto, T., Kaiser, K. & Quinn, W. G. (2000). The amnesiac gene product is expressed in two neurons in the Drosophila brain that are critical for memory. Cell, 103(5), 805-813. PMID: 11114336.

Kitamoto, T., Xie, X., Wu, C. F. & Salvaterra, P. M. (2000). Isolation and characterization of mutants for the vesicular acetylcholine transporter gene in Drosophila melanogaster. J Neurobiol, 42(2), 161-171. PMID: 10640324.

Wang, W., Kitamoto, T. & Salvaterra, P. M. (1999). Drosophila choline acetyltransferase temperature-sensitive mutants. Neurochem Res, 24(8), 1081-1087. PMID: 10478949.

Kitamoto, T. (1999). The Drosophila cholinergic locus – its operon-like structure and gene regulation. Reviews of Physiology, Biochemistry and Pharmacology 159, 16, 98-107.

Kitamoto, T., Wang, W. & Salvaterra, P. M. (1998). Structure and organization of the Drosophila cholinergic locus. J Biol Chem, 273(5), 2706-2713. PMID: 9446576.

Wang, W., Kitamoto, T. & Salvaterra, P. M. (1998). Heterologous expression and structure-function studies of choline acetyltransferase using temperature-sensitive mutants. (Vols. 24). pp. 1321. Society Neuroscience – Abstracts.

Yasuyama, K., Kitamoto, T. & Salvaterra, P. M. (1997). Distribution of putative cholinergic sensory neurons associated with proprioceptive and taste sensilla in the legs of Drosophila melanogaster. Comp Biochem Physiol, 14, 289.

Yasuyama, K., Kitamoto, T. & Salvaterra, P. M. (1996). Differential regulation of choline acetyltransferase expression in adult Drosophila melanogaster brain. J Neurobiol, 30(2), 205-218. PMID: 8738750.

Yasuyama, K., Kitamoto, T. & Salvaterra, P. M. (1996). Distribution and central projections of putative cholinergic leg sensory neurons in Drosophila. Zoolog Sci, 13(Suppl), 120.

Kitamoto, T., Wang, W., Sun, B. & Salvaterra, P. M. (1996). Structure and regulation of choline acetyltransferase and vesicular acetylcholine transporter genes in Drosophila. (Vols. 22). pp. 1032. Society Neuroscience – Abstracts.

Yasuyama, K., Kitamoto, T. & Salvaterra, P. M. (1996). Differential regulation of choline acetyltransferase expression in the central nervous system of Drosophila: a study using temperature-sensitive mutants. (Vols. 25). pp. 103. Neuroscience Research.

Yasuyama, K., Kitamoto, T. & Salvaterra, P. M. (1995). Localization of choline acetyltransferase-expressing neurons in the larval visual system of Drosophila melanogaster. Cell Tissue Res, 282(2), 193-202. PMID: 8565051.

Yasuyama, K., Kitamoto, T. & Salvaterra, P. M. (1995). Immunocytochemical study of choline acetyltransferase in Drosophila melanogaster: an analysis of cis-regulatory regions controlling expression in the brain of cDNA-transformed flies. J Comp Neurol, 361(1), 25-37. PMID: 8550879.

Kitamoto, T., Ikeda, K. & Salvaterra, P. M. (1995). Regulation of choline acetyltransferase/lacZ fusion gene expression in putative cholinergic neurons of Drosophila melanogaster. J Neurobiol, 28(1), 70-81. PMID: 8586966.

Kitamoto, T., Salvaterra, P. M. (1995). A POU homeo domain protein related to dPOU-19/pdm-1 binds to the regulatory DNA necessary for vital expression of the Drosophila choline acetyltransferase gene. J Neurosci, 15(5 Pt 1), 3509-3518. PMID: 7751926.

Kitamoto, T., Salv, P. M. & McCaman, R. E. (1994). A POU homeo domain protein related to dPOU-19/pdm-1 binds to the regulatory DNA necessary for vital expression of the Drosophila choline acetyltransferase gene. (Vols. 20). pp. 80. Society Neuroscience – Abstracts.

Liang, S., Kitamoto, T. & Salvaterra, P. M. (1994). An octamer-like motif may play an important role in ChAT gene regulation: cloning the ChAT gene regulatory region of D. virilis. (Vols. 20). pp. 80. Society Neuroscience – Abstracts.

Kitamoto, T., Salvaterra, P. M. (1993). Developmental regulatory elements in the 5' flanking DNA of the Drosophila choline acetyltransferase gene. Roux Arch Dev Biol, 202(3), 159-169. PMID: 28305993.

Salvaterra, P. M., Kitamoto, T. & Ikeda, K. (1993). Molecular genetic specification of cholinergic neurons. Prog Brain Res, 98, 167-173. PMID: 8248505.

Yasuyama, K., Kitamoto, T. & Salvaterra, P. M. (1993). Choline acetyltransferase expression in Drosophila cDNA transformants. (Vols. 19). pp. 915. Society Neuroscience – Abstracts.

Miyagawa-Tomita, S., Kitamoto, T., Momma, K., Takao, A. & Momoi, T. (1992). Cellular retinoic acid binding protein type II was preferentially localized in medium and posterior parts of the progress zone of the chick limb bud. Biochem Biophys Res Commun, 185(1), 217-223. PMID: 1318041.

Kitamoto, T., Ikeda, K. & Salvaterra, P. M. (1992). Analysis of cis-regulatory elements in the 5' flanking region of the Drosophila melanogaster choline acetyltransferase gene. J Neurosci, 12(5), 1628-1639. PMID: 1374460.

Kitamoto, T., Ikeda, K. & Salvaterra, P. M. (1992). Distribution of cholinergic neurons in whole mount preparations of Drosophila. (Vols. 18). pp. 1504. Society Neuroscience – Abstracts.

Andrisani, V., Kitamoto, T. & Sa, P. M. (1992). Feedback regulation of choline acetyltransferase expression in Drosophila. (Vols. 18). pp. 1504. Society Neuroscience – Abstracts.

Ikeda, K., Kitamoto, T. & Salvaterra, P. M. (1991). Analysis of regulatory elements in the 5’ flanking region of the Drosophila choline acetyltransferase gene. (Vols. 17). pp. 1521. Society Neuroscience – Abstracts.

Kitamoto, T., Ikeda, K. & Salvaterra, P. M. (1990). cis-Regulatory elements of the Drosophila choline acetyltransferase gene. (Vols. 16). pp. 199. Society for Neuroscience - Abstracts.

Kitamoto, T., Momoi, M. & Momoi, T. (1989). Expression of cellular retinoic acid binding protein II (chick-CRABP II) in the chick embryo. Biochem Biophys Res Commun, 164(1), 531-536. PMID: 2553021.

Momoi, T., Kitamoto, T., Kasuya-Sato, J., Seno, H. & Momoi, M. (1989). Developmental changes in the expression and distribution of cellular retinoic acid binding-protein (CRABP) in the central nervous system of the chick embryo. Biomedical Research, 10(1), 43-48.

Aikawa, H., Momoi, T., Kitamoto, T., Arahata, K. & Momoi, M. (1989). Expression of cellular retinoic acid binding protein (CRABP) in adult rat brain. Biomedical Research, 10(3), 247-250. DOI: 10.2220/biomedres.10.247.

Kitamoto, T., Momoi, T. & Momoi, M. (1988). The presence of a novel cellular retinoic acid-binding protein in chick embryos: purification and partial characterization. Biochem Biophys Res Commun, 157(3), 1302-1308. PMID: 2849937.

Momoi, T., Kitamoto, T., Seno, H. & Momoi, M. (1988). The distribution of cellular retinoic acid binding protein (CRABP) in the central nervous system of the chick embryo during the development. Proceedings of the Japan Academy, Series B, 64(9), 294-297. DOI: 10.2183/pjab.64.294.

Kitamoto, T., Nishigai, M., Sasaki, T. & Ikai, A. (1988). Structure of fatty acid synthetase from the Harderian gland of guinea pig. Proteolytic dissection and electron microscopic studies. J Mol Biol, 203(1), 183-195. PMID: 3184185.

Kitamoto, T., Nishigai, M., Ikai, A., Ohashi, K. & Seyama, Y. (1985). The quaternary structure and activity of newly purified fatty acid synthetase from the Harderian gland of guinea-pig. Biochim Biophys Acta, 827(2), 164-173. PMID: 3967036.

Ikai, A., Kitamoto, T. & Nishigai, M. (1983). Alpha-2-macroglobulin-like protease inhibitor from the egg white of cuban crocodile (Crocodylus rhombifer). J Biochem, 93(1), 121-127. PMID: 6188750.

Kitamoto, T., Nakashima, M. & Ikai, A. (1982). Hen egg white ovomacroglobulin has a protease inhibitory activity. J Biochem, 92(5), 1679-1682. PMID: 6185473.