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Kaczka Laboratory

David Kaczka

David Kaczka, MD, PhD, D.ABA
Associate Professor

Research Interests

My research interests focus on quantifying mechanical heterogeneity in diseases of the respiratory system, such as asthma, COPD, and acute lung injury. My lab relies on several advanced engineering techniques to quantify lung heterogeneity and optimize ventilation distribution, such as forced oscillation measurements of lung impedance, digital signal processing, image analysis, and computational modeling of respiratory mechanics.

  • Mechanical ventilation in ARDS
  • Respiratory physiology and gas exchange
  • Anesthetic delivery systems
  • Functional lung imaging


  • Amini, R., Herrmann, J., & Kaczka, D.W. (2017). Intratidal overdistention and derecruitment in the injured lung: A simulation study. IEEE Trans Biomed Eng 64: 681-689. [PubMed]
  • Herrmann, J., Hoffman, E.A., & Kaczka, D.W. (2017). Frequency-selective computed tomography: Applications during periodic thoracic motion. IEEE Trans Med Imaging 36: 1722-1732. [PubMed]
  • Herrmann, J., Tawhai, M.H., & Kaczka, D.W. (2016). Regional gas transport in the heterogeneous lung during oscillatory ventilation. J Appl Physiol (1985) 121: 1306-1318. [PubMed]
  • Kaczka, D.W., Herrmann, J., Zonneveld, C.E., Tingay, D.G., Lavizzari, A., Noble, P.B., & Pillow, J.J. (2015). Multifrequency oscillatory ventilation in the premature lung: Effects on gas exchange, mechanics, and ventilation distribution. Anesthesiology 123: 1394-1403. [PubMed]